HIVEP1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein 40''' is a [[protein]] that in humans is encoded by the ''HIVEP1'' [[gene]].<ref name="pmid2037300">{{cite journal |vauthors=Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ | title = Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24 | journal = Genomics | volume = 9 | issue = 4 | pages = 758–61 |date=Jul 1991 | pmid = 2037300 | pmc =  | doi =10.1016/0888-7543(91)90371-K }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3096| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_HIVEP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bbo.
| PDB = {{PDB2|1bbo}}, {{PDB2|3znf}}, {{PDB2|4znf}}
| Name = Human immunodeficiency virus type I enhancer binding protein 1
| HGNCid = 4920
| Symbol = HIVEP1
| AltSymbols =; MBP-1; CIRIP; CRYBP1; PRDII-BF1; ZNF40
| OMIM = 194540
| ECnumber = 
| Homologene = 1596
| MGIid = 96100
| GeneAtlas_image1 = PBB_GE_HIVEP1_204512_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
  | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3096
    | Hs_Ensembl = ENSG00000095951
    | Hs_RefseqProtein = NP_002105
    | Hs_RefseqmRNA = NM_002114
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 12120557
    | Hs_GenLoc_end = 12273218
    | Hs_Uniprot = P15822
    | Mm_EntrezGene = 110521
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_007772
    | Mm_RefseqProtein = NP_031798
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Human immunodeficiency virus type I enhancer binding protein 1''', also known as '''HIVEP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3096| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3096| accessdate = }}</ref>
| summary_text = Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Omichinski JG, Clore GM, Robien M, ''et al.'' |title=High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1. |journal=Biochemistry |volume=31 |issue= 16 |pages= 3907-17 |year= 1992 |pmid= 1567844 |doi=  }}
*{{cite journal   |vauthors=Omichinski JG, Clore GM, Robien M, etal |title=High-resolution solution structure of the double Cys2His2 zinc finger from the human enhancer binding protein MBP-1 |journal=Biochemistry |volume=31 |issue= 16 |pages= 3907–17 |year= 1992 |pmid= 1567844 |doi=10.1021/bi00131a004 }}
*{{cite journal | author=Nakamura T, Donovan DM, Hamada K, ''et al.'' |title=Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. |journal=Mol. Cell. Biol. |volume=10 |issue= 7 |pages= 3700-8 |year= 1990 |pmid= 1694016 |doi=  }}
*{{cite journal   |vauthors=Nakamura T, Donovan DM, Hamada K, etal |title=Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes |journal=Mol. Cell. Biol. |volume=10 |issue= 7 |pages= 3700–8 |year= 1990 |pmid= 1694016 |doi= | pmc=360816 }}
*{{cite journal | author=Muchardt C, Seeler JS, Nirula A, ''et al.'' |title=Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products. |journal=J. Virol. |volume=66 |issue= 1 |pages= 244-50 |year= 1992 |pmid= 1727488 |doi=  }}
*{{cite journal   |vauthors=Muchardt C, Seeler JS, Nirula A, etal |title=Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products |journal=J. Virol. |volume=66 |issue= 1 |pages= 244–50 |year= 1992 |pmid= 1727488 |doi=  | pmc=238281 }}
*{{cite journal  | author=Gaynor RB, Muchardt C, Diep A, ''et al.'' |title=Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24. |journal=Genomics |volume=9 |issue= 4 |pages= 758-61 |year= 1991 |pmid= 2037300 |doi=  }}
*{{cite journal  |vauthors=Fan CM, Maniatis T |title=A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence |journal=Genes Dev. |volume=4 |issue= 1 |pages= 29–42 |year= 1990 |pmid= 2106471 |doi=10.1101/gad.4.1.29 }}
*{{cite journal  | author=Fan CM, Maniatis T |title=A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. |journal=Genes Dev. |volume=4 |issue= 1 |pages= 29-42 |year= 1990 |pmid= 2106471 |doi=  }}
*{{cite journal  |vauthors=Baldwin AS, LeClair KP, Singh H, Sharp PA |title=A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes |journal=Mol. Cell. Biol. |volume=10 |issue= 4 |pages= 1406–14 |year= 1990 |pmid= 2108316 |doi= | pmc=362243 }}
*{{cite journal  | author=Baldwin AS, LeClair KP, Singh H, Sharp PA |title=A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. |journal=Mol. Cell. Biol. |volume=10 |issue= 4 |pages= 1406-14 |year= 1990 |pmid= 2108316 |doi=  }}
*{{cite journal   |vauthors=Omichinski JG, Clore GM, Appella E, etal |title=High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution |journal=Biochemistry |volume=29 |issue= 40 |pages= 9324–34 |year= 1991 |pmid= 2248949 |doi=10.1021/bi00492a004 }}
*{{cite journal | author=Omichinski JG, Clore GM, Appella E, ''et al.'' |title=High-resolution three-dimensional structure of a single zinc finger from a human enhancer binding protein in solution. |journal=Biochemistry |volume=29 |issue= 40 |pages= 9324-34 |year= 1991 |pmid= 2248949 |doi=  }}
*{{cite journal  |vauthors=Maekawa T, Sakura H, Sudo T, Ishii S |title=Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1 |journal=J. Biol. Chem. |volume=264 |issue= 25 |pages= 14591–3 |year= 1989 |pmid= 2504707 |doi=  }}
*{{cite journal  | author=Maekawa T, Sakura H, Sudo T, Ishii S |title=Putative metal finger structure of the human immunodeficiency virus type 1 enhancer binding protein HIV-EP1. |journal=J. Biol. Chem. |volume=264 |issue= 25 |pages= 14591-3 |year= 1989 |pmid= 2504707 |doi=  }}
*{{cite journal   |vauthors=Otsuka M, Fujita M, Aoki T, etal |title=Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B |journal=J. Med. Chem. |volume=38 |issue= 17 |pages= 3264–70 |year= 1995 |pmid= 7650680 |doi=10.1021/jm00017a011 }}
*{{cite journal | author=Otsuka M, Fujita M, Aoki T, ''et al.'' |title=Novel zinc chelators with dual activity in the inhibition of the kappa B site-binding proteins HIV-EP1 and NF-kappa B. |journal=J. Med. Chem. |volume=38 |issue= 17 |pages= 3264-70 |year= 1995 |pmid= 7650680 |doi=  }}
*{{cite journal  |vauthors=Seeler JS, Muchardt C, Suessle A, Gaynor RB |title=Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression |journal=J. Virol. |volume=68 |issue= 2 |pages= 1002–9 |year= 1994 |pmid= 8289330 |doi= | pmc=236538 }}
*{{cite journal  | author=Seeler JS, Muchardt C, Suessle A, Gaynor RB |title=Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression. |journal=J. Virol. |volume=68 |issue= 2 |pages= 1002-9 |year= 1994 |pmid= 8289330 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Wissmüller S, Kosian T, Wolf M, etal |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735–44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105 | pmc=1421504 }}
*{{cite journal | author=Wissmüller S, Kosian T, Wolf M, ''et al.'' |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735-44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=3096}}


== External links ==
== External links ==
* {{MeshName|HIVEP1+protein,+human}}
* {{MeshName|HIVEP1+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]
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Latest revision as of 13:44, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.[1][2]

Members of the ZAS family, such as ZAS1 (HIVEP1), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][2]

References

  1. ↑ Gaynor RB, Muchardt C, Diep A, Mohandas TK, Sparkes RS, Lusis AJ (Jul 1991). "Localization of the zinc finger DNA-binding protein HIV-EP1/MBP-1/PRDII-BF1 to human chromosome 6p22.3-p24". Genomics. 9 (4): 758–61. doi:10.1016/0888-7543(91)90371-K. PMID 2037300.
  2. ↑ 2.0 2.1 "Entrez Gene: HIVEP1 human immunodeficiency virus type I enhancer binding protein 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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