Estrogen-related receptor gamma: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS (v470))
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Estrogen-related receptor gamma''' ('''ERR-gamma'''), also known as '''NR3B3''' (nuclear receptor subfamily 3, group B, member 3), is a [[nuclear receptor]] that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ESRRG estrogen-related receptor gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2104| accessdate = }}</ref><ref name="pmid9676434">{{cite journal | vauthors = Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmadge CB, Cheng JJ, Kimberling WJ, Sumegi J | title = Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41 | journal = Genomics | volume = 50 | issue = 3 | pages = 382–4 | date = Jun 1998 | pmid = 9676434 | doi = 10.1006/geno.1998.5345 }}</ref><ref name="pmid10072763">{{cite journal | vauthors = Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT | title = Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR | journal = Gene | volume = 228 | issue = 1-2 | pages = 101–9 | date = Mar 1999 | pmid = 10072763 | doi = 10.1016/S0378-1119(98)00619-2 }}</ref> It behaves as a constitutive activator of transcription.<ref name="matsushima"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This protein is a member of [[nuclear receptor|nuclear hormone receptor]] family of [[steroid hormone receptor]]s. No physiological activating ligand is known for this [[orphan receptor]], but [[4-hydroxytamoxifen]] and [[diethylstilbestrol]] act as [[inverse agonist]]s and deactivate ESRRG.<ref name="pmid14751226">{{cite journal | vauthors = Huppunen J, Aarnisalo P | title = Dimerization modulates the activity of the orphan nuclear receptor ERRgamma | journal = Biochemical and Biophysical Research Communications | volume = 314 | issue = 4 | pages = 964–70 | date = Feb 2004 | pmid = 14751226 | doi = 10.1016/j.bbrc.2003.12.194 }}</ref> It also seems to be the target of [[bisphenol A]] (see below).
{{GNF_Protein_box
| image = PBB_Protein_ESRRG_image.jpg
  | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kv6.
| PDB = {{PDB2|1kv6}}, {{PDB2|1lo1}}, {{PDB2|1s9p}}, {{PDB2|1s9q}}, {{PDB2|1tfc}}, {{PDB2|1vjb}}, {{PDB2|2ewp}}, {{PDB2|2gp7}}, {{PDB2|2gpo}}, {{PDB2|2gpp}}, {{PDB2|2gpu}}, {{PDB2|2gpv}}
| Name = Estrogen-related receptor gamma
| HGNCid = 3474
| Symbol = ESRRG
| AltSymbols =; DKFZp781L1617; ERR3; FLJ16023; KIAA0832; NR3B3
| OMIM = 602969
| ECnumber = 
| Homologene = 55581
| MGIid = 1347056
| GeneAtlas_image1 = PBB_GE_ESRRG_207981_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_ESRRG_209966_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0050682 |text = AF-2 domain binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2104
    | Hs_Ensembl = ENSG00000196482
    | Hs_RefseqProtein = NP_001429
    | Hs_RefseqmRNA = NM_001438
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 214743218
    | Hs_GenLoc_end = 215377720
    | Hs_Uniprot = P62508
    | Mm_EntrezGene = 26381
    | Mm_Ensembl = ENSMUSG00000026610
    | Mm_RefseqmRNA = NM_011935
    | Mm_RefseqProtein = NP_036065
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 189698647
    | Mm_GenLoc_end = 189915672
    | Mm_Uniprot = Q3US92
  }}
}}
'''Estrogen-related receptor gamma''' ('''ERR-gamma'''), also known as '''NR3B3''' (nuclear receptor subfamily 3, group B, member 3), is a [[nuclear receptor]] which is encoded by the gene {{gene|ESRRG}} (EStrogen Related Receptor Gamma).<ref name="entrez">{{cite web | title = Entrez Gene: ESRRG estrogen-related receptor gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2104| accessdate = }}</ref>


This protein is a member of [[nuclear receptor|nuclear hormone receptor]] family of [[steroid hormone receptor]]s. No physiological activating ligand is known for this [[orphan receptor]], but [[4-hydroxytamoxifen]] and [[diethylstilbestrol]] act as [[inverse agonist]]s and deactivate ESRRG.
== Bisphenol A binding ==
{{Further|Bisphenol A}}
There is evidence that bisphenol A functions as an [[endocrine disruptor]] by binding strongly to ERR-γ.<ref name="matsushima"/> BPA as well as its nitrated and chlorinated metabolites seems to binds strongly to ERR-γ ([[dissociation constant]] = 5.5 nM), but not to the [[estrogen receptor]] (ER).,<ref name="matsushima"/><ref name="babu">{{cite journal | vauthors = Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM | title = Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma | journal = Biochemical and Biophysical Research Communications | volume = 426 | issue = 2 | pages = 215–20 | date = Sep 2012 | pmid = 22935422 | doi = 10.1016/j.bbrc.2012.08.065 }}</ref> BPA binding to ERR-γ preserves its basal constitutive activity.<ref name=matsushima/> It can also protect it from deactivation from the [[selective estrogen receptor modulator]] [[4-hydroxytamoxifen]].<ref name="matsushima">{{cite journal | vauthors = Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y | title = Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma | journal = Journal of Biochemistry | volume = 142 | issue = 4 | pages = 517–24 | date = Oct 2007 | pmid = 17761695 | doi = 10.1093/jb/mvm158 }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the [[placenta]], explaining reports of high bisphenol A accumulation there.<ref name="pmid19304792">{{cite journal | vauthors = Takeda Y, Liu X, Sumiyoshi M, Matsushima A, Shimohigashi M, Shimohigashi Y | title = Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform | journal = Journal of Biochemistry | volume = 146 | issue = 1 | pages = 113–22 | date = Jul 2009 | pmid = 19304792 | doi = 10.1093/jb/mvp049 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
== External links ==
* {{Cite news|url = http://www.kurzweilai.net/master-protein-found-to-enhance-both-muscles-and-the-brain|title = Master protein found to enhance both muscles and the brain|date = April 7, 2015|work = KurzweilAI|access-date = March 2015}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = Dec 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
* {{cite journal | vauthors = Hong H, Yang L, Stallcup MR | title = Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 32 | pages = 22618–26 | date = Aug 1999 | pmid = 10428842 | doi = 10.1074/jbc.274.32.22618 }}
*{{cite journal  | author=Eudy JD, Yao S, Weston MD, ''et al.'' |title=Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41. |journal=Genomics |volume=50 |issue= 3 |pages= 382-4 |year= 1998 |pmid= 9676434 |doi= 10.1006/geno.1998.5345 }}
* {{cite journal | vauthors = Heard DJ, Norby PL, Holloway J, Vissing H | title = Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult | journal = Molecular Endocrinology | volume = 14 | issue = 3 | pages = 382–92 | date = Mar 2000 | pmid = 10707956 | doi = 10.1210/me.14.3.382 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi= }}
* {{cite journal | vauthors = Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dorsselaer A, Moras D, Renaud JP | title = Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3 | journal = Molecular Cell | volume = 9 | issue = 2 | pages = 303–13 | date = Feb 2002 | pmid = 11864604 | doi = 10.1016/S1097-2765(02)00444-6 }}
*{{cite journal  | author=Chen F, Zhang Q, McDonald T, ''et al.'' |title=Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. |journal=Gene |volume=228 |issue= 1-2 |pages= 101-9 |year= 1999 |pmid= 10072763 |doi=  }}
* {{cite journal | vauthors = Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants | journal = Molecular Vision | volume = 8 | issue =  | pages = 205–20 | date = Jun 2002 | pmid = 12107410 | doi =  }}
*{{cite journal | author=Hong H, Yang L, Stallcup MR |title=Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3. |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22618-26 |year= 1999 |pmid= 10428842 |doi= }}
* {{cite journal | vauthors = Hentschke M, Süsens U, Borgmeyer U | title = Domains of ERRgamma that mediate homodimerization and interaction with factors stimulating DNA binding | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 16 | pages = 4086–97 | date = Aug 2002 | pmid = 12180985 | doi = 10.1046/j.1432-1033.2002.03102.x }}
*{{cite journal | author=Heard DJ, Norby PL, Holloway J, Vissing H |title=Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult. |journal=Mol. Endocrinol. |volume=14 |issue= 3 |pages= 382-92 |year= 2000 |pmid= 10707956 |doi= }}
* {{cite journal | vauthors = Hentschke M, Süsens U, Borgmeyer U | title = PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 5 | pages = 872–9 | date = Dec 2002 | pmid = 12470660 | doi = 10.1016/S0006-291X(02)02753-5 }}
*{{cite journal | author=Greschik H, Wurtz JM, Sanglier S, ''et al.'' |title=Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. |journal=Mol. Cell |volume=9 |issue= 2 |pages= 303-13 |year= 2002 |pmid= 11864604 |doi= }}
* {{cite journal | vauthors = Hentschke M, Schulze C, Süsens U, Borgmeyer U | title = Characterization of calmodulin binding to the orphan nuclear receptor Errgamma | journal = Biological Chemistry | volume = 384 | issue = 3 | pages = 473–82 | date = Mar 2003 | pmid = 12715898 | doi = 10.1515/BC.2003.053 }}
*{{cite journal | author=Wistow G, Bernstein SL, Wyatt MK, ''et al.'' |title=Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. |journal=Mol. Vis. |volume=8 |issue=  |pages= 205-20 |year= 2002 |pmid= 12107410 |doi=  }}
* {{cite journal | vauthors = Hentschke M, Borgmeyer U | title = Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma | journal = Biochemical and Biophysical Research Communications | volume = 312 | issue = 4 | pages = 975–82 | date = Dec 2003 | pmid = 14651967 | doi = 10.1016/j.bbrc.2003.11.025 }}
*{{cite journal | author=Hentschke M, Süsens U, Borgmeyer U |title=Domains of ERRgamma that mediate homodimerization and interaction with factors stimulating DNA binding. |journal=Eur. J. Biochem. |volume=269 |issue= 16 |pages= 4086-97 |year= 2002 |pmid= 12180985 |doi= }}
* {{cite journal | vauthors = Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL | title = Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 90 | issue = 3 | pages = 1830–44 | date = Mar 2005 | pmid = 15598686 | doi = 10.1210/jc.2004-1421 }}
*{{cite journal | author=Hentschke M, Süsens U, Borgmeyer U |title=PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 872-9 |year= 2003 |pmid= 12470660 |doi= }}
* {{cite journal | vauthors = Liu D, Zhang Z, Teng CT | title = Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element | journal = Journal of Molecular Endocrinology | volume = 34 | issue = 2 | pages = 473–87 | date = Apr 2005 | pmid = 15821111 | doi = 10.1677/jme.1.01586 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Gao M, Sun P, Wang J, Zhao D, Wei L | title = Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma | journal = International Journal of Gynecological Cancer | volume = 16 | issue = 2 | pages = 827–33 | year = 2006 | pmid = 16681769 | doi = 10.1111/j.1525-1438.2006.00527.x }}
*{{cite journal | author=Hentschke M, Schulze C, Süsens U, Borgmeyer U |title=Characterization of calmodulin binding to the orphan nuclear receptor Errgamma. |journal=Biol. Chem. |volume=384 |issue= 3 |pages= 473-82 |year= 2003 |pmid= 12715898 |doi= }}
* {{cite journal | vauthors = Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT | title = X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation | journal = The Journal of Biological Chemistry | volume = 281 | issue = 49 | pages = 37773–81 | date = Dec 2006 | pmid = 16990259 | doi = 10.1074/jbc.M608410200 }}
*{{cite journal | author=Hentschke M, Borgmeyer U |title=Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma. |journal=Biochem. Biophys. Res. Commun. |volume=312 |issue= 4 |pages= 975-82 |year= 2004 |pmid= 14651967 |doi=  }}
* {{cite journal | vauthors = Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM | title = Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma | journal = Biochemical and Biophysical Research Communications | volume = 426 | issue = 2 | pages = 215–20 | date = Sep 2012 | pmid = 22935422 | doi = 10.1016/j.bbrc.2012.08.065 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Cheung CP, Yu S, Wong KB, ''et al.'' |title=Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 3 |pages= 1830-44 |year= 2005 |pmid= 15598686 |doi= 10.1210/jc.2004-1421 }}
*{{cite journal | author=Liu D, Zhang Z, Teng CT |title=Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element. |journal=J. Mol. Endocrinol. |volume=34 |issue= 2 |pages= 473-87 |year= 2005 |pmid= 15821111 |doi= 10.1677/jme.1.01586 }}
*{{cite journal | author=Gao M, Sun P, Wang J, ''et al.'' |title=Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma. |journal=Int. J. Gynecol. Cancer |volume=16 |issue= 2 |pages= 827-33 |year= 2006 |pmid= 16681769 |doi= 10.1111/j.1525-1438.2006.00527.x }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Wang L, Zuercher WJ, Consler TG, ''et al.'' |title=X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation. |journal=J. Biol. Chem. |volume=281 |issue= 49 |pages= 37773-81 |year= 2007 |pmid= 16990259 |doi= 10.1074/jbc.M608410200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=2104}}
{{Transcription factors}}
{{Transcription factors|g2}}
{{Nuclear receptor ligands}}
 
 
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
[[Category:Human female endocrine system]]

Latest revision as of 00:44, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Estrogen-related receptor gamma (ERR-gamma), also known as NR3B3 (nuclear receptor subfamily 3, group B, member 3), is a nuclear receptor that in humans is encoded by the ESRRG (EStrogen Related Receptor Gamma) gene.[1][2][3] It behaves as a constitutive activator of transcription.[4]

This protein is a member of nuclear hormone receptor family of steroid hormone receptors. No physiological activating ligand is known for this orphan receptor, but 4-hydroxytamoxifen and diethylstilbestrol act as inverse agonists and deactivate ESRRG.[5] It also seems to be the target of bisphenol A (see below).

Bisphenol A binding

Further information: Bisphenol A

There is evidence that bisphenol A functions as an endocrine disruptor by binding strongly to ERR-γ.[4] BPA as well as its nitrated and chlorinated metabolites seems to binds strongly to ERR-γ (dissociation constant = 5.5 nM), but not to the estrogen receptor (ER).,[4][6] BPA binding to ERR-γ preserves its basal constitutive activity.[4] It can also protect it from deactivation from the selective estrogen receptor modulator 4-hydroxytamoxifen.[4]

Different expression of ERR-γ in different parts of the body may account for variations in bisphenol A effects. For instance, ERR-γ has been found in high concentration in the placenta, explaining reports of high bisphenol A accumulation there.[7]

References

  1. ↑ "Entrez Gene: ESRRG estrogen-related receptor gamma".
  2. ↑ Eudy JD, Yao S, Weston MD, Ma-Edmonds M, Talmadge CB, Cheng JJ, Kimberling WJ, Sumegi J (Jun 1998). "Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41". Genomics. 50 (3): 382–4. doi:10.1006/geno.1998.5345. PMID 9676434.
  3. ↑ Chen F, Zhang Q, McDonald T, Davidoff MJ, Bailey W, Bai C, Liu Q, Caskey CT (Mar 1999). "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR". Gene. 228 (1–2): 101–9. doi:10.1016/S0378-1119(98)00619-2. PMID 10072763.
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Matsushima A, Kakuta Y, Teramoto T, Koshiba T, Liu X, Okada H, Tokunaga T, Kawabata S, Kimura M, Shimohigashi Y (Oct 2007). "Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma". Journal of Biochemistry. 142 (4): 517–24. doi:10.1093/jb/mvm158. PMID 17761695.
  5. ↑ Huppunen J, Aarnisalo P (Feb 2004). "Dimerization modulates the activity of the orphan nuclear receptor ERRgamma". Biochemical and Biophysical Research Communications. 314 (4): 964–70. doi:10.1016/j.bbrc.2003.12.194. PMID 14751226.
  6. ↑ Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma". Biochemical and Biophysical Research Communications. 426 (2): 215–20. doi:10.1016/j.bbrc.2012.08.065. PMID 22935422.
  7. ↑ Takeda Y, Liu X, Sumiyoshi M, Matsushima A, Shimohigashi M, Shimohigashi Y (Jul 2009). "Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform". Journal of Biochemistry. 146 (1): 113–22. doi:10.1093/jb/mvp049. PMID 19304792.

External links

Further reading

  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  • Hong H, Yang L, Stallcup MR (Aug 1999). "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3". The Journal of Biological Chemistry. 274 (32): 22618–26. doi:10.1074/jbc.274.32.22618. PMID 10428842.
  • Heard DJ, Norby PL, Holloway J, Vissing H (Mar 2000). "Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult". Molecular Endocrinology. 14 (3): 382–92. doi:10.1210/me.14.3.382. PMID 10707956.
  • Greschik H, Wurtz JM, Sanglier S, Bourguet W, van Dorsselaer A, Moras D, Renaud JP (Feb 2002). "Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3". Molecular Cell. 9 (2): 303–13. doi:10.1016/S1097-2765(02)00444-6. PMID 11864604.
  • Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Molecular Vision. 8: 205–20. PMID 12107410.
  • Hentschke M, Süsens U, Borgmeyer U (Aug 2002). "Domains of ERRgamma that mediate homodimerization and interaction with factors stimulating DNA binding". European Journal of Biochemistry / FEBS. 269 (16): 4086–97. doi:10.1046/j.1432-1033.2002.03102.x. PMID 12180985.
  • Hentschke M, Süsens U, Borgmeyer U (Dec 2002). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochemical and Biophysical Research Communications. 299 (5): 872–9. doi:10.1016/S0006-291X(02)02753-5. PMID 12470660.
  • Hentschke M, Schulze C, Süsens U, Borgmeyer U (Mar 2003). "Characterization of calmodulin binding to the orphan nuclear receptor Errgamma". Biological Chemistry. 384 (3): 473–82. doi:10.1515/BC.2003.053. PMID 12715898.
  • Hentschke M, Borgmeyer U (Dec 2003). "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma". Biochemical and Biophysical Research Communications. 312 (4): 975–82. doi:10.1016/j.bbrc.2003.11.025. PMID 14651967.
  • Cheung CP, Yu S, Wong KB, Chan LW, Lai FM, Wang X, Suetsugi M, Chen S, Chan FL (Mar 2005). "Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues". The Journal of Clinical Endocrinology and Metabolism. 90 (3): 1830–44. doi:10.1210/jc.2004-1421. PMID 15598686.
  • Liu D, Zhang Z, Teng CT (Apr 2005). "Estrogen-related receptor-gamma and peroxisome proliferator-activated receptor-gamma coactivator-1alpha regulate estrogen-related receptor-alpha gene expression via a conserved multi-hormone response element". Journal of Molecular Endocrinology. 34 (2): 473–87. doi:10.1677/jme.1.01586. PMID 15821111.
  • Gao M, Sun P, Wang J, Zhao D, Wei L (2006). "Expression of estrogen receptor-related receptor isoforms and clinical significance in endometrial adenocarcinoma". International Journal of Gynecological Cancer. 16 (2): 827–33. doi:10.1111/j.1525-1438.2006.00527.x. PMID 16681769.
  • Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT (Dec 2006). "X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation". The Journal of Biological Chemistry. 281 (49): 37773–81. doi:10.1074/jbc.M608410200. PMID 16990259.
  • Babu S, Vellore NA, Kasibotla AV, Dwayne HJ, Stubblefield MA, Uppu RM (Sep 2012). "Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma". Biochemical and Biophysical Research Communications. 426 (2): 215–20. doi:10.1016/j.bbrc.2012.08.065. PMID 22935422.
Retrieved from "https://www.wikidoc.org/index.php?title=Estrogen-related_receptor_gamma&oldid=1410892"