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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor SOX-11''' is a [[protein]] that in humans is encoded by the ''SOX11'' [[gene]].<ref name="pmid8666406">{{cite journal | vauthors = Jay P, Gozé C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P | title = The human SOX11 gene: cloning, chromosomal assignment and tissue expression | journal = Genomics | volume = 29 | issue = 2 | pages = 541–5 | date = Sep 1995 | pmid = 8666406 | pmc =  | doi = 10.1006/geno.1995.9970 }}</ref><ref name="pmid12637543">{{cite journal | vauthors = Wiebe MS, Nowling TK, Rizzino A | title = Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 17901–11 | date = May 2003 | pmid = 12637543 | pmc =  | doi = 10.1074/jbc.M212211200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SOX11 SRY (sex determining region Y)-box 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6664| accessdate = }}</ref>
| update_page = yes
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| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SRY (sex determining region Y)-box 11
| HGNCid = 11191
| Symbol = SOX11
| AltSymbols =;
| OMIM = 600898
| ECnumber = 
| Homologene = 37733
| MGIid = 98359
| GeneAtlas_image1 = PBB_GE_SOX11_204915_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOX11_204913_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SOX11_204914_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6664
    | Hs_Ensembl = ENSG00000176887
    | Hs_RefseqProtein = XP_001128542
    | Hs_RefseqmRNA = XM_001128542
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 5750250
    | Hs_GenLoc_end = 5758968
    | Hs_Uniprot = P35716
    | Mm_EntrezGene = 20666
    | Mm_Ensembl = ENSMUSG00000063632
    | Mm_RefseqmRNA = NM_009234
    | Mm_RefseqProtein = NP_033260
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 27927489
    | Mm_GenLoc_end = 27928676
    | Mm_Uniprot = Q6AZA6
  }}
}}
'''SRY (sex determining region Y)-box 11''', also known as '''SOX11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOX11 SRY (sex determining region Y)-box 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6664| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This intronless gene encodes a member of the group C SOX ([[SOX gene family|SRY-related HMG-box]]) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.<ref name="entrez" /><ref name="pmid19490090">{{cite journal | vauthors = Haslinger A, Schwarz TJ, Covic M, Lie DC | title = Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis | journal = The European Journal of Neuroscience | volume = 29 | issue = 11 | pages = 2103–14 | date = Jun 2009 | pmid = 19490090 | pmc =  | doi = 10.1111/j.1460-9568.2009.06768.x }}</ref> Tuj1 and Tead2 are suggested as direct target of Sox11.<ref name="pmid17182872">{{cite journal | vauthors = Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J | title = The establishment of neuronal properties is controlled by Sox4 and Sox11 | journal = Genes & Development | volume = 20 | issue = 24 | pages = 3475–86 | date = Dec 2006 | pmid = 17182872 | pmc = 1698453 | doi = 10.1101/gad.403406 }}</ref><ref name="pmid20596238">{{cite journal | vauthors = Bhattaram P, Penzo-Méndez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V | title = Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors | journal = Nature Communications | volume = 1 | issue = 1 | pages = 9 | date = Apr 2010 | pmid = 20596238 | pmc = 2892298 | doi = 10.1038/ncomms1008 }}</ref><ref>{{cite journal | vauthors = Larson BL, Ylostalo J, Lee RH, Gregory C, Prockop DJ | title = Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells | journal = Tissue Engineering. Part A | volume = 16 | issue = 11 | pages = 3385–94 | date = Nov 2010 | pmc = 2965191 | doi = 10.1089/ten.tea.2010.0085 | pmid = 20626275 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.<ref name="entrez">{{cite web | title = Entrez Gene: SOX11 SRY (sex determining region Y)-box 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6664| accessdate = }}</ref>
}}


==See also==
==Clinical aspect==
Mutations in SOX11 are associated to {{SWL|type=mutations_associated_to|target=Coffin-Siris syndrome|label=Coffin-Siris syndrome}}.<ref>{{cite journal | vauthors = Tsurusaki Y, Koshimizu E, Ohashi H, Phadke S, Kou I, Shiina M, Suzuki T, Okamoto N, Imamura S, Yamashita M, Watanabe S, Yoshiura K, Kodera H, Miyatake S, Nakashima M, Saitsu H, Ogata K, Ikegawa S, Miyake N, Matsumoto N | title = De novo SOX11 mutations cause Coffin-Siris syndrome | journal = Nature Communications | volume = 5 | pages = 4011 | year = 2014 | pmid = 24886874 | doi = 10.1038/ncomms5011 }}</ref>
 
== See also ==
* [[SOX genes]]
* [[SOX genes]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wilson M, Koopman P | title = Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators | journal = Current Opinion in Genetics & Development | volume = 12 | issue = 4 | pages = 441–6 | date = Aug 2002 | pmid = 12100890 | doi = 10.1016/S0959-437X(02)00323-4 }}
| citations =
* {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Developmental Cell | volume = 3 | issue = 2 | pages = 167–70 | date = Aug 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X }}
*{{cite journal | author=Wilson M, Koopman P |title=Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 4 |pages= 441-6 |year= 2003 |pmid= 12100890 |doi= }}
* {{cite journal | vauthors = Gozé C, Poulat F, Berta P | title = Partial cloning of SOX-11 and SOX-12, two new human SOX genes | journal = Nucleic Acids Research | volume = 21 | issue = 12 | pages = 2943 | date = Jun 1993 | pmid = 8332506 | pmc = 309692 | doi = 10.1093/nar/21.12.2943 }}
*{{cite journal | author=Schepers GE, Teasdale RD, Koopman P |title=Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. |journal=Dev. Cell |volume=3 |issue= 2 |pages= 167-70 |year= 2002 |pmid= 12194848 |doi= }}
* {{cite journal | vauthors = Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M | title = Cooperative function of POU proteins and SOX proteins in glial cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 26 | pages = 16050–7 | date = Jun 1998 | pmid = 9632656 | doi = 10.1074/jbc.273.26.16050 }}
*{{cite journal | author=Gozé C, Poulat F, Berta P |title=Partial cloning of SOX-11 and SOX-12, two new human SOX genes. |journal=Nucleic Acids Res. |volume=21 |issue= 12 |pages= 2943 |year= 1993 |pmid= 8332506 |doi=  }}
* {{cite journal | vauthors = Azuma T, Ao S, Saito Y, Yano K, Seki N, Wakao H, Masuho Y, Muramatsu M | title = Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region | journal = DNA Research | volume = 6 | issue = 5 | pages = 357–60 | date = Oct 1999 | pmid = 10574465 | doi = 10.1093/dnares/6.5.357 }}
*{{cite journal  | author=Jay P, Gozé C, Marsollier C, ''et al.'' |title=The human SOX11 gene: cloning, chromosomal assignment and tissue expression. |journal=Genomics |volume=29 |issue= 2 |pages= 541-5 |year= 1996 |pmid= 8666406 |doi= 10.1006/geno.1995.9970 }}
* {{cite journal | vauthors = Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ | title = Differential expression of SOX4 and SOX11 in medulloblastoma | journal = Journal of Neuro-Oncology | volume = 57 | issue = 3 | pages = 201–14 | date = May 2002 | pmid = 12125983 | doi = 10.1023/A:1015773818302 }}
*{{cite journal | author=Kuhlbrodt K, Herbarth B, Sock E, ''et al.'' |title=Cooperative function of POU proteins and SOX proteins in glial cells. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16050-7 |year= 1998 |pmid= 9632656 |doi= }}
* {{cite journal | vauthors = Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain | journal = Molecular & Cellular Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | date = Nov 2004 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 }}
*{{cite journal | author=Azuma T, Ao S, Saito Y, ''et al.'' |title=Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region. |journal=DNA Res. |volume=6 |issue= 5 |pages= 357-60 |year= 2000 |pmid= 10574465 |doi= }}
* {{cite journal | vauthors = Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM | title = Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells | journal = Development | volume = 132 | issue = 13 | pages = 3045–54 | date = Jul 2005 | pmid = 15944188 | doi = 10.1242/dev.01890 }}
*{{cite journal | author=Lee CJ, Appleby VJ, Orme AT, ''et al.'' |title=Differential expression of SOX4 and SOX11 in medulloblastoma. |journal=J. Neurooncol. |volume=57 |issue= 3 |pages= 201-14 |year= 2003 |pmid= 12125983 |doi=  }}
* {{cite journal | vauthors = Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F | title = NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY | journal = The Journal of Biological Chemistry | volume = 280 | issue = 46 | pages = 38625–30 | date = Nov 2005 | pmid = 16166090 | doi = 10.1074/jbc.M504127200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = DesGroseilliers M, Fortin F, Lemyre E, Lemieux N | title = Complex mosaicism in sex reversed SRY+ male twins | journal = Cytogenetic and Genome Research | volume = 112 | issue = 1-2 | pages = 176–9 | year = 2006 | pmid = 16276109 | doi = 10.1159/000087532 }}
*{{cite journal  | author=Wiebe MS, Nowling TK, Rizzino A |title=Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 17901-11 |year= 2003 |pmid= 12637543 |doi= 10.1074/jbc.M212211200 }}
*{{cite journal | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal | author=Bouma GJ, Albrecht KH, Washburn LL, ''et al.'' |title=Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. |journal=Development |volume=132 |issue= 13 |pages= 3045-54 |year= 2005 |pmid= 15944188 |doi= 10.1242/dev.01890 }}
*{{cite journal | author=Thevenet L, Albrecht KH, Malki S, ''et al.'' |title=NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY. |journal=J. Biol. Chem. |volume=280 |issue= 46 |pages= 38625-30 |year= 2006 |pmid= 16166090 |doi= 10.1074/jbc.M504127200 }}
*{{cite journal | author=DesGroseilliers M, Fortin F, Lemyre E, Lemieux N |title=Complex mosaicism in sex reversed SRY+ male twins. |journal=Cytogenet. Genome Res. |volume=112 |issue= 1-2 |pages= 176-9 |year= 2006 |pmid= 16276109 |doi= 10.1159/000087532 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Transcription factors|g4}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 02:55, 10 July 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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n/a

Ensembl

n/a

n/a

UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.[1][2][3]

Function

This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis.[3][4] Tuj1 and Tead2 are suggested as direct target of Sox11.[5][6][7]

Clinical aspect

Mutations in SOX11 are associated to Coffin-Siris syndrome .[8]

See also

References

  1. ↑ Jay P, Gozé C, Marsollier C, Taviaux S, Hardelin JP, Koopman P, Berta P (Sep 1995). "The human SOX11 gene: cloning, chromosomal assignment and tissue expression". Genomics. 29 (2): 541–5. doi:10.1006/geno.1995.9970. PMID 8666406.
  2. ↑ Wiebe MS, Nowling TK, Rizzino A (May 2003). "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity". The Journal of Biological Chemistry. 278 (20): 17901–11. doi:10.1074/jbc.M212211200. PMID 12637543.
  3. ↑ 3.0 3.1 "Entrez Gene: SOX11 SRY (sex determining region Y)-box 11".
  4. ↑ Haslinger A, Schwarz TJ, Covic M, Lie DC (Jun 2009). "Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis". The European Journal of Neuroscience. 29 (11): 2103–14. doi:10.1111/j.1460-9568.2009.06768.x. PMID 19490090.
  5. ↑ Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J (Dec 2006). "The establishment of neuronal properties is controlled by Sox4 and Sox11". Genes & Development. 20 (24): 3475–86. doi:10.1101/gad.403406. PMC 1698453. PMID 17182872.
  6. ↑ Bhattaram P, Penzo-Méndez A, Sock E, Colmenares C, Kaneko KJ, Vassilev A, Depamphilis ML, Wegner M, Lefebvre V (Apr 2010). "Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors". Nature Communications. 1 (1): 9. doi:10.1038/ncomms1008. PMC 2892298. PMID 20596238.
  7. ↑ Larson BL, Ylostalo J, Lee RH, Gregory C, Prockop DJ (Nov 2010). "Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells". Tissue Engineering. Part A. 16 (11): 3385–94. doi:10.1089/ten.tea.2010.0085. PMC 2965191. PMID 20626275.
  8. ↑ Tsurusaki Y, Koshimizu E, Ohashi H, Phadke S, Kou I, Shiina M, Suzuki T, Okamoto N, Imamura S, Yamashita M, Watanabe S, Yoshiura K, Kodera H, Miyatake S, Nakashima M, Saitsu H, Ogata K, Ikegawa S, Miyake N, Matsumoto N (2014). "De novo SOX11 mutations cause Coffin-Siris syndrome". Nature Communications. 5: 4011. doi:10.1038/ncomms5011. PMID 24886874.

Further reading

  • Wilson M, Koopman P (Aug 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
  • Schepers GE, Teasdale RD, Koopman P (Aug 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
  • Gozé C, Poulat F, Berta P (Jun 1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Research. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.
  • Kuhlbrodt K, Herbarth B, Sock E, Enderich J, Hermans-Borgmeyer I, Wegner M (Jun 1998). "Cooperative function of POU proteins and SOX proteins in glial cells". The Journal of Biological Chemistry. 273 (26): 16050–7. doi:10.1074/jbc.273.26.16050. PMID 9632656.
  • Azuma T, Ao S, Saito Y, Yano K, Seki N, Wakao H, Masuho Y, Muramatsu M (Oct 1999). "Human SOX11, an upregulated gene during the neural differentiation, has a long 3' untranslated region". DNA Research. 6 (5): 357–60. doi:10.1093/dnares/6.5.357. PMID 10574465.
  • Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ (May 2002). "Differential expression of SOX4 and SOX11 in medulloblastoma". Journal of Neuro-Oncology. 57 (3): 201–14. doi:10.1023/A:1015773818302. PMID 12125983.
  • Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM (Jul 2005). "Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells". Development. 132 (13): 3045–54. doi:10.1242/dev.01890. PMID 15944188.
  • Thevenet L, Albrecht KH, Malki S, Berta P, Boizet-Bonhoure B, Poulat F (Nov 2005). "NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY". The Journal of Biological Chemistry. 280 (46): 38625–30. doi:10.1074/jbc.M504127200. PMID 16166090.
  • DesGroseilliers M, Fortin F, Lemyre E, Lemieux N (2006). "Complex mosaicism in sex reversed SRY+ male twins". Cytogenetic and Genome Research. 112 (1–2): 176–9. doi:10.1159/000087532. PMID 16276109.


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