MLX (gene): Difference between revisions

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{{DISPLAYTITLE:''MLX'' (gene)}}
{{DISPLAYTITLE:''MLX'' (gene)}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Max-like protein X''' is a [[protein]] that in humans is encoded by the ''MLX'' [[gene]].<ref name="pmid8973301">{{cite journal |vauthors=Bjerknes M, Cheng H | title = TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor | journal = Gene | volume = 181 | issue = 1–2 | pages = 7–11 |date=January 1997 | pmid = 8973301 | pmc =  | doi =10.1016/S0378-1119(96)00376-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLX MAX-like protein X| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6945| accessdate = }}</ref>
'''Max-like protein X''' is a [[protein]] that in humans is encoded by the ''MLX'' [[gene]].<ref name="pmid8973301">{{cite journal | vauthors = Bjerknes M, Cheng H | title = TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor | journal = Gene | volume = 181 | issue = 1–2 | pages = 7–11 | date = November 1996 | pmid = 8973301 | pmc =  | doi = 10.1016/S0378-1119(96)00376-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MLX MAX-like protein X| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6945| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the family of [[basic helix-loop-helix]] [[leucine zipper]] (bHLH-Zip) [[transcription factors]]. These factors form [[heterodimer]]s with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely [[Mad1]] and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez" />
}}


==Interactions==
The product of this gene belongs to the family of [[basic helix-loop-helix]] [[leucine zipper]] (bHLH-Zip) [[transcription factors]]. These factors form [[heterodimer]]s with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely [[Mad1]] and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.<ref name="entrez" />
MLX (gene) has been shown to [[Protein-protein interaction|interact]] with [[MNT (gene)|MNT]],<ref name=pmid11230181>{{cite journal |last=Cairo |first=S |authorlink= |author2=Merla G |author3=Urbinati F |author4=Ballabio A |author5=Reymond A  |date=March 2001  |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network |journal=Hum. Mol. Genet. |volume=10 |issue=6 |pages=617–27 |publisher= |location = England| issn = 0964-6906| pmid = 11230181 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/hmg/10.6.617 }}</ref><ref name=pmid10918583>{{cite journal |last=Meroni |first=G |authorlink= |author2=Cairo S |author3=Merla G |author4=Messali S |author5=Brent R |author6=Ballabio A |author7=Reymond A  |date=July 2000  |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue=29 |pages=3266–77 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10918583 |doi = 10.1038/sj.onc.1203634 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[MXD1]]<ref name=pmid11230181/><ref name=pmid10918583/> and [[MLXIPL]].<ref name=pmid11230181/>


==References==
== Interactions ==
 
MLX (gene) has been shown to [[Protein-protein interaction|interact]] with [[MNT (gene)|MNT]],<ref name=pmid11230181>{{cite journal | vauthors = Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A | title = WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network | journal = Human Molecular Genetics | volume = 10 | issue = 6 | pages = 617–27 | date = March 2001 | pmid = 11230181 | doi = 10.1093/hmg/10.6.617 }}</ref><ref name=pmid10918583>{{cite journal | vauthors = Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A | title = Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? | journal = Oncogene | volume = 19 | issue = 29 | pages = 3266–77 | date = July 2000 | pmid = 10918583 | doi = 10.1038/sj.onc.1203634 }}</ref> [[MXD1]]<ref name=pmid11230181/><ref name=pmid10918583/> and [[MLXIPL]].<ref name=pmid11230181/>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rommens JM, Durocher F, McArthur J, Tonin P, LeBlanc JF, Allen T, Samson C, Ferri L, Narod S, Morgan K | title = Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21 | journal = Genomics | volume = 28 | issue = 3 | pages = 530–42 | date = August 1995 | pmid = 7490091 | doi = 10.1006/geno.1995.1185 }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
* {{cite journal | author=Rommens JM |title=Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21 |journal=Genomics |volume=28 |issue= 3 |pages= 530–42 |year= 1996 |pmid= 7490091 |doi=10.1006/geno.1995.1185 |name-list-format=vanc| author2=Durocher F  | author3=McArthur J  | display-authors=3  | last4=Tonin  | first4=Patricia  | last5=Leblanc  | first5=Jean-François  | last6=Allen  | first6=Todd  | last7=Samson  | first7=Carolle  | last8=Ferri  | first8=Lorenzo  | last9=Narod  | first9=Steven  }}
* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | date = September 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
* {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
* {{cite journal | vauthors = Billin AN, Eilers AL, Queva C, Ayer DE | title = Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors | journal = The Journal of Biological Chemistry | volume = 274 | issue = 51 | pages = 36344–50 | date = December 1999 | pmid = 10593926 | doi = 10.1074/jbc.274.51.36344 }}
* {{cite journal | author=Hillier LD |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 |name-list-format=vanc| author2=Lennon G  | author3=Becker M  | display-authors=3  | last4=Bonaldo  | first4=M F  | last5=Chiapelli  | first5=B  | last6=Chissoe  | first6=S  | last7=Dietrich  | first7=N  | last8=Dubuque  | first8=T  | last9=Favello  | first9=A  }}
* {{cite journal | vauthors = Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A | title = Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? | journal = Oncogene | volume = 19 | issue = 29 | pages = 3266–77 | date = July 2000 | pmid = 10918583 | doi = 10.1038/sj.onc.1203634 }}
* {{cite journal |vauthors=Billin AN, Eilers AL, Queva C, Ayer DE |title=Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36344–50 |year= 2000 |pmid= 10593926 |doi=10.1074/jbc.274.51.36344 }}
* {{cite journal | vauthors = Billin AN, Eilers AL, Coulter KL, Logan JS, Ayer DE | title = MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network | journal = Molecular and Cellular Biology | volume = 20 | issue = 23 | pages = 8845–54 | date = December 2000 | pmid = 11073985 | pmc = 86535 | doi = 10.1128/MCB.20.23.8845-8854.2000 }}
* {{cite journal | author=Meroni G |title=Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway? |journal=Oncogene |volume=19 |issue= 29 |pages= 3266–77 |year= 2000 |pmid= 10918583 |doi= 10.1038/sj.onc.1203634 |name-list-format=vanc| author2=Cairo S  | author3=Merla G  | display-authors=3  | last4=Messali  | first4=Silvia  | last5=Brent  | first5=Roger  | last6=Ballabio  | first6=Andrea  | last7=Reymond  | first7=Alexandre }}
* {{cite journal | vauthors = Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A | title = WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network | journal = Human Molecular Genetics | volume = 10 | issue = 6 | pages = 617–27 | date = March 2001 | pmid = 11230181 | doi = 10.1093/hmg/10.6.617 }}
* {{cite journal | author=Billin AN |title=MondoA, a Novel Basic Helix-Loop-Helix–Leucine Zipper Transcriptional Activator That Constitutes a Positive Branch of a Max-Like Network |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8845–54 |year= 2000 |pmid= 11073985 |doi=10.1128/MCB.20.23.8845-8854.2000 | pmc=86535  |name-list-format=vanc| author2=Eilers AL  | author3=Coulter KL  | display-authors=3  | last4=Logan  | first4=J. S.  | last5=Ayer  | first5=D. E.  }}
* {{cite journal | vauthors = Eilers AL, Sundwall E, Lin M, Sullivan AA, Ayer DE | title = A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex | journal = Molecular and Cellular Biology | volume = 22 | issue = 24 | pages = 8514–26 | date = December 2002 | pmid = 12446771 | pmc = 139889 | doi = 10.1128/MCB.22.24.8514-8526.2002 }}
* {{cite journal | author=Cairo S |title=WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network |journal=Hum. Mol. Genet. |volume=10 |issue= 6 |pages= 617–27 |year= 2001 |pmid= 11230181 |doi=10.1093/hmg/10.6.617 |name-list-format=vanc| author2=Merla G  | author3=Urbinati F  | display-authors=3  | last4=Ballabio  | first4=A  | last5=Reymond  | first5=A  }}
* {{cite journal | vauthors = Merla G, Howald C, Antonarakis SE, Reymond A | title = The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3 | journal = Human Molecular Genetics | volume = 13 | issue = 14 | pages = 1505–14 | date = July 2004 | pmid = 15163635 | doi = 10.1093/hmg/ddh163 }}
* {{cite journal | author=Eilers AL |title=A Novel Heterodimerization Domain, CRM1, and 14-3-3 Control Subcellular Localization of the MondoA-Mlx Heterocomplex |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8514–26 |year= 2003 |pmid= 12446771 |doi=10.1128/MCB.22.24.8514-8526.2002 | pmc=139889  |name-list-format=vanc| author2=Sundwall E  | author3=Lin M  | display-authors=3  | last4=Sullivan  | first4=A. A.  | last5=Ayer  | first5=D. E.  }}
* {{cite journal | vauthors = Ma L, Tsatsos NG, Towle HC | title = Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes | journal = The Journal of Biological Chemistry | volume = 280 | issue = 12 | pages = 12019–27 | date = March 2005 | pmid = 15664996 | doi = 10.1074/jbc.M413063200 }}
* {{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
* {{cite journal | vauthors = Sans CL, Satterwhite DJ, Stoltzman CA, Breen KT, Ayer DE | title = MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis | journal = Molecular and Cellular Biology | volume = 26 | issue = 13 | pages = 4863–71 | date = July 2006 | pmid = 16782875 | pmc = 1489152 | doi = 10.1128/MCB.00657-05 }}
* {{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
* {{cite journal  |vauthors=Merla G, Howald C, Antonarakis SE, Reymond A |title=The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3 |journal=Hum. Mol. Genet. |volume=13 |issue= 14 |pages= 1505–14 |year= 2005 |pmid= 15163635 |doi= 10.1093/hmg/ddh163 }}
* {{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
* {{cite journal  |vauthors=Ma L, Tsatsos NG, Towle HC |title=Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes |journal=J. Biol. Chem. |volume=280 |issue= 12 |pages= 12019–27 |year= 2005 |pmid= 15664996 |doi= 10.1074/jbc.M413063200 }}
* {{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
* {{cite journal  | author=Sans CL |title=MondoA-Mlx Heterodimers Are Candidate Sensors of Cellular Energy Status: Mitochondrial Localization and Direct Regulation of Glycolysis |journal=Mol. Cell. Biol. |volume=26 |issue= 13 |pages= 4863–71 |year= 2006 |pmid= 16782875 |doi= 10.1128/MCB.00657-05 | pmc=1489152  |name-list-format=vanc| author2=Satterwhite DJ  | author3=Stoltzman CA  | display-authors=3  | last4=Breen  | first4=K. T.  | last5=Ayer  | first5=D. E. }}
}}
{{refend}}
{{refend}}


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{{Transcription factors|g1}}
{{Transcription factors|g1}}


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[[Category:Transcription factors]]
[[Category:Transcription factors]]


{{gene-17-stub}}
{{gene-17-stub}}

Latest revision as of 11:01, 2 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Max-like protein X is a protein that in humans is encoded by the MLX gene.[1][2]

Function

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[2]

Interactions

MLX (gene) has been shown to interact with MNT,[3][4] MXD1[3][4] and MLXIPL.[3]

References

  1. ↑ Bjerknes M, Cheng H (November 1996). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301.
  2. ↑ 2.0 2.1 "Entrez Gene: MLX MAX-like protein X".
  3. ↑ 3.0 3.1 3.2 Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181.
  4. ↑ 4.0 4.1 Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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