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{{Infobox_gene}}
{{PBB_Controls
'''L-myc-1 proto-oncogene protein''' is a [[protein]] that in humans is encoded by the ''MYCL1'' [[gene]].<ref name="pmid8978772">{{cite journal | vauthors = Speleman F, Van Camp G, Van Roy N | title = Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization | journal = Cytogenet Cell Genet | volume = 72 | issue = 2–3 | pages = 189–190 | date = Jan 1997 | pmid = 8978772 | pmc = | doi = 10.1159/000134185 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4610| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MYCL1 is a [[bHLH]] (basic helix-loop-helix) [[transcription factor]] implicated in lung cancer.<ref>{{cite journal | vauthors = Ikegaki N, Minna J, Kennett RH | title = The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences | journal = EMBO J. | volume = 8 | issue = 6 | pages = 1793–9 | year = 1989 | pmid = 2548855 | pmc = 401025 | doi = }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)
| HGNCid = 7555
| Symbol = MYCL1
| AltSymbols =; LMYC; MYCL
| OMIM = 164850
| ECnumber = 
| Homologene = 3921
| MGIid = 96799
| GeneAtlas_image1 = PBB_GE_MYCL1_214058_at_tn.png
| GeneAtlas_image2 = PBB_GE_MYCL1_215491_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4610
    | Hs_Ensembl = ENSG00000116990
    | Hs_RefseqProtein = NP_001028253
    | Hs_RefseqmRNA = NM_001033081
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 40133685
    | Hs_GenLoc_end = 40140274
    | Hs_Uniprot = P12524
    | Mm_EntrezGene = 16918
    | Mm_Ensembl = ENSMUSG00000028654
    | Mm_RefseqmRNA = NM_008506
    | Mm_RefseqProtein = NP_032532
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 122498402
    | Mm_GenLoc_end = 122504788
    | Mm_Uniprot = Q3UIE0
  }}
}}
'''V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)''', also known as '''MYCL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4610| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
MYCL1 is a [[bHLH]] (basic helix-loop-helix) [[transcription factor]] implicated in lung cancer.<ref>{{cite journal |author=Ikegaki N, Minna J, Kennett RH |title=The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences |journal=EMBO J. |volume=8 |issue=6 |pages=1793–9 |year=1989 |pmid=2548855 |doi=}}</ref>


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MYCL1 has been shown to [[Protein-protein interaction|interact]] with [[MAX (gene)|MAX]].<ref name=pmid2006410>{{cite journal | vauthors = Blackwood EM, Eisenman RN | title = Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc  | journal = [[Science (journal)|Science]] | volume = 251 | issue = 4998 | pages = 1211–1217 | date = Mar 1991 | pmid = 2006410 | doi = 10.1126/science.2006410 }}</ref><ref name=pmid10229200>{{cite journal | vauthors = FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE | title = Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc  | journal = Oncogene | volume = 18 | issue = 15 | pages = 2489–2498 | date = Apr 1999 | pmid = 10229200 | doi = 10.1038/sj.onc.1202611 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lüscher B | title = Function and regulation of the transcription factors of the Myc/Max/Mad network | journal = Gene | volume = 277 | issue = 1–2 | pages = 1–14 | year = 2001 | pmid = 11602341 | doi = 10.1016/S0378-1119(01)00697-7 }}
| citations =
* {{cite journal | vauthors = Ikegaki N, Minna J, Kennett RH | title = The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences | journal = EMBO J. | volume = 8 | issue = 6 | pages = 1793–9 | year = 1989 | pmid = 2548855 | pmc = 401025 | doi =  }}
*{{cite journal | author=Lüscher B |title=Function and regulation of the transcription factors of the Myc/Max/Mad network. |journal=Gene |volume=277 |issue= 1-2 |pages= 1-14 |year= 2001 |pmid= 11602341 |doi= }}
* {{cite journal | vauthors = Kaye F, Battey J, Nau M, Brooks B, Seifter E, De Greve J, Birrer M, Sausville E, Minna J | title = Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing | journal = Mol. Cell. Biol. | volume = 8 | issue = 1 | pages = 186–95 | year = 1988 | pmid = 2827002 | pmc = 363100 | doi =  }}
*{{cite journal | author=Ikegaki N, Minna J, Kennett RH |title=The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences. |journal=EMBO J. |volume=8 |issue= 6 |pages= 1793-9 |year= 1989 |pmid= 2548855 |doi=  }}
* {{cite journal | vauthors = De Greve J, Battey J, Fedorko J, Birrer M, Evan G, Kaye F, Sausville E, Minna J | title = The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs | journal = Mol. Cell. Biol. | volume = 8 | issue = 10 | pages = 4381–8 | year = 1988 | pmid = 3054516 | pmc = 365511 | doi =  }}
*{{cite journal | author=Kaye F, Battey J, Nau M, ''et al.'' |title=Structure and expression of the human L-myc gene reveal a complex pattern of alternative mRNA processing. |journal=Mol. Cell. Biol. |volume=8 |issue= 1 |pages= 186-95 |year= 1988 |pmid= 2827002 |doi=  }}
* {{cite journal | vauthors = DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW | title = The human myc gene family: structure and activity of L-myc and an L-myc pseudogene | journal = Genes Dev. | volume = 1 | issue = 10 | pages = 1311–1326 | year = 1988 | pmid = 3322939 | doi = 10.1101/gad.1.10.1311 }}
*{{cite journal | author=De Greve J, Battey J, Fedorko J, ''et al.'' |title=The human L-myc gene encodes multiple nuclear phosphoproteins from alternatively processed mRNAs. |journal=Mol. Cell. Biol. |volume=8 |issue= 10 |pages= 4381-8 |year= 1988 |pmid= 3054516 |doi=  }}
* {{cite journal | vauthors = Atchley WR, Fitch WM | title = Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 22 | pages = 10217–10221 | year = 1995 | pmid = 7479755 | pmc = 40767 | doi = 10.1073/pnas.92.22.10217 }}
*{{cite journal | author=DePinho RA, Hatton KS, Tesfaye A, ''et al.'' |title=The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. |journal=Genes Dev. |volume=1 |issue= 10 |pages= 1311-26 |year= 1988 |pmid= 3322939 |doi= }}
* {{cite journal | vauthors = FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE | title = Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc | journal = Oncogene | volume = 18 | issue = 15 | pages = 2489–2498 | year = 1999 | pmid = 10229200 | doi = 10.1038/sj.onc.1202611 }}
*{{cite journal | author=Atchley WR, Fitch WM |title=Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization partner. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 22 |pages= 10217-21 |year= 1995 |pmid= 7479755 |doi= }}
* {{cite journal | vauthors = Kumimoto H, Hamajima N, Nishimoto Y, Matsuo K, Shinoda M, Hatooka S, Ishizaki K | title = L-myc genotype is associated with different susceptibility to lung cancer in smokers | journal = Jpn. J. Cancer Res. | volume = 93 | issue = 1 | pages = 1–5 | year = 2002 | pmid = 11802801 | doi = 10.1111/j.1349-7006.2002.tb01193.x }}
*{{cite journal  | author=Speleman F, Van Camp G, Van Roy N |title=Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 189-90 |year= 1997 |pmid= 8978772 |doi=  }}
* {{cite journal | vauthors = Suzuki H, Yamashiro K | title = L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma | journal = Oncol. Rep. | volume = 9 | issue = 2 | pages = 345–7 | year = 2002 | pmid = 11836605 | doi = 10.3892/or.9.2.345 }}
*{{cite journal | author=FitzGerald MJ, Arsura M, Bellas RE, ''et al.'' |title=Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. |journal=Oncogene |volume=18 |issue= 15 |pages= 2489-98 |year= 1999 |pmid= 10229200 |doi= 10.1038/sj.onc.1202611 }}
* {{cite journal | vauthors = Primdahl H, von der Maase H, Christensen M, Wolf H, Ørntoft TF | title = Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ | journal = Oncol. Rep. | volume = 9 | issue = 3 | pages = 551–5 | year = 2002 | pmid = 11956626 | doi = 10.3892/or.9.3.551 }}
*{{cite journal | author=Kumimoto H, Hamajima N, Nishimoto Y, ''et al.'' |title=L-myc genotype is associated with different susceptibility to lung cancer in smokers. |journal=Jpn. J. Cancer Res. |volume=93 |issue= 1 |pages= 1-5 |year= 2002 |pmid= 11802801 |doi= }}
* {{cite journal | vauthors = Demopoulos K, Arvanitis DA, Vassilakis DA, Siafakas NM, Spandidos DA | title = MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis | journal = J. Cell. Mol. Med. | volume = 6 | issue = 2 | pages = 215–222 | year = 2003 | pmid = 12169206 | doi = 10.1111/j.1582-4934.2002.tb00188.x }}
*{{cite journal | author=Suzuki H, Yamashiro K |title=L-myc restriction fragment length polymorphism and histological pattern of invasion in lung adenocarcinoma. |journal=Oncol. Rep. |volume=9 |issue= 2 |pages= 345-7 |year= 2002 |pmid= 11836605 |doi= }}
* {{cite journal | vauthors = Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER, Cho KR | title = Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas | journal = Am. J. Pathol. | volume = 162 | issue = 5 | pages = 1603–10 | year = 2003 | pmid = 12707044 | pmc = 1851191 | doi = 10.1016/S0002-9440(10)64294-0 }}
*{{cite journal | author=Primdahl H, von der Maase H, Christensen M, ''et al.'' |title=Allelic deletions of Rb and L-myc in urine sediments from patients with bladder tumors or carcinoma in situ. |journal=Oncol. Rep. |volume=9 |issue= 3 |pages= 551-5 |year= 2002 |pmid= 11956626 |doi= }}
* {{cite journal | vauthors = Kambara T, Sharp GB, Nagasaka T, Takeda M, Sasamoto H, Nakagawa H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N | title = Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer | journal = Clin. Cancer Res. | volume = 10 | issue = 5 | pages = 1758–1763 | year = 2004 | pmid = 15014029 | doi = 10.1158/1078-0432.CCR-0779-3 }}
*{{cite journal | author=Demopoulos K, Arvanitis DA, Vassilakis DA, ''et al.'' |title=MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis. |journal=J. Cell. Mol. Med. |volume=6 |issue= 2 |pages= 215-22 |year= 2003 |pmid= 12169206 |doi= }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Spinola M, Falvella FS, Galvan A, Pignatiello C, Leoni VP, Pastorino U, Paroni R, Chen S, Skaug V, Haugen A, Dragani TA | title = Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival | journal = Lung Cancer | volume = 55 | issue = 3 | pages = 271–277 | year = 2007 | pmid = 17145094 | doi = 10.1016/j.lungcan.2006.10.023 | url = https://air.unimi.it/bitstream/2434/25016/2/93-Ethnic%20differences%20in%20frequencies%20of%20gene%20Lung%20cancer.pdf }}
*{{cite journal | author=Wu R, Lin L, Beer DG, ''et al.'' |title=Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas. |journal=Am. J. Pathol. |volume=162 |issue= 5 |pages= 1603-10 |year= 2003 |pmid= 12707044 |doi= }}
*{{cite journal | author=Kambara T, Sharp GB, Nagasaka T, ''et al.'' |title=Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 5 |pages= 1758-63 |year= 2004 |pmid= 15014029 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Spinola M, Falvella FS, Galvan A, ''et al.'' |title=Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival. |journal=Lung Cancer |volume=55 |issue= 3 |pages= 271-7 |year= 2007 |pmid= 17145094 |doi= 10.1016/j.lungcan.2006.10.023 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|MYCL1+protein,+human}}
* {{MeshName|MYCL1+protein,+human}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-1-stub}}

Latest revision as of 14:08, 9 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene.[1][2]

MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.[3]

Interactions

MYCL1 has been shown to interact with MAX.[4][5]

References

  1. ↑ Speleman F, Van Camp G, Van Roy N (Jan 1997). "Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 72 (2–3): 189–190. doi:10.1159/000134185. PMID 8978772.
  2. ↑ "Entrez Gene: MYCL1 v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)".
  3. ↑ Ikegaki N, Minna J, Kennett RH (1989). "The human L-myc gene is expressed as two forms of protein in small cell lung carcinoma cell lines: detection by monoclonal antibodies specific to two myc homology box sequences". EMBO J. 8 (6): 1793–9. PMC 401025. PMID 2548855.
  4. ↑ Blackwood EM, Eisenman RN (Mar 1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science. 251 (4998): 1211–1217. doi:10.1126/science.2006410. PMID 2006410.
  5. ↑ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–2498. doi:10.1038/sj.onc.1202611. PMID 10229200.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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