MLLT1: Difference between revisions
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'''Protein ENL''' is a [[protein]] that in humans is encoded by the ''MLLT1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4298| accessdate = }}</ref> | '''Protein ENL''' is a [[protein]] that in humans is encoded by the ''MLLT1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4298| accessdate = }}</ref> | ||
==Interactions== | == Interactions == | ||
==References== | MLLT1 has been shown to [[Protein-protein interaction|interact]] with [[CBX8]].<ref name=pmid11313972>{{cite journal | vauthors = García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK | title = The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 | journal = Oncogene | volume = 20 | issue = 4 | pages = 411–9 | date = January 2001 | pmid = 11313972 | doi = 10.1038/sj.onc.1204108 }}</ref> | ||
== References == | |||
{{reflist}} | {{reflist}} | ||
==Further reading== | == Further reading == | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Tkachuk DC, Kohler S, Cleary ML | title = Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias | journal = Cell | volume = 71 | issue = 4 | pages = 691–700 | date = November 1992 | pmid = 1423624 | doi = 10.1016/0092-8674(92)90602-9 }} | |||
* {{cite journal | vauthors = Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD | title = Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 25 | pages = 12110–4 | date = December 1994 | pmid = 7991593 | pmc = 45386 | doi = 10.1073/pnas.91.25.12110 }} | |||
*{{cite journal | * {{cite journal | vauthors = Rubnitz JE, Morrissey J, Savage PA, Cleary ML | title = ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells | journal = Blood | volume = 84 | issue = 6 | pages = 1747–52 | date = September 1994 | pmid = 8080983 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T | title = Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia | journal = Oncogene | volume = 8 | issue = 10 | pages = 2617–25 | date = October 1993 | pmid = 8378076 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Lavau C, Luo RT, Du C, Thirman MJ | title = Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 20 | pages = 10984–9 | date = September 2000 | pmid = 10995463 | pmc = 27135 | doi = 10.1073/pnas.190167297 }} | ||
*{{cite journal | * {{cite journal | vauthors = García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK | title = The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 | journal = Oncogene | volume = 20 | issue = 4 | pages = 411–9 | date = January 2001 | pmid = 11313972 | doi = 10.1038/sj.onc.1204108 }} | ||
*{{cite journal | * {{cite journal | vauthors = Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W | title = Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner | journal = Molecular and Cellular Biology | volume = 23 | issue = 8 | pages = 2942–52 | date = April 2003 | pmid = 12665591 | pmc = 152562 | doi = 10.1128/MCB.23.8.2942-2952.2003 }} | ||
*{{cite journal | * {{cite journal | vauthors = Gué M, Sun JS, Boudier T | title = Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited | journal = BMC Cancer | volume = 6 | pages = 20 | date = January 2006 | pmid = 16433901 | pmc = 1388228 | doi = 10.1186/1471-2407-6-20 }} | ||
*{{cite journal | * {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }} | ||
* {{cite journal | vauthors = Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O, Haas O, Klingebiel T, Dingermann T, Marschalek R | title = Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia | journal = Leukemia | volume = 21 | issue = 3 | pages = 588–90 | date = March 2007 | pmid = 17252016 | doi = 10.1038/sj.leu.2404542 }} | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
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{{NLM content}} | {{NLM content}} | ||
{{Transcription factors|g0}} | {{Transcription factors|g0}} | ||
[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
{{gene-19-stub}} | {{gene-19-stub}} |
Latest revision as of 11:22, 2 January 2018
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Protein ENL is a protein that in humans is encoded by the MLLT1 gene.[1]
Interactions
MLLT1 has been shown to interact with CBX8.[2]
References
- ↑ "Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1".
- ↑ García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Further reading
- Tkachuk DC, Kohler S, Cleary ML (November 1992). "Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias". Cell. 71 (4): 691–700. doi:10.1016/0092-8674(92)90602-9. PMID 1423624.
- Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD (December 1994). "Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12110–4. doi:10.1073/pnas.91.25.12110. PMC 45386. PMID 7991593.
- Rubnitz JE, Morrissey J, Savage PA, Cleary ML (September 1994). "ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells". Blood. 84 (6): 1747–52. PMID 8080983.
- Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T (October 1993). "Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia". Oncogene. 8 (10): 2617–25. PMID 8378076.
- Lavau C, Luo RT, Du C, Thirman MJ (September 2000). "Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice". Proceedings of the National Academy of Sciences of the United States of America. 97 (20): 10984–9. doi:10.1073/pnas.190167297. PMC 27135. PMID 10995463.
- García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
- Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W (April 2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10.1128/MCB.23.8.2942-2952.2003. PMC 152562. PMID 12665591.
- Gué M, Sun JS, Boudier T (January 2006). "Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited". BMC Cancer. 6: 20. doi:10.1186/1471-2407-6-20. PMC 1388228. PMID 16433901.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O, Haas O, Klingebiel T, Dingermann T, Marschalek R (March 2007). "Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia". Leukemia. 21 (3): 588–90. doi:10.1038/sj.leu.2404542. PMID 17252016.
External links
- MLLT1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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