GTF3A: Difference between revisions

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{{Infobox_gene}}
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'''Transcription factor IIIA''' is a [[protein]] that in humans is encoded by the ''GTF3A'' [[gene]].<ref name="pmid7789179">  {{cite journal | vauthors = Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, Takahashi E, Shin S, Nakamura Y | title = Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA | journal = Cytogenetics and Cell Genetics | volume = 70 | issue = 3-4 | pages = 235–8 | date = Jul 1995 | pmid = 7789179 | pmc =  | doi = 10.1159/000134041 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GTF3A general transcription factor IIIA| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2971| accessdate = }}</ref> It was first isolated and characterized by Wolffe and Brown in 1988.
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== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = General transcription factor IIIA
| HGNCid = 4662
| Symbol = GTF3A
| AltSymbols =; AP2; TFIIIA
| OMIM = 600860
| ECnumber = 
| Homologene = 
| MGIid = 
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003709 |text = RNA polymerase III transcription factor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006383 |text = transcription from RNA polymerase III promoter}} {{GNF_GO|id=GO:0009303 |text = rRNA transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2971
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_002088
    | Hs_RefseqmRNA = NM_002097
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
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    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
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'''General transcription factor IIIA''', also known as '''GTF3A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GTF3A general transcription factor IIIA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2971| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
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| summary_text =
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==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Murphy JE, Keen JH | title = Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia | journal = The Journal of Biological Chemistry | volume = 267 | issue = 15 | pages = 10850–5 | date = May 1992 | pmid = 1587861 | doi =  }}
| citations =
* {{cite journal | vauthors = Seifart KH, Wang L, Waldschmidt R, Jahn D, Wingender E | title = Purification of human transcription factor IIIA and its interaction with a chemically synthesized gene encoding human 5 S rRNA | journal = The Journal of Biological Chemistry | volume = 264 | issue = 3 | pages = 1702–9 | date = Jan 1989 | pmid = 2912980 | doi =  }}
*{{cite journal | author=Murphy JE, Keen JH |title=Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10850-5 |year= 1992 |pmid= 1587861 |doi=  }}
* {{cite journal | vauthors = Drew PD, Nagle JW, Canning RD, Ozato K, Biddison WE, Becker KG | title = Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA | journal = Gene | volume = 159 | issue = 2 | pages = 215–8 | date = Jul 1995 | pmid = 7622052 | doi = 10.1016/0378-1119(95)00145-V }}
*{{cite journal | author=Seifart KH, Wang L, Waldschmidt R, ''et al.'' |title=Purification of human transcription factor IIIA and its interaction with a chemically synthesized gene encoding human 5 S rRNA. |journal=J. Biol. Chem. |volume=264 |issue= 3 |pages= 1702-9 |year= 1989 |pmid= 2912980 |doi=  }}
* {{cite journal | vauthors = Moorefield B, Roeder RG | title = Purification and characterization of human transcription factor IIIA | journal = The Journal of Biological Chemistry | volume = 269 | issue = 33 | pages = 20857–65 | date = Aug 1994 | pmid = 8063702 | doi =  }}
*{{cite journal | author=Drew PD, Nagle JW, Canning RD, ''et al.'' |title=Cloning and expression analysis of a human cDNA homologous to Xenopus TFIIIA. |journal=Gene |volume=159 |issue= 2 |pages= 215-8 |year= 1995 |pmid= 7622052 |doi= }}
* {{cite journal | vauthors = Fridell RA, Fischer U, Lührmann R, Meyer BE, Meinkoth JL, Malim MH, Cullen BR | title = Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 7 | pages = 2936–40 | date = Apr 1996 | pmid = 8610146 | pmc = 39738 | doi = 10.1073/pnas.93.7.2936 }}
*{{cite journal  | author=Arakawa H, Nagase H, Hayashi N, ''et al.'' |title=Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 235-8 |year= 1995 |pmid= 7789179 |doi=  }}
* {{cite journal | vauthors = Oettel S, Härtel F, Kober I, Iben S, Seifart KH | title = Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes | journal = Nucleic Acids Research | volume = 25 | issue = 12 | pages = 2440–7 | date = Jun 1997 | pmid = 9171097 | pmc = 146769 | doi = 10.1093/nar/25.12.2440 }}
*{{cite journal | author=Moorefield B, Roeder RG |title=Purification and characterization of human transcription factor IIIA. |journal=J. Biol. Chem. |volume=269 |issue= 33 |pages= 20857-65 |year= 1994 |pmid= 8063702 |doi=  }}
* {{cite journal | vauthors = Moreland RJ, Dresser ME, Rodgers JS, Roe BA, Conaway JW, Conaway RC, Hanas JS | title = Identification of a transcription factor IIIA-interacting protein | journal = Nucleic Acids Research | volume = 28 | issue = 9 | pages = 1986–93 | date = May 2000 | pmid = 10756201 | pmc = 103300 | doi = 10.1093/nar/28.9.1986 }}
*{{cite journal | author=Fridell RA, Fischer U, Lührmann R, ''et al.'' |title=Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 7 |pages= 2936-40 |year= 1996 |pmid= 8610146 |doi= }}
* {{cite journal | vauthors = Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS | title = Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors | journal = Molecular and Cellular Biology | volume = 21 | issue = 22 | pages = 7796–806 | date = Nov 2001 | pmid = 11604514 | pmc = 99949 | doi = 10.1128/MCB.21.22.7796-7806.2001 }}
*{{cite journal | author=Oettel S, Härtel F, Kober I, ''et al.'' |title=Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes. |journal=Nucleic Acids Res. |volume=25 |issue= 12 |pages= 2440-7 |year= 1997 |pmid= 9171097 |doi= }}
* {{cite journal | vauthors = Hanas JS, Hocker JR, Cheng YG, Lerner MR, Brackett DJ, Lightfoot SA, Hanas RJ, Madhusudhan KT, Moreland RJ | title = cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA | journal = Gene | volume = 282 | issue = 1-2 | pages = 43–52 | date = Jan 2002 | pmid = 11814676 | doi = 10.1016/S0378-1119(01)00796-X }}
*{{cite journal | author=Moreland RJ, Dresser ME, Rodgers JS, ''et al.'' |title=Identification of a transcription factor IIIA-interacting protein. |journal=Nucleic Acids Res. |volume=28 |issue= 9 |pages= 1986-93 |year= 2000 |pmid= 10756201 |doi= }}
* {{cite journal | vauthors = Weser S, Riemann J, Seifart KH, Meissner W | title = Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene | journal = Nucleic Acids Research | volume = 31 | issue = 9 | pages = 2408–16 | date = May 2003 | pmid = 12711686 | pmc = 154231 | doi = 10.1093/nar/gkg345 }}
*{{cite journal | author=Rao DS, Chang JC, Kumar PD, ''et al.'' |title=Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7796-806 |year= 2001 |pmid= 11604514 |doi= 10.1128/MCB.21.22.7796-7806.2001 }}
* {{cite journal | vauthors = Pellikainen JM, Ropponen KM, Kataja VV, Kellokoski JK, Eskelinen MJ, Kosma VM | title = Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis | journal = Clinical Cancer Research | volume = 10 | issue = 22 | pages = 7621–8 | date = Nov 2004 | pmid = 15569994 | doi = 10.1158/1078-0432.CCR-04-1061 }}
*{{cite journal | author=Hanas JS, Hocker JR, Cheng YG, ''et al.'' |title=cDNA cloning, DNA binding, and evolution of mammalian transcription factor IIIA. |journal=Gene |volume=282 |issue= 1-2 |pages= 43-52 |year= 2002 |pmid= 11814676 |doi= }}
* {{cite journal | vauthors = Paing MM, Johnston CA, Siderovski DP, Trejo J | title = Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization | journal = Molecular and Cellular Biology | volume = 26 | issue = 8 | pages = 3231–42 | date = Apr 2006 | pmid = 16581796 | pmc = 1446942 | doi = 10.1128/MCB.26.8.3231-3242.2006 }}
*{{cite journal | author=Weser S, Riemann J, Seifart KH, Meissner W |title=Assembly and isolation of intermediate steps of transcription complexes formed on the human 5S rRNA gene. |journal=Nucleic Acids Res. |volume=31 |issue= 9 |pages= 2408-16 |year= 2003 |pmid= 12711686 |doi= }}
* {{cite journal | vauthors = Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R | title = Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage | journal = FEBS Letters | volume = 580 | issue = 17 | pages = 4121–5 | date = Jul 2006 | pmid = 16828750 | doi = 10.1016/j.febslet.2006.06.057 }}
*{{cite journal | author=Pellikainen JM, Ropponen KM, Kataja VV, ''et al.'' |title=Expression of matrix metalloproteinase (MMP)-2 and MMP-9 in breast cancer with a special reference to activator protein-2, HER2, and prognosis. |journal=Clin. Cancer Res. |volume=10 |issue= 22 |pages= 7621-8 |year= 2005 |pmid= 15569994 |doi= 10.1158/1078-0432.CCR-04-1061 }}
* {{cite journal | vauthors = Schwartz B, Melnikova VO, Tellez C, Mourad-Zeidan A, Blehm K, Zhao YJ, McCarty M, Adam L, Bar-Eli M | title = Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo | journal = Oncogene | volume = 26 | issue = 28 | pages = 4049–58 | date = Jun 2007 | pmid = 17224907 | doi = 10.1038/sj.onc.1210193 }}
*{{cite journal | author=Paing MM, Johnston CA, Siderovski DP, Trejo J |title=Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. |journal=Mol. Cell. Biol. |volume=26 |issue= 8 |pages= 3231-42 |year= 2006 |pmid= 16581796 |doi= 10.1128/MCB.26.8.3231-3242.2006 }}
*{{cite journal | author=Yamashita A, Takada T, Nemoto K, ''et al.'' |title=Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage. |journal=FEBS Lett. |volume=580 |issue= 17 |pages= 4121-5 |year= 2006 |pmid= 16828750 |doi= 10.1016/j.febslet.2006.06.057 }}
*{{cite journal | author=Schwartz B, Melnikova VO, Tellez C, ''et al.'' |title=Loss of AP-2alpha results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo. |journal=Oncogene |volume=26 |issue= 28 |pages= 4049-58 |year= 2007 |pmid= 17224907 |doi= 10.1038/sj.onc.1210193 }}
*{{cite journal  | author=Hannay JA, Liu J, Zhu QS, ''et al.'' |title=Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation. |journal=Mol. Cancer Ther. |volume=6 |issue= 5 |pages= 1650-60 |year= 2007 |pmid= 17513613 |doi= 10.1158/1535-7163.MCT-06-0636 }}
}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|GTF3A+protein,+human}}
* {{MeshName|GTF3A+protein,+human}}
{{NLM content}}
{{Transcription factors|g2}}
[[Category:Transcription factors]]




{{protein-stub}}
{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 11:32, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.[1][2] It was first isolated and characterized by Wolffe and Brown in 1988.

References

  1. Arakawa H, Nagase H, Hayashi N, Ogawa M, Nagata M, Fujiwara T, Takahashi E, Shin S, Nakamura Y (Jul 1995). "Molecular cloning, characterization, and chromosomal mapping of a novel human gene (GTF3A) that is highly homologous to Xenopus transcription factor IIIA". Cytogenetics and Cell Genetics. 70 (3–4): 235–8. doi:10.1159/000134041. PMID 7789179.
  2. "Entrez Gene: GTF3A general transcription factor IIIA".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.