HOXD1: Difference between revisions

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Latest revision as of 14:01, 31 August 2017

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.^[1]^[2]^[3]

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.^[3]

References

↑ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
↑ ^3.0 ^3.1 "Entrez Gene: HOXD1 homeobox D1".

Boncinelli E, Acampora D, Pannese M, et al. (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
Manohar CF, Salwen HR, Furtado MR, Cohn SL (1996). "Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation". Tumour Biol. 17 (1): 34–47. doi:10.1159/000217965. PMID 7501971.
Guazzi S, Lonigro R, Pintonello L, et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. PMC 395231. PMID 7913891.
Manohar CF, Furtado MR, Salwen HR, Cohn SL (1993). "Hox gene expression in differentiating human neuroblastoma cells". Biochem. Mol. Biol. Int. 30 (4): 733–41. PMID 8104620.
Del Campo M, Jones MC, Veraksa AN, et al. (1999). "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". Am. J. Hum. Genet. 65 (1): 104–10. doi:10.1086/302467. PMC 1378080. PMID 10364522.
Adjaye J, Monk M (2000). "Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos". Mol. Hum. Reprod. 6 (8): 707–11. doi:10.1093/molehr/6.8.707. PMID 10908280.
Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1–2): 151–3. doi:10.1159/000015651. PMID 11060466.
Appukuttan B, Sood R, Ott S, et al. (2001). "Isolation and characterization of the human homeobox gene HOX D1". Mol. Biol. Rep. 27 (4): 195–201. doi:10.1023/A:1011048931477. PMID 11455954.
Pitera JE, Milla PJ, Scambler P, Adjaye J (2002). "Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis". Mech. Dev. 109 (2): 377–81. doi:10.1016/S0925-4773(01)00530-5. PMID 11731253.
Kosaki K, Kosaki R, Suzuki T, et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

HOXD1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[pmid1973146-1] McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[pmid1358459-2] Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.

[entrez-3] 3.0 ^3.1 "Entrez Gene: HOXD1 homeobox D1".

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Homeobox protein Hox-D1''' is a [[protein]] that in humans is encoded by the ''HOXD1'' [[gene]].<ref name="pmid1973146">{{cite journal |vauthors=McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 |date=Aug 1990 | pmid = 1973146 | pmc =  | doi =10.1016/0888-7543(90)90186-X  }}</ref><ref name="pmid1358459">{{cite journal | author = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 |date=Dec 1992 | pmid = 1358459 | pmc =  | doi =10.1016/0092-8674(92)90588-4  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXD1 homeobox D1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3231| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Homeobox D1
- | HGNCid = 5132
- | Symbol = HOXD1
- | AltSymbols =; HOX4; HOX4G; Hox-4.7
- | OMIM = 142987
- | ECnumber =
- | Homologene = 7772
- | MGIid = 96201
- | GeneAtlas_image1 = PBB_GE_HOXD1_205975_s_at_tn.png
-  | GeneAtlas_image2 = PBB_GE_HOXD1_205974_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
-  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3231
-    | Hs_Ensembl = ENSG00000128645
-    | Hs_RefseqProtein = NP_078777
-    | Hs_RefseqmRNA = NM_024501
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 176761650
-    | Hs_GenLoc_end = 176763880
-    | Hs_Uniprot = Q9GZZ0
-    | Mm_EntrezGene = 15429
-    | Mm_Ensembl = ENSMUSG00000042448
-    | Mm_RefseqmRNA = NM_010467
-    | Mm_RefseqProtein = NP_034597
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 74563819
-    | Mm_GenLoc_end = 74565982
-    | Mm_Uniprot = Q0VBQ9
-  }}
-}}
-'''Homeobox D1''', also known as '''HOXD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXD1 homeobox D1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3231| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.<ref name="entrez">{{cite web | title = Entrez Gene: HOXD1 homeobox D1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3231| accessdate = }}</ref>
+| summary_text = This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and limb development. Mutations in this gene have been associated with severe developmental defects on the anterior-posterior (a-p) limb axis.<ref name="entrez"/>
 }}
@@ Line 59: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 65: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
+*{{cite journal   |vauthors=Boncinelli E, Acampora D, Pannese M, etal |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=  10.1139/g89-133}}
-*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
+*{{cite journal  |vauthors=Manohar CF, Salwen HR, Furtado MR, Cohn SL |title=Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. |journal=Tumour Biol. |volume=17 |issue= 1 |pages= 34–47 |year= 1996 |pmid= 7501971 |doi=10.1159/000217965  }}
-*{{cite journal  | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi=  }}
+*{{cite journal   |vauthors=Guazzi S, Lonigro R, Pintonello L, etal |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi=  | pmc=395231  }}
-*{{cite journal  | author=Manohar CF, Salwen HR, Furtado MR, Cohn SL |title=Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. |journal=Tumour Biol. |volume=17 |issue= 1 |pages= 34-47 |year= 1996 |pmid= 7501971 |doi=  }}
+*{{cite journal  |vauthors=Manohar CF, Furtado MR, Salwen HR, Cohn SL |title=Hox gene expression in differentiating human neuroblastoma cells. |journal=Biochem. Mol. Biol. Int. |volume=30 |issue= 4 |pages= 733–41 |year= 1993 |pmid= 8104620 |doi=  }}
-*{{cite journal  | author=Guazzi S, Lonigro R, Pintonello L, ''et al.'' |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339-47 |year= 1994 |pmid= 7913891 |doi=  }}
+*{{cite journal   |vauthors=Del Campo M, Jones MC, Veraksa AN, etal |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104–10 |year= 1999 |pmid= 10364522 |doi=10.1086/302467  | pmc=1378080  }}
-*{{cite journal  | author=Manohar CF, Furtado MR, Salwen HR, Cohn SL |title=Hox gene expression in differentiating human neuroblastoma cells. |journal=Biochem. Mol. Biol. Int. |volume=30 |issue= 4 |pages= 733-41 |year= 1993 |pmid= 8104620 |doi=  }}
+*{{cite journal  |vauthors=Adjaye J, Monk M |title=Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos. |journal=Mol. Hum. Reprod. |volume=6 |issue= 8 |pages= 707–11 |year= 2000 |pmid= 10908280 |doi=10.1093/molehr/6.8.707  }}
-*{{cite journal  | author=Del Campo M, Jones MC, Veraksa AN, ''et al.'' |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104-10 |year= 1999 |pmid= 10364522 |doi=  }}
+*{{cite journal  |vauthors=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151–3 |year= 2000 |pmid= 11060466 |doi=10.1159/000015651  }}
-*{{cite journal  | author=Adjaye J, Monk M |title=Transcription of homeobox-containing genes detected in cDNA libraries derived from human unfertilized oocytes and preimplantation embryos. |journal=Mol. Hum. Reprod. |volume=6 |issue= 8 |pages= 707-11 |year= 2000 |pmid= 10908280 |doi=  }}
+*{{cite journal   |vauthors=Appukuttan B, Sood R, Ott S, etal |title=Isolation and characterization of the human homeobox gene HOX D1. |journal=Mol. Biol. Rep. |volume=27 |issue= 4 |pages= 195–201 |year= 2001 |pmid= 11455954 |doi=10.1023/A:1011048931477  }}
-*{{cite journal  | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151-3 |year= 2000 |pmid= 11060466 |doi=  }}
+*{{cite journal  |vauthors=Pitera JE, Milla PJ, Scambler P, Adjaye J |title=Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis. |journal=Mech. Dev. |volume=109 |issue= 2 |pages= 377–81 |year= 2002 |pmid= 11731253 |doi=10.1016/S0925-4773(01)00530-5  }}
-*{{cite journal  | author=Appukuttan B, Sood R, Ott S, ''et al.'' |title=Isolation and characterization of the human homeobox gene HOX D1. |journal=Mol. Biol. Rep. |volume=27 |issue= 4 |pages= 195-201 |year= 2001 |pmid= 11455954 |doi=  }}
+*{{cite journal   |vauthors=Kosaki K, Kosaki R, Suzuki T, etal |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
-*{{cite journal  | author=Pitera JE, Milla PJ, Scambler P, Adjaye J |title=Cloning of HOXD1 from unfertilised human oocytes and expression analyses during murine oogenesis and embryogenesis. |journal=Mech. Dev. |volume=109 |issue= 2 |pages= 377-81 |year= 2002 |pmid= 11731253 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
 }}
 {{refend}}
@@ Line 85: / Line 36: @@
 {{NLM content}}
-{{protein-stub}}
-{{Transcription factors}}
+{{Transcription factors|g3}}
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+{{PBB_Controls
+| update_page = yes
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+| update_protein_box = yes
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 [[Category:Transcription factors]]
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HOXD1: Difference between revisions

Latest revision as of 14:01, 31 August 2017

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References

Further reading

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