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m →Function: mention BP1 by name, as quoted for NP_612138.1 on entrez
 
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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein DLX-4''' is a [[protein]] that in humans is encoded by the ''DLX4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DLX4 distal-less homeobox 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1748| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Distal-less homeobox 4
| HGNCid = 2917
| Symbol = DLX4
| AltSymbols =; BP1; DLX7; DLX8; DLX9
| OMIM = 601911
| ECnumber = 
| Homologene = 7292
| MGIid = 94904
| GeneAtlas_image1 = PBB_GE_DLX4_208216_at_tn.png
| GeneAtlas_image2 = PBB_GE_DLX4_210259_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1748
    | Hs_Ensembl = ENSG00000108813
    | Hs_RefseqProtein = NP_001925
    | Hs_RefseqmRNA = NM_001934
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 45401561
    | Hs_GenLoc_end = 45406948
    | Hs_Uniprot = Q92988
    | Mm_EntrezGene = 13394
    | Mm_Ensembl = ENSMUSG00000020871
    | Mm_RefseqmRNA = NM_007867
    | Mm_RefseqProtein = NP_031893
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 94956546
    | Mm_GenLoc_end = 94962353
    | Mm_Uniprot = P70436
  }}
}}
'''Distal-less homeobox 4''', also known as '''DLX4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DLX4 distal-less homeobox 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1748| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Many vertebrate [[homeobox]]-containing genes have been identified on the basis of their sequence similarity with ''[[Drosophila]]'' developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform (BP1) functions as a repressor of the [[HBB|beta-globin]] gene while the other isoform lacks that function.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.<ref name="entrez">{{cite web | title = Entrez Gene: DLX4 distal-less homeobox 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1748| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Nakamura S |title=Genomic analysis of a new mammalian distal-less gene: Dlx7 |journal=Genomics |volume=38 |issue= 3 |pages= 314–24 |year= 1997 |pmid= 8975708 |doi= 10.1006/geno.1996.0634  |name-list-format=vanc| author2=Stock DW  | author3=Wydner KL  | display-authors=3  | last4=Bollekens  | first4=Jacques A.  | last5=Takeshita  | first5=Kenichi  | last6=Nagai  | first6=Brian M. | last7=Chiba | first7=Shigeru  | last8=Kitamura  | first8=Toshio  | last9=Freeland  | first9=Thomas M. }}
| citations =
*{{cite journal | author=Quinn LM |title=Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4 |journal=Gene |volume=187 |issue= 1 |pages= 55–61 |year= 1997 |pmid= 9073066 |doi=10.1016/S0378-1119(96)00706-8 |name-list-format=vanc| author2=Johnson BV  | author3=Nicholl J  | display-authors=3  | last4=Sutherland  | first4=GR  | last5=Kalionis  | first5=B }}
*{{cite journal  | author=Nakamura S, Stock DW, Wydner KL, ''et al.'' |title=Genomic analysis of a new mammalian distal-less gene: Dlx7. |journal=Genomics |volume=38 |issue= 3 |pages= 314-24 |year= 1997 |pmid= 8975708 |doi= 10.1006/geno.1996.0634 }}
*{{cite journal  | vauthors=Morasso MI, Yonescu R, Griffin CA, Sargent TD |title=Localization of human DLX8 to chromosome 17q21.3-q22 by fluorescence in situ hybridization |journal=Mamm. Genome |volume=8 |issue= 4 |pages= 302–3 |year= 1997 |pmid= 9096128 |doi=10.1007/s003359900427 }}
*{{cite journal | author=Quinn LM, Johnson BV, Nicholl J, ''et al.'' |title=Isolation and identification of homeobox genes from the human placenta including a novel member of the Distal-less family, DLX4. |journal=Gene |volume=187 |issue= 1 |pages= 55-61 |year= 1997 |pmid= 9073066 |doi=  }}
*{{cite journal  | author=Price JA |title=Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome |journal=Hum. Mol. Genet. |volume=7 |issue= 3 |pages= 563–9 |year= 1998 |pmid= 9467018 |doi=10.1093/hmg/7.3.563 |name-list-format=vanc| author2=Bowden DW  | author3=Wright JT  | display-authors=3  | last4=Pettenati  | first4=MJ | last5=Hart  | first5=TC  }}
*{{cite journal | author=Morasso MI, Yonescu R, Griffin CA, Sargent TD |title=Localization of human DLX8 to chromosome 17q21.3-q22 by fluorescence in situ hybridization. |journal=Mamm. Genome |volume=8 |issue= 4 |pages= 302-3 |year= 1997 |pmid= 9096128 |doi=  }}
*{{cite journal  | vauthors=Quinn LM, Latham SE, Kalionis B |title=A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta |journal=Placenta |volume=19 |issue= 1 |pages= 87–93 |year= 1998 |pmid= 9481790 |doi=10.1016/S0143-4004(98)90103-5 }}
*{{cite journal  | author=Price JA, Bowden DW, Wright JT, ''et al.'' |title=Identification of a mutation in DLX3 associated with tricho-dento-osseous (TDO) syndrome. |journal=Hum. Mol. Genet. |volume=7 |issue= 3 |pages= 563-9 |year= 1998 |pmid= 9467018 |doi=  }}
*{{cite journal  | vauthors=Quinn LM, Kilpatrick LM, Latham SE, Kalionis B |title=Homeobox genes DLX4 and HB24 are expressed in regions of epithelial-mesenchymal cell interaction in the adult human endometrium |journal=Mol. Hum. Reprod. |volume=4 |issue= 5 |pages= 497–501 |year= 1998 |pmid= 9665637 |doi=10.1093/molehr/4.5.497  }}
*{{cite journal  | author=Quinn LM, Latham SE, Kalionis B |title=A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta. |journal=Placenta |volume=19 |issue= 1 |pages= 87-93 |year= 1998 |pmid= 9481790 |doi=  }}
*{{cite journal  | vauthors=Quinn LM, Latham SE, Kalionis B |title=The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta |journal=Placenta |volume=21 Suppl A |issue= |pages= S50–4 |year= 2000 |pmid= 10831122 |doi=  10.1053/plac.1999.0514}}
*{{cite journal  | author=Quinn LM, Kilpatrick LM, Latham SE, Kalionis B |title=Homeobox genes DLX4 and HB24 are expressed in regions of epithelial-mesenchymal cell interaction in the adult human endometrium. |journal=Mol. Hum. Reprod. |volume=4 |issue= 5 |pages= 497-501 |year= 1998 |pmid= 9665637 |doi= }}
*{{cite journal  | author=Haga SB |title=BP1, a new homeobox gene, is frequently expressed in acute leukemias |journal=Leukemia |volume=14 |issue= 11 |pages= 1867–75 |year= 2000 |pmid= 11069021 |doi=10.1038/sj.leu.2401912  |name-list-format=vanc| author2=Fu S | author3=Karp JE  | display-authors=3  | last4=Ross  | first4=D D  | last5=Williams  | first5=D M  | last6=Hankins  | first6=W D  | last7=Behm | first7=F | last8=Ruscetti  | first8=F W  | last9=Chang  | first9=M  }}
*{{cite journal | author=Quinn LM, Latham SE, Kalionis B |title=The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta. |journal=Placenta |volume=21 Suppl A |issue=  |pages= S50-4 |year= 2000 |pmid= 10831122 |doi=  }}
*{{cite journal  | author=Masuda Y |title=Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5331–8 |year= 2001 |pmid= 11084035 |doi= 10.1074/jbc.M008590200  |name-list-format=vanc| author2=Sasaki A  | author3=Shibuya H  | display-authors=3  | last4=Ueno  | first4=N  | last5=Ikeda  | first5=K  | last6=Watanabe  | first6=K }}
*{{cite journal  | author=Haga SB, Fu S, Karp JE, ''et al.'' |title=BP1, a new homeobox gene, is frequently expressed in acute leukemias. |journal=Leukemia |volume=14 |issue= 11 |pages= 1867-75 |year= 2000 |pmid= 11069021 |doi=  }}
*{{cite journal  | author=Fu S |title=Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene |journal=Gene |volume=278 |issue= 1–2 |pages= 131–9 |year= 2002 |pmid= 11707330 |doi=10.1016/S0378-1119(01)00716-8 |name-list-format=vanc| author2=Stevenson H  | author3=Strovel JW  | display-authors=3  | last4=Haga  | first4=SB  | last5=Stamberg  | first5=J  | last6=Do  | first6=K  | last7=Berg  | first7=PE  }}
*{{cite journal  | author=Masuda Y, Sasaki A, Shibuya H, ''et al.'' |title=Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5331-8 |year= 2001 |pmid= 11084035 |doi= 10.1074/jbc.M008590200 }}
*{{cite journal  | author=Sumiyama K |title=Genomic structure and functional control of the Dlx3-7 bigene cluster |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 780–5 |year= 2002 |pmid= 11792834 |doi= 10.1073/pnas.012584999  | pmc=117382 |name-list-format=vanc| author2=Irvine SQ  | author3=Stock DW  | display-authors=3  | last4=Weiss  | first4=KM  | last5=Kawasaki  | first5=K  | last6=Shimizu  | first6=N  | last7=Shashikant  | first7=CS  | last8=Miller  | first8=W  | last9=Ruddle  | first9=FH }}
*{{cite journal  | author=Fu S, Stevenson H, Strovel JW, ''et al.'' |title=Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. |journal=Gene |volume=278 |issue= 1-2 |pages= 131-9 |year= 2002 |pmid= 11707330 |doi=  }}
*{{cite journal  | author=Chase MB |title=BP1, a Homeodomain-Containing Isoform of DLX4, Represses the β-Globin Gene |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2505–14 |year= 2002 |pmid= 11909945 |doi=10.1128/MCB.22.8.2505-2514.2002  | pmc=133721  |name-list-format=vanc| author2=Fu S  | author3=Haga SB  | display-authors=3  | last4=Davenport  | first4=G.  | last5=Stevenson  | first5=H.  | last6=Do  | first6=K.  | last7=Morgan  | first7=D.  | last8=Mah  | first8=A. L.  | last9=Berg  | first9=P. E.  }}
*{{cite journal  | author=Sumiyama K, Irvine SQ, Stock DW, ''et al.'' |title=Genomic structure and functional control of the Dlx3-7 bigene cluster. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 2 |pages= 780-5 |year= 2002 |pmid= 11792834 |doi= 10.1073/pnas.012584999 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Chase MB, Fu S, Haga SB, ''et al.'' |title=BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2505-14 |year= 2002 |pmid= 11909945 |doi=  }}
*{{cite journal  | author=Neufing PJ |title=Expression and localization of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues |journal=Anticancer Res. |volume=23 |issue= 2B |pages= 1479–88 |year= 2003 |pmid= 12820413 |doi=  |name-list-format=vanc| author2=Kalionis B  | author3=Horsfall DJ  | display-authors=3  | last4=Ricciardelli  | first4=C  | last5=Stahl  | first5=J  | last6=Vivekanandan  | first6=S  | last7=Raymond  | first7=W  | last8=Tilley  | first8=WD  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Zoueva OP, Rodgers GP |title=Inhibition of beta protein 1 expression enhances beta-globin promoter activity and beta-globin mRNA levels in the human erythroleukemia (K562) cell line |journal=Exp. Hematol. |volume=32 |issue= 8 |pages= 700–8 |year= 2004 |pmid= 15308321 |doi= 10.1016/j.exphem.2004.05.024 }}
*{{cite journal  | author=Neufing PJ, Kalionis B, Horsfall DJ, ''et al.'' |title=Expression and localization of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues. |journal=Anticancer Res. |volume=23 |issue= 2B |pages= 1479-88 |year= 2003 |pmid= 12820413 |doi= }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Zoueva OP, Rodgers GP |title=Inhibition of beta protein 1 expression enhances beta-globin promoter activity and beta-globin mRNA levels in the human erythroleukemia (K562) cell line. |journal=Exp. Hematol. |volume=32 |issue= 8 |pages= 700-8 |year= 2004 |pmid= 15308321 |doi= 10.1016/j.exphem.2004.05.024 }}
*{{cite journal  | author=Mpollo MS |title=BP1 is a negative modulator of definitive erythropoiesis |journal=Nucleic Acids Res. |volume=34 |issue= 18 |pages= 5232–7 |year= 2006 |pmid= 17003054 |doi= 10.1093/nar/gkl680  | pmc=1636446  |name-list-format=vanc| author2=Beaudoin M  | author3=Berg PE  | display-authors=3  | last4=Beauchemin  | first4=H.  | last5=d'Agati  | first5=V.  | last6=Trudel  | first6=M. }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Murthi P |title=Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction |journal=Mol. Hum. Reprod. |volume=12 |issue= 12 |pages= 763–9 |year= 2007 |pmid= 17062780 |doi= 10.1093/molehr/gal087  |name-list-format=vanc| author2=Said JM  | author3=Doherty VL  | display-authors=3  | last4=Donath  | first4=S.  | last5=Nowell  | first5=C.J.  | last6=Brennecke  | first6=S.P.  | last7=Kalionis  | first7=B. }}
*{{cite journal  | author=Mpollo MS, Beaudoin M, Berg PE, ''et al.'' |title=BP1 is a negative modulator of definitive erythropoiesis. |journal=Nucleic Acids Res. |volume=34 |issue= 18 |pages= 5232-7 |year= 2006 |pmid= 17003054 |doi= 10.1093/nar/gkl680 }}
*{{cite journal  | author=Tomida S |title=Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach |journal=Oncogene |volume=26 |issue= 31 |pages= 4600–8 |year= 2007 |pmid= 17260014 |doi= 10.1038/sj.onc.1210242  |name-list-format=vanc| author2=Yanagisawa K  | author3=Koshikawa K  | display-authors=3  | last4=Yatabe  | first4=Y  | last5=Mitsudomi  | first5=T  | last6=Osada  | first6=H  | last7=Takahashi  | first7=T }}
*{{cite journal | author=Murthi P, Said JM, Doherty VL, ''et al.'' |title=Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction. |journal=Mol. Hum. Reprod. |volume=12 |issue= 12 |pages= 763-9 |year= 2007 |pmid= 17062780 |doi= 10.1093/molehr/gal087 }}
*{{cite journal  | author=Tomida S, Yanagisawa K, Koshikawa K, ''et al.'' |title=Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach. |journal=Oncogene |volume=26 |issue= 31 |pages= 4600-8 |year= 2007 |pmid= 17260014 |doi= 10.1038/sj.onc.1210242 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|DLX4+protein,+human}}
* {{MeshName|DLX4+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}


{{protein-stub}}
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[[Category:Transcription factors]]
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Latest revision as of 01:09, 13 March 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.[1]

Function

Many vertebrate homeobox-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform (BP1) functions as a repressor of the beta-globin gene while the other isoform lacks that function.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DLX4 distal-less homeobox 4".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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