ZEB1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
imported>OAbot
m (Open access bot: add pmc identifier to citation with #oabot.)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger E-box-binding homeobox 1''' is a [[protein]] that in humans is encoded by the ''ZEB1'' [[gene]].<ref name="pmid1427828">{{cite journal | vauthors = Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB | title = The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2 | journal = Genomics | volume = 14 | issue = 1 | pages = 194–6 | date = September 1992 | pmid = 1427828 | pmc =  | doi = 10.1016/S0888-7543(05)80307-6 }}</ref><ref name="pmid1840704">{{cite journal | vauthors = Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA | title = Identification of a zinc finger protein that inhibits IL-2 gene expression | journal = Science | volume = 254 | issue = 5039 | pages = 1791–4 | date = December 1991 | pmid = 1840704 | pmc = | doi = 10.1126/science.1840704 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
ZEB1 (previously known as TCF8) encodes a [[zinc finger]] and [[homeodomain]] [[transcription factor]] that represses T-lymphocyte-specific [[interleukin 2|IL2]] gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 [[transcription start site]].<ref name="entrez" /><ref name=autogenerated1>{{cite journal | vauthors = Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA | title = Identification of a zinc finger protein that inhibits IL-2 gene expression | journal = Science | volume = 254 | issue = 5039 | pages = 1791–4 | date = December 1991 | pmid = 1840704 | doi = 10.1126/science.1840704 }}</ref> ZEB1 and its mammalian paralog [[ZEB2]] belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.<ref name="pmid26464018">{{cite journal | vauthors = Bürglin TR, Affolter M | title = Homeodomain proteins: an update | journal = Chromosoma | volume = 125 | issue = 3 | pages = 497–521 | date = July 2016 | pmid = 26464018 | pmc = 4901127 | doi = 10.1007/s00412-015-0543-8 }}</ref> The structure of the homeodomain shown on the right.
{{GNF_Protein_box
| image = PBB_Protein_ZEB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2e19.
| PDB = {{PDB2|2e19}}
| Name = Zinc finger E-box binding homeobox 1
| HGNCid = 11642
| Symbol = ZEB1
| AltSymbols =; AREB6; BZP; MGC133261; NIL-2-A; NIL-2A; TCF8; ZEB; ZFHEP; ZFHX1A
| OMIM = 189909
| ECnumber =
| Homologene = 31779
| MGIid = 1344313
| GeneAtlas_image1 = PBB_GE_ZEB1_210875_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZEB1_212758_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_ZEB1_212764_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0048598 |text = embryonic morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6935
    | Hs_Ensembl = ENSG00000148516
    | Hs_RefseqProtein = NP_110378
    | Hs_RefseqmRNA = NM_030751
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 31647430
    | Hs_GenLoc_end = 31858748
    | Hs_Uniprot = P37275
    | Mm_EntrezGene = 21417
    | Mm_Ensembl = ENSMUSG00000024238
    | Mm_RefseqmRNA = NM_011546
    | Mm_RefseqProtein = NP_035676
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 5591872
    | Mm_GenLoc_end = 5774908
    | Mm_Uniprot = Q3URK4
  }}
}}
'''Zinc finger E-box binding homeobox 1''', also known as '''ZEB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{PBB_Summary
Mutations of the gene are linked to [[posterior polymorphous corneal dystrophy 3]]. A recent study suggested its contributing role in [[lung cancer]] invasiveness and metastasis development.<ref name="pmid24468793">{{cite journal | vauthors = Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL | title = Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1 | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 94 | issue = 4 | pages = 362–70 | date = April 2014 | pmid = 24468793 | doi = 10.1038/labinvest.2013.153 }}</ref>
| section_title =  
| summary_text = TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6935| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Franklin AJ, Jetton TL, Shelton KD, Magnuson MA | title = BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription | journal = Molecular and Cellular Biology | volume = 14 | issue = 10 | pages = 6773–88 | date = October 1994 | pmid = 7935395 | pmc = 359208 | doi =  }}
| citations =
* {{cite journal | vauthors = Watanabe Y, Kawakami K, Hirayama Y, Nagano K | title = Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene | journal = Journal of Biochemistry | volume = 114 | issue = 6 | pages = 849–55 | date = December 1993 | pmid = 8138542 | doi =  }}
*{{cite journal | author=Williams TM, Montoya G, Wu Y, ''et al.'' |title=The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. |journal=Genomics |volume=14 |issue= 1 |pages= 194-6 |year= 1992 |pmid= 1427828 |doi=  }}
* {{cite journal | vauthors = Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K | title = Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6 | journal = Molecular and Cellular Biology | volume = 18 | issue = 1 | pages = 10–8 | date = January 1998 | pmid = 9418848 | pmc = 121442 | doi = 10.1128/mcb.18.1.10 }}
*{{cite journal  | author=Williams TM, Moolten D, Burlein J, ''et al.'' |title=Identification of a zinc finger protein that inhibits IL-2 gene expression. |journal=Science |volume=254 |issue= 5039 |pages= 1791-4 |year= 1992 |pmid= 1840704 |doi=  }}
* {{cite journal | vauthors = Turner J, Crossley M | title = Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators | journal = The EMBO Journal | volume = 17 | issue = 17 | pages = 5129–40 | date = September 1998 | pmid = 9724649 | pmc = 1170841 | doi = 10.1093/emboj/17.17.5129 }}
*{{cite journal  | author=Franklin AJ, Jetton TL, Shelton KD, Magnuson MA |title=BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. |journal=Mol. Cell. Biol. |volume=14 |issue= 10 |pages= 6773-88 |year= 1994 |pmid= 7935395 |doi=  }}
* {{cite journal | vauthors = Postigo AA, Dean DC | title = ZEB represses transcription through interaction with the corepressor CtBP | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 12 | pages = 6683–8 | date = June 1999 | pmid = 10359772 | pmc = 21975 | doi = 10.1073/pnas.96.12.6683 }}
*{{cite journal | author=Watanabe Y, Kawakami K, Hirayama Y, Nagano K |title=Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene. |journal=J. Biochem. |volume=114 |issue= 6 |pages= 849-55 |year= 1994 |pmid= 8138542 |doi=  }}
* {{cite journal | vauthors = Hlubek F, Löhberg C, Meiler J, Jung A, Kirchner T, Brabletz T | title = Tip60 is a cell-type-specific transcriptional regulator | journal = Journal of Biochemistry | volume = 129 | issue = 4 | pages = 635–41 | date = April 2001 | pmid = 11275565 | doi = 10.1093/oxfordjournals.jbchem.a002901 }}
*{{cite journal | author=Ikeda K, Halle JP, Stelzer G, ''et al.'' |title=Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 10-8 |year= 1998 |pmid= 9418848 |doi= }}
* {{cite journal | vauthors = Locklin RM, Riggs BL, Hicok KC, Horton HF, Byrne MC, Khosla S | title = Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology | journal = Journal of Bone and Mineral Research | volume = 16 | issue = 12 | pages = 2192–204 | date = December 2001 | pmid = 11760832 | doi = 10.1359/jbmr.2001.16.12.2192 }}
*{{cite journal | author=Turner J, Crossley M |title=Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators. |journal=EMBO J. |volume=17 |issue= 17 |pages= 5129-40 |year= 1998 |pmid= 9724649 |doi= 10.1093/emboj/17.17.5129 }}
* {{cite journal | vauthors = Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S | title = Effects of HIV-1 Nef on cellular gene expression profiles | journal = Journal of Biomedical Science | volume = 9 | issue = 1 | pages = 82–96 | year = 2002 | pmid = 11810028 | doi = 10.1007/BF02256581 }}
*{{cite journal | author=Postigo AA, Dean DC |title=ZEB represses transcription through interaction with the corepressor CtBP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6683-8 |year= 1999 |pmid= 10359772 |doi= }}
* {{cite journal | vauthors = Guaita S, Puig I, Franci C, Garrido M, Dominguez D, Batlle E, Sancho E, Dedhar S, De Herreros AG, Baulida J | title = Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 42 | pages = 39209–16 | date = October 2002 | pmid = 12161443 | doi = 10.1074/jbc.M206400200 }}
*{{cite journal | author=Hlubek F, Löhberg C, Meiler J, ''et al.'' |title=Tip60 is a cell-type-specific transcriptional regulator. |journal=J. Biochem. |volume=129 |issue= 4 |pages= 635-41 |year= 2001 |pmid= 11275565 |doi= }}
* {{cite journal | vauthors = Costantino ME, Stearman RP, Smith GE, Darling DS | title = Cell-specific phosphorylation of Zfhep transcription factor | journal = Biochemical and Biophysical Research Communications | volume = 296 | issue = 2 | pages = 368–73 | date = August 2002 | pmid = 12163027 | doi = 10.1016/S0006-291X(02)00880-X | pmc = 3682420 }}
*{{cite journal | author=Locklin RM, Riggs BL, Hicok KC, ''et al.'' |title=Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology. |journal=J. Bone Miner. Res. |volume=16 |issue= 12 |pages= 2192-204 |year= 2002 |pmid= 11760832 |doi= }}
* {{cite journal | vauthors = Postigo AA | title = Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway | journal = The EMBO Journal | volume = 22 | issue = 10 | pages = 2443–52 | date = May 2003 | pmid = 12743038 | pmc = 155983 | doi = 10.1093/emboj/cdg225 }}
*{{cite journal | author=Shaheduzzaman S, Krishnan V, Petrovic A, ''et al.'' |title=Effects of HIV-1 Nef on cellular gene expression profiles. |journal=J. Biomed. Sci. |volume=9 |issue= 1 |pages= 82-96 |year= 2002 |pmid= 11810028 |doi= }}
* {{cite journal | vauthors = Postigo AA, Depp JL, Taylor JJ, Kroll KL | title = Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins | journal = The EMBO Journal | volume = 22 | issue = 10 | pages = 2453–62 | date = May 2003 | pmid = 12743039 | pmc = 155984 | doi = 10.1093/emboj/cdg226 }}
*{{cite journal | author=Guaita S, Puig I, Franci C, ''et al.'' |title=Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39209-16 |year= 2002 |pmid= 12161443 |doi= 10.1074/jbc.M206400200 }}
* {{cite journal | vauthors = Dillner NB, Sanders MM | title = Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades | journal = DNA and Cell Biology | volume = 23 | issue = 1 | pages = 25–34 | date = January 2004 | pmid = 14965470 | doi = 10.1089/104454904322745907 }}
*{{cite journal | author=Costantino ME, Stearman RP, Smith GE, Darling DS |title=Cell-specific phosphorylation of Zfhep transcription factor. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 2 |pages= 368-73 |year= 2002 |pmid= 12163027 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Shimizu S, Krafchak C, Fuse N, Epstein MP, Schteingart MT, Sugar A, Eibschitz-Tsimhoni M, Downs CA, Rozsa F, Trager EH, Reed DM, Boehnke M, Moroi SE, Richards JE | title = A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10 | journal = American Journal of Medical Genetics. Part A | volume = 130A | issue = 4 | pages = 372–7 | date = November 2004 | pmid = 15384081 | pmc = 1249494 | doi = 10.1002/ajmg.a.30267 }}
*{{cite journal | author=Postigo AA |title=Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. |journal=EMBO J. |volume=22 |issue= 10 |pages= 2443-52 |year= 2003 |pmid= 12743038 |doi= 10.1093/emboj/cdg225 }}
* {{cite journal | vauthors = Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, Berx G, Cano A, Beug H, Foisner R | title = DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells | journal = Oncogene | volume = 24 | issue = 14 | pages = 2375–85 | date = March 2005 | pmid = 15674322 | doi = 10.1038/sj.onc.1208429 }}
*{{cite journal | author=Postigo AA, Depp JL, Taylor JJ, Kroll KL |title=Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. |journal=EMBO J. |volume=22 |issue= 10 |pages= 2453-62 |year= 2003 |pmid= 12743039 |doi= 10.1093/emboj/cdg226 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Dillner NB, Sanders MM |title=Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades. |journal=DNA Cell Biol. |volume=23 |issue= 1 |pages= 25-34 |year= 2004 |pmid= 14965470 |doi= 10.1089/104454904322745907 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Shimizu S, Krafchak C, Fuse N, ''et al.'' |title=A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10. |journal=Am. J. Med. Genet. A |volume=130 |issue= 4 |pages= 372-7 |year= 2005 |pmid= 15384081 |doi= 10.1002/ajmg.a.30267 }}
*{{cite journal | author=Eger A, Aigner K, Sonderegger S, ''et al.'' |title=DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. |journal=Oncogene |volume=24 |issue= 14 |pages= 2375-85 |year= 2005 |pmid= 15674322 |doi= 10.1038/sj.onc.1208429 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{FactorBook|ZEB1}}
 
{{PDB Gallery|geneid=6935}}
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
 
{{Gene-10-stub}}

Latest revision as of 15:53, 15 May 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.[1][2][3]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.[3][4] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.[5] The structure of the homeodomain shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.[6]

References

  1. ↑ Williams TM, Montoya G, Wu Y, Eddy RL, Byers MG, Shows TB (September 1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2". Genomics. 14 (1): 194–6. doi:10.1016/S0888-7543(05)80307-6. PMID 1427828.
  2. ↑ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  3. ↑ 3.0 3.1 "Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1".
  4. ↑ Williams TM, Moolten D, Burlein J, Romano J, Bhaerman R, Godillot A, Mellon M, Rauscher FJ, Kant JA (December 1991). "Identification of a zinc finger protein that inhibits IL-2 gene expression". Science. 254 (5039): 1791–4. doi:10.1126/science.1840704. PMID 1840704.
  5. ↑ Bürglin TR, Affolter M (July 2016). "Homeodomain proteins: an update". Chromosoma. 125 (3): 497–521. doi:10.1007/s00412-015-0543-8. PMC 4901127. PMID 26464018.
  6. ↑ Liu W, Huang YJ, Liu C, Yang YY, Liu H, Cui JG, Cheng Y, Gao F, Cai JM, Li BL (April 2014). "Inhibition of TBK1 attenuates radiation-induced epithelial-mesenchymal transition of A549 human lung cancer cells via activation of GSK-3β and repression of ZEB1". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (4): 362–70. doi:10.1038/labinvest.2013.153. PMID 24468793.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=ZEB1&oldid=1527266"