HOXD3: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein Hox-D3''' is a [[protein]] that in humans is encoded by the ''HOXD3'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | pmc = | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXD3 homeobox D3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3232| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Homeobox D3
| HGNCid = 5137
| Symbol = HOXD3
| AltSymbols =; HOX1D; HOX4; HOX4A; Hox-4.1; MGC10470
| OMIM = 142980
| ECnumber = 
| Homologene = 5034
| MGIid = 96207
| GeneAtlas_image1 = PBB_GE_HOXD3_206602_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HOXD3_206601_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_HOXD3_217076_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009653 |text = anatomical structure morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3232
    | Hs_Ensembl = ENSG00000128652
    | Hs_RefseqProtein = NP_008829
    | Hs_RefseqmRNA = NM_006898
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 176737051
    | Hs_GenLoc_end = 176746072
    | Hs_Uniprot = P31249
    | Mm_EntrezGene = 15434
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_010468
    | Mm_RefseqProtein = NP_034598
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Homeobox D3''', also known as '''HOXD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXD3 homeobox D3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3232| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.<ref name="entrez">{{cite web | title = Entrez Gene: HOXD3 homeobox D3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3232| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Homeobox]]
* [[Homeobox]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Taniguchi Y, Fujii A, Moriuchi T | title = Cloning and sequencing of the human homeobox gene HOX4A | journal = Biochimica et Biophysica Acta | volume = 1132 | issue = 3 | pages = 332–4 | date = Oct 1992 | pmid = 1358204 | doi = 10.1016/0167-4781(92)90173-w }}
| citations =
* {{cite journal | vauthors = Magli MC, Barba P, Celetti A, De Vita G, Cillo C, Boncinelli E | title = Coordinate regulation of HOX genes in human hematopoietic cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 14 | pages = 6348–52 | date = Jul 1991 | pmid = 1712489 | pmc = 52080 | doi = 10.1073/pnas.88.14.6348 }}
*{{cite journal | author=Taniguchi Y, Fujii A, Moriuchi T |title=Cloning and sequencing of the human homeobox gene HOX4A. |journal=Biochim. Biophys. Acta |volume=1132 |issue= 3 |pages= 332-4 |year= 1992 |pmid= 1358204 |doi= }}
* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
* {{cite journal | vauthors = Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A | title = Organization of human class I homeobox genes | journal = Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada | volume = 31 | issue = 2 | pages = 745–56 | year = 1990 | pmid = 2576652 | doi = 10.1139/g89-133 }}
*{{cite journal | author=Magli MC, Barba P, Celetti A, ''et al.'' |title=Coordinate regulation of HOX genes in human hematopoietic cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 14 |pages= 6348-52 |year= 1991 |pmid= 1712489 |doi= }}
* {{cite journal | vauthors = Cannizzaro LA, Croce CM, Griffin CA, Simeone A, Boncinelli E, Huebner K | title = Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13 | journal = American Journal of Human Genetics | volume = 41 | issue = 1 | pages = 1–15 | date = Jul 1987 | pmid = 2886047 | pmc = 1684175 | doi =  }}
*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
* {{cite journal | vauthors = Taniguchi Y, Komatsu N, Moriuchi T | title = Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties | journal = Blood | volume = 85 | issue = 10 | pages = 2786–94 | date = May 1995 | pmid = 7742539 | doi =  }}
*{{cite journal | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi= }}
* {{cite journal | vauthors = Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F | title = The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins | journal = The EMBO Journal | volume = 13 | issue = 14 | pages = 3339–47 | date = Jul 1994 | pmid = 7913891 | pmc = 395231 | doi =  }}
*{{cite journal | author=Boncinelli E, Acampora D, Pannese M, ''et al.'' |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745-56 |year= 1990 |pmid= 2576652 |doi= }}
* {{cite journal | vauthors = Manley NR, Capecchi MR | title = Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands | journal = Developmental Biology | volume = 195 | issue = 1 | pages = 1–15 | date = Mar 1998 | pmid = 9520319 | doi = 10.1006/dbio.1997.8827 }}
*{{cite journal | author=Cannizzaro LA, Croce CM, Griffin CA, ''et al.'' |title=Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13. |journal=Am. J. Hum. Genet. |volume=41 |issue= 1 |pages= 1-15 |year= 1987 |pmid= 2886047 |doi=  }}
* {{cite journal | vauthors = Del Campo M, Jones MC, Veraksa AN, Curry CJ, Jones KL, Mascarello JT, Ali-Kahn-Catts Z, Drumheller T, McGinnis W | title = Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster | journal = American Journal of Human Genetics | volume = 65 | issue = 1 | pages = 104–10 | date = Jul 1999 | pmid = 10364522 | pmc = 1378080 | doi = 10.1086/302467 }}
*{{cite journal | author=Taniguchi Y, Komatsu N, Moriuchi T |title=Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties. |journal=Blood |volume=85 |issue= 10 |pages= 2786-94 |year= 1995 |pmid= 7742539 |doi=  }}
* {{cite journal | vauthors = Myers C, Charboneau A, Boudreau N | title = Homeobox B3 promotes capillary morphogenesis and angiogenesis | journal = The Journal of Cell Biology | volume = 148 | issue = 2 | pages = 343–51 | date = Jan 2000 | pmid = 10648567 | pmc = 2174277 | doi = 10.1083/jcb.148.2.343 }}
*{{cite journal | author=Guazzi S, Lonigro R, Pintonello L, ''et al.'' |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339-47 |year= 1994 |pmid= 7913891 |doi=  }}
* {{cite journal | vauthors = Limongi MZ, Pelliccia F, Gaddini L, Rocchi A | title = Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1 | journal = Cytogenetics and Cell Genetics | volume = 90 | issue = 1-2 | pages = 151–3 | year = 2000 | pmid = 11060466 | doi = 10.1159/000015651 }}
*{{cite journal | author=Manley NR, Capecchi MR |title=Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. |journal=Dev. Biol. |volume=195 |issue= 1 |pages= 1-15 |year= 1998 |pmid= 9520319 |doi= 10.1006/dbio.1997.8827 }}
* {{cite journal | vauthors = Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N | title = Complete mutation analysis panel of the 39 human HOX genes | journal = Teratology | volume = 65 | issue = 2 | pages = 50–62 | date = Feb 2002 | pmid = 11857506 | doi = 10.1002/tera.10009 }}
*{{cite journal | author=Del Campo M, Jones MC, Veraksa AN, ''et al.'' |title=Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. |journal=Am. J. Hum. Genet. |volume=65 |issue= 1 |pages= 104-10 |year= 1999 |pmid= 10364522 |doi= }}
* {{cite journal | vauthors = Okubo Y, Hamada J, Takahashi Y, Tada M, Tsutsumida A, Furuuchi K, Aoyama T, Sugihara T, Moriuchi T | title = Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities | journal = Clinical & Experimental Metastasis | volume = 19 | issue = 6 | pages = 503–11 | year = 2002 | pmid = 12405287 | doi = 10.1023/A:1020346211686 }}
*{{cite journal | author=Myers C, Charboneau A, Boudreau N |title=Homeobox B3 promotes capillary morphogenesis and angiogenesis. |journal=J. Cell Biol. |volume=148 |issue= 2 |pages= 343-51 |year= 2000 |pmid= 10648567 |doi= }}
* {{cite journal | vauthors = Boudreau NJ, Varner JA | title = The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis | journal = The Journal of Biological Chemistry | volume = 279 | issue = 6 | pages = 4862–8 | date = Feb 2004 | pmid = 14610084 | doi = 10.1074/jbc.M305190200 }}
*{{cite journal | author=Limongi MZ, Pelliccia F, Gaddini L, Rocchi A |title=Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. |journal=Cytogenet. Cell Genet. |volume=90 |issue= 1-2 |pages= 151-3 |year= 2000 |pmid= 11060466 |doi= }}
* {{cite journal | vauthors = Hansen SL, Myers CA, Charboneau A, Young DM, Boudreau N | title = HoxD3 accelerates wound healing in diabetic mice | journal = The American Journal of Pathology | volume = 163 | issue = 6 | pages = 2421–31 | date = Dec 2003 | pmid = 14633614 | pmc = 1892363 | doi = 10.1016/S0002-9440(10)63597-3 }}
*{{cite journal | author=Kosaki K, Kosaki R, Suzuki T, ''et al.'' |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50-62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009 }}
* {{cite journal | vauthors = Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, Yang GY | title = Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice | journal = Journal of Cerebral Blood Flow and Metabolism | volume = 24 | issue = 11 | pages = 1280–7 | date = Nov 2004 | pmid = 15545924 | doi = 10.1097/01.WCB.0000141770.09022.AB }}
*{{cite journal | author=Okubo Y, Hamada J, Takahashi Y, ''et al.'' |title=Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities. |journal=Clin. Exp. Metastasis |volume=19 |issue= 6 |pages= 503-11 |year= 2002 |pmid= 12405287 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Boudreau NJ, Varner JA |title=The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4862-8 |year= 2004 |pmid= 14610084 |doi= 10.1074/jbc.M305190200 }}
*{{cite journal | author=Hansen SL, Myers CA, Charboneau A, ''et al.'' |title=HoxD3 accelerates wound healing in diabetic mice. |journal=Am. J. Pathol. |volume=163 |issue= 6 |pages= 2421-31 |year= 2004 |pmid= 14633614 |doi= }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Chen Y, Xu B, Arderiu G, ''et al.'' |title=Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice. |journal=J. Cereb. Blood Flow Metab. |volume=24 |issue= 11 |pages= 1280-7 |year= 2004 |pmid= 15545924 |doi= }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{protein-stub}}
 
{{Transcription factors}}
{{Transcription factors|g3}}
 
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-2-stub}}

Latest revision as of 14:02, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein Hox-D3 is a protein that in humans is encoded by the HOXD3 gene.[1][2][3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.[3]

See also

References

  1. ↑ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
  2. ↑ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  3. ↑ 3.0 3.1 "Entrez Gene: HOXD3 homeobox D3".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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