KLF6: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Krueppel-like factor 6''' is a [[protein]] that in humans is encoded by the ''KLF6'' [[gene]].<ref name="pmid9503030">{{cite journal | vauthors = Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A | title = Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization | journal = Genomics | volume = 48 | issue = 1 | pages = 143–4 | date = Feb 1998 | pmid = 9503030 | pmc = | doi = 10.1006/geno.1997.5124 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
It is a [[tumor suppressor gene]].<ref name="pmid16230382">{{cite journal | vauthors = Li D, Yea S, Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ, Friedman SL | title = Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation | journal = Cancer Research | volume = 65 | issue = 20 | pages = 9216–25 | date = Oct 2005 | pmid = 16230382 | doi = 10.1158/0008-5472.CAN-05-1040 | url = http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16230382 }}</ref>
{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Kruppel-like factor 6
| HGNCid = 2235
| Symbol = KLF6
| AltSymbols =; BCD1; COPEB; CPBP; DKFZp686N0199; GBF; PAC1; ST12; ZF9
| OMIM = 602053
| ECnumber =
| Homologene = 996
| MGIid = 1346318
| GeneAtlas_image1 = PBB_GE_KLF6_208961_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KLF6_208960_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_KLF6_211610_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0016049 |text = cell growth}} {{GNF_GO|id=GO:0019221 |text = cytokine and chemokine mediated signaling pathway}} {{GNF_GO|id=GO:0030183 |text = B cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1316
    | Hs_Ensembl = ENSG00000067082
    | Hs_RefseqProtein = NP_001008490
    | Hs_RefseqmRNA = NM_001008490
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 3808188
    | Hs_GenLoc_end = 3817467
    | Hs_Uniprot = Q99612
    | Mm_EntrezGene = 23849
    | Mm_Ensembl = ENSMUSG00000000078
    | Mm_RefseqmRNA = NM_011803
    | Mm_RefseqProtein = NP_035933
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 5860735
    | Mm_GenLoc_end = 5869639
    | Mm_Uniprot = Q3U9J1
  }}
}}
'''Kruppel-like factor 6''', also known as '''KLF6''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: KLF6 Kruppel-like factor 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1316| accessdate = }}</ref>
}}


==See also==
This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: KLF6 Kruppel-like factor 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1316| accessdate = }}</ref>
 
== Interactions ==
 
KLF6 has been shown to [[Protein-protein interaction|interact]] with [[Sp1 transcription factor]].<ref name=pmid12433697>{{cite journal | vauthors = Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabéu C | title = Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury | journal = Blood | volume = 100 | issue = 12 | pages = 4001–10 | date = Dec 2002 | pmid = 12433697 | doi = 10.1182/blood.V100.12.4001 }}</ref>
 
== See also ==
* [[Kruppel-like factors]]
* [[Kruppel-like factors]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Narla G, Friedman SL, Martignetti JA | title = Krüppel cripples prostate cancer: KLF6 progress and prospects | journal = The American Journal of Pathology | volume = 162 | issue = 4 | pages = 1047–52 | date = Apr 2003 | pmid = 12651597 | pmc = 1851219 | doi = 10.1016/S0002-9440(10)63901-6 }}
| citations =
* {{cite journal | vauthors = El Rouby S, Newcomb EW | title = Identification of Bcd, a novel proto-oncogene expressed in B-cells | journal = Oncogene | volume = 13 | issue = 12 | pages = 2623–30 | date = Dec 1996 | pmid = 9000136 | doi =  }}
*{{cite journal | author=Narla G, Friedman SL, Martignetti JA |title=Krüppel cripples prostate cancer: KLF6 progress and prospects. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1047-52 |year= 2003 |pmid= 12651597 |doi= }}
* {{cite journal | vauthors = Koritschoner NP, Bocco JL, Panzetta-Dutari GM, Dumur CI, Flury A, Patrito LC | title = A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene | journal = The Journal of Biological Chemistry | volume = 272 | issue = 14 | pages = 9573–80 | date = Apr 1997 | pmid = 9083102 | doi = 10.1074/jbc.272.14.9573 }}
*{{cite journal | author=El Rouby S, Newcomb EW |title=Identification of Bcd, a novel proto-oncogene expressed in B-cells. |journal=Oncogene |volume=13 |issue= 12 |pages= 2623-30 |year= 1997 |pmid= 9000136 |doi=  }}
* {{cite journal | vauthors = Suzuki T, Yamamoto T, Kurabayashi M, Nagai R, Yazaki Y, Horikoshi M | title = Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter | journal = Journal of Biochemistry | volume = 124 | issue = 2 | pages = 389–95 | date = Aug 1998 | pmid = 9685731 | doi = 10.1093/oxfordjournals.jbchem.a022124 }}
*{{cite journal | author=Koritschoner NP, Bocco JL, Panzetta-Dutari GM, ''et al.'' |title=A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9573-80 |year= 1997 |pmid= 9083102 |doi=  }}
* {{cite journal | vauthors = Ratziu V, Lalazar A, Wong L, Dang Q, Collins C, Shaulian E, Jensen S, Friedman SL | title = Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 16 | pages = 9500–5 | date = Aug 1998 | pmid = 9689109 | pmc = 21367 | doi = 10.1073/pnas.95.16.9500 }}
*{{cite journal  | author=Onyango P, Koritschoner NP, Patrito LC, ''et al.'' |title=Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization. |journal=Genomics |volume=48 |issue= 1 |pages= 143-4 |year= 1998 |pmid= 9503030 |doi= 10.1006/geno.1997.5124 }}
* {{cite journal | vauthors = Okano J, Opitz OG, Nakagawa H, Jenkins TD, Friedman SL, Rustgi AK | title = The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact | journal = FEBS Letters | volume = 473 | issue = 1 | pages = 95–100 | date = May 2000 | pmid = 10802067 | doi = 10.1016/S0014-5793(00)01468-X }}
*{{cite journal | author=Suzuki T, Yamamoto T, Kurabayashi M, ''et al.'' |title=Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter. |journal=J. Biochem. |volume=124 |issue= 2 |pages= 389-95 |year= 1998 |pmid= 9685731 |doi= }}
* {{cite journal | vauthors = Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Friedman SL | title = KLF6, a candidate tumor suppressor gene mutated in prostate cancer | journal = Science | volume = 294 | issue = 5551 | pages = 2563–6 | date = Dec 2001 | pmid = 11752579 | doi = 10.1126/science.1066326 }}
*{{cite journal | author=Ratziu V, Lalazar A, Wong L, ''et al.'' |title=Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9500-5 |year= 1998 |pmid= 9689109 |doi= }}
* {{cite journal | vauthors = Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabéu C | title = Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury | journal = Blood | volume = 100 | issue = 12 | pages = 4001–10 | date = Dec 2002 | pmid = 12433697 | doi = 10.1182/blood.V100.12.4001 }}
*{{cite journal | author=Okano J, Opitz OG, Nakagawa H, ''et al.'' |title=The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact. |journal=FEBS Lett. |volume=473 |issue= 1 |pages= 95-100 |year= 2000 |pmid= 10802067 |doi= }}
* {{cite journal | vauthors = Chen HK, Liu XQ, Lin J, Chen TY, Feng QS, Zeng YX | title = [Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas] | journal = Ai Zheng = Aizheng = Chinese Journal of Cancer | volume = 21 | issue = 10 | pages = 1047–50 | date = Oct 2002 | pmid = 12508640 | doi =  }}
*{{cite journal | author=Narla G, Heath KE, Reeves HL, ''et al.'' |title=KLF6, a candidate tumor suppressor gene mutated in prostate cancer. |journal=Science |volume=294 |issue= 5551 |pages= 2563-6 |year= 2002 |pmid= 11752579 |doi= 10.1126/science.1066326 }}
* {{cite journal | vauthors = Warke VG, Nambiar MP, Krishnan S, Tenbrock K, Geller DA, Koritschoner NP, Atkins JL, Farber DL, Tsokos GC | title = Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 14812–9 | date = Apr 2003 | pmid = 12590140 | doi = 10.1074/jbc.M300787200 }}
*{{cite journal | author=Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, ''et al.'' |title=Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury. |journal=Blood |volume=100 |issue= 12 |pages= 4001-10 |year= 2003 |pmid= 12433697 |doi= 10.1182/blood.V100.12.4001 }}
* {{cite journal | vauthors = Chen C, Hyytinen ER, Sun X, Helin HJ, Koivisto PA, Frierson HF, Vessella RL, Dong JT | title = Deletion, mutation, and loss of expression of KLF6 in human prostate cancer | journal = The American Journal of Pathology | volume = 162 | issue = 4 | pages = 1349–54 | date = Apr 2003 | pmid = 12651626 | pmc = 1851229 | doi = 10.1016/S0002-9440(10)63930-2 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Jeng YM, Hsu HC | title = KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas | journal = International Journal of Cancer | volume = 105 | issue = 5 | pages = 625–9 | date = Jul 2003 | pmid = 12740910 | doi = 10.1002/ijc.11123 }}
*{{cite journal  | author=Chen HK, Liu XQ, Lin J, ''et al.'' |title=[Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas] |journal=Ai Zheng |volume=21 |issue= 10 |pages= 1047-50 |year= 2003 |pmid= 12508640 |doi=  }}
* {{cite journal | vauthors = Bayat A, Watson JS, Stanley JK, Ferguson MW, Ollier WE | title = Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene | journal = Plastic and Reconstructive Surgery | volume = 111 | issue = 7 | pages = 2133–9 | date = Jun 2003 | pmid = 12794452 | doi = 10.1097/01.PRS.0000060531.98180.32 }}
*{{cite journal | author=Warke VG, Nambiar MP, Krishnan S, ''et al.'' |title=Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 14812-9 |year= 2003 |pmid= 12590140 |doi= 10.1074/jbc.M300787200 }}
* {{cite journal | vauthors = Reeves HL, Narla G, Ogunbiyi O, Haq AI, Katz A, Benzeno S, Hod E, Harpaz N, Goldberg S, Tal-Kremer S, Eng FJ, Arthur MJ, Martignetti JA, Friedman SL | title = Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer | journal = Gastroenterology | volume = 126 | issue = 4 | pages = 1090–103 | date = Apr 2004 | pmid = 15057748 | doi = 10.1053/j.gastro.2004.01.005 }}
*{{cite journal | author=Chen C, Hyytinen ER, Sun X, ''et al.'' |title=Deletion, mutation, and loss of expression of KLF6 in human prostate cancer. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1349-54 |year= 2003 |pmid= 12651626 |doi= }}
* {{cite journal | vauthors = Kimmelman AC, Qiao RF, Narla G, Banno A, Lau N, Bos PD, Nuñez Rodriguez N, Liang BC, Guha A, Martignetti JA, Friedman SL, Chan AM | title = Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6 | journal = Oncogene | volume = 23 | issue = 29 | pages = 5077–83 | date = Jun 2004 | pmid = 15064720 | doi = 10.1038/sj.onc.1207662 }}
*{{cite journal | author=Jeng YM, Hsu HC |title=KLF6, a putative tumor suppressor gene, is mutated in astrocytic gliomas. |journal=Int. J. Cancer |volume=105 |issue= 5 |pages= 625-9 |year= 2003 |pmid= 12740910 |doi= 10.1002/ijc.11123 }}
* {{cite journal | vauthors = Glinsky GV, Glinskii AB, Stephenson AJ, Hoffman RM, Gerald WL | title = Gene expression profiling predicts clinical outcome of prostate cancer | journal = The Journal of Clinical Investigation | volume = 113 | issue = 6 | pages = 913–23 | date = Mar 2004 | pmid = 15067324 | pmc = 362118 | doi = 10.1172/JCI20032 }}
*{{cite journal | author=Bayat A, Watson JS, Stanley JK, ''et al.'' |title=Genetic susceptibility to dupuytren disease: association of Zf9 transcription factor gene. |journal=Plast. Reconstr. Surg. |volume=111 |issue= 7 |pages= 2133-9 |year= 2003 |pmid= 12794452 |doi= 10.1097/01.PRS.0000060531.98180.32 }}
* {{cite journal | vauthors = Rubinstein M, Idelman G, Plymate SR, Narla G, Friedman SL, Werner H | title = Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53 | journal = Endocrinology | volume = 145 | issue = 8 | pages = 3769–77 | date = Aug 2004 | pmid = 15131018 | doi = 10.1210/en.2004-0173 }}
*{{cite journal | author=Reeves HL, Narla G, Ogunbiyi O, ''et al.'' |title=Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer. |journal=Gastroenterology |volume=126 |issue= 4 |pages= 1090-103 |year= 2004 |pmid= 15057748 |doi= }}
*{{cite journal | author=Kimmelman AC, Qiao RF, Narla G, ''et al.'' |title=Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6. |journal=Oncogene |volume=23 |issue= 29 |pages= 5077-83 |year= 2004 |pmid= 15064720 |doi= 10.1038/sj.onc.1207662 }}
*{{cite journal | author=Glinsky GV, Glinskii AB, Stephenson AJ, ''et al.'' |title=Gene expression profiling predicts clinical outcome of prostate cancer. |journal=J. Clin. Invest. |volume=113 |issue= 6 |pages= 913-23 |year= 2004 |pmid= 15067324 |doi= 10.1172/JCI200420032 }}
*{{cite journal | author=Rubinstein M, Idelman G, Plymate SR, ''et al.'' |title=Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53. |journal=Endocrinology |volume=145 |issue= 8 |pages= 3769-77 |year= 2004 |pmid= 15131018 |doi= 10.1210/en.2004-0173 }}
}}
{{refend}}
{{refend}}


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{{Transcription factors}}
{{Transcription factors|g2}}
{{Tumor suppressor genes}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]


[[fi:KLF6]]
 
{{WikiDoc Sources}}
{{gene-10-stub}}

Latest revision as of 21:59, 25 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.[1]

It is a tumor suppressor gene.[2]

Function

This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region. The zinc fingers of this protein are responsible for the specific DNA binding with the guanine-rich core promoter elements. The central region might be involved in activation or posttranslational regulatory pathways, and the acidic N-terminal domain might play an important role in the process of transcriptional activation. It is capable of activating transcription approximately 4-fold either on homologous or heterologous promoters. The DNA binding and transcriptional activity of this protein, in conjunction with its expression pattern, suggests that this protein may participate in the regulation and/or maintenance of the basal expression of pregnancy-specific glycoprotein genes and possibly other TATA box-less genes. Two transcript variants encoding the same protein have been found for this gene.[3]

Interactions

KLF6 has been shown to interact with Sp1 transcription factor.[4]

See also

References

  1. ↑ Onyango P, Koritschoner NP, Patrito LC, Zenke M, Weith A (Feb 1998). "Assignment of the gene encoding the core promoter element binding protein (COPEB) to human chromosome 10p15 by somatic hybrid analysis and fluorescence in situ hybridization". Genomics. 48 (1): 143–4. doi:10.1006/geno.1997.5124. PMID 9503030.
  2. ↑ Li D, Yea S, Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ, Friedman SL (Oct 2005). "Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation". Cancer Research. 65 (20): 9216–25. doi:10.1158/0008-5472.CAN-05-1040. PMID 16230382.
  3. ↑ "Entrez Gene: KLF6 Kruppel-like factor 6".
  4. ↑ Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabéu C (Dec 2002). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood. 100 (12): 4001–10. doi:10.1182/blood.V100.12.4001. PMID 12433697.

Further reading

  • Narla G, Friedman SL, Martignetti JA (Apr 2003). "Krüppel cripples prostate cancer: KLF6 progress and prospects". The American Journal of Pathology. 162 (4): 1047–52. doi:10.1016/S0002-9440(10)63901-6. PMC 1851219. PMID 12651597.
  • El Rouby S, Newcomb EW (Dec 1996). "Identification of Bcd, a novel proto-oncogene expressed in B-cells". Oncogene. 13 (12): 2623–30. PMID 9000136.
  • Koritschoner NP, Bocco JL, Panzetta-Dutari GM, Dumur CI, Flury A, Patrito LC (Apr 1997). "A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene". The Journal of Biological Chemistry. 272 (14): 9573–80. doi:10.1074/jbc.272.14.9573. PMID 9083102.
  • Suzuki T, Yamamoto T, Kurabayashi M, Nagai R, Yazaki Y, Horikoshi M (Aug 1998). "Isolation and initial characterization of GBF, a novel DNA-binding zinc finger protein that binds to the GC-rich binding sites of the HIV-1 promoter". Journal of Biochemistry. 124 (2): 389–95. doi:10.1093/oxfordjournals.jbchem.a022124. PMID 9685731.
  • Ratziu V, Lalazar A, Wong L, Dang Q, Collins C, Shaulian E, Jensen S, Friedman SL (Aug 1998). "Zf9, a Kruppel-like transcription factor up-regulated in vivo during early hepatic fibrosis". Proceedings of the National Academy of Sciences of the United States of America. 95 (16): 9500–5. doi:10.1073/pnas.95.16.9500. PMC 21367. PMID 9689109.
  • Okano J, Opitz OG, Nakagawa H, Jenkins TD, Friedman SL, Rustgi AK (May 2000). "The Krüppel-like transcriptional factors Zf9 and GKLF coactivate the human keratin 4 promoter and physically interact". FEBS Letters. 473 (1): 95–100. doi:10.1016/S0014-5793(00)01468-X. PMID 10802067.
  • Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Friedman SL (Dec 2001). "KLF6, a candidate tumor suppressor gene mutated in prostate cancer". Science. 294 (5551): 2563–6. doi:10.1126/science.1066326. PMID 11752579.
  • Botella LM, Sánchez-Elsner T, Sanz-Rodriguez F, Kojima S, Shimada J, Guerrero-Esteo M, Cooreman MP, Ratziu V, Langa C, Vary CP, Ramirez JR, Friedman S, Bernabéu C (Dec 2002). "Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury". Blood. 100 (12): 4001–10. doi:10.1182/blood.V100.12.4001. PMID 12433697.
  • Chen HK, Liu XQ, Lin J, Chen TY, Feng QS, Zeng YX (Oct 2002). "[Mutation analysis of KLF6 gene in human nasopharyngeal carcinomas]". Ai Zheng = Aizheng = Chinese Journal of Cancer. 21 (10): 1047–50. PMID 12508640.
  • Warke VG, Nambiar MP, Krishnan S, Tenbrock K, Geller DA, Koritschoner NP, Atkins JL, Farber DL, Tsokos GC (Apr 2003). "Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6". The Journal of Biological Chemistry. 278 (17): 14812–9. doi:10.1074/jbc.M300787200. PMID 12590140.
  • Chen C, Hyytinen ER, Sun X, Helin HJ, Koivisto PA, Frierson HF, Vessella RL, Dong JT (Apr 2003). "Deletion, mutation, and loss of expression of KLF6 in human prostate cancer". The American Journal of Pathology. 162 (4): 1349–54. doi:10.1016/S0002-9440(10)63930-2. PMC 1851229. PMID 12651626.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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