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{{ | '''Homeobox protein Hox-B2''' is a [[protein]] that in humans is encoded by the ''HOXB2'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | pmc = | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXB2 homeobox B2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3212| accessdate = }}</ref> | ||
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== Function == | |||
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.<ref name="entrez" /> | |||
==See also== | == See also == | ||
* [[Homeobox]] | * [[Homeobox]] | ||
==References== | == References == | ||
{{reflist | {{reflist}} | ||
==Further reading== | == Further reading == | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J | title = A homeodomain protein binds to gamma-globin gene regulatory sequences | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 16 | pages = 7318–22 | date = Aug 1991 | pmid = 1871139 | pmc = 52286 | doi = 10.1073/pnas.88.16.7318 }} | |||
* {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation; Research in Biological Diversity | volume = 40 | issue = 3 | pages = 191–7 | date = Jun 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }} | |||
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }} | |||
*{{cite journal | * {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada | volume = 31 | issue = 2 | pages = 745–56 | year = 1990 | pmid = 2576652 | doi = 10.1139/g89-133 }} | ||
* {{cite journal | vauthors = Kongsuwan K, Webb E, Housiaux P, Adams JM | title = Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages | journal = The EMBO Journal | volume = 7 | issue = 7 | pages = 2131–8 | date = Jul 1988 | pmid = 2901346 | pmc = 454515 | doi = }} | |||
*{{cite journal | * {{cite journal | vauthors = Vieille-Grosjean I, Huber P | title = Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells | journal = The Journal of Biological Chemistry | volume = 270 | issue = 9 | pages = 4544–50 | date = Mar 1995 | pmid = 7876223 | doi = 10.1074/jbc.270.9.4544 }} | ||
*{{cite journal | * {{cite journal | vauthors = Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F | title = The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins | journal = The EMBO Journal | volume = 13 | issue = 14 | pages = 3339–47 | date = Jul 1994 | pmid = 7913891 | pmc = 395231 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Guazzi S, Pintonello ML, Viganò A, Boncinelli E | title = Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 18 | pages = 11092–9 | date = May 1998 | pmid = 9556594 | doi = 10.1074/jbc.273.18.11092 }} | ||
*{{cite journal | * {{cite journal | vauthors = Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM | title = Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain | journal = Neuron | volume = 22 | issue = 4 | pages = 677–91 | date = Apr 1999 | pmid = 10230789 | doi = 10.1016/S0896-6273(00)80728-X }} | ||
*{{cite journal | * {{cite journal | vauthors = Case SS, Huber P, Lloyd JA | title = The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation | journal = DNA and Cell Biology | volume = 18 | issue = 11 | pages = 805–17 | date = Nov 1999 | pmid = 10595394 | doi = 10.1089/104454999314809 }} | ||
*{{cite journal | * {{cite journal | vauthors = Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF | title = HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema | journal = The American Journal of Pathology | volume = 158 | issue = 3 | pages = 955–66 | date = Mar 2001 | pmid = 11238043 | pmc = 1850338 | doi = 10.1016/S0002-9440(10)64042-4 }} | ||
*{{cite journal | * {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }} | ||
*{{cite journal | * {{cite journal | vauthors = Liu X, Zhang X | title = Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells | journal = Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi / Chinese Medical Association | volume = 5 | issue = 1 | pages = 12–5 | date = Feb 2002 | pmid = 11835749 | doi = }} | ||
*{{cite journal | * {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }} | ||
*{{cite journal | * {{cite journal | vauthors = Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A | title = Regulation of Hoxb2 by APL-associated PLZF protein | journal = Oncogene | volume = 22 | issue = 24 | pages = 3685–97 | date = Jun 2003 | pmid = 12802276 | doi = 10.1038/sj.onc.1206328 }} | ||
*{{cite journal | * {{cite journal | vauthors = Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM | title = Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia | journal = Clinical Cancer Research | volume = 11 | issue = 9 | pages = 3587–96 | date = May 2005 | pmid = 15867264 | doi = 10.1158/1078-0432.CCR-04-1813 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
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{{NLM content}} | {{NLM content}} | ||
{{Transcription factors}} | {{Transcription factors|g3}} | ||
[[Category:Transcription factors]] | [[Category:Transcription factors]] | ||
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
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Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.[1][2][3]
Function
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer.[3]
See also
References
- ↑ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "Entrez Gene: HOXB2 homeobox B2".
Further reading
- Lavelle D, Ducksworth J, Eves E, Gomes G, Keller M, Heller P, DeSimone J (Aug 1991). "A homeodomain protein binds to gamma-globin gene regulatory sequences". Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 7318–22. doi:10.1073/pnas.88.16.7318. PMC 52286. PMID 1871139.
- Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
- Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
- Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
- Kongsuwan K, Webb E, Housiaux P, Adams JM (Jul 1988). "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages". The EMBO Journal. 7 (7): 2131–8. PMC 454515. PMID 2901346.
- Vieille-Grosjean I, Huber P (Mar 1995). "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells". The Journal of Biological Chemistry. 270 (9): 4544–50. doi:10.1074/jbc.270.9.4544. PMID 7876223.
- Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". The EMBO Journal. 13 (14): 3339–47. PMC 395231. PMID 7913891.
- Guazzi S, Pintonello ML, Viganò A, Boncinelli E (May 1998). "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". The Journal of Biological Chemistry. 273 (18): 11092–9. doi:10.1074/jbc.273.18.11092. PMID 9556594.
- Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM (Apr 1999). "Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain". Neuron. 22 (4): 677–91. doi:10.1016/S0896-6273(00)80728-X. PMID 10230789.
- Case SS, Huber P, Lloyd JA (Nov 1999). "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation". DNA and Cell Biology. 18 (11): 805–17. doi:10.1089/104454999314809. PMID 10595394.
- Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF (Mar 2001). "HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema". The American Journal of Pathology. 158 (3): 955–66. doi:10.1016/S0002-9440(10)64042-4. PMC 1850338. PMID 11238043.
- Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
- Liu X, Zhang X (Feb 2002). "Effect of anti-sense oligodeoxynucleotides homeobox B2 on the proliferation and expression of primary human umbilical vein endothelial cells". Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi / Chinese Medical Association. 5 (1): 12–5. PMID 11835749.
- Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
- Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A (Jun 2003). "Regulation of Hoxb2 by APL-associated PLZF protein". Oncogene. 22 (24): 3685–97. doi:10.1038/sj.onc.1206328. PMID 12802276.
- Segara D, Biankin AV, Kench JG, Langusch CC, Dawson AC, Skalicky DA, Gotley DC, Coleman MJ, Sutherland RL, Henshall SM (May 2005). "Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia". Clinical Cancer Research. 11 (9): 3587–96. doi:10.1158/1078-0432.CCR-04-1813. PMID 15867264.
External links
- HOXB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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