ELF4: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>Boghog
(removed no longer needed PBB controls and templates; removed further reading citations not specific to this gene; consistent citation formatting)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ETS-related transcription factor Elf-4''' is a [[protein]] that in humans is encoded by the ''ELF4'' [[gene]].<ref name="pmid8895518">{{cite journal | vauthors = Miyazaki Y, Sun X, Uchida H, Zhang J, Nimer S | title = MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties | journal = Oncogene | volume = 13 | issue = 8 | pages = 1721–9 | date = October 1996 | pmid = 8895518 | pmc = | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ELF4 E74-like factor 4 (ets domain transcription factor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2000| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = E74-like factor 4 (ets domain transcription factor)
| HGNCid = 3319
| Symbol = ELF4
| AltSymbols =; ELFR; MEF
| OMIM = 
| ECnumber = 
| Homologene = 31036
| MGIid = 1928377
| GeneAtlas_image1 = PBB_GE_ELF4_31845_at_tn.png
| GeneAtlas_image2 = PBB_GE_ELF4_203490_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016605 |text = PML body}}
| Process = {{GNF_GO|id=GO:0001787 |text = natural killer cell proliferation}} {{GNF_GO|id=GO:0001866 |text = NK T cell proliferation}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2000
    | Hs_Ensembl = ENSG00000102034
    | Hs_RefseqProtein = NP_001412
    | Hs_RefseqmRNA = NM_001421
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 129026530
    | Hs_GenLoc_end = 129072372
    | Hs_Uniprot = Q99607
    | Mm_EntrezGene = 56501
    | Mm_Ensembl = ENSMUSG00000031103
    | Mm_RefseqmRNA = XM_989007
    | Mm_RefseqProtein = XP_994101
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 44657866
    | Mm_GenLoc_end = 44668983
    | Mm_Uniprot = Q32MF0
  }}
}}
'''E74-like factor 4 (ets domain transcription factor)''', also known as '''ELF4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ELF4 E74-like factor 4 (ets domain transcription factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2000| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
{{reflist}}
| section_title =
| summary_text =
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD | title = The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2 | journal = Molecular and Cellular Biology | volume = 26 | issue = 8 | pages = 3114–23 | date = April 2006 | pmid = 16581786 | pmc = 1446966 | doi = 10.1128/MCB.26.8.3114-3123.2006 }}
| citations =
* {{cite journal | vauthors = Moore SD, Offor O, Ferry JA, Amrein PC, Morton CC, Dal Cin P | title = ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22) | journal = Leukemia Research | volume = 30 | issue = 8 | pages = 1037–42 | date = August 2006 | pmid = 16303180 | doi = 10.1016/j.leukres.2005.10.014 }}
*{{cite journal | author=Liu Y, Hedvat CV, Mao S, ''et al.'' |title=The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. |journal=Mol. Cell. Biol. |volume=26 |issue= 8 |pages= 3114-23 |year= 2006 |pmid= 16581786 |doi= 10.1128/MCB.26.8.3114-3123.2006 }}
* {{cite journal | vauthors = Lu Z, Kim KA, Suico MA, Shuto T, Li JD, Kai H | title = MEF up-regulates human beta-defensin 2 expression in epithelial cells | journal = FEBS Letters | volume = 561 | issue = 1–3 | pages = 117–21 | date = March 2004 | pmid = 15013761 | doi = 10.1016/S0014-5793(04)00138-3 }}
*{{cite journal | author=Moore SD, Offor O, Ferry JA, ''et al.'' |title=ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22). |journal=Leuk. Res. |volume=30 |issue= 8 |pages= 1037-42 |year= 2007 |pmid= 16303180 |doi= 10.1016/j.leukres.2005.10.014 }}
* {{cite journal | vauthors = Suico MA, Yoshida H, Seki Y, Uchikawa T, Lu Z, Shuto T, Matsuzaki K, Nakao M, Li JD, Kai H | title = Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein | journal = The Journal of Biological Chemistry | volume = 279 | issue = 18 | pages = 19091–8 | date = April 2004 | pmid = 14976184 | doi = 10.1074/jbc.M312439200 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
* {{cite journal | vauthors = Cho JY, Akbarali Y, Zerbini LF, Gu X, Boltax J, Wang Y, Oettgen P, Zhang DE, Libermann TA | title = Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene | journal = The Journal of Biological Chemistry | volume = 279 | issue = 19 | pages = 19512–22 | date = May 2004 | pmid = 14970218 | doi = 10.1074/jbc.M309074200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Hedvat CV, Yao J, Sokolic RA, Nimer SD | title = Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 8 | pages = 6395–400 | date = February 2004 | pmid = 14625302 | doi = 10.1074/jbc.M307524200 }}
*{{cite journal  | author=Lu Z, Kim KA, Suico MA, ''et al.'' |title=MEF up-regulates human beta-defensin 2 expression in epithelial cells. |journal=FEBS Lett. |volume=561 |issue= 1-3 |pages= 117-21 |year= 2004 |pmid= 15013761 |doi= 10.1016/S0014-5793(04)00138-3 }}
* {{cite journal | vauthors = Suico MA, Koyanagi T, Ise S, Lu Z, Hisatsune A, Seki Y, Shuto T, Isohama Y, Miyata T, Kai H | title = Functional dissection of the ETS transcription factor MEF | journal = Biochimica et Biophysica Acta | volume = 1577 | issue = 1 | pages = 113–20 | date = August 2002 | pmid = 12151102 | doi = 10.1016/s0167-4781(02)00370-6 }}
*{{cite journal | author=Suico MA, Yoshida H, Seki Y, ''et al.'' |title=Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19091-8 |year= 2004 |pmid= 14976184 |doi= 10.1074/jbc.M312439200 }}
* {{cite journal | vauthors = Mao S, Frank RC, Zhang J, Miyazaki Y, Nimer SD | title = Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias | journal = Molecular and Cellular Biology | volume = 19 | issue = 5 | pages = 3635–44 | date = May 1999 | pmid = 10207087 | pmc = 84165 | doi = 10.1128/mcb.19.5.3635 }}
*{{cite journal | author=Cho JY, Akbarali Y, Zerbini LF, ''et al.'' |title=Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 19512-22 |year= 2004 |pmid= 14970218 |doi= 10.1074/jbc.M309074200 }}
* {{cite journal | vauthors = Aryee DN, Petermann R, Kos K, Henn T, Haas OA, Kovar H | title = Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1 | journal = Gene | volume = 210 | issue = 1 | pages = 71–8 | date = March 1998 | pmid = 9524226 | doi = 10.1016/S0378-1119(98)00022-5 }}
*{{cite journal | author=Hedvat CV, Yao J, Sokolic RA, Nimer SD |title=Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 6395-400 |year= 2004 |pmid= 14625302 |doi= 10.1074/jbc.M307524200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Suico MA, Koyanagi T, Ise S, ''et al.'' |title=Functional dissection of the ETS transcription factor MEF. |journal=Biochim. Biophys. Acta |volume=1577 |issue= 1 |pages= 113-20 |year= 2002 |pmid= 12151102 |doi= }}
*{{cite journal | author=Mao S, Frank RC, Zhang J, ''et al.'' |title=Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3635-44 |year= 1999 |pmid= 10207087 |doi= }}
*{{cite journal | author=Aryee DN, Petermann R, Kos K, ''et al.'' |title=Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1. |journal=Gene |volume=210 |issue= 1 |pages= 71-8 |year= 1998 |pmid= 9524226 |doi= }}
*{{cite journal  | author=Miyazaki Y, Sun X, Uchida H, ''et al.'' |title=MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties. |journal=Oncogene |volume=13 |issue= 8 |pages= 1721-9 |year= 1996 |pmid= 8895518 |doi=  }}
}}
{{refend}}
{{refend}}


Line 80: Line 22:
* {{MeshName|ELF4+protein,+human}}
* {{MeshName|ELF4+protein,+human}}


{{protein-stub}}
{{Transcription factors|g3}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-X-stub}}

Latest revision as of 11:24, 2 January 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ETS-related transcription factor Elf-4 is a protein that in humans is encoded by the ELF4 gene.[1][2]


References

  1. ↑ Miyazaki Y, Sun X, Uchida H, Zhang J, Nimer S (October 1996). "MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties". Oncogene. 13 (8): 1721–9. PMID 8895518.
  2. ↑ "Entrez Gene: ELF4 E74-like factor 4 (ets domain transcription factor)".

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=ELF4&oldid=1534226"