KLF13: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (1 revision imported)
 
(2 intermediate revisions by 2 users not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Kruppel-like factor 13''', also known as '''KLF13''', is a [[protein]] that in humans is encoded by the ''KLF13'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLF13 Kruppel-like factor 13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621| accessdate = }}</ref><ref name="pmid10415854">{{cite journal | vauthors = Cook T, Gebelein B, Urrutia R | title = Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors | journal = Annals of the New York Academy of Sciences | volume = 880 | issue = 1 CELL AND MOLE | pages = 94–102 | date = Jun 1999 | pmid = 10415854 | doi = 10.1111/j.1749-6632.1999.tb09513.x }}</ref><ref name="pmid10023774"/> 
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
There is some evidence for ''KLF13'' having a role in obesity.  A methylation site, cg07814318, within the first [[intron]] of ''KLF13'' has been associated with obesity and orexigenic processes.<ref name="pmid28194012">{{cite journal | vauthors = Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB | title = A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels. | journal = Int J Obes (Lond) | volume = 43 | date = 14 Feb 2017 | pmid = 28194012 | doi = 10.1038/ijo.2017.43 }}</ref> [[Ghrelin]] levels also positively correlated with methylation levels of cg07814318.<ref name="pmid28194012" /> Moreover, expression levels of ''KLF13'' were decreased and increased in the brains of starved and obese mice, respectively.<ref name="pmid28194012" />
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Kruppel-like factor 13
| HGNCid = 13672
| Symbol = KLF13
| AltSymbols =; BTEB3; FKLF2; NSLP1; RFLAT-1; RFLAT1
| OMIM = 605328
| ECnumber =
| Homologene = 32288
| MGIid = 1354948
| GeneAtlas_image1 = PBB_GE_KLF13_219878_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
  | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51621
    | Hs_Ensembl = ENSG00000169926
    | Hs_RefseqProtein = NP_057079
    | Hs_RefseqmRNA = NM_015995
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 29406375
    | Hs_GenLoc_end = 29457393
    | Hs_Uniprot = Q9Y2Y9
    | Mm_EntrezGene = 50794
    | Mm_Ensembl = ENSMUSG00000052040
    | Mm_RefseqmRNA = NM_021366
    | Mm_RefseqProtein = NP_067341
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 63770327
    | Mm_GenLoc_end = 63817865
    | Mm_Uniprot = Q3U2G6
  }}
}}
'''Kruppel-like factor 13''', also known as '''KLF13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLF13 Kruppel-like factor 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: KLF13 Kruppel-like factor 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621| accessdate = }}</ref>
}}


==See also==
KLF13 belongs to a family of [[transcription factors]] that contain 3 classical [[zinc finger]] DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.<ref name="entrez" /><ref name="pmid11087666">{{cite journal | vauthors = Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C | title = Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family | journal = Genomics | volume = 70 | issue = 1 | pages = 93–101 | date = Nov 2000 | pmid = 11087666 | doi = 10.1006/geno.2000.6362 }}</ref>
 
KLF13 was first described as the [[RANTES]] factor of late activated [[T lymphocyte]]s (RFLAT)-1.<ref name="pmid10023774">{{cite journal | vauthors = Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM | title = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes | journal = Immunity | volume = 10 | issue = 1 | pages = 93–103 | date = Jan 1999 | pmid = 10023774 | doi = 10.1016/S1074-7613(00)80010-2 }}</ref>  It regulates the expression of the [[chemokine]] RANTES in T lymphocytes.  It functions as a lynchpin, inducing a large enhancesome.  KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of [[Bcl-xL]] expression.<ref name="pmid10023774" /><ref name="pmid11138780">{{cite journal | vauthors = Song A, Nikolcheva T, Krensky AM | title = Transcriptional regulation of RANTES expression in T lymphocytes | journal = Immunological Reviews | volume = 177 | issue = 1 | pages = 236–45 | date = Oct 2000 | pmid = 11138780 | doi = 10.1034/j.1600-065X.2000.17610.x }}</ref><ref name="pmid12093895">{{cite journal | vauthors = Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM | title = A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes | journal = The Journal of Clinical Investigation | volume = 110 | issue = 1 | pages = 119–26 | date = Jul 2002 | pmid = 12093895 | pmc = 151028 | doi = 10.1172/JCI15336 }}</ref><ref name="pmid12050170">{{cite journal | vauthors = Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM | title = Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30055–65 | date = Aug 2002 | pmid = 12050170 | doi = 10.1074/jbc.M204278200 }}</ref><ref name="pmid17442931">{{cite journal | vauthors = Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM | title = Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo | journal = Journal of Immunology | volume = 178 | issue = 9 | pages = 5496–504 | date = May 2007 | pmid = 17442931 | pmc = 2664650 | doi = 10.4049/jimmunol.178.9.5496 | url = http://www.jimmunol.org/cgi/content/abstract/178/9/5496 }}</ref><ref name="pmid17513757">{{cite journal | vauthors = Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM | title = Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription | journal = Journal of Immunology | volume = 178 | issue = 11 | pages = 7081–7 | date = Jun 2007 | pmid = 17513757 | pmc = 2674583 | doi = 10.4049/jimmunol.178.11.7081 | url = http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=17513757 }}</ref><ref name="pmid17074812">{{cite journal | vauthors = Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM | title = Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes | journal = Molecular and Cellular Biology | volume = 27 | issue = 1 | pages = 253–66 | date = Jan 2007 | pmid = 17074812 | pmc = 1800668 | doi = 10.1128/MCB.01071-06 }}</ref>
 
== Interactions ==
 
KLF13 has been shown to [[Protein-protein interaction|interact]] with [[CREB-binding protein]],<ref name=pmid11748222>{{cite journal | vauthors = Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G |authorlink5=George Stamatoyannopoulos | title = Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7029–36 | date = Mar 2002 | pmid = 11748222 | pmc = 2808425 | doi = 10.1074/jbc.M108826200 }}</ref> [[Heat shock protein 47]]<ref name=pmid11748222/> and [[PCAF]].<ref name=pmid11748222/>
 
== See also ==
* [[Kruppel-like factors]]
* [[Kruppel-like factors]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cook T, Gebelein B, Urrutia R | title = Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors | journal = Annals of the New York Academy of Sciences | volume = 880 | issue = 1 CELL AND MOLE | pages = 94–102 | date = Jun 1999 | pmid = 10415854 | doi = 10.1111/j.1749-6632.1999.tb09513.x }}
| citations =
* {{cite journal | vauthors = Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM | title = RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes | journal = Immunity | volume = 10 | issue = 1 | pages = 93–103 | date = Jan 1999 | pmid = 10023774 | doi = 10.1016/S1074-7613(00)80010-2 }}
*{{cite journal | author=Cook T, Gebelein B, Urrutia R |title=Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors. |journal=Ann. N. Y. Acad. Sci. |volume=880 |issue= |pages= 94-102 |year= 1999 |pmid= 10415854 |doi= }}
* {{cite journal | vauthors = Asano H, Li XS, Stamatoyannopoulos G | title = FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes | journal = Blood | volume = 95 | issue = 11 | pages = 3578–84 | date = Jun 2000 | pmid = 10828046 | doi =  }}
*{{cite journal | author=Song A, Chen YF, Thamatrakoln K, ''et al.'' |title=RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes. |journal=Immunity |volume=10 |issue= 1 |pages= 93-103 |year= 1999 |pmid= 10023774 |doi= }}
* {{cite journal | vauthors = Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C | title = Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family | journal = Genomics | volume = 70 | issue = 1 | pages = 93–101 | date = Nov 2000 | pmid = 11087666 | doi = 10.1006/geno.2000.6362 }}
*{{cite journal | author=Asano H, Li XS, Stamatoyannopoulos G |title=FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes. |journal=Blood |volume=95 |issue= 11 |pages= 3578-84 |year= 2000 |pmid= 10828046 |doi=  }}
* {{cite journal | vauthors = Kaczynski J, Zhang JS, Ellenrieder V, Conley A, Duenes T, Kester H, van Der Burg B, Urrutia R | title = The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 39 | pages = 36749–56 | date = Sep 2001 | pmid = 11477107 | doi = 10.1074/jbc.M105831200 }}
*{{cite journal | author=Scohy S, Gabant P, Van Reeth T, ''et al.'' |title=Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family. |journal=Genomics |volume=70 |issue= 1 |pages= 93-101 |year= 2001 |pmid= 11087666 |doi= 10.1006/geno.2000.6362 }}
* {{cite journal | vauthors = Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G | title = Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7029–36 | date = Mar 2002 | pmid = 11748222 | pmc = 2808425 | doi = 10.1074/jbc.M108826200 }}
*{{cite journal | author=Kaczynski J, Zhang JS, Ellenrieder V, ''et al.'' |title=The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1. |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36749-56 |year= 2001 |pmid= 11477107 |doi= 10.1074/jbc.M105831200 }}
* {{cite journal | vauthors = Kaczynski JA, Conley AA, Fernandez Zapico M, Delgado SM, Zhang JS, Urrutia R | title = Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter | journal = The Biochemical Journal | volume = 366 | issue = Pt 3 | pages = 873–82 | date = Sep 2002 | pmid = 12036432 | pmc = 1222816 | doi = 10.1042/BJ20020388 }}
*{{cite journal | author=Song CZ, Keller K, Murata K, ''et al.'' |title=Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7029-36 |year= 2002 |pmid= 11748222 |doi= 10.1074/jbc.M108826200 }}
* {{cite journal | vauthors = Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM | title = Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes | journal = The Journal of Biological Chemistry | volume = 277 | issue = 33 | pages = 30055–65 | date = Aug 2002 | pmid = 12050170 | doi = 10.1074/jbc.M204278200 }}
*{{cite journal | author=Kaczynski JA, Conley AA, Fernandez Zapico M, ''et al.'' |title=Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. |journal=Biochem. J. |volume=366 |issue= Pt 3 |pages= 873-82 |year= 2002 |pmid= 12036432 |doi= 10.1042/BJ20020388 }}
* {{cite journal | vauthors = Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM | title = A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes | journal = The Journal of Clinical Investigation | volume = 110 | issue = 1 | pages = 119–26 | date = Jul 2002 | pmid = 12093895 | pmc = 151028 | doi = 10.1172/JCI15336 }}
*{{cite journal | author=Song A, Patel A, Thamatrakoln K, ''et al.'' |title=Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30055-65 |year= 2002 |pmid= 12050170 |doi= 10.1074/jbc.M204278200 }}
* {{cite journal | vauthors = Mitsuma A, Asano H, Kinoshita T, Murate T, Saito H, Stamatoyannopoulos G, Naoe T | title = Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells | journal = Biochimica et Biophysica Acta | volume = 1727 | issue = 2 | pages = 125–33 | date = Feb 2005 | pmid = 15716005 | pmc = 2808416 | doi = 10.1016/j.bbaexp.2004.12.007 }}
*{{cite journal | author=Nikolcheva T, Pyronnet S, Chou SY, ''et al.'' |title=A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. |journal=J. Clin. Invest. |volume=110 |issue= 1 |pages= 119-26 |year= 2002 |pmid= 12093895 |doi=  }}
* {{cite journal | vauthors = Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA | title = A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element | journal = Blood Cells, Molecules & Diseases | volume = 35 | issue = 2 | pages = 227–35 | year = 2006 | pmid = 16023392 | doi = 10.1016/j.bcmd.2005.04.009 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM | title = Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes | journal = Molecular and Cellular Biology | volume = 27 | issue = 1 | pages = 253–66 | date = Jan 2007 | pmid = 17074812 | pmc = 1800668 | doi = 10.1128/MCB.01071-06 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM | title = Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription | journal = Journal of Immunology | volume = 178 | issue = 11 | pages = 7081–7 | date = Jun 2007 | pmid = 17513757 | pmc = 2674583 | doi = 10.4049/jimmunol.178.11.7081 }}
*{{cite journal | author=Mitsuma A, Asano H, Kinoshita T, ''et al.'' |title=Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells. |journal=Biochim. Biophys. Acta |volume=1727 |issue= 2 |pages= 125-33 |year= 2005 |pmid= 15716005 |doi= 10.1016/j.bbaexp.2004.12.007 }}
*{{cite journal | author=Zhang P, Basu P, Redmond LC, ''et al.'' |title=A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element. |journal=Blood Cells Mol. Dis. |volume=35 |issue= 2 |pages= 227-35 |year= 2006 |pmid= 16023392 |doi= 10.1016/j.bcmd.2005.04.009 }}
*{{cite journal | author=Ahn YT, Huang B, McPherson L, ''et al.'' |title=Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes. |journal=Mol. Cell. Biol. |volume=27 |issue= 1 |pages= 253-66 |year= 2007 |pmid= 17074812 |doi= 10.1128/MCB.01071-06 }}
*{{cite journal | author=Huang B, Ahn YT, McPherson L, ''et al.'' |title=Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription. |journal=J. Immunol. |volume=178 |issue= 11 |pages= 7081-7 |year= 2007 |pmid= 17513757 |doi= }}
}}
{{refend}}
{{refend}}


Line 86: Line 41:


{{NLM content}}
{{NLM content}}
{{protein-stub}}
{{Transcription factors|g2}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 12:45, 9 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[1][2][3]

There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.[4] Ghrelin levels also positively correlated with methylation levels of cg07814318.[4] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.[4]

Function

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[1][5]

KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[3] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[3][6][7][8][9][10][11]

Interactions

KLF13 has been shown to interact with CREB-binding protein,[12] Heat shock protein 47[12] and PCAF.[12]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: KLF13 Kruppel-like factor 13".
  2. ↑ Cook T, Gebelein B, Urrutia R (Jun 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences. 880 (1 CELL AND MOLE): 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.
  3. ↑ 3.0 3.1 3.2 Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (Jan 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity. 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
  4. ↑ 4.0 4.1 4.2 Wiemerslage L, Islam R, van der Kamp C, Cao H, Olivo G, Ence-Eriksson F, Castillo S, Larsen AL, Bandstein M, Dahlberg LS, Perland E, Gustavsson V, Nilsson J, Vogel H, Schürmann A, Larsson EM, Rask-Andersen M, Benedict C, Schiöth HB (14 Feb 2017). "A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels". Int J Obes (Lond). 43. doi:10.1038/ijo.2017.43. PMID 28194012.
  5. ↑ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics. 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
  6. ↑ Song A, Nikolcheva T, Krensky AM (Oct 2000). "Transcriptional regulation of RANTES expression in T lymphocytes". Immunological Reviews. 177 (1): 236–45. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.
  7. ↑ Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM (Jul 2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation. 110 (1): 119–26. doi:10.1172/JCI15336. PMC 151028. PMID 12093895.
  8. ↑ Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (Aug 2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.
  9. ↑ Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM (May 2007). "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". Journal of Immunology. 178 (9): 5496–504. doi:10.4049/jimmunol.178.9.5496. PMC 2664650. PMID 17442931.
  10. ↑ Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM (Jun 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC 2674583. PMID 17513757.
  11. ↑ Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM (Jan 2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC 1800668. PMID 17074812.
  12. ↑ 12.0 12.1 12.2 Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G (Mar 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry. 277 (9): 7029–36. doi:10.1074/jbc.M108826200. PMC 2808425. PMID 11748222.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=KLF13&oldid=1519549"