KLF8: Difference between revisions
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'''Krueppel-like factor 8''' is a [[protein]] that in humans is encoded by the ''KLF8'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLF8 Kruppel-like factor 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11279| accessdate = }}</ref> | '''Krueppel-like factor 8''' is a [[protein]] that in humans is encoded by the ''KLF8'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KLF8 Kruppel-like factor 8| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11279| accessdate = }}</ref> | ||
KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.<ref name="molecular and cell biology">{{cite web| url=https://mcb.asm.org/content/33/15/2976#sec-22|title=Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing|website=asm.org|accessdate=12 January 2019|author=Alister P. W. Funnell et al}}</ref> | |||
== Interactions == | == Interactions == | ||
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* {{cite journal | vauthors = Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA | title = A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element | journal = Blood Cells, Molecules & Diseases | volume = 35 | issue = 2 | pages = 227–35 | year = 2006 | pmid = 16023392 | doi = 10.1016/j.bcmd.2005.04.009 }} | * {{cite journal | vauthors = Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA | title = A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element | journal = Blood Cells, Molecules & Diseases | volume = 35 | issue = 2 | pages = 227–35 | year = 2006 | pmid = 16023392 | doi = 10.1016/j.bcmd.2005.04.009 }} | ||
* {{cite journal | vauthors = Wang X, Zhao J | title = KLF8 transcription factor participates in oncogenic transformation | journal = Oncogene | volume = 26 | issue = 3 | pages = 456–61 | date = Jan 2007 | pmid = 16832343 | doi = 10.1038/sj.onc.1209796 }} | * {{cite journal | vauthors = Wang X, Zhao J | title = KLF8 transcription factor participates in oncogenic transformation | journal = Oncogene | volume = 26 | issue = 3 | pages = 456–61 | date = Jan 2007 | pmid = 16832343 | doi = 10.1038/sj.onc.1209796 }} | ||
* {{cite journal | vauthors = Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ | title = Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation | journal = Journal of Molecular Biology | volume = 366 | issue = 4 | pages = 1064–73 | date = Mar 2007 | pmid = 17224162 | pmc = 1907364 | doi = 10.1016/j.jmb.2006.12.047 }} | * {{cite journal | vauthors = Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ |authorlink4=George Stamatoyannopoulos | title = Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation | journal = Journal of Molecular Biology | volume = 366 | issue = 4 | pages = 1064–73 | date = Mar 2007 | pmid = 17224162 | pmc = 1907364 | doi = 10.1016/j.jmb.2006.12.047 }} | ||
* {{cite journal | vauthors = Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J | title = Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion | journal = Cancer Research | volume = 67 | issue = 15 | pages = 7184–93 | date = Aug 2007 | pmid = 17671186 | doi = 10.1158/0008-5472.CAN-06-4729 }} | * {{cite journal | vauthors = Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J | title = Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion | journal = Cancer Research | volume = 67 | issue = 15 | pages = 7184–93 | date = Aug 2007 | pmid = 17671186 | doi = 10.1158/0008-5472.CAN-06-4729 }} | ||
{{refend}} | {{refend}} | ||
Latest revision as of 23:46, 12 January 2019
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Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.[1] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.[2]
Interactions
KLF8 has been shown to interact with CTBP2.[3]
References
- ↑ "Entrez Gene: KLF8 Kruppel-like factor 8".
- ↑ Alister P. W. Funnell; et al. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". asm.org. Retrieved 12 January 2019.
- ↑ van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.
Further reading
- van Vliet J, Turner J, Crossley M (May 2000). "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research. 28 (9): 1955–62. doi:10.1093/nar/28.9.1955. PMC 103308. PMID 10756197.
- Lossi AM, Laugier-Anfossi F, Depetris D, Gecz J, Gedeon A, Kooy F, Schwartz C, Mattei MG, Croquette MF, Villard L (Feb 2002). "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation". Journal of Medical Genetics. 39 (2): 113–7. doi:10.1136/jmg.39.2.113. PMC 1735036. PMID 11836360.
- Turner J, Nicholas H, Bishop D, Matthews JM, Crossley M (Apr 2003). "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". The Journal of Biological Chemistry. 278 (15): 12786–95. doi:10.1074/jbc.M300587200. PMID 12556451.
- Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL (Jun 2003). "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression". Molecular Cell. 11 (6): 1503–15. doi:10.1016/S1097-2765(03)00179-5. PMID 12820964.
- Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
- Wang X, Zhao J (Jan 2007). "KLF8 transcription factor participates in oncogenic transformation". Oncogene. 26 (3): 456–61. doi:10.1038/sj.onc.1209796. PMID 16832343.
- Hu JH, Navas P, Cao H, Stamatoyannopoulos G, Song CZ (Mar 2007). "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation". Journal of Molecular Biology. 366 (4): 1064–73. doi:10.1016/j.jmb.2006.12.047. PMC 1907364. PMID 17224162.
- Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J (Aug 2007). "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion". Cancer Research. 67 (15): 7184–93. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186.
External links
- KLF8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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