ZEB1: Difference between revisions

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* {{cite journal | vauthors = Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S | title = Effects of HIV-1 Nef on cellular gene expression profiles | journal = Journal of Biomedical Science | volume = 9 | issue = 1 | pages = 82–96 | year = 2002 | pmid = 11810028 | doi = 10.1007/BF02256581 }}
* {{cite journal | vauthors = Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S | title = Effects of HIV-1 Nef on cellular gene expression profiles | journal = Journal of Biomedical Science | volume = 9 | issue = 1 | pages = 82–96 | year = 2002 | pmid = 11810028 | doi = 10.1007/BF02256581 }}
* {{cite journal | vauthors = Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J | title = Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 42 | pages = 39209–16 | date = October 2002 | pmid = 12161443 | doi = 10.1074/jbc.M206400200 }}
* {{cite journal | vauthors = Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J | title = Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 42 | pages = 39209–16 | date = October 2002 | pmid = 12161443 | doi = 10.1074/jbc.M206400200 }}
* {{cite journal | vauthors = Costantino ME, Stearman RP, Smith GE, Darling DS | title = Cell-specific phosphorylation of Zfhep transcription factor | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 2 | pages = 368–73 | date = August 2002 | pmid = 12163027 | doi = 10.1016/S0006-291X(02)00880-X }}
* {{cite journal | vauthors = Costantino ME, Stearman RP, Smith GE, Darling DS | title = Cell-specific phosphorylation of Zfhep transcription factor | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 2 | pages = 368–73 | date = August 2002 | pmid = 12163027 | doi = 10.1016/S0006-291X(02)00880-X | pmc = 3682420 }}
* {{cite journal | vauthors = Postigo AA | title = Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway | journal = The EMBO Journal | volume = 22 | issue = 10 | pages = 2443–52 | date = May 2003 | pmid = 12743038 | pmc = 155983 | doi = 10.1093/emboj/cdg225 }}
* {{cite journal | vauthors = Postigo AA | title = Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway | journal = The EMBO Journal | volume = 22 | issue = 10 | pages = 2443–52 | date = May 2003 | pmid = 12743038 | pmc = 155983 | doi = 10.1093/emboj/cdg225 }}
* {{cite journal | vauthors = Postigo AA, Depp JL, Taylor JJ, Kroll KL | title = Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins | journal = The EMBO Journal | volume = 22 | issue = 10 | pages = 2453–62 | date = May 2003 | pmid = 12743039 | pmc = 155984 | doi = 10.1093/emboj/cdg226 }}
* {{cite journal | vauthors = Postigo AA, Depp JL, Taylor JJ, Kroll KL | title = Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins | journal = The EMBO Journal | volume = 22 | issue = 10 | pages = 2453–62 | date = May 2003 | pmid = 12743039 | pmc = 155984 | doi = 10.1093/emboj/cdg226 }}

Latest revision as of 15:53, 15 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[1][2][3]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[3][4] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[5] The structure of the homeodomain shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[6]

References

  1. Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
  2. Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  3. 3.0 3.1 "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
  4. Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  5. Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.
  6. Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

Further reading

External links