ARID3A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''AT-rich interactive domain-containing protein 3A''' is a [[protein]] that in humans is encoded by the ''ARID3A'' [[gene]].<ref name="pmid9722953">{{cite journal | vauthors = Kortschak RD, Reimann H, Zimmer M, Eyre HJ, Saint R, Jenne DE | title = The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome | journal = Genomics | volume = 51 | issue = 2 | pages = 288–92 | date = Jul 1998 | pmid = 9722953 | pmc =  | doi = 10.1006/geno.1998.5259 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARID3A AT rich interactive domain 3A (BRIGHT-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1820| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = AT rich interactive domain 3A (BRIGHT-like)
| HGNCid = 3031
| Symbol = ARID3A
| AltSymbols =; BRIGHT; DRIL1; DRIL3; E2FBP1
| OMIM = 603265
| ECnumber = 
| Homologene = 3827
| MGIid = 1328360
| GeneAtlas_image1 = PBB_GE_ARID3A_205865_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1820
    | Hs_Ensembl = ENSG00000116017
    | Hs_RefseqProtein = NP_005215
    | Hs_RefseqmRNA = NM_005224
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 877037
    | Hs_GenLoc_end = 923781
    | Hs_Uniprot = Q99856
    | Mm_EntrezGene = 13496
    | Mm_Ensembl = ENSMUSG00000019564
    | Mm_RefseqmRNA = NM_007880
    | Mm_RefseqProtein = NP_031906
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 79330201
    | Mm_GenLoc_end = 79358141
    | Mm_Uniprot = Q3U338
  }}
}}
'''AT rich interactive domain 3A (BRIGHT-like)''', also known as '''ARID3A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARID3A AT rich interactive domain 3A (BRIGHT-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1820| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the [[ARID domain|ARID]] (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.<ref name="entrez">{{cite web | title = Entrez Gene: ARID3A AT rich interactive domain 3A (BRIGHT-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1820| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
ARID3A has been shown to [[Protein-protein interaction|interact]] with:
==Further reading==
* [[Bruton's tyrosine kinase|BTK]],<ref name = pmid15203319>{{cite journal | vauthors = Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF | title = The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations | journal = Cellular Immunology | volume = 228 | issue = 1 | pages = 42–53 | date = Mar 2004 | pmid = 15203319 | doi = 10.1016/j.cellimm.2004.03.004 }}</ref> and
{{refbegin | 2}}
* [[E2F1]]<ref name = pmid9780002>{{cite journal | vauthors = Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K | title = A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer | journal = Oncogene | volume = 17 | issue = 7 | pages = 853–65 | date = Aug 1998 | pmid = 9780002 | doi = 10.1038/sj.onc.1202163 }}</ref>
{{PBB_Further_reading
 
| citations =  
== References ==
*{{cite journal | author=Kortschak RD, Tucker PW, Saint R |title=ARID proteins come in from the desert. |journal=Trends Biochem. Sci. |volume=25 |issue= 6 |pages= 294-9 |year= 2000 |pmid= 10838570 |doi= }}
{{reflist}}
*{{cite journal | author=Kortschak RD, Reimann H, Zimmer M, ''et al.'' |title=The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome. |journal=Genomics |volume=51 |issue= 2 |pages= 288-92 |year= 1998 |pmid= 9722953 |doi= 10.1006/geno.1998.5259 }}
{{clear}}
*{{cite journal | author=Suzuki M, Okuyama S, Okamoto S, ''et al.'' |title=A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer. |journal=Oncogene |volume=17 |issue= 7 |pages= 853-65 |year= 1998 |pmid= 9780002 |doi= 10.1038/sj.onc.1202163 }}
== Further reading ==
*{{cite journal | author=Peeper DS, Shvarts A, Brummelkamp T, ''et al.'' |title=A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 148-53 |year= 2002 |pmid= 11812999 |doi= 10.1038/ncb742 }}
{{refbegin|33em}}
*{{cite journal | author=Kaiwen M |title=[Involvement of E2FBP1, an ARID family member protein, in the p53 regulatory pathway] |journal=Kokubyo Gakkai Zasshi |volume=69 |issue= 2 |pages= 152-61 |year= 2002 |pmid= 12136662 |doi= }}
* {{cite journal | vauthors = Kortschak RD, Tucker PW, Saint R | title = ARID proteins come in from the desert | journal = Trends in Biochemical Sciences | volume = 25 | issue = 6 | pages = 294–9 | date = Jun 2000 | pmid = 10838570 | doi = 10.1016/S0968-0004(00)01597-8 }}
*{{cite journal | author=Goebel P, Montalbano A, Ayers N, ''et al.'' |title=High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes. |journal=J. Immunol. |volume=169 |issue= 5 |pages= 2477-87 |year= 2002 |pmid= 12193717 |doi= }}
* {{cite journal | vauthors = Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K | title = A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer | journal = Oncogene | volume = 17 | issue = 7 | pages = 853–65 | date = Aug 1998 | pmid = 9780002 | doi = 10.1038/sj.onc.1202163 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Peeper DS, Shvarts A, Brummelkamp T, Douma S, Koh EY, Daley GQ, Bernards R | title = A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence | journal = Nature Cell Biology | volume = 4 | issue = 2 | pages = 148–53 | date = Feb 2002 | pmid = 11812999 | doi = 10.1038/ncb742 }}
*{{cite journal | author=Ma K, Araki K, Ichwan SJ, ''et al.'' |title=E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53. |journal=Mol. Cancer Res. |volume=1 |issue= 6 |pages= 438-44 |year= 2004 |pmid= 12692263 |doi=  }}
* {{cite journal | vauthors = Kaiwen M | title = [Involvement of E2FBP1, an ARID family member protein, in the p53 regulatory pathway] | journal = Kōkūbyō Gakkai Zasshi. the Journal of the Stomatological Society, Japan | volume = 69 | issue = 2 | pages = 152–61 | date = Jun 2002 | pmid = 12136662 | doi = 10.5357/koubyou.69.152 }}
*{{cite journal | author=Fukuyo Y, Mogi K, Tsunematsu Y, Nakajima T |title=E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies. |journal=Cell Death Differ. |volume=11 |issue= 7 |pages= 747-59 |year= 2005 |pmid= 15017387 |doi= 10.1038/sj.cdd.4401412 }}
* {{cite journal | vauthors = Goebel P, Montalbano A, Ayers N, Kompfner E, Dickinson L, Webb CF, Feeney AJ | title = High frequency of matrix attachment regions and cut-like protein x/CCAAT-displacement protein and B cell regulator of IgH transcription binding sites flanking Ig V region genes | journal = Journal of Immunology | volume = 169 | issue = 5 | pages = 2477–87 | date = Sep 2002 | pmid = 12193717 | doi = 10.4049/jimmunol.169.5.2477 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
* {{cite journal | vauthors = Ma K, Araki K, Ichwan SJ, Suganuma T, Tamamori-Adachi M, Ikeda MA | title = E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53 | journal = Molecular Cancer Research | volume = 1 | issue = 6 | pages = 438–44 | date = Apr 2003 | pmid = 12692263 | doi =  }}
*{{cite journal  | author=Nixon JC, Rajaiya JB, Ayers N, ''et al.'' |title=The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. |journal=Cell. Immunol. |volume=228 |issue= 1 |pages= 42-53 |year= 2004 |pmid= 15203319 |doi= 10.1016/j.cellimm.2004.03.004 }}
* {{cite journal | vauthors = Fukuyo Y, Mogi K, Tsunematsu Y, Nakajima T | title = E2FBP1/hDril1 modulates cell growth through downregulation of promyelocytic leukemia bodies | journal = Cell Death and Differentiation | volume = 11 | issue = 7 | pages = 747–59 | date = Jul 2004 | pmid = 15017387 | doi = 10.1038/sj.cdd.4401412 }}
*{{cite journal | author=Rajaiya J, Nixon JC, Ayers N, ''et al.'' |title=Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. |journal=Mol. Cell. Biol. |volume=26 |issue= 12 |pages= 4758-68 |year= 2006 |pmid= 16738337 |doi= 10.1128/MCB.02009-05 }}
* {{cite journal | vauthors = Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF | title = The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations | journal = Cellular Immunology | volume = 228 | issue = 1 | pages = 42–53 | date = Mar 2004 | pmid = 15203319 | doi = 10.1016/j.cellimm.2004.03.004 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
* {{cite journal | vauthors = Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF | title = Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I | journal = Molecular and Cellular Biology | volume = 26 | issue = 12 | pages = 4758–68 | date = Jun 2006 | pmid = 16738337 | pmc = 1489113 | doi = 10.1128/MCB.02009-05 }}
*{{cite journal | author=Lin D, Ippolito GC, Zong RT, ''et al.'' |title=Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer. |journal=Mol. Cancer |volume=6 |issue=  |pages= 23 |year= 2007 |pmid= 17386101 |doi= 10.1186/1476-4598-6-23 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
}}
* {{cite journal | vauthors = Lin D, Ippolito GC, Zong RT, Bryant J, Koslovsky J, Tucker P | title = Bright/ARID3A contributes to chromatin accessibility of the immunoglobulin heavy chain enhancer | journal = Molecular Cancer | volume = 6 | issue =  | pages = 23 | year = 2007 | pmid = 17386101 | pmc = 1852116 | doi = 10.1186/1476-4598-6-23 }}
* {{cite journal | vauthors = Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH | title = let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex | journal = Cell Reports | volume = 14 | issue = 3 | pages = 520–33 | date = January 2016 | pmid =  26776511| doi = 10.1016/j.celrep.2015.12.064 | quote = <small>ARID3A was identified as [[let-7 microRNA precursor|let-7]] target. Let-7i repressed ARID3A expression by binding to the 3′ UTR of the ARID3A transcript. In the absence of let-7, [[IPO9|importin-9]] facilitates the nuclear import of ARID3A, which then forms a complex with [[ARID3B]].</small> }}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ARID3A+protein,+human}}
* {{MeshName|ARID3A+protein,+human}}
* {{UCSC gene info|ARID3A}}


{{NLM content}}
{{Transcription factors|g0}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-19-stub}}

Latest revision as of 02:28, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

AT-rich interactive domain-containing protein 3A is a protein that in humans is encoded by the ARID3A gene.[1][2]

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification.[2]

Interactions

ARID3A has been shown to interact with:

References

  1. ↑ Kortschak RD, Reimann H, Zimmer M, Eyre HJ, Saint R, Jenne DE (Jul 1998). "The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome". Genomics. 51 (2): 288–92. doi:10.1006/geno.1998.5259. PMID 9722953.
  2. ↑ 2.0 2.1 "Entrez Gene: ARID3A AT rich interactive domain 3A (BRIGHT-like)".
  3. ↑ Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF (Mar 2004). "The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations". Cellular Immunology. 228 (1): 42–53. doi:10.1016/j.cellimm.2004.03.004. PMID 15203319.
  4. ↑ Suzuki M, Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K (Aug 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene. 17 (7): 853–65. doi:10.1038/sj.onc.1202163. PMID 9780002.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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