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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''E74-like factor 5 (ets domain transcription factor)''', is a [[gene]] found in both mice and humans.<ref name="entrez">{{cite web | title = Entrez Gene: ELF5 E74-like factor 5 (ets domain transcription factor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2001| accessdate = }}</ref> In humans it is also called ESE2.
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ELF5_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wwx.
| PDB = {{PDB2|1wwx}}
| Name = E74-like factor 5 (ets domain transcription factor)
| HGNCid = 3320
| Symbol = ELF5
| AltSymbols =; ESE2
| OMIM = 605169
| ECnumber = 
| Homologene = 7702
| MGIid = 1335079
| GeneAtlas_image1 = PBB_GE_ELF5_220625_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ELF5_220624_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007398 |text = ectoderm development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2001
    | Hs_Ensembl = ENSG00000135374
    | Hs_RefseqProtein = NP_001413
    | Hs_RefseqmRNA = NM_001422
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 34456918
    | Hs_GenLoc_end = 34491906
    | Hs_Uniprot = Q9UKW6
    | Mm_EntrezGene = 13711
    | Mm_Ensembl = ENSMUSG00000027186
    | Mm_RefseqmRNA = NM_010125
    | Mm_RefseqProtein = NP_034255
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 103224916
    | Mm_GenLoc_end = 103251828
    | Mm_Uniprot = Q3ULZ4
  }}
}}
'''E74-like factor 5 (ets domain transcription factor)''', is a [[gene]] found in both mice and humans.<ref name="entrez">{{cite web | title = Entrez Gene: ELF5 E74-like factor 5 (ets domain transcription factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2001| accessdate = }}</ref> In humans it is also called ESE2.


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of an epithelium-specific subclass of the [[Ets transcritpion factor family]]. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of an epithelium-specific subclass of the [[Ets transcritpion factor family]]. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: ELF5 E74-like factor 5 (ets domain transcription factor)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2001| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sharrocks AD, Brown AL, Ling Y, Yates PR | title = The ETS-domain transcription factor family | journal = The International Journal of Biochemistry & Cell Biology | volume = 29 | issue = 12 | pages = 1371–87 | date = Dec 1997 | pmid = 9570133 | doi = 10.1016/S1357-2725(97)00086-1 }}
| citations =
* {{cite journal | vauthors = Zhou J, Ng AY, Tymms MJ, Jermiin LS, Seth AK, Thomas RS, Kola I | title = A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines | journal = Oncogene | volume = 17 | issue = 21 | pages = 2719–32 | date = Nov 1998 | pmid = 9840936 | doi = 10.1038/sj.onc.1202198 }}
*{{cite journal | author=Sharrocks AD, Brown AL, Ling Y, Yates PR |title=The ETS-domain transcription factor family. |journal=Int. J. Biochem. Cell Biol. |volume=29 |issue= 12 |pages= 1371-87 |year= 1998 |pmid= 9570133 |doi= }}
* {{cite journal | vauthors = Oettgen P, Kas K, Dube A, Gu X, Grall F, Thamrongsak U, Akbarali Y, Finger E, Boltax J, Endress G, Munger K, Kunsch C, Libermann TA | title = Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes | journal = The Journal of Biological Chemistry | volume = 274 | issue = 41 | pages = 29439–52 | date = Oct 1999 | pmid = 10506207 | doi = 10.1074/jbc.274.41.29439 }}
*{{cite journal | author=Zhou J, Ng AY, Tymms MJ, ''et al.'' |title=A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines. |journal=Oncogene |volume=17 |issue= 21 |pages= 2719-32 |year= 1998 |pmid= 9840936 |doi= 10.1038/sj.onc.1202198 }}
* {{cite journal | vauthors = Lapinskas EJ, Palmer J, Ricardo S, Hertzog PJ, Hammacher A, Pritchard MA | title = A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands | journal = Histochemistry and Cell Biology | volume = 122 | issue = 6 | pages = 521–6 | date = Dec 2004 | pmid = 15655699 | doi = 10.1007/s00418-004-0713-x }}
*{{cite journal | author=Oettgen P, Kas K, Dube A, ''et al.'' |title=Characterization of ESE-2, a novel ESE-1-related Ets transcription factor that is restricted to glandular epithelium and differentiated keratinocytes. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29439-52 |year= 1999 |pmid= 10506207 |doi=  }}
* {{cite journal | vauthors = Yaniw D, Hu J | title = Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1 | journal = Cell Research | volume = 15 | issue = 6 | pages = 423–9 | date = Jun 2005 | pmid = 15987600 | doi = 10.1038/sj.cr.7290310 | pmc = 4494830 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Tummala R, Sinha S | title = Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor | journal = Journal of Cellular Biochemistry | volume = 97 | issue = 4 | pages = 766–81 | date = Mar 2006 | pmid = 16229011 | doi = 10.1002/jcb.20685 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Choi YS, Sinha S | title = Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2 | journal = The Biochemical Journal | volume = 398 | issue = 3 | pages = 497–507 | date = Sep 2006 | pmid = 16704374 | pmc = 1559455 | doi = 10.1042/BJ20060375 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lapinskas EJ, Palmer J, Ricardo S, ''et al.'' |title=A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands. |journal=Histochem. Cell Biol. |volume=122 |issue= 6 |pages= 521-6 |year= 2005 |pmid= 15655699 |doi= 10.1007/s00418-004-0713-x }}
*{{cite journal | author=Yaniw D, Hu J |title=Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1. |journal=Cell Res. |volume=15 |issue= 6 |pages= 423-9 |year= 2005 |pmid= 15987600 |doi= 10.1038/sj.cr.7290310 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Tummala R, Sinha S |title=Differentiation-specific transcriptional regulation of the ESE-2 gene by a novel keratinocyte-restricted factor. |journal=J. Cell. Biochem. |volume=97 |issue= 4 |pages= 766-81 |year= 2006 |pmid= 16229011 |doi= 10.1002/jcb.20685 }}
*{{cite journal | author=Taylor TD, Noguchi H, Totoki Y, ''et al.'' |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497-500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 }}
*{{cite journal  | author=Choi YS, Sinha S |title=Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2. |journal=Biochem. J. |volume=398 |issue= 3 |pages= 497-507 |year= 2006 |pmid= 16704374 |doi= 10.1042/BJ20060375 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|ELF5+protein,+human}}
* {{MeshName|ELF5+protein,+human}}


 
{{gene-11-stub}}
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{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{PDB Gallery|geneid=2001}}
{{Transcription factors|g3}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 22:19, 22 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E74-like factor 5 (ets domain transcription factor), is a gene found in both mice and humans.[1] In humans it is also called ESE2.

Function

The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: ELF5 E74-like factor 5 (ets domain transcription factor)".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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