SOX4: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor SOX-4''' is a [[protein]] that in humans is encoded by the ''SOX4'' [[gene]].<ref name="pmid8268656">{{cite journal | vauthors = Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN | title = Characterization and mapping of the human SOX4 gene | journal = Mammalian Genome | volume = 4 | issue = 10 | pages = 577–84 | date = January 1994 | pmid = 8268656 | pmc =  | doi = 10.1007/BF00361388 }}</ref><ref name="pmid9730625">{{cite journal | vauthors = Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ | title = Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3 | journal = Cytogenetics and Cell Genetics | volume = 81 | issue = 3-4 | pages = 294–5 | date = October 1998 | pmid = 9730625 | pmc =  | doi = 10.1159/000015052 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SOX4 SRY (sex determining region Y)-box 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6659| access-date = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SRY (sex determining region Y)-box 4
| HGNCid = 11200
| Symbol = SOX4
| AltSymbols =; EVI16
| OMIM = 184430
| ECnumber = 
| Homologene = 2338
| MGIid = 98366
| GeneAtlas_image1 = PBB_GE_SOX4_201417_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOX4_201416_at_tn.png
| GeneAtlas_image3 = PBB_GE_SOX4_201418_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0031017 |text = exocrine pancreas development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6659
    | Hs_Ensembl = ENSG00000124766
    | Hs_RefseqProtein = NP_003098
    | Hs_RefseqmRNA = NM_003107
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 21700979
    | Hs_GenLoc_end = 21706829
    | Hs_Uniprot = Q06945
    | Mm_EntrezGene = 20677
    | Mm_Ensembl = ENSMUSG00000076431
    | Mm_RefseqmRNA = NM_009238
    | Mm_RefseqProtein = NP_033264
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 28956384
    | Mm_GenLoc_end = 28961178
    | Mm_Uniprot = Q5SW95
  }}
}}
'''SRY (sex determining region Y)-box 4''', also known as '''SOX4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOX4 SRY (sex determining region Y)-box 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6659| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.<ref name="entrez">{{cite web | title = Entrez Gene: SOX4 SRY (sex determining region Y)-box 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6659| accessdate = }}</ref>
}}


==See also==
Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.<ref name="pmid14982952">{{cite journal | vauthors = Smith E, Sigvardsson M | title = The roles of transcription factors in B lymphocyte commitment, development, and transformation | journal = Journal of Leukocyte Biology | volume = 75 | issue = 6 | pages = 973–81 | date = June 2004 | pmid = 14982952 | doi = 10.1189/jlb.1103554 }}</ref>
 
== Clinical significance ==
 
A genomic region close to the ''SOX4'' gene has been associated with endometrial cancer development.<ref>{{cite journal | vauthors = O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, Black A, Bolla MK, Brauch H, Brenner H, Brinton L, Buchanan DD, Burwinkel B, Chang-Claude J, Chanock SJ, Chen C, Chen MM, Cheng TH, Clarke CL, Clendenning M, Cook LS, Couch FJ, Cox A, Crous-Bous M, Czene K, Day F, Dennis J, Depreeuw J, Doherty JA, Dörk T, Dowdy SC, Dürst M, Ekici AB, Fasching PA, Fridley BL, Friedenreich CM, Fritschi L, Fung J, García-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankison SE, Healey CS, Hein A, Hillemanns P, Hodgson S, Hoivik EA, Holliday EG, Hopper JL, Hunter DJ, Jones A, Krakstad C, Kristensen VN, Lambrechts D, Marchand LL, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, Meindl A, Michailidou K, Milne RL, Mints M, Montgomery GW, Nassir R, Olsson H, Orlow I, Otton G, Palles C, Perry JR, Peto J, Pooler L, Prescott J, Proietto T, Rebbeck TR, Risch HA, Rogers PA, Rübner M, Runnebaum I, Sacerdote C, Sarto GE, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng X, Shu XO, Southey MC, Swerdlow AJ, Tham E, Trovik J, Turman C, Tyrer JP, Vachon C, VanDen Berg D, Vanderstichele A, Wang Z, Webb PM, Wentzensen N, Werner HM, Winham SJ, Wolk A, Xia L, Xiang YB, Yang HP, Yu H, Zheng W, Pharoah PD, Dunning AM, Kraft P, De Vivo I, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ | display-authors = 8 | title = Identification of nine new susceptibility loci for endometrial cancer | language = En | journal = Nature Communications | volume = 9 | issue = 1 | pages = 3166 | date = August 2018 | pmid = 30093612 | pmc = 6085317 | doi = 10.1038/s41467-018-05427-7 }}</ref><ref>{{cite journal | vauthors = Chen MM, O'Mara TA, Thompson DJ, Painter JN, Attia J, Black A, Brinton L, Chanock S, Chen C, Cheng TH, Cook LS, Crous-Bou M, Doherty J, Friedenreich CM, Garcia-Closas M, Gaudet MM, Gorman M, Haiman C, Hankinson SE, Hartge P, Henderson BE, Hodgson S, Holliday EG, Horn-Ross PL, Hunter DJ, Le Marchand L, Liang X, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, McEvoy M, Olson SH, Orlow I, Pooler L, Prescott J, Rastogi R, Rebbeck TR, Risch H, Sacerdote C, Schumacher F, Wendy Setiawan V, Scott RJ, Sheng X, Shu XO, Turman C, Van Den Berg D, Wang Z, Weiss NS, Wentzensen N, Xia L, Xiang YB, Yang HP, Yu H, Zheng W, Pharoah PD, Dunning AM, Tomlinson I, Easton DF, Kraft P, Spurdle AB, De Vivo I | display-authors = 6 | title = GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer | journal = Human Molecular Genetics | volume = 25 | issue = 12 | pages = 2612–2620 | date = June 2016 | pmid = 27008869 | pmc = 5868213 | doi = 10.1093/hmg/ddw092 | first8 = Louise | first9 = Stephen | first6 = John | first7 = Amanda }}</ref>
 
== Interactions ==
SOX4 has been shown to [[Protein-protein interaction|interact]] with [[SDCBP]].<ref name=pmid11498591>{{cite journal | vauthors = Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ | title = Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein | journal = Science | volume = 293 | issue = 5532 | pages = 1136–8 | date = August 2001 | pmid = 11498591 | doi = 10.1126/science.1059157 }}</ref>
 
== See also ==
* [[SOX genes]]
* [[SOX genes]]


==References==
== References ==
{{reflist|2}}
{{Reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Kamachi Y, Uchikawa M, Kondoh H | title = Pairing SOX off: with partners in the regulation of embryonic development | journal = Trends in Genetics | volume = 16 | issue = 4 | pages = 182–7 | date = April 2000 | pmid = 10729834 | doi = 10.1016/S0168-9525(99)01955-1 }}
| citations =
* {{cite journal | vauthors = Bowles J, Schepers G, Koopman P | title = Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators | journal = Developmental Biology | volume = 227 | issue = 2 | pages = 239–55 | date = November 2000 | pmid = 11071752 | doi = 10.1006/dbio.2000.9883 }}
*{{cite journal | author=Kamachi Y, Uchikawa M, Kondoh H |title=Pairing SOX off: with partners in the regulation of embryonic development. |journal=Trends Genet. |volume=16 |issue= 4 |pages= 182-7 |year= 2000 |pmid= 10729834 |doi= }}
* {{cite journal | vauthors = Wilson M, Koopman P | title = Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators | journal = Current Opinion in Genetics & Development | volume = 12 | issue = 4 | pages = 441–6 | date = August 2002 | pmid = 12100890 | doi = 10.1016/S0959-437X(02)00323-4 }}
*{{cite journal | author=Bowles J, Schepers G, Koopman P |title=Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. |journal=Dev. Biol. |volume=227 |issue= 2 |pages= 239-55 |year= 2001 |pmid= 11071752 |doi= 10.1006/dbio.2000.9883 }}
* {{cite journal | vauthors = Schepers GE, Teasdale RD, Koopman P | title = Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families | journal = Developmental Cell | volume = 3 | issue = 2 | pages = 167–70 | date = August 2002 | pmid = 12194848 | doi = 10.1016/S1534-5807(02)00223-X }}
*{{cite journal | author=Wilson M, Koopman P |title=Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 4 |pages= 441-6 |year= 2003 |pmid= 12100890 |doi= }}
* {{cite journal | vauthors = Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A | title = A conserved family of genes related to the testis determining gene, SRY | journal = Nucleic Acids Research | volume = 20 | issue = 11 | pages = 2887 | date = June 1992 | pmid = 1614875 | pmc = 336939 | doi = 10.1093/nar/20.11.2887 }}
*{{cite journal | author=Schepers GE, Teasdale RD, Koopman P |title=Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families. |journal=Dev. Cell |volume=3 |issue= 2 |pages= 167-70 |year= 2002 |pmid= 12194848 |doi= }}
* {{cite journal | vauthors = Wotton D, Lake RA, Farr CJ, Owen MJ | title = The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer | journal = The Journal of Biological Chemistry | volume = 270 | issue = 13 | pages = 7515–22 | date = March 1995 | pmid = 7706298 | doi = 10.1074/jbc.270.13.7515 }}
*{{cite journal | author=Denny P, Swift S, Brand N, ''et al.'' |title=A conserved family of genes related to the testis determining gene, SRY. |journal=Nucleic Acids Res. |volume=20 |issue= 11 |pages= 2887 |year= 1992 |pmid= 1614875 |doi= }}
* {{cite journal | vauthors = van de Wetering M, Oosterwegel M, van Norren K, Clevers H | title = Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes | journal = The EMBO Journal | volume = 12 | issue = 10 | pages = 3847–54 | date = October 1993 | pmid = 8404853 | pmc = 413668 | doi =  }}
*{{cite journal | author=Wotton D, Lake RA, Farr CJ, Owen MJ |title=The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer. |journal=J. Biol. Chem. |volume=270 |issue= 13 |pages= 7515-22 |year= 1995 |pmid= 7706298 |doi= }}
* {{cite journal | vauthors = van Houte LP, Chuprina VP, van der Wetering M, Boelens R, Kaptein R, Clevers H | title = Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4 | journal = The Journal of Biological Chemistry | volume = 270 | issue = 51 | pages = 30516–24 | date = December 1995 | pmid = 8530483 | doi = 10.1074/jbc.270.51.30516 }}
*{{cite journal  | author=Farr CJ, Easty DJ, Ragoussis J, ''et al.'' |title=Characterization and mapping of the human SOX4 gene. |journal=Mamm. Genome |volume=4 |issue= 10 |pages= 577-84 |year= 1994 |pmid= 8268656 |doi=  }}
* {{cite journal | vauthors = Ahn SG, Cho GH, Jeong SY, Rhim H, Choi JY, Kim IK | title = Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells | journal = Biochemical and Biophysical Research Communications | volume = 260 | issue = 1 | pages = 216–21 | date = June 1999 | pmid = 10381369 | doi = 10.1006/bbrc.1999.0856 }}
*{{cite journal | author=van de Wetering M, Oosterwegel M, van Norren K, Clevers H |title=Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes. |journal=EMBO J. |volume=12 |issue= 10 |pages= 3847-54 |year= 1993 |pmid= 8404853 |doi=  }}
* {{cite journal | vauthors = van Beest M, Dooijes D, van De Wetering M, Kjaerulff S, Bonvin A, Nielsen O, Clevers H | title = Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs | journal = The Journal of Biological Chemistry | volume = 275 | issue = 35 | pages = 27266–73 | date = September 2000 | pmid = 10867006 | doi = 10.1074/jbc.M004102200 }}
*{{cite journal | author=van Houte LP, Chuprina VP, van der Wetering M, ''et al.'' |title=Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4. |journal=J. Biol. Chem. |volume=270 |issue= 51 |pages= 30516-24 |year= 1996 |pmid= 8530483 |doi= }}
* {{cite journal | vauthors = Reppe S, Rian E, Jemtland R, Olstad OK, Gautvik VT, Gautvik KM | title = Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells | journal = Journal of Bone and Mineral Research | volume = 15 | issue = 12 | pages = 2402–12 | date = December 2000 | pmid = 11127205 | doi = 10.1359/jbmr.2000.15.12.2402 }}
*{{cite journal  | author=Critcher R, Stitson RN, Wade-Martins R, ''et al.'' |title=Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 294-5 |year= 1998 |pmid= 9730625 |doi=  }}
* {{cite journal | vauthors = Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ | title = Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein | journal = Science | volume = 293 | issue = 5532 | pages = 1136–8 | date = August 2001 | pmid = 11498591 | doi = 10.1126/science.1059157 }}
*{{cite journal | author=Ahn SG, Cho GH, Jeong SY, ''et al.'' |title=Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 216-21 |year= 1999 |pmid= 10381369 |doi= 10.1006/bbrc.1999.0856 }}
* {{cite journal | vauthors = Lee CJ, Appleby VJ, Orme AT, Chan WI, Scotting PJ | title = Differential expression of SOX4 and SOX11 in medulloblastoma | journal = Journal of Neuro-Oncology | volume = 57 | issue = 3 | pages = 201–14 | date = May 2002 | pmid = 12125983 | doi = 10.1023/A:1015773818302 }}
*{{cite journal | author=van Beest M, Dooijes D, van De Wetering M, ''et al.'' |title=Sequence-specific high mobility group box factors recognize 10-12-base pair minor groove motifs. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27266-73 |year= 2000 |pmid= 10867006 |doi= 10.1074/jbc.M004102200 }}
* {{cite journal | vauthors = Ahn SG, Kim HS, Jeong SW, Kim BE, Rhim H, Shim JY, Kim JW, Lee JH, Kim IK | title = Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2) | journal = Experimental & Molecular Medicine | volume = 34 | issue = 3 | pages = 243–9 | date = July 2002 | pmid = 12216117 | doi = 10.1038/emm.2002.34 }}
*{{cite journal | author=Reppe S, Rian E, Jemtland R, ''et al.'' |title=Sox-4 messenger RNA is expressed in the embryonic growth plate and regulated via the parathyroid hormone/parathyroid hormone-related protein receptor in osteoblast-like cells. |journal=J. Bone Miner. Res. |volume=15 |issue= 12 |pages= 2402-12 |year= 2001 |pmid= 11127205 |doi= }}
{{Refend}}
*{{cite journal | author=Geijsen N, Uings IJ, Pals C, ''et al.'' |title=Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. |journal=Science |volume=293 |issue= 5532 |pages= 1136-8 |year= 2001 |pmid= 11498591 |doi= 10.1126/science.1059157 }}
*{{cite journal | author=Lee CJ, Appleby VJ, Orme AT, ''et al.'' |title=Differential expression of SOX4 and SOX11 in medulloblastoma. |journal=J. Neurooncol. |volume=57 |issue= 3 |pages= 201-14 |year= 2003 |pmid= 12125983 |doi= }}
*{{cite journal | author=Ahn SG, Kim HS, Jeong SW, ''et al.'' |title=Sox-4 is a positive regulator of Hep3B and HepG2 cells' apoptosis induced by prostaglandin (PG)A(2) and delta(12)-PGJ(2). |journal=Exp. Mol. Med. |volume=34 |issue= 3 |pages= 243-9 |year= 2003 |pmid= 12216117 |doi= }}
}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|SOX4+protein,+human}}
* {{MeshName|SOX4+protein,+human}}


{{NLM content}}
{{Transcription factors|g4}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{Gene-6-stub}}

Latest revision as of 05:40, 15 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.[1][2][3]

Function

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.[3]

Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.[4]

Clinical significance

A genomic region close to the SOX4 gene has been associated with endometrial cancer development.[5][6]

Interactions

SOX4 has been shown to interact with SDCBP.[7]

See also

References

  1. ↑ Farr CJ, Easty DJ, Ragoussis J, Collignon J, Lovell-Badge R, Goodfellow PN (January 1994). "Characterization and mapping of the human SOX4 gene". Mammalian Genome. 4 (10): 577–84. doi:10.1007/BF00361388. PMID 8268656.
  2. ↑ Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (October 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenetics and Cell Genetics. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625.
  3. ↑ 3.0 3.1 "Entrez Gene: SOX4 SRY (sex determining region Y)-box 4".
  4. ↑ Smith E, Sigvardsson M (June 2004). "The roles of transcription factors in B lymphocyte commitment, development, and transformation". Journal of Leukocyte Biology. 75 (6): 973–81. doi:10.1189/jlb.1103554. PMID 14982952.
  5. ↑ O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann MW, et al. (August 2018). "Identification of nine new susceptibility loci for endometrial cancer". Nature Communications. 9 (1): 3166. doi:10.1038/s41467-018-05427-7. PMC 6085317. PMID 30093612.
  6. ↑ Chen MM, O'Mara TA, Thompson DJ, Painter JN, Attia J, Black A, et al. (June 2016). "GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer". Human Molecular Genetics. 25 (12): 2612–2620. doi:10.1093/hmg/ddw092. PMC 5868213. PMID 27008869.
  7. ↑ Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ (August 2001). "Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein". Science. 293 (5532): 1136–8. doi:10.1126/science.1059157. PMID 11498591.

Further reading

  • Kamachi Y, Uchikawa M, Kondoh H (April 2000). "Pairing SOX off: with partners in the regulation of embryonic development". Trends in Genetics. 16 (4): 182–7. doi:10.1016/S0168-9525(99)01955-1. PMID 10729834.
  • Bowles J, Schepers G, Koopman P (November 2000). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators". Developmental Biology. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752.
  • Wilson M, Koopman P (August 2002). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Current Opinion in Genetics & Development. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
  • Schepers GE, Teasdale RD, Koopman P (August 2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Developmental Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
  • Denny P, Swift S, Brand N, Dabhade N, Barton P, Ashworth A (June 1992). "A conserved family of genes related to the testis determining gene, SRY". Nucleic Acids Research. 20 (11): 2887. doi:10.1093/nar/20.11.2887. PMC 336939. PMID 1614875.
  • Wotton D, Lake RA, Farr CJ, Owen MJ (March 1995). "The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer". The Journal of Biological Chemistry. 270 (13): 7515–22. doi:10.1074/jbc.270.13.7515. PMID 7706298.
  • van de Wetering M, Oosterwegel M, van Norren K, Clevers H (October 1993). "Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes". The EMBO Journal. 12 (10): 3847–54. PMC 413668. PMID 8404853.
  • van Houte LP, Chuprina VP, van der Wetering M, Boelens R, Kaptein R, Clevers H (December 1995). "Solution structure of the sequence-specific HMG box of the lymphocyte transcriptional activator Sox-4". The Journal of Biological Chemistry. 270 (51): 30516–24. doi:10.1074/jbc.270.51.30516. PMID 8530483.
  • Ahn SG, Cho GH, Jeong SY, Rhim H, Choi JY, Kim IK (June 1999). "Identification of cDNAs for Sox-4, an HMG-Box protein, and a novel human homolog of yeast splicing factor SSF-1 differentially regulated during apoptosis induced by prostaglandin A2/delta12-PGJ2 in Hep3B cells". Biochemical and Biophysical Research Communications. 260 (1): 216–21. doi:10.1006/bbrc.1999.0856. PMID 10381369.
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