E2F2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Transcription factor E2F2''' is a [[protein]] that in humans is encoded by the ''E2F2'' [[gene]].<ref name="pmid8246995">{{cite journal | vauthors = Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC | title = Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F | journal = Mol Cell Biol | volume = 13 | issue = 12 | pages = 7802–12 | date = January 1994 | pmid = 8246995 | pmc = 364852 | doi =  }}</ref><ref name="pmid8246996">{{cite journal | vauthors = Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K | title = The retinoblastoma protein binds to a family of E2F transcription factors | journal = Mol Cell Biol | volume = 13 | issue = 12 | pages = 7813–25 | date = January 1994 | pmid = 8246996 | pmc = 364853 | doi = 10.1128/mcb.13.12.7813}}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = E2F transcription factor 2
| HGNCid = 3114
| Symbol = E2F2
| AltSymbols =; E2F-2
| OMIM = 600426
| ECnumber = 
| Homologene = 48264
| MGIid = 1096341
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006367 |text = transcription initiation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1870
    | Hs_Ensembl = ENSG00000007968
    | Hs_RefseqProtein = NP_004082
    | Hs_RefseqmRNA = NM_004091
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 23705509
    | Hs_GenLoc_end = 23730300
    | Hs_Uniprot = Q14209
    | Mm_EntrezGene = 242705
    | Mm_Ensembl = ENSMUSG00000018983
    | Mm_RefseqmRNA = NM_177733
    | Mm_RefseqProtein = NP_808401
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 135444470
    | Mm_GenLoc_end = 135468133
    | Mm_Uniprot = Q3TZQ9
  }}
}}
'''E2F transcription factor 2''', also known as '''E2F2''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the E2F family of [[transcription factor]]s. The E2F family plays a crucial role in the control of [[cell cycle]] and action of [[tumor suppressor]] proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, [[E2F1]] and [[E2F3]], have an additional [[cyclin]] binding domain. This protein binds specifically to [[retinoblastoma protein]] pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.<ref name="entrez">{{cite web | title = Entrez Gene: E2F2 E2F transcription factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1870| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.<ref name="entrez">{{cite web | title = Entrez Gene: E2F2 E2F transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1870| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
E2F2 has been shown to [[Protein-protein interaction|interact]] with:
* [[BRD2]],<ref name = pmid12145330>{{cite journal | vauthors = Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ | title = Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein | journal = Mol. Endocrinol. | volume = 16 | issue = 8 | pages = 1727–37 | date = August 2002 | pmid = 12145330 | doi = 10.1210/me.2001-0353 }}</ref><ref name = pmid10965846>{{cite journal | vauthors = Denis GV, Vaziri C, Guo N, Faller DV | title = RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F | journal = Cell Growth Differ. | volume = 11 | issue = 8 | pages = 417–24 | date = August 2000 | pmid = 10965846 | pmc = 3968681 | doi =  }}</ref>
* [[RYBP]],<ref name = pmid12411495>{{cite journal | vauthors = Schlisio S, Halperin T, Vidal M, Nevins JR | title = Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function | journal = EMBO J. | volume = 21 | issue = 21 | pages = 5775–86 | date = November 2002 | pmid = 12411495 | pmc = 131074 | doi =  10.1093/emboj/cdf577}}</ref> and
* [[Retinoblastoma protein|RB1]].<ref name = pmid12502741>{{cite journal | vauthors = Lee C, Chang JH, Lee HS, Cho Y | title = Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor | journal = Genes Dev. | volume = 16 | issue = 24 | pages = 3199–212 | date = December 2002 | pmid = 12502741 | pmc = 187509 | doi = 10.1101/gad.1046102 }}</ref>
 
== See also ==
* [[E2F]]
* [[E2F]]
{{Clear}}


==References==
== References ==
{{reflist|2}}
{{reflist|35em}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|35em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Dyson N | title = The regulation of E2F by pRB-family proteins. | journal = Genes Dev. | volume = 12 | issue = 15 | pages = 2245–62 | year = 1998 | pmid = 9694791 | doi = 10.1101/gad.12.15.2245 }}
| citations =
* {{cite journal | vauthors = Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA | title = In vivo association of E2F and DP family proteins | journal = Mol. Cell. Biol. | volume = 15 | issue = 5 | pages = 2536–46 | year = 1995 | pmid = 7739537 | pmc = 230484 | doi =  10.1128/mcb.15.5.2536}}
*{{cite journal | author=Dyson N |title=The regulation of E2F by pRB-family proteins. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2245-62 |year= 1998 |pmid= 9694791 |doi= }}
* {{cite journal | vauthors = Karlseder J, Rotheneder H, Wintersberger E | title = Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1659–67 | year = 1996 | pmid = 8657141 | pmc = 231152 | doi =  10.1128/mcb.16.4.1659}}
*{{cite journal | author=Wu CL, Zukerberg LR, Ngwu C, ''et al.'' |title=In vivo association of E2F and DP family proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2536-46 |year= 1995 |pmid= 7739537 |doi=  }}
* {{cite journal | vauthors = Lin SY, Black AR, Kostic D, Pajovic S, Hoover CN, Azizkhan JC | title = Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction | journal = Mol. Cell. Biol. | volume = 16 | issue = 4 | pages = 1668–75 | year = 1996 | pmid = 8657142 | pmc = 231153 | doi =  }}
*{{cite journal  | author=Ivey-Hoyle M, Conroy R, Huber HE, ''et al.'' |title=Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7802-12 |year= 1994 |pmid= 8246995 |doi=  }}
* {{cite journal | vauthors = Rogers KT, Higgins PD, Milla MM, Phillips RS, Horowitz JM | title = DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 15 | pages = 7594–9 | year = 1996 | pmid = 8755520 | pmc = 38791 | doi = 10.1073/pnas.93.15.7594 }}
*{{cite journal  | author=Lees JA, Saito M, Vidal M, ''et al.'' |title=The retinoblastoma protein binds to a family of E2F transcription factors. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7813-25 |year= 1994 |pmid= 8246996 |doi=  }}
* {{cite journal | vauthors = Magae J, Wu CL, Illenye S, Harlow E, Heintz NH | title = Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members | journal = J. Cell Sci. | volume = 109 | issue = 7 | pages = 1717–26 | year = 1997 | pmid = 8832394 | doi =  }}
*{{cite journal | author=Karlseder J, Rotheneder H, Wintersberger E |title=Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1659-67 |year= 1996 |pmid= 8657141 |doi=  }}
* {{cite journal | vauthors = Hofmann F, Livingston DM | title = Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit | journal = Genes Dev. | volume = 10 | issue = 7 | pages = 851–61 | year = 1996 | pmid = 8846921 | doi = 10.1101/gad.10.7.851 }}
*{{cite journal | author=Lin SY, Black AR, Kostic D, ''et al.'' |title=Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1668-75 |year= 1996 |pmid= 8657142 |doi=  }}
* {{cite journal | vauthors = Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D | title = The subcellular localization of E2F-4 is cell-cycle dependent | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 10 | pages = 5095–100 | year = 1997 | pmid = 9144196 | pmc = 24637 | doi = 10.1073/pnas.94.10.5095 }}
*{{cite journal | author=Rogers KT, Higgins PD, Milla MM, ''et al.'' |title=DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 7594-9 |year= 1996 |pmid= 8755520 |doi= }}
* {{cite journal | vauthors = Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG | title = Differential activities of E2F family members: unique functions in regulating transcription | journal = Mol. Carcinog. | volume = 22 | issue = 3 | pages = 190–8 | year = 1998 | pmid = 9688145 | doi = 10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P }}
*{{cite journal | author=Magae J, Wu CL, Illenye S, ''et al.'' |title=Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. |journal=J. Cell. Sci. |volume=109 ( Pt 7) |issue= |pages= 1717-26 |year= 1997 |pmid= 8832394 |doi=  }}
* {{cite journal | vauthors = Halaban R, Cheng E, Smicun Y, Germino J | title = Deregulated E2F transcriptional activity in autonomously growing melanoma cells | journal = J. Exp. Med. | volume = 191 | issue = 6 | pages = 1005–16 | year = 2000 | pmid = 10727462 | pmc = 2193116 | doi = 10.1084/jem.191.6.1005 }}
*{{cite journal | author=Hofmann F, Livingston DM |title=Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. |journal=Genes Dev. |volume=10 |issue= 7 |pages= 851-61 |year= 1996 |pmid= 8846921 |doi= }}
* {{cite journal | vauthors = Takahashi Y, Rayman JB, Dynlacht BD | title = Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression | journal = Genes Dev. | volume = 14 | issue = 7 | pages = 804–16 | year = 2000 | pmid = 10766737 | pmc = 316494 | doi =  10.1101/gad.14.7.804}}
*{{cite journal | author=Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D |title=The subcellular localization of E2F-4 is cell-cycle dependent. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 5095-100 |year= 1997 |pmid= 9144196 |doi= }}
* {{cite journal | vauthors = Denis GV, Vaziri C, Guo N, Faller DV | title = RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F | journal = Cell Growth Differ. | volume = 11 | issue = 8 | pages = 417–24 | year = 2001 | pmid = 10965846 | doi = | pmc=3968681}}
*{{cite journal | author=Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG |title=Differential activities of E2F family members: unique functions in regulating transcription. |journal=Mol. Carcinog. |volume=22 |issue= 3 |pages= 190-8 |year= 1998 |pmid= 9688145 |doi= }}
* {{cite journal | vauthors = Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, Giangrande P, Wright FA, Field SJ, Greenberg ME, Orkin S, Nevins JR, Robinson ML, Leone G | title = The E2F1-3 transcription factors are essential for cellular proliferation | journal = Nature | volume = 414 | issue = 6862 | pages = 457–62 | year = 2001 | pmid = 11719808 | doi = 10.1038/35106593 }}
*{{cite journal | author=Halaban R, Cheng E, Smicun Y, Germino J |title=Deregulated E2F transcriptional activity in autonomously growing melanoma cells. |journal=J. Exp. Med. |volume=191 |issue= 6 |pages= 1005-16 |year= 2000 |pmid= 10727462 |doi= }}
* {{cite journal | vauthors = Yamochi T, Semba K, Tsuji K, Mizumoto K, Sato H, Matsuura Y, Nishimoto I, Matsuoka M | title = ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) | journal = Eur. J. Biochem. | volume = 268 | issue = 23 | pages = 6076–82 | year = 2002 | pmid = 11733001 | doi = 10.1046/j.0014-2956.2001.02555.x }}
*{{cite journal | author=Takahashi Y, Rayman JB, Dynlacht BD |title=Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. |journal=Genes Dev. |volume=14 |issue= 7 |pages= 804-16 |year= 2000 |pmid= 10766737 |doi=  }}
* {{cite journal | vauthors = Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ | title = Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis | journal = Genes Dev. | volume = 16 | issue = 2 | pages = 235–44 | year = 2002 | pmid = 11799066 | pmc = 155318 | doi = 10.1101/gad.943102 }}
*{{cite journal | author=Denis GV, Vaziri C, Guo N, Faller DV |title=RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. |journal=Cell Growth Differ. |volume=11 |issue= 8 |pages= 417-24 |year= 2001 |pmid= 10965846 |doi= }}
* {{cite journal | vauthors = Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ | title = Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein | journal = Mol. Endocrinol. | volume = 16 | issue = 8 | pages = 1727–37 | year = 2003 | pmid = 12145330 | doi = 10.1210/me.2001-0353 }}
*{{cite journal | author=Wu L, Timmers C, Maiti B, ''et al.'' |title=The E2F1-3 transcription factors are essential for cellular proliferation. |journal=Nature |volume=414 |issue= 6862 |pages= 457-62 |year= 2001 |pmid= 11719808 |doi= 10.1038/35106593 }}
* {{cite journal | vauthors = Schlisio S, Halperin T, Vidal M, Nevins JR | title = Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function | journal = EMBO J. | volume = 21 | issue = 21 | pages = 5775–86 | year = 2002 | pmid = 12411495 | pmc = 131074 | doi = 10.1093/emboj/cdf577 }}
*{{cite journal | author=Yamochi T, Semba K, Tsuji K, ''et al.'' |title=ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). |journal=Eur. J. Biochem. |volume=268 |issue= 23 |pages= 6076-82 |year= 2002 |pmid= 11733001 |doi= }}
*{{cite journal | author=Weinmann AS, Yan PS, Oberley MJ, ''et al.'' |title=Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 235-44 |year= 2002 |pmid= 11799066 |doi= 10.1101/gad.943102 }}
*{{cite journal | author=Crowley TE, Kaine EM, Yoshida M, ''et al.'' |title=Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. |journal=Mol. Endocrinol. |volume=16 |issue= 8 |pages= 1727-37 |year= 2003 |pmid= 12145330 |doi= }}
*{{cite journal | author=Schlisio S, Halperin T, Vidal M, Nevins JR |title=Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. |journal=EMBO J. |volume=21 |issue= 21 |pages= 5775-86 |year= 2002 |pmid= 12411495 |doi= }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|E2F2+protein,+human}}
* {{MeshName|E2F2+protein,+human}}
{{Transcription factors|g3}}


{{NLM content}}
{{NLM content}}
[[Category:Transcription factors]]
{{gene-1-stub}}
{{gene-1-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 19:49, 8 November 2017

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Ensembl

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RefSeq (mRNA)

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View/Edit Human

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[1][2]

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[3]

Interactions

E2F2 has been shown to interact with:

See also

References

  1. ↑ Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (January 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol. 13 (12): 7802–12. PMC 364852. PMID 8246995.
  2. ↑ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (January 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.
  3. ↑ "Entrez Gene: E2F2 E2F transcription factor 2".
  4. ↑ Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. doi:10.1210/me.2001-0353. PMID 12145330.
  5. ↑ Denis GV, Vaziri C, Guo N, Faller DV (August 2000). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8): 417–24. PMC 3968681. PMID 10965846.
  6. ↑ Schlisio S, Halperin T, Vidal M, Nevins JR (November 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
  7. ↑ Lee C, Chang JH, Lee HS, Cho Y (December 2002). "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes Dev. 16 (24): 3199–212. doi:10.1101/gad.1046102. PMC 187509. PMID 12502741.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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