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{{Infobox_gene}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
'''Myeloid cell Nuclear Differentiation Antigen''' is a [[protein]] that in humans is encoded as ''MNDA'' [[gene]].<ref name="pmid1644857">{{cite journal | vauthors = Briggs JA, Burrus GR, Stickney BD, Briggs RC | title = Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha | journal = Journal of Cellular Biochemistry | volume = 49 | issue = 1 | pages = 82–92 | date = May 1992 | pmid = 1644857 | pmc =  | doi = 10.1002/jcb.240490114 }}</ref><ref name="pmid7512843">{{cite journal | vauthors = Briggs RC, Briggs JA, Ozer J, Sealy L, Dworkin LL, Kingsmore SF, Seldin MF, Kaur GP, Athwal RS, Dessypris EN | title = The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells | journal = Blood | volume = 83 | issue = 8 | pages = 2153–62 | date = April 1994 | pmid = 7512843 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MNDA myeloid cell nuclear differentiation antigen| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4332| accessdate = }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_MNDA_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dbg.
| PDB = {{PDB2|2dbg}}
| Name = Myeloid cell nuclear differentiation antigen
| HGNCid = 7183
| Symbol = MNDA
| AltSymbols =; PYHIN3
| OMIM = 159553
| ECnumber =
| Homologene = 74438
| MGIid =
  | GeneAtlas_image1 = PBB_GE_MNDA_204959_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4332
    | Hs_Ensembl = ENSG00000163563
    | Hs_RefseqProtein = NP_002423
    | Hs_RefseqmRNA = NM_002432
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 157067731
    | Hs_GenLoc_end = 157085918
    | Hs_Uniprot = P41218
    | Mm_EntrezGene =
    | Mm_Ensembl =
    | Mm_RefseqmRNA =
    | Mm_RefseqProtein =
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr =
    | Mm_GenLoc_start =   
    | Mm_GenLoc_end =   
    | Mm_Uniprot = 
  }}
}}
'''Myeloid cell nuclear differentiation antigen''', also known as '''MNDA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MNDA myeloid cell nuclear differentiation antigen| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4332| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.<ref name="entrez">{{cite web | title = Entrez Gene: MNDA myeloid cell nuclear differentiation antigen| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4332| accessdate = }}</ref>
}}


==References==
The myeloid cell nuclear differentiation antigen (MNDA) is detected only in [[Cell nucleus|nuclei]] of cells of the [[granulocyte]]-[[monocyte]] lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, [[Ifi202]], and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the [[Five prime untranslated region|5' UTR]], was significantly upregulated in human monocytes exposed to [[Interferon type I|interferon alpha]]. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to [[interferon]]s.<ref name="entrez"/>
{{reflist|2}}


==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Burrus GR, Briggs JA, Briggs RC | title = Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins | journal = Journal of Cellular Biochemistry | volume = 48 | issue = 2 | pages = 190–202 | date = February 1992 | pmid = 1377701 | doi = 10.1002/jcb.240480210 }}
| citations =
* {{cite journal | vauthors = Ott J, Fràter-Schröder M | title = Absence of linkage between transcobalamin II and ABO | journal = Human Genetics | volume = 59 | issue = 2 | pages = 164–5 | year = 1982 | pmid = 7327575 | doi = 10.1007/BF00293068 }}
*{{cite journal | author=Burrus GR, Briggs JA, Briggs RC |title=Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins. |journal=J. Cell. Biochem. |volume=48 |issue= 2 |pages= 190-202 |year= 1992 |pmid= 1377701 |doi= 10.1002/jcb.240480210 }}
* {{cite journal | vauthors = Dawson MJ, Trapani JA, Briggs RC, Nicholl JK, Sutherland GR, Baker E | title = The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression | journal = Immunogenetics | volume = 41 | issue = 1 | pages = 40–3 | year = 1995 | pmid = 7806273 | doi = 10.1007/BF00188431 }}
*{{cite journal | author=Briggs JA, Burrus GR, Stickney BD, Briggs RC |title=Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. |journal=J. Cell. Biochem. |volume=49 |issue= 1 |pages= 82-92 |year= 1992 |pmid= 1644857 |doi= 10.1002/jcb.240490114 }}
* {{cite journal | vauthors = Briggs R, Dworkin L, Briggs J, Dessypris E, Stein J, Stein G, Lian J | title = Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage | journal = Journal of Cellular Biochemistry | volume = 54 | issue = 2 | pages = 198–206 | date = February 1994 | pmid = 8175894 | doi = 10.1002/jcb.240540208 }}
*{{cite journal  | author=Ott J, Fràter-Schröder M |title=Absence of linkage between transcobalamin II and ABO. |journal=Hum. Genet. |volume=59 |issue= 2 |pages= 164-5 |year= 1982 |pmid= 7327575 |doi= }}
* {{cite journal | vauthors = Xie J, Briggs JA, Briggs RC | title = Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding | journal = Journal of Cellular Biochemistry | volume = 70 | issue = 4 | pages = 489–506 | date = September 1998 | pmid = 9712147 | doi = 10.1002/(SICI)1097-4644(19980915)70:4<489::AID-JCB6>3.0.CO;2-F }}
*{{cite journal  | author=Briggs RC, Briggs JA, Ozer J, ''et al.'' |title=The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. |journal=Blood |volume=83 |issue= 8 |pages= 2153-62 |year= 1994 |pmid= 7512843 |doi=  }}
* {{cite journal | vauthors = Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC | title = Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression | journal = Journal of Cellular Biochemistry | volume = 86 | issue = 1 | pages = 56–66 | year = 2002 | pmid = 12112016 | doi = 10.1002/jcb.10190 }}
*{{cite journal | author=Dawson MJ, Trapani JA, Briggs RC, ''et al.'' |title=The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. |journal=Immunogenetics |volume=41 |issue= 1 |pages= 40-3 |year= 1995 |pmid= 7806273 |doi= }}
* {{cite journal | vauthors = Fukushi M, Higuchi M, Oie M, Tetsuka T, Kasolo F, Ichiyama K, Yamamoto N, Katano H, Sata T, Fujii M | title = Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha | journal = Virus Genes | volume = 27 | issue = 3 | pages = 237–47 | date = December 2003 | pmid = 14618084 | doi = 10.1023/A:1026391715071 }}
*{{cite journal | author=Briggs R, Dworkin L, Briggs J, ''et al.'' |title=Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. |journal=J. Cell. Biochem. |volume=54 |issue= 2 |pages= 198-206 |year= 1994 |pmid= 8175894 |doi= 10.1002/jcb.240540208 }}
* {{cite journal | vauthors = Briggs RC, Atkinson JB, Miranda RN | title = Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis | journal = Journal of Cellular Biochemistry | volume = 95 | issue = 2 | pages = 293–301 | date = May 2005 | pmid = 15778972 | doi = 10.1002/jcb.20435 }}
*{{cite journal | author=Xie J, Briggs JA, Briggs RC |title=Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding. |journal=J. Cell. Biochem. |volume=70 |issue= 4 |pages= 489-506 |year= 1998 |pmid= 9712147 |doi= }}
* {{cite journal | vauthors = Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ, Keller JR | title = p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation | journal = FEBS Letters | volume = 580 | issue = 5 | pages = 1205–14 | date = February 2006 | pmid = 16458891 | doi = 10.1016/j.febslet.2006.01.032 }}
*{{cite journal | author=Doggett KL, Briggs JA, Linton MF, ''et al.'' |title=Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression. |journal=J. Cell. Biochem. |volume=86 |issue= 1 |pages= 56-66 |year= 2002 |pmid= 12112016 |doi= 10.1002/jcb.10190 }}
* {{cite journal | vauthors = Briggs RC, Shults KE, Flye LA, McClintock-Treep SA, Jagasia MH, Goodman SA, Boulos FI, Jacobberger JW, Stelzer GT, Head DR | title = Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis | journal = Cancer Research | volume = 66 | issue = 9 | pages = 4645–51 | date = May 2006 | pmid = 16651415 | doi = 10.1158/0008-5472.CAN-06-0229 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Fukushi M, Higuchi M, Oie M, ''et al.'' |title=Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha. |journal=Virus Genes |volume=27 |issue= 3 |pages= 237-47 |year= 2004 |pmid= 14618084 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Briggs RC, Atkinson JB, Miranda RN |title=Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis. |journal=J. Cell. Biochem. |volume=95 |issue= 2 |pages= 293-301 |year= 2005 |pmid= 15778972 |doi= 10.1002/jcb.20435 }}
*{{cite journal | author=Asefa B, Dermott JM, Kaldis P, ''et al.'' |title=p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. |journal=FEBS Lett. |volume=580 |issue= 5 |pages= 1205-14 |year= 2006 |pmid= 16458891 |doi= 10.1016/j.febslet.2006.01.032 }}
*{{cite journal | author=Briggs RC, Shults KE, Flye LA, ''et al.'' |title=Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis. |journal=Cancer Res. |volume=66 |issue= 9 |pages= 4645-51 |year= 2006 |pmid= 16651415 |doi= 10.1158/0008-5472.CAN-06-0229 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4332}}


== External links ==
== External links ==
* {{MeshName|MNDA+protein,+human}}
* {{MeshName|MNDA+protein,+human}}


{{NLM content}}
{{Transcription factors|g0}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-1-stub}}

Latest revision as of 01:55, 25 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.[1][2][3]

Function

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.[3]

References

  1. ↑ Briggs JA, Burrus GR, Stickney BD, Briggs RC (May 1992). "Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha". Journal of Cellular Biochemistry. 49 (1): 82–92. doi:10.1002/jcb.240490114. PMID 1644857.
  2. ↑ Briggs RC, Briggs JA, Ozer J, Sealy L, Dworkin LL, Kingsmore SF, Seldin MF, Kaur GP, Athwal RS, Dessypris EN (April 1994). "The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells". Blood. 83 (8): 2153–62. PMID 7512843.
  3. ↑ 3.0 3.1 "Entrez Gene: MNDA myeloid cell nuclear differentiation antigen".

Further reading

  • Burrus GR, Briggs JA, Briggs RC (February 1992). "Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins". Journal of Cellular Biochemistry. 48 (2): 190–202. doi:10.1002/jcb.240480210. PMID 1377701.
  • Ott J, Fràter-Schröder M (1982). "Absence of linkage between transcobalamin II and ABO". Human Genetics. 59 (2): 164–5. doi:10.1007/BF00293068. PMID 7327575.
  • Dawson MJ, Trapani JA, Briggs RC, Nicholl JK, Sutherland GR, Baker E (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression". Immunogenetics. 41 (1): 40–3. doi:10.1007/BF00188431. PMID 7806273.
  • Briggs R, Dworkin L, Briggs J, Dessypris E, Stein J, Stein G, Lian J (February 1994). "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage". Journal of Cellular Biochemistry. 54 (2): 198–206. doi:10.1002/jcb.240540208. PMID 8175894.
  • Xie J, Briggs JA, Briggs RC (September 1998). "Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding". Journal of Cellular Biochemistry. 70 (4): 489–506. doi:10.1002/(SICI)1097-4644(19980915)70:4<489::AID-JCB6>3.0.CO;2-F. PMID 9712147.
  • Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression". Journal of Cellular Biochemistry. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID 12112016.
  • Fukushi M, Higuchi M, Oie M, Tetsuka T, Kasolo F, Ichiyama K, Yamamoto N, Katano H, Sata T, Fujii M (December 2003). "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha". Virus Genes. 27 (3): 237–47. doi:10.1023/A:1026391715071. PMID 14618084.
  • Briggs RC, Atkinson JB, Miranda RN (May 2005). "Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis". Journal of Cellular Biochemistry. 95 (2): 293–301. doi:10.1002/jcb.20435. PMID 15778972.
  • Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ, Keller JR (February 2006). "p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation". FEBS Letters. 580 (5): 1205–14. doi:10.1016/j.febslet.2006.01.032. PMID 16458891.
  • Briggs RC, Shults KE, Flye LA, McClintock-Treep SA, Jagasia MH, Goodman SA, Boulos FI, Jacobberger JW, Stelzer GT, Head DR (May 2006). "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis". Cancer Research. 66 (9): 4645–51. doi:10.1158/0008-5472.CAN-06-0229. PMID 16651415.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=MNDA&oldid=1530741"