EGR3: Difference between revisions

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{{Infobox_gene}}
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'''Early growth response protein 3''' is a [[protein]] in humans, encoded by the ''EGR3'' [[gene]].<ref name="pmid1906159">{{cite journal | vauthors = Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP | title = EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors | journal = Oncogene | volume = 6 | issue = 6 | pages = 917–28 |date=Aug 1991 | pmid = 1906159 | pmc =  | doi = }}</ref><ref name="pmid11909874">{{cite journal | vauthors = Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD | title = HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter | journal = J Biol Chem | volume = 277 | issue = 22 | pages = 19482–19487 |date=May 2002 | pmid = 11909874 | pmc =  | doi = 10.1074/jbc.M201687200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EGR3 early growth response 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1960| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Early growth response 3
| HGNCid = 3240
| Symbol = EGR3
| AltSymbols =; MGC138484; PILOT
| OMIM = 602419
| ECnumber = 
| Homologene = 37923
| MGIid = 1306780
| GeneAtlas_image1 = PBB_GE_EGR3_206115_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007274 |text = neuromuscular synaptic transmission}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0007517 |text = muscle development}} {{GNF_GO|id=GO:0007623 |text = circadian rhythm}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1960
    | Hs_Ensembl = ENSG00000179388
    | Hs_RefseqProtein = XP_001130047
    | Hs_RefseqmRNA = XM_001130047
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 22601117
    | Hs_GenLoc_end = 22606760
    | Hs_Uniprot = Q06889
    | Mm_EntrezGene = 13655
    | Mm_Ensembl = ENSMUSG00000033730
    | Mm_RefseqmRNA = NM_018781
    | Mm_RefseqProtein = NP_061251
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 68812525
    | Mm_GenLoc_end = 68815237
    | Mm_Uniprot = Q3ZB14
  }}
}}
'''Early growth response 3''', also known as '''EGR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EGR3 early growth response 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1960| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic  stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also plays a role in muscle development.<ref name="entrez">{{cite web | title = Entrez Gene: EGR3 early growth response 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1960| accessdate = }}</ref>
| summary_text = The gene encodes a [[transcriptional regulator]] that belongs to the [[early growth response proteins|EGR]] family of C2H2-type [[zinc-finger]] proteins. It is an immediate-early growth response gene which is induced by [[mitogenic]] stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling [[biological rhythm]]. It may also play a role in [[muscle]] development.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yamada K, Gerber DJ, Iwayama Y, ''et al.'' |title=Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 8 |pages= 2815-20 |year= 2007 |pmid= 17360599 |doi= 10.1073/pnas.0610765104 }}
*{{cite journal  | author=Yamada K |title=Genetic analysis of the calcineurin pathway identifies members of the EGR gene family, specifically EGR3, as potential susceptibility candidates in schizophrenia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 8 |pages= 2815–2820 |year= 2007 |pmid= 17360599 |doi= 10.1073/pnas.0610765104 | pmc=1815264  |name-list-format=vanc| author2=Gerber DJ  | author3=Iwayama Y  | display-authors=3  | last4=Ohnishi  | first4=T.  | last5=Ohba  | first5=H.  | last6=Toyota  | first6=T.  | last7=Aruga  | first7=J.  | last8=Minabe  | first8=Y.  | last9=Tonegawa  | first9=S. }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Yoo YG, Lee MO |title=Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor. |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36242-9 |year= 2004 |pmid= 15173177 |doi= 10.1074/jbc.M401290200 }}
*{{cite journal  | vauthors=Yoo YG, Lee MO |title=Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor |journal=J. Biol. Chem. |volume=279 |issue= 35 |pages= 36242–36249 |year= 2004 |pmid= 15173177 |doi= 10.1074/jbc.M401290200 }}
*{{cite journal  | author=Inoue A, Omoto Y, Yamaguchi Y, ''et al.'' |title=Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. |journal=J. Mol. Endocrinol. |volume=32 |issue= 3 |pages= 649-61 |year= 2005 |pmid= 15171706 |doi=  }}
*{{cite journal  | author=Inoue A |title=Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells |journal=J. Mol. Endocrinol. |volume=32 |issue= 3 |pages= 649–661 |year= 2005 |pmid= 15171706 |doi=10.1677/jme.0.0320649  |name-list-format=vanc| author2=Omoto Y  | author3=Yamaguchi Y  | display-authors=3  | last4=Kiyama  | first4=R  | last5=Hayashi  | first5=SI }}
*{{cite journal  | author=Liu D, Jia H, Holmes DI, ''et al.'' |title=Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 11 |pages= 2002-7 |year= 2004 |pmid= 14525795 |doi= 10.1161/01.ATV.0000098644.03153.6F }}
*{{cite journal  | author=Liu D |title=Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1 |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 11 |pages= 2002–2007 |year= 2004 |pmid= 14525795 |doi= 10.1161/01.ATV.0000098644.03153.6F |name-list-format=vanc| author2=Jia H  | author3=Holmes DI  | display-authors=3  | last4=Stannard  | first4=A  | last5=Zachary  | first5=I }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Yang Y, Dong B, Mittelstadt PR, ''et al.'' |title=HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19482-7 |year= 2002 |pmid= 11909874 |doi= 10.1074/jbc.M201687200 }}
*{{cite journal  | vauthors=Tourtellotte WG, Milbrandt J |title=Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3 |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 87–91 |year= 1998 |pmid= 9731539 |doi= 10.1038/1757 }}
*{{cite journal  | author=Tourtellotte WG, Milbrandt J |title=Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 87-91 |year= 1998 |pmid= 9731539 |doi= 10.1038/1757 }}
*{{cite journal  | author=Morris ME |title=A screen for genes induced in the suprachiasmatic nucleus by light |journal=Science |volume=279 |issue= 5356 |pages= 1544–1547 |year= 1998 |pmid= 9488654 |doi=10.1126/science.279.5356.1544  |name-list-format=vanc| author2=Viswanathan N  | author3=Kuhlman S  | display-authors=3  | last4=Davis  | first4=FC  | last5=Weitz  | first5=CJ }}
*{{cite journal  | author=Morris ME, Viswanathan N, Kuhlman S, ''et al.'' |title=A screen for genes induced in the suprachiasmatic nucleus by light. |journal=Science |volume=279 |issue= 5356 |pages= 1544-7 |year= 1998 |pmid= 9488654 |doi=  }}
*{{cite journal  | author=Hillier LD |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–828 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807  |name-list-format=vanc| author2=Lennon G  | author3=Becker M  | display-authors=3  | last4=Bonaldo  | first4=M F  | last5=Chiapelli  | first5=B  | last6=Chissoe  | first6=S  | last7=Dietrich  | first7=N  | last8=Dubuque  | first8=T  | last9=Favello  | first9=A }}
*{{cite journal  | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal  | author=Mages HW |title=Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells |journal=Int. Immunol. |volume=5 |issue= 1 |pages= 63–70 |year= 1993 |pmid= 8443122 |doi=10.1093/intimm/5.1.63 |name-list-format=vanc| author2=Stamminger T  | author3=Rilke O  | display-authors=3  | last4=Bravo  | first4=Rodrigo  | last5=Kroczek  | first5=Richard A. }}
*{{cite journal  | author=Mages HW, Stamminger T, Rilke O, ''et al.'' |title=Expression of PILOT, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells. |journal=Int. Immunol. |volume=5 |issue= 1 |pages= 63-70 |year= 1993 |pmid= 8443122 |doi= }}
*{{cite journal | author=Patwardhan S, Gashler A, Siegel MG, ''et al.'' |title=EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. |journal=Oncogene |volume=6 |issue= 6 |pages= 917-28 |year= 1991 |pmid= 1906159 |doi=  }}
}}
}}
{{refend}}
{{refend}}
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* {{MeshName|EGR3+protein,+human}}
* {{MeshName|EGR3+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]
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Latest revision as of 08:43, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.[1][2][3]

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.[3]

References

  1. ↑ Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene. 6 (6): 917–28. PMID 1906159.
  2. ↑ Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem. 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874.
  3. ↑ 3.0 3.1 "Entrez Gene: EGR3 early growth response 3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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