HOXB13: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-B13''' is a [[protein]] that in humans is encoded by the ''HOXB13'' [[gene]].<ref name="pmid8756292">{{cite journal | vauthors = Zeltser L, Desplan C, Heintz N | title = Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity | journal = Development | volume = 122 | issue = 8 | pages = 2475–84 | date = Aug 1996 | pmid = 8756292 | pmc =  | doi =  }}</ref><ref name="pmid9665387">{{cite journal | vauthors = Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M, Largman C | title = Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds | journal = The Journal of Investigative Dermatology | volume = 111 | issue = 1 | pages = 57–63 | date = Jul 1998 | pmid = 9665387 | pmc =  | doi = 10.1046/j.1523-1747.1998.00238.x }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXB13 homeobox B13| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10481| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_HOXB13_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cra.
| PDB = {{PDB2|2cra}}
| Name = Homeobox B13
| HGNCid = 5112
| Symbol = HOXB13
| AltSymbols =; PSGD
| OMIM = 604607
| ECnumber = 
| Homologene = 4640
| MGIid = 107730
| GeneAtlas_image1 = PBB_GE_HOXB13_209844_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008544 |text = epidermis development}} {{GNF_GO|id=GO:0009611 |text = response to wounding}} {{GNF_GO|id=GO:0040008 |text = regulation of growth}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10481
    | Hs_Ensembl = ENSG00000159184
    | Hs_RefseqProtein = NP_006352
    | Hs_RefseqmRNA = NM_006361
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 44157132
    | Hs_GenLoc_end = 44161119
    | Hs_Uniprot = Q92826
    | Mm_EntrezGene = 15408
    | Mm_Ensembl = ENSMUSG00000049604
    | Mm_RefseqmRNA = NM_008267
    | Mm_RefseqProtein = NP_032293
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96010473
    | Mm_GenLoc_end = 96013535
    | Mm_Uniprot = P70321
  }}
}}
'''Homeobox B13''', also known as '''HOXB13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXB13 homeobox B13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10481| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21-22 region.<ref name="entrez"/>
{{PBB_Summary
Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.<ref name="pmid22236224">{{cite journal | vauthors = Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng SL, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA | title = Germline mutations in HOXB13 and prostate-cancer risk | journal = The New England Journal of Medicine | volume = 366 | issue = 2 | pages = 141–9 | date = Jan 2012 | pmid = 22236224 | pmc = 3779870| doi = 10.1056/NEJMoa1110000 }}</ref>
| section_title =
| summary_text = This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.<ref name="entrez">{{cite web | title = Entrez Gene: HOXB13 homeobox B13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10481| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C | title = AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6448–58 | date = Nov 1997 | pmid = 9343407 | pmc = 232497 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Zeltser L, Desplan C, Heintz N |title=Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. |journal=Development |volume=122 |issue= 8 |pages= 2475-84 |year= 1996 |pmid= 8756292 |doi=  }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=Shen WF, Montgomery JC, Rozenfeld S, ''et al.'' |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448-58 |year= 1997 |pmid= 9343407 |doi=  }}
* {{cite journal | vauthors = Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C | title = HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development | journal = Developmental Dynamics | volume = 227 | issue = 2 | pages = 192–202 | date = Jun 2003 | pmid = 12761847 | doi = 10.1002/dvdy.10290 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
* {{cite journal | vauthors = Jung C, Kim RS, Lee SJ, Wang C, Jeng MH | title = HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4 | journal = Cancer Research | volume = 64 | issue = 9 | pages = 3046–51 | date = May 2004 | pmid = 15126340 | doi = 10.1158/0008-5472.CAN-03-2614 }}
*{{cite journal  | author=Stelnicki EJ, Arbeit J, Cass DL, ''et al.'' |title=Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. |journal=J. Invest. Dermatol. |volume=111 |issue= 1 |pages= 57-63 |year= 1998 |pmid= 9665387 |doi= 10.1046/j.1523-1747.1998.00238.x }}
* {{cite journal | vauthors = Jung C, Kim RS, Zhang HJ, Lee SJ, Jeng MH | title = HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling | journal = Cancer Research | volume = 64 | issue = 24 | pages = 9185–92 | date = Dec 2004 | pmid = 15604291 | doi = 10.1158/0008-5472.CAN-04-1330 }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
* {{cite journal | vauthors = Zhao Y, Yamashita T, Ishikawa M | title = Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer | journal = Oncology Reports | volume = 13 | issue = 4 | pages = 721–6 | date = Apr 2005 | pmid = 15756448 | doi = 10.3892/or.13.4.721 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Jung C, Kim RS, Zhang H, Lee SJ, Sheng H, Loehrer PJ, Gardner TA, Jeng MH, Kao C | title = HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation | journal = British Journal of Cancer | volume = 92 | issue = 12 | pages = 2233–9 | date = Jun 2005 | pmid = 15928669 | pmc = 2361828 | doi = 10.1038/sj.bjc.6602631 }}
*{{cite journal  | author=Kömüves LG, Ma XK, Stelnicki E, ''et al.'' |title=HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. |journal=Dev. Dyn. |volume=227 |issue= 2 |pages= 192-202 |year= 2004 |pmid= 12761847 |doi= 10.1002/dvdy.10290 }}
* {{cite journal | vauthors = Symmans WF | title = Genomic testing for sensitivity of breast cancer to hormonal therapy | journal = Clinical Cancer Research | volume = 12 | issue = 7 Pt 1 | pages = 1954–5 | date = Apr 2006 | pmid = 16609001 | doi = 10.1158/1078-0432.CCR-06-0289 }}
*{{cite journal | author=Jung C, Kim RS, Lee SJ, ''et al.'' |title=HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. |journal=Cancer Res. |volume=64 |issue= 9 |pages= 3046-51 |year= 2004 |pmid= 15126340 |doi= }}
* {{cite journal | vauthors = Goetz MP, Suman VJ, Ingle JN, Nibbe AM, Visscher DW, Reynolds CA, Lingle WL, Erlander M, Ma XJ, Sgroi DC, Perez EA, Couch FJ | title = A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen | journal = Clinical Cancer Research | volume = 12 | issue = 7 Pt 1 | pages = 2080–7 | date = Apr 2006 | pmid = 16609019 | doi = 10.1158/1078-0432.CCR-05-1263 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Cazal C, Sobral AP, de Almeida FC, das Graças Silva-Valenzuela M, Durazzo MD, Nunes FD | title = The homeobox HOXB13 is expressed in human minor salivary gland | journal = Oral Diseases | volume = 12 | issue = 4 | pages = 424–7 | date = Jul 2006 | pmid = 16792730 | doi = 10.1111/j.1601-0825.2005.01218.x }}
*{{cite journal | author=Jung C, Kim RS, Zhang HJ, ''et al.'' |title=HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. |journal=Cancer Res. |volume=64 |issue= 24 |pages= 9185-92 |year= 2005 |pmid= 15604291 |doi= 10.1158/0008-5472.CAN-04-1330 }}
* {{cite journal | vauthors = Ma XJ, Hilsenbeck SG, Wang W, Ding L, Sgroi DC, Bender RA, Osborne CK, Allred DC, Erlander MG | title = The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer | journal = Journal of Clinical Oncology | volume = 24 | issue = 28 | pages = 4611–9 | date = Oct 2006 | pmid = 17008703 | doi = 10.1200/JCO.2006.06.6944 }}
*{{cite journal | author=Zhao Y, Yamashita T, Ishikawa M |title=Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer. |journal=Oncol. Rep. |volume=13 |issue= 4 |pages= 721-6 |year= 2005 |pmid= 15756448 |doi= }}
* {{cite journal | vauthors = Muthusamy V, Duraisamy S, Bradbury CM, Hobbs C, Curley DP, Nelson B, Bosenberg M | title = Epigenetic silencing of novel tumor suppressors in malignant melanoma | journal = Cancer Research | volume = 66 | issue = 23 | pages = 11187–93 | date = Dec 2006 | pmid = 17145863 | doi = 10.1158/0008-5472.CAN-06-1274 }}
*{{cite journal | author=Jung C, Kim RS, Zhang H, ''et al.'' |title=HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. |journal=Br. J. Cancer |volume=92 |issue= 12 |pages= 2233-9 |year= 2005 |pmid= 15928669 |doi= 10.1038/sj.bjc.6602631 }}
* {{cite journal | vauthors = Miao J, Wang Z, Provencher H, Muir B, Dahiya S, Carney E, Leong CO, Sgroi DC, Orsulic S | title = HOXB13 promotes ovarian cancer progression | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 43 | pages = 17093–8 | date = Oct 2007 | pmid = 17942676 | pmc = 2040435 | doi = 10.1073/pnas.0707938104 }}
*{{cite journal | author=Symmans WF |title=Genomic testing for sensitivity of breast cancer to hormonal therapy. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 1954-5 |year= 2006 |pmid= 16609001 |doi= 10.1158/1078-0432.CCR-06-0289 }}
* {{cite journal | vauthors = Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng SL, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA | title = Germline mutations in HOXB13 and prostate-cancer risk | journal = The New England Journal of Medicine | volume = 366 | issue = 2 | pages = 141–9 | date = Jan 2012 | pmid = 22236224 | doi = 10.1056/NEJMoa1110000 | pmc = 3779870 }}
*{{cite journal | author=Goetz MP, Suman VJ, Ingle JN, ''et al.'' |title=A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2080-7 |year= 2006 |pmid= 16609019 |doi= 10.1158/1078-0432.CCR-05-1263 }}
*{{cite journal | author=Cazal C, Sobral AP, de Almeida FC, ''et al.'' |title=The homeobox HOXB13 is expressed in human minor salivary gland. |journal=Oral diseases |volume=12 |issue= 4 |pages= 424-7 |year= 2006 |pmid= 16792730 |doi= 10.1111/j.1601-0825.2005.01218.x }}
*{{cite journal | author=Ma XJ, Hilsenbeck SG, Wang W, ''et al.'' |title=The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. |journal=J. Clin. Oncol. |volume=24 |issue= 28 |pages= 4611-9 |year= 2006 |pmid= 17008703 |doi= 10.1200/JCO.2006.06.6944 }}
*{{cite journal | author=Muthusamy V, Duraisamy S, Bradbury CM, ''et al.'' |title=Epigenetic silencing of novel tumor suppressors in malignant melanoma. |journal=Cancer Res. |volume=66 |issue= 23 |pages= 11187-93 |year= 2007 |pmid= 17145863 |doi= 10.1158/0008-5472.CAN-06-1274 }}
*{{cite journal | author=Miao J, Wang Z, Provencher H, ''et al.'' |title=HOXB13 promotes ovarian cancer progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 43 |pages= 17093-8 |year= 2007 |pmid= 17942676 |doi= 10.1073/pnas.0707938104 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
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{{Transcription factors}}
{{PDB Gallery|geneid=10481}}
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-17-stub}}

Latest revision as of 22:03, 22 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene.[1][2][3]

Function

This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21-22 region.[3] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.[4]

See also

References

  1. ↑ Zeltser L, Desplan C, Heintz N (Aug 1996). "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity". Development. 122 (8): 2475–84. PMID 8756292.
  2. ↑ Stelnicki EJ, Arbeit J, Cass DL, Saner C, Harrison M, Largman C (Jul 1998). "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". The Journal of Investigative Dermatology. 111 (1): 57–63. doi:10.1046/j.1523-1747.1998.00238.x. PMID 9665387.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXB13 homeobox B13".
  4. ↑ Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, Izatt T, Sinari S, Craig DW, Zheng SL, Walsh PC, Montie JE, Xu J, Carpten JD, Isaacs WB, Cooney KA (Jan 2012). "Germline mutations in HOXB13 and prostate-cancer risk". The New England Journal of Medicine. 366 (2): 141–9. doi:10.1056/NEJMoa1110000. PMC 3779870. PMID 22236224.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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