HOXB2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-B2''' is a [[protein]] that in humans is encoded by the ''HOXB2'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXB2 homeobox B2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox B2
| HGNCid = 5113
| Symbol = HOXB2
| AltSymbols =; HOX2; HOX2H; Hox-2.8; K8
| OMIM = 142967
| ECnumber = 
| Homologene = 37584
| MGIid = 96183
| GeneAtlas_image1 = PBB_GE_HOXB2_205453_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3212
    | Hs_Ensembl = ENSG00000173917
    | Hs_RefseqProtein = NP_002136
    | Hs_RefseqmRNA = NM_002145
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 43975020
    | Hs_GenLoc_end = 43977391
    | Hs_Uniprot = P14652
    | Mm_EntrezGene = 103889
    | Mm_Ensembl = ENSMUSG00000075588
    | Mm_RefseqmRNA = XM_001052073
    | Mm_RefseqProtein = XP_001052073
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96167901
    | Mm_GenLoc_end = 96169716
    | Mm_Uniprot = Q61682
  }}
}}
'''Homeobox B2''', also known as '''HOXB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXB2 homeobox B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.<ref name="entrez">{{cite web | title = Entrez Gene: HOXB2 homeobox B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J | title = A homeodomain protein binds to gamma-globin gene regulatory sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 16 | pages = 7318–22 | date = Aug 1991 | pmid = 1871139 | pmc = 52286 | doi = 10.1073/pnas.88.16.7318 }}
| citations =
* {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation; Research in Biological Diversity | volume = 40 | issue = 3 | pages = 191–7 | date = Jun 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }}
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
*{{cite journal | author=Lavelle D, Ducksworth J, Eves E, ''et al.'' |title=A homeodomain protein binds to gamma-globin gene regulatory sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 16 |pages= 7318-22 |year= 1991 |pmid= 1871139 |doi= }}
* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada | volume = 31 | issue = 2 | pages = 745–56 | year = 1990 | pmid = 2576652 | doi = 10.1139/g89-133 }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
* {{cite journal | vauthors = Kongsuwan K, Webb E, Housiaux P, Adams JM | title = Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages | journal = The EMBO Journal | volume = 7 | issue = 7 | pages = 2131–8 | date = Jul 1988 | pmid = 2901346 | pmc = 454515 | doi =  }}
*{{cite journal | author=Giampaolo A, Acampora D, Zappavigna V, ''et al.'' |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191-7 |year= 1989 |pmid= 2570724 |doi= }}
* {{cite journal | vauthors = Vieille-Grosjean I, Huber P | title = Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells | journal = The Journal of Biological Chemistry | volume = 270 | issue = 9 | pages = 4544–50 | date = Mar 1995 | pmid = 7876223 | doi = 10.1074/jbc.270.9.4544 }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
* {{cite journal | vauthors = Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F | title = The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins | journal = The EMBO Journal | volume = 13 | issue = 14 | pages = 3339–47 | date = Jul 1994 | pmid = 7913891 | pmc = 395231 | doi =  }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi= }}
* {{cite journal | vauthors = Guazzi S, Pintonello ML, Viganò A, Boncinelli E | title = Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 18 | pages = 11092–9 | date = May 1998 | pmid = 9556594 | doi = 10.1074/jbc.273.18.11092 }}
*{{cite journal | author=Kongsuwan K, Webb E, Housiaux P, Adams JM |title=Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. |journal=EMBO J. |volume=7 |issue= 7 |pages= 2131-8 |year= 1988 |pmid= 2901346 |doi=  }}
* {{cite journal | vauthors = Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM | title = Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain | journal = Neuron | volume = 22 | issue = 4 | pages = 677–91 | date = Apr 1999 | pmid = 10230789 | doi = 10.1016/S0896-6273(00)80728-X }}
*{{cite journal | author=Vieille-Grosjean I, Huber P |title=Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. |journal=J. Biol. Chem. |volume=270 |issue= 9 |pages= 4544-50 |year= 1995 |pmid= 7876223 |doi= }}
* {{cite journal | vauthors = Case SS, Huber P, Lloyd JA | title = The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation | journal = DNA and Cell Biology | volume = 18 | issue = 11 | pages = 805–17 | date = Nov 1999 | pmid = 10595394 | doi = 10.1089/104454999314809 }}
*{{cite journal | author=Guazzi S, Lonigro R, Pintonello L, ''et al.'' |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339-47 |year= 1994 |pmid= 7913891 |doi=  }}
* {{cite journal | vauthors = Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF | title = HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema | journal = The American Journal of Pathology | volume = 158 | issue = 3 | pages = 955–66 | date = Mar 2001 | pmid = 11238043 | pmc = 1850338 | doi = 10.1016/S0002-9440(10)64042-4 }}
*{{cite journal | author=Guazzi S, Pintonello ML, Viganò A, Boncinelli E |title=Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11092-9 |year= 1998 |pmid= 9556594 |doi= }}
* {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}
*{{cite journal | author=Davenne M, Maconochie MK, Neun R, ''et al.'' |title=Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. |journal=Neuron |volume=22 |issue= 4 |pages= 677-91 |year= 1999 |pmid= 10230789 |doi= }}
* {{cite journal | vauthors = Liu X, Zhang X | title = Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells | journal = Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi / Chinese Medical Association | volume = 5 | issue = 1 | pages = 12–5 | date = Feb 2002 | pmid = 11835749 | doi =  }}
*{{cite journal | author=Case SS, Huber P, Lloyd JA |title=The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. |journal=DNA Cell Biol. |volume=18 |issue= 11 |pages= 805-17 |year= 2000 |pmid= 10595394 |doi= 10.1089/104454999314809 }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=Golpon HA, Geraci MW, Moore MD, ''et al.'' |title=HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema. |journal=Am. J. Pathol. |volume=158 |issue= 3 |pages= 955-66 |year= 2001 |pmid= 11238043 |doi= }}
* {{cite journal | vauthors = Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A | title = Regulation of Hoxb2 by APL-associated PLZF protein | journal = Oncogene | volume = 22 | issue = 24 | pages = 3685–97 | date = Jun 2003 | pmid = 12802276 | doi = 10.1038/sj.onc.1206328 }}
*{{cite journal | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509-22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001 }}
* {{cite journal | vauthors = Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM | title = Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia | journal = Clinical Cancer Research | volume = 11 | issue = 9 | pages = 3587–96 | date = May 2005 | pmid = 15867264 | doi = 10.1158/1078-0432.CCR-04-1813 }}
*{{cite journal | author=Liu X, Zhang X |title=Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells. |journal=Chin. J. Traumatol. |volume=5 |issue= 1 |pages= 12-5 |year= 2002 |pmid= 11835749 |doi=  }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ivins S, Pemberton K, Guidez F, ''et al.'' |title=Regulation of Hoxb2 by APL-associated PLZF protein. |journal=Oncogene |volume=22 |issue= 24 |pages= 3685-97 |year= 2003 |pmid= 12802276 |doi= 10.1038/sj.onc.1206328 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Segara D, Biankin AV, Kench JG, ''et al.'' |title=Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia. |journal=Clin. Cancer Res. |volume=11 |issue= 9 |pages= 3587-96 |year= 2005 |pmid= 15867264 |doi= 10.1158/1078-0432.CCR-04-1813 }}
}}
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{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g3}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-17-stub}}

Latest revision as of 02:05, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.[1][2][3]

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[3]

See also

References

  1. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. 3.0 3.1 "Entrez Gene: HOXB2 homeobox B2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.