PHF1: Difference between revisions

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'''PHD finger protein 1''' is a [[protein]] that in humans is encoded by the ''PHF1'' [[gene]].<ref name="pmid9545646">{{cite journal | vauthors = Coulson M, Robert S, Eyre HJ, Saint R | title = The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster | journal = Genomics | volume = 48 | issue = 3 | pages = 381–3 |date=Jun 1998 | pmid = 9545646 | pmc =  | doi = 10.1006/geno.1997.5201 }}</ref><ref name="pmid18385154">{{cite journal | vauthors = Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A | title = A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell | journal = Nucleic Acids Res | volume = 36 | issue = 9 | pages = 2939–47 |date=May 2008 | pmid = 18385154 | pmc = 2396414 | doi = 10.1093/nar/gkn146 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PHF1 PHD finger protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5252| accessdate = }}</ref>
'''PHD finger protein 1''' is a [[protein]] that in humans is encoded by the ''PHF1'' [[gene]].<ref name="pmid9545646">{{cite journal | vauthors = Coulson M, Robert S, Eyre HJ, Saint R | title = The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster | journal = Genomics | volume = 48 | issue = 3 | pages = 381–3 | date = March 1998 | pmid = 9545646 | pmc =  | doi = 10.1006/geno.1997.5201 }}</ref><ref name="pmid18385154">{{cite journal | vauthors = Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A | title = A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell | journal = Nucleic Acids Research | volume = 36 | issue = 9 | pages = 2939–47 | date = May 2008 | pmid = 18385154 | pmc = 2396414 | doi = 10.1093/nar/gkn146 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PHF1 PHD finger protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5252| accessdate = }}</ref>


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== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.<ref name="entrez" />
}}


==References==
This gene encodes a protein with significant sequence similarity to ''[[Drosophila]]'' [[Polycomb]]like. The encoded protein contains a [[zinc finger]]-like [[PHD finger|PHD]] (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing [[chromatin]] structure. Two transcript variants have been found for this gene.<ref name="entrez" />
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y | title = Role of hPHF1 in H3K27 methylation and Hox gene silencing | journal = Molecular and Cellular Biology | volume = 28 | issue = 5 | pages = 1862–72 | date = March 2008 | pmid = 18086877 | pmc = 2258785 | doi = 10.1128/MCB.01589-07 }}
| citations =
* {{cite journal | vauthors = O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS | title = Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein | journal = The Journal of Biological Chemistry | volume = 276 | issue = 46 | pages = 43065–73 | date = November 2001 | pmid = 11571280 | doi = 10.1074/jbc.M104294200 }}
*{{cite journal   |vauthors=Cao R, Wang H, He J, etal |title=Role of hPHF1 in H3K27 Methylation and Hox Gene Silencing |journal=Mol. Cell. Biol. |volume=28 |issue= 5 |pages= 1862–72 |year= 2008 |pmid= 18086877 |doi= 10.1128/MCB.01589-07 | pmc=2258785 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal   |vauthors=O'Connell S, Wang L, Robert S, etal |title=Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43065–73 |year= 2001 |pmid= 11571280 |doi= 10.1074/jbc.M104294200 }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
}}
{{refend}}
{{refend}}


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{{Transcription factors|g3}}
{{Transcription factors|g3}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]


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Latest revision as of 11:05, 2 January 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.[1][2][3]

Function

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.[3]

References

  1. ↑ Coulson M, Robert S, Eyre HJ, Saint R (March 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics. 48 (3): 381–3. doi:10.1006/geno.1997.5201. PMID 9545646.
  2. ↑ Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Research. 36 (9): 2939–47. doi:10.1093/nar/gkn146. PMC 2396414. PMID 18385154.
  3. ↑ 3.0 3.1 "Entrez Gene: PHF1 PHD finger protein 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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