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{{Infobox_gene}}
{{PBB_Controls
'''Protein deltex-2''' also known as '''E3 ubiquitin-protein ligase DTX2''' is an [[enzyme]] that in humans is encoded by the ''DTX2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DTX2 deltex homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113878| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
DTX2 functions as a [[Ubiquitin ligase#Individual E3 ubiquitin ligases|ubiquitin E3 ligase]] in conjunction with the E2 enzyme [[UBE2D1|UBCH5A]].<ref name="pmid12670957">{{cite journal | vauthors = Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA | title = The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity | journal = J. Biol. Chem. | volume = 278 | issue = 24 | pages = 21930–7 | year = 2003  | pmid = 12670957 | doi = 10.1074/jbc.M301157200 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Deltex homolog 2 (Drosophila)
| HGNCid = 15973
| Symbol = DTX2
| AltSymbols =; KIAA1528; MGC71098; RNF58
| OMIM = 
| ECnumber = 
| Homologene = 56904
| MGIid = 1921448
| GeneAtlas_image1 = PBB_GE_DTX2_215732_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 113878
    | Hs_Ensembl = ENSG00000091073
    | Hs_RefseqProtein = XP_001133140
    | Hs_RefseqmRNA = XM_001133140
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 75928954
    | Hs_GenLoc_end = 75973241
    | Hs_Uniprot = Q86UW9
    | Mm_EntrezGene = 74198
    | Mm_Ensembl = ENSMUSG00000004947
    | Mm_RefseqmRNA = NM_023742
    | Mm_RefseqProtein = NP_076231
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 136279432
    | Mm_GenLoc_end = 136317491
    | Mm_Uniprot = Q8R3P2
  }}
}}
'''Deltex homolog 2 (Drosophila)''', also known as '''DTX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DTX2 deltex homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113878| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==References==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Matsuno K |title=Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats |journal=Development |volume=121 |issue= 8 |pages= 2633–44 |year= 1995 |pmid= 7671825 |doi=  |name-list-format=vanc| author2=Diederich RJ  | author3=Go MJ  | display-authors=3  | last4=Blaumueller  | first4=CM  | last5=Artavanis-Tsakonas  | first5=S }}
| citations =
*{{cite journal  | author=Kishi N |title=Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis |journal=Int. J. Dev. Neurosci. |volume=19 |issue= 1 |pages= 21–35 |year= 2001 |pmid= 11226752 |doi=10.1016/S0736-5748(00)00071-X |name-list-format=vanc| author2=Tang Z  | author3=Maeda Y  | display-authors=3  | last4=Hirai  | first4=Asami  | last5=Mo | first5=Rong  | last6=Ito  | first6=Mikiko  | last7=Suzuki  | first7=Satoshi  | last8=Nakao  | first8=Keiko  | last9=Kinoshita  | first9=Tsutomu  }}
*{{cite journal  | author=Matsuno K, Diederich RJ, Go MJ, ''et al.'' |title=Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. |journal=Development |volume=121 |issue= 8 |pages= 2633-44 |year= 1995 |pmid= 7671825 |doi= }}
*{{cite journal  | author=Yamamoto N |title=Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45031–40 |year= 2002 |pmid= 11564735 |doi= 10.1074/jbc.M105245200 |name-list-format=vanc| author2=Yamamoto S  | author3=Inagaki F | display-authors=3  | last4=Kawaichi | first4=M | last5=Fukamizu  | first5=A  | last6=Kishi  | first6=N  | last7=Matsuno  | first7=K  | last8=Nakamura  | first8=K | last9=Weinmaster  | first9=G }}
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 2 |pages= 143-50 |year= 2000 |pmid= 10819331 |doi=  }}
*{{cite journal  | author=Benzinger A |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200  |name-list-format=vanc| author2=Muster N  | author3=Koch HB  | display-authors=3  | last4=Yates Jr  | first4=3rd | last5=Hermeking  | first5=H }}
*{{cite journal  | author=Kishi N, Tang Z, Maeda Y, ''et al.'' |title=Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. |journal=Int. J. Dev. Neurosci. |volume=19 |issue= 1 |pages= 21-35 |year= 2001 |pmid= 11226752 |doi= }}
*{{cite journal  | author=Hiller M |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291–302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151 | pmc=1380236  |name-list-format=vanc| author2=Huse K  | author3=Szafranski K  | display-authors=3  | last4=Jahn  | first4=Niels  | last5=Hampe  | first5=Jochen  | last6=Schreiber  | first6=Stefan  | last7=Backofen  | first7=Rolf  | last8=Platzer  | first8=Matthias }}
*{{cite journal | author=Yamamoto N, Yamamoto S, Inagaki F, ''et al.'' |title=Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45031-40 |year= 2002 |pmid= 11564735 |doi= 10.1074/jbc.M105245200 }}
*{{cite journal  | author=Lim J |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |name-list-format=vanc| author2=Hao T  | author3=Shaw C  | display-authors=3  | last4=Patel  | first4=Akash J  | last5=Szabó  | first5=Gábor  | last6=Rual  | first6=Jean-François  | last7=Fisk  | first7=C. Joseph  | last8=Li  | first8=Ning  | last9=Smolyar  | first9=Alex }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Yi Z, Yi T, Wu Z |title=cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos |journal=DNA Seq. |volume=17 |issue= 3 |pages= 175–80 |year= 2007 |pmid= 17286044 |doi=10.1080/10425170600857616 }}
*{{cite journal  | author=Takeyama K, Aguiar RC, Gu L, ''et al.'' |title=The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21930-7 |year= 2003 |pmid= 12670957 |doi= 10.1074/jbc.M301157200 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Hiller M, Huse K, Szafranski K, ''et al.'' |title=Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. |journal=Am. J. Hum. Genet. |volume=78 |issue= 2 |pages= 291-302 |year= 2007 |pmid= 16400609 |doi= 10.1086/500151 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Yi Z, Yi T, Wu Z |title=cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. |journal=DNA Seq. |volume=17 |issue= 3 |pages= 175-80 |year= 2007 |pmid= 17286044 |doi=  }}
}}
{{refend}}
{{refend}}


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* {{MeshName|DTX2+protein,+human}}
* {{MeshName|DTX2+protein,+human}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
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{{gene-7-stub}}

Latest revision as of 18:44, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.[1]

DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.[2]

References

  1. ↑ "Entrez Gene: DTX2 deltex homolog 2 (Drosophila)".
  2. ↑ Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC, Shipp MA (2003). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". J. Biol. Chem. 278 (24): 21930–7. doi:10.1074/jbc.M301157200. PMID 12670957.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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