HES6: Difference between revisions

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
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Latest revision as of 01:39, 13 September 2018

Transcription cofactor HES-6 is a protein that in humans is encoded by the HES6 gene.^[1]^[2]

Interactions

HES6 has been shown to interact with TLE1.^[3]

References

↑ Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. PMID 10851137.
↑ "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".
↑ Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.

Bech P, Bolwig TG, Dein E, Jacobsen O, Gram LF (1975). "Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale". Acta Psychiatr Scand. 52 (1): 1–6. doi:10.1111/j.1600-0447.1975.tb00017.x. PMID 1155198.
Vasiliauskas D, Stern CD (2000). "Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors". Mech. Dev. 98 (1–2): 133–7. doi:10.1016/S0925-4773(00)00443-3. PMID 11044617.
Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.
Swearingen ML, Sun D, Bourner M, Weinstein EJ (2003). "Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array". Cancer Lett. 198 (2): 229–39. doi:10.1016/S0304-3835(03)00313-6. PMID 12957362.
Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S (2003). "Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms". Mol. Cell. Biol. 23 (19): 6922–35. doi:10.1128/MCB.23.19.6922-6935.2003. PMC 193938. PMID 12972610.
Kang SA, Seol JH, Kim J (2005). "The conserved WRPW motif of Hes6 mediates proteasomal degradation". Biochem. Biophys. Res. Commun. 332 (1): 33–6. doi:10.1016/j.bbrc.2005.04.089. PMID 15896295.
Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F (2007). "HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion". Biochem. Biophys. Res. Commun. 355 (2): 331–7. doi:10.1016/j.bbrc.2007.01.153. PMC 1852427. PMID 17300753.
Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D (2007). "Impaired expression of Notch signaling genes in aged human skeletal muscle". J. Gerontol. A Biol. Sci. Med. Sci. 62 (1): 9–17. doi:10.1093/gerona/62.1.9. PMID 17301032.
Scheffer D, Sage C, Corey DP, Pingault V (2007). "Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells". FEBS Lett. 581 (24): 4651–6. doi:10.1016/j.febslet.2007.08.059. PMID 17826772.

External links

HES6+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[pmid10851137-1] Bae S, Bessho Y, Hojo M, Kageyama R (Aug 2000). "The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation". Development. 127 (13): 2933–43. PMID 10851137.

[entrez-2] "Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)".

[pmid11551980-3] Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". J. Cell Biol. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Transcription cofactor HES-6''' is a [[protein]] that in humans is encoded by the ''HES6'' [[gene]].<ref name="pmid10851137">{{cite journal | vauthors = Bae S, Bessho Y, Hojo M, Kageyama R | title = The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation | journal = Development | volume = 127 | issue = 13 | pages = 2933–43  | date = Aug 2000 | pmid = 10851137 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55502| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Hairy and enhancer of split 6 (Drosophila)
- | HGNCid = 18254
- | Symbol = HES6
- | AltSymbols =;
- | OMIM = 610331
- | ECnumber =
- | Homologene = 23111
- | MGIid = 1859852
- | GeneAtlas_image1 = PBB_GE_HES6_gnf1h00306_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
- | Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 55502
-    | Hs_Ensembl = ENSG00000144485
-    | Hs_RefseqProtein = NP_061115
-    | Hs_RefseqmRNA = NM_018645
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 238812207
-    | Hs_GenLoc_end = 238813418
-    | Hs_Uniprot = Q96HZ4
-    | Mm_EntrezGene = 55927
-    | Mm_Ensembl = ENSMUSG00000067071
-    | Mm_RefseqmRNA = NM_019479
-    | Mm_RefseqProtein = NP_062352
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 93241889
-    | Mm_GenLoc_end = 93243628
-    | Mm_Uniprot = Q9JHE6
-  }}
-}}
-'''Hairy and enhancer of split 6 (Drosophila)''', also known as '''HES6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HES6 hairy and enhancer of split 6 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55502| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+HES6 has been shown to [[Protein-protein interaction|interact]] with [[TLE1]].<ref name=pmid11551980>{{cite journal | vauthors = Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R | title = HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program | journal = J. Cell Biol. | volume = 154 | issue = 6 | pages = 1161–71  | date = Sep 2001 | pmid = 11551980 | pmc = 2150829 | doi = 10.1083/jcb.200104058 }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Bech P, Bolwig TG, Dein E, Jacobsen O, Gram LF | title = Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale | journal = [[Acta Psychiatr Scand]] | volume = 52 | issue = 1 | pages = 1–6 | year = 1975 | pmid = 1155198 | doi = 10.1111/j.1600-0447.1975.tb00017.x }}
-| citations =
+* {{cite journal | vauthors = Vasiliauskas D, Stern CD | title = Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors | journal = Mech. Dev. | volume = 98 | issue = 1-2 | pages = 133–7 | year = 2000 | pmid = 11044617 | doi = 10.1016/S0925-4773(00)00443-3 }}
-*{{cite journal  | author=Bech P, Bolwig TG, Dein E, ''et al.'' |title=Quantitative rating of manic states. Correlation between clinical assessment and Biegel's Objective Rating Scale. |journal=[[Acta Psychiatrica Scandinavica]] |volume=52 |issue= 1 |pages= 1-6 |year= 1975 |pmid= 1155198 |doi=  }}
+* {{cite journal | vauthors = Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R | title = HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program | journal = J. Cell Biol. | volume = 154 | issue = 6 | pages = 1161–71 | year = 2001 | pmid = 11551980 | pmc = 2150829 | doi = 10.1083/jcb.200104058 }}
-*{{cite journal  | author=Bae S, Bessho Y, Hojo M, Kageyama R |title=The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. |journal=Development |volume=127 |issue= 13 |pages= 2933-43 |year= 2000 |pmid= 10851137 |doi=  }}
+* {{cite journal | vauthors = Swearingen ML, Sun D, Bourner M, Weinstein EJ | title = Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array | journal = Cancer Lett. | volume = 198 | issue = 2 | pages = 229–39 | year = 2003 | pmid = 12957362 | doi = 10.1016/S0304-3835(03)00313-6 }}
-*{{cite journal  | author=Vasiliauskas D, Stern CD |title=Expression of mouse HES-6, a new member of the Hairy/Enhancer of split family of bHLH transcription factors. |journal=Mech. Dev. |volume=98 |issue= 1-2 |pages= 133-7 |year= 2001 |pmid= 11044617 |doi=  }}
+* {{cite journal | vauthors = Gratton MO, Torban E, Jasmin SB, Theriault FM, German MS, Stifani S | title = Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms | journal = Mol. Cell. Biol. | volume = 23 | issue = 19 | pages = 6922–35 | year = 2003 | pmid = 12972610 | pmc = 193938 | doi = 10.1128/MCB.23.19.6922-6935.2003 }}
-*{{cite journal  | author=Gao X, Chandra T, Gratton MO, ''et al.'' |title=HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program. |journal=J. Cell Biol. |volume=154 |issue= 6 |pages= 1161-71 |year= 2001 |pmid= 11551980 |doi= 10.1083/jcb.200104058 }}
+* {{cite journal | vauthors = Kang SA, Seol JH, Kim J | title = The conserved WRPW motif of Hes6 mediates proteasomal degradation | journal = Biochem. Biophys. Res. Commun. | volume = 332 | issue = 1 | pages = 33–6 | year = 2005 | pmid = 15896295 | doi = 10.1016/j.bbrc.2005.04.089 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Ball AJ, Abrahamsson AE, Tyrberg B, Itkin-Ansari P, Levine F | title = HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion | journal = Biochem. Biophys. Res. Commun. | volume = 355 | issue = 2 | pages = 331–7 | year = 2007 | pmid = 17300753 | pmc = 1852427 | doi = 10.1016/j.bbrc.2007.01.153 }}
-*{{cite journal  | author=Swearingen ML, Sun D, Bourner M, Weinstein EJ |title=Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array. |journal=Cancer Lett. |volume=198 |issue= 2 |pages= 229-39 |year= 2003 |pmid= 12957362 |doi=  }}
+* {{cite journal | vauthors = Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D | title = Impaired expression of Notch signaling genes in aged human skeletal muscle | journal = J. Gerontol. A Biol. Sci. Med. Sci. | volume = 62 | issue = 1 | pages = 9–17 | year = 2007 | pmid = 17301032 | doi = 10.1093/gerona/62.1.9 }}
-*{{cite journal  | author=Gratton MO, Torban E, Jasmin SB, ''et al.'' |title=Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms. |journal=Mol. Cell. Biol. |volume=23 |issue= 19 |pages= 6922-35 |year= 2003 |pmid= 12972610 |doi=  }}
+* {{cite journal | vauthors = Scheffer D, Sage C, Corey DP, Pingault V | title = Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells | journal = FEBS Lett. | volume = 581 | issue = 24 | pages = 4651–6 | year = 2007 | pmid = 17826772 | doi = 10.1016/j.febslet.2007.08.059 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
-*{{cite journal  | author=Kang SA, Seol JH, Kim J |title=The conserved WRPW motif of Hes6 mediates proteasomal degradation. |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 1 |pages= 33-6 |year= 2005 |pmid= 15896295 |doi= 10.1016/j.bbrc.2005.04.089 }}
-*{{cite journal  | author=Ball AJ, Abrahamsson AE, Tyrberg B, ''et al.'' |title=HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion. |journal=Biochem. Biophys. Res. Commun. |volume=355 |issue= 2 |pages= 331-7 |year= 2007 |pmid= 17300753 |doi= 10.1016/j.bbrc.2007.01.153 }}
-*{{cite journal  | author=Carey KA, Farnfield MM, Tarquinio SD, Cameron-Smith D |title=Impaired expression of Notch signaling genes in aged human skeletal muscle. |journal=J. Gerontol. A Biol. Sci. Med. Sci. |volume=62 |issue= 1 |pages= 9-17 |year= 2007 |pmid= 17301032 |doi=  }}
-*{{cite journal  | author=Scheffer D, Sage C, Corey DP, Pingault V |title=Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells. |journal=FEBS Lett. |volume=581 |issue= 24 |pages= 4651-6 |year= 2007 |pmid= 17826772 |doi= 10.1016/j.febslet.2007.08.059 }}
-}}
 {{refend}}
@@ Line 80: / Line 25: @@
 * {{MeshName|HES6+protein,+human}}
+{{Transcription factors|g1}}
+{{NLM content}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-2-stub}}

HES6: Difference between revisions

Latest revision as of 01:39, 13 September 2018

Contents

Interactions

References

Further reading

External links

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