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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-B4''' is a [[protein]] that in humans is encoded by the ''HOXB4'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXB4 homeobox B4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3214| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox B4
| HGNCid = 5115
| Symbol = HOXB4
| AltSymbols =; HOX2; HOX-2.6; HOX2F
| OMIM = 142965
| ECnumber = 
| Homologene = 32095
| MGIid = 96185
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0048103 |text = somatic stem cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3214
    | Hs_Ensembl = ENSG00000182742
    | Hs_RefseqProtein = NP_076920
    | Hs_RefseqmRNA = NM_024015
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 44007875
    | Hs_GenLoc_end = 44010742
    | Hs_Uniprot = P17483
    | Mm_EntrezGene = 15412
    | Mm_Ensembl = ENSMUSG00000038692
    | Mm_RefseqmRNA = NM_010459
    | Mm_RefseqProtein = NP_034589
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 96134357
    | Mm_GenLoc_end = 96136703
    | Mm_Uniprot = P10284
  }}
}}
'''Homeobox B4''', also known as '''HOXB4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXB4 homeobox B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3214| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.<ref name="entrez">{{cite web | title = Entrez Gene: HOXB4 homeobox B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3214| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Petrini M, Quaranta MT, Testa U, Samoggia P, Tritarelli E, Carè A, Cianetti L, Valtieri M, Barletta C, Peschle C | title = Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes | journal = Blood | volume = 80 | issue = 1 | pages = 185–93 | date = Jul 1992 | pmid = 1351762 | doi =  }}
| citations =
* {{cite journal | vauthors = Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A | title = Expression of HOX homeogenes in human neuroblastoma cell culture lines | journal = Differentiation; Research in Biological Diversity | volume = 45 | issue = 1 | pages = 61–9 | date = Oct 1990 | pmid = 1981366 | doi = 10.1111/j.1432-0436.1990.tb00458.x }}
*{{cite journal | author=Petrini M, Quaranta MT, Testa U, ''et al.'' |title=Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes. |journal=Blood |volume=80 |issue= 1 |pages= 185-93 |year= 1992 |pmid= 1351762 |doi=  }}
* {{cite journal | vauthors = Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A | title = Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system | journal = Differentiation; Research in Biological Diversity | volume = 40 | issue = 3 | pages = 191–7 | date = Jun 1989 | pmid = 2570724 | doi = 10.1111/j.1432-0436.1989.tb00598.x }}
*{{cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada | volume = 31 | issue = 2 | pages = 745–56 | year = 1990 | pmid = 2576652 | doi = 10.1139/g89-133 }}
*{{cite journal  | author=Peverali FA, D'Esposito M, Acampora D, ''et al.'' |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61-9 |year= 1991 |pmid= 1981366 |doi= }}
* {{cite journal | vauthors = Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, Verlinsky O, Ivakhnenko V, Gindilis V, Strom C, Verlinsky Y | title = Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies | journal = Journal of Assisted Reproduction and Genetics | volume = 13 | issue = 2 | pages = 177–81 | date = Feb 1996 | pmid = 8688592 | doi = 10.1007/BF02072541 }}
*{{cite journal | author=Giampaolo A, Acampora D, Zappavigna V, ''et al.'' |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191-7 |year= 1989 |pmid= 2570724 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
* {{cite journal | vauthors = Bodey B, Bodey B, Siegel SE, Kaiser HE | title = Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment | journal = In Vivo | volume = 14 | issue = 3 | pages = 419–24 | year = 2000 | pmid = 10904875 | doi =  }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi= }}
* {{cite journal | vauthors = Giannola DM, Shlomchik WD, Jegathesan M, Liebowitz D, Abrams CS, Kadesch T, Dancis A, Emerson SG | title = Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2 | journal = The Journal of Experimental Medicine | volume = 192 | issue = 10 | pages = 1479–90 | date = Nov 2000 | pmid = 11085749 | pmc = 2193192 | doi = 10.1084/jem.192.10.1479 }}
*{{cite journal | author=Kuliev A, Kukharenko V, Morozov G, ''et al.'' |title=Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies. |journal=J. Assist. Reprod. Genet. |volume=13 |issue= 2 |pages= 177-81 |year= 1996 |pmid= 8688592 |doi= }}
* {{cite journal | vauthors = Pan Q, Simpson RU | title = Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression | journal = The Journal of Endocrinology | volume = 169 | issue = 1 | pages = 153–9 | date = Apr 2001 | pmid = 11250656 | doi = 10.1677/joe.0.1690153 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}
*{{cite journal | author=Bodey B, Bodey B, Siegel SE, Kaiser HE |title=Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment. |journal=In Vivo |volume=14 |issue= 3 |pages= 419-24 |year= 2000 |pmid= 10904875 |doi=  }}
* {{cite journal | vauthors = Kömüves LG, Michael E, Arbeit JM, Ma XK, Kwong A, Stelnicki E, Rozenfeld S, Morimune M, Yu QC, Largman C | title = HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation | journal = Developmental Dynamics | volume = 224 | issue = 1 | pages = 58–68 | date = May 2002 | pmid = 11984874 | doi = 10.1002/dvdy.10085 }}
*{{cite journal | author=Giannola DM, Shlomchik WD, Jegathesan M, ''et al.'' |title=Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. |journal=J. Exp. Med. |volume=192 |issue= 10 |pages= 1479-90 |year= 2000 |pmid= 11085749 |doi= }}
* {{cite journal | vauthors = Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, Humphries RK | title = Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells | journal = Blood | volume = 100 | issue = 3 | pages = 862–8 | date = Aug 2002 | pmid = 12130496 | doi = 10.1182/blood-2002-01-0220 }}
*{{cite journal | author=Pan Q, Simpson RU |title=Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression. |journal=J. Endocrinol. |volume=169 |issue= 1 |pages= 153-9 |year= 2001 |pmid= 11250656 |doi= }}
* {{cite journal | vauthors = Schiedlmeier B, Klump H, Will E, Arman-Kalcek G, Li Z, Wang Z, Rimek A, Friel J, Baum C, Ostertag W | title = High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation | journal = Blood | volume = 101 | issue = 5 | pages = 1759–68 | date = Mar 2003 | pmid = 12406897 | doi = 10.1182/blood-2002-03-0767 }}
*{{cite journal | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509-22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001 }}
* {{cite journal | vauthors = Theokli C, Morsi El-Kadi AS, Morgan R | title = TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation | journal = Developmental Dynamics | volume = 227 | issue = 1 | pages = 48–55 | date = May 2003 | pmid = 12701098 | doi = 10.1002/dvdy.10287 }}
*{{cite journal | author=Kömüves LG, Michael E, Arbeit JM, ''et al.'' |title=HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation. |journal=Dev. Dyn. |volume=224 |issue= 1 |pages= 58-68 |year= 2002 |pmid= 11984874 |doi= 10.1002/dvdy.10085 }}
* {{cite journal | vauthors = Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C | title = HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development | journal = Developmental Dynamics | volume = 227 | issue = 2 | pages = 192–202 | date = Jun 2003 | pmid = 12761847 | doi = 10.1002/dvdy.10290 }}
*{{cite journal | author=Buske C, Feuring-Buske M, Abramovich C, ''et al.'' |title=Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. |journal=Blood |volume=100 |issue= 3 |pages= 862-8 |year= 2002 |pmid= 12130496 |doi= 10.1182/blood-2002-01-0220 }}
* {{cite journal | vauthors = Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG | title = NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4 | journal = Blood | volume = 102 | issue = 7 | pages = 2420–7 | date = Oct 2003 | pmid = 12791656 | doi = 10.1182/blood-2003-01-0251 }}
*{{cite journal | author=Schiedlmeier B, Klump H, Will E, ''et al.'' |title=High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. |journal=Blood |volume=101 |issue= 5 |pages= 1759-68 |year= 2003 |pmid= 12406897 |doi= 10.1182/blood-2002-03-0767 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Theokli C, Morsi El-Kadi AS, Morgan R |title=TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation. |journal=Dev. Dyn. |volume=227 |issue= 1 |pages= 48-55 |year= 2004 |pmid= 12701098 |doi= 10.1002/dvdy.10287 }}
*{{cite journal | author=Kömüves LG, Ma XK, Stelnicki E, ''et al.'' |title=HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. |journal=Dev. Dyn. |volume=227 |issue= 2 |pages= 192-202 |year= 2004 |pmid= 12761847 |doi= 10.1002/dvdy.10290 }}
*{{cite journal | author=Zhu J, Giannola DM, Zhang Y, ''et al.'' |title=NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4. |journal=Blood |volume=102 |issue= 7 |pages= 2420-7 |year= 2003 |pmid= 12791656 |doi= 10.1182/blood-2003-01-0251 }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
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{{gene-17-stub}}
{{Transcription factors}}
{{Transcription factors|g3}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 02:02, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.[1][2][3]

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.[3]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXB4 homeobox B4".

Further reading

  • Petrini M, Quaranta MT, Testa U, Samoggia P, Tritarelli E, Carè A, Cianetti L, Valtieri M, Barletta C, Peschle C (Jul 1992). "Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes". Blood. 80 (1): 185–93. PMID 1351762.
  • Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (Oct 1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity. 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
  • Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
  • Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
  • Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
  • Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, Verlinsky O, Ivakhnenko V, Gindilis V, Strom C, Verlinsky Y (Feb 1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". Journal of Assisted Reproduction and Genetics. 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Bodey B, Bodey B, Siegel SE, Kaiser HE (2000). "Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment". In Vivo. 14 (3): 419–24. PMID 10904875.
  • Giannola DM, Shlomchik WD, Jegathesan M, Liebowitz D, Abrams CS, Kadesch T, Dancis A, Emerson SG (Nov 2000). "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2". The Journal of Experimental Medicine. 192 (10): 1479–90. doi:10.1084/jem.192.10.1479. PMC 2193192. PMID 11085749.
  • Pan Q, Simpson RU (Apr 2001). "Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression". The Journal of Endocrinology. 169 (1): 153–9. doi:10.1677/joe.0.1690153. PMID 11250656.
  • Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
  • Kömüves LG, Michael E, Arbeit JM, Ma XK, Kwong A, Stelnicki E, Rozenfeld S, Morimune M, Yu QC, Largman C (May 2002). "HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation". Developmental Dynamics. 224 (1): 58–68. doi:10.1002/dvdy.10085. PMID 11984874.
  • Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, Humphries RK (Aug 2002). "Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells". Blood. 100 (3): 862–8. doi:10.1182/blood-2002-01-0220. PMID 12130496.
  • Schiedlmeier B, Klump H, Will E, Arman-Kalcek G, Li Z, Wang Z, Rimek A, Friel J, Baum C, Ostertag W (Mar 2003). "High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation". Blood. 101 (5): 1759–68. doi:10.1182/blood-2002-03-0767. PMID 12406897.
  • Theokli C, Morsi El-Kadi AS, Morgan R (May 2003). "TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation". Developmental Dynamics. 227 (1): 48–55. doi:10.1002/dvdy.10287. PMID 12701098.
  • Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C (Jun 2003). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development". Developmental Dynamics. 227 (2): 192–202. doi:10.1002/dvdy.10290. PMID 12761847.
  • Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG (Oct 2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood. 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=HOXB4&oldid=1417933"