MEOX2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Homeobox protein MOX-2''' is a [[protein]] that in humans is encoded by the ''MEOX2'' [[gene]].<ref name="pmid7713505">{{cite journal | vauthors = LePage DF, Altomare DA, Testa JR, Walsh K | title = Molecular cloning and localization of the human GAX gene to 7p21 | journal = Genomics | volume = 24 | issue = 3 | pages = 535–40 | date = May 1995 | pmid = 7713505 | pmc = | doi = 10.1006/geno.1994.1663 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MEOX2 mesenchyme homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4223| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mesenchyme homeobox 2
| HGNCid = 7014
| Symbol = MEOX2
| AltSymbols =; GAX; MOX2
| OMIM = 600535
| ECnumber = 
| Homologene = 4330
| MGIid = 103219
| GeneAtlas_image1 = PBB_GE_MEOX2_206201_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001757 |text = somite specification}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008015 |text = circulation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4223
    | Hs_Ensembl = ENSG00000106511
    | Hs_RefseqProtein = NP_005915
    | Hs_RefseqmRNA = NM_005924
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 15617362
    | Hs_GenLoc_end = 15692819
    | Hs_Uniprot = P50222
    | Mm_EntrezGene = 17286
    | Mm_Ensembl = ENSMUSG00000036144
    | Mm_RefseqmRNA = NM_008584
    | Mm_RefseqProtein = NP_032610
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 37618812
    | Mm_GenLoc_end = 37689794
    | Mm_Uniprot = Q99M23
  }}
}}
'''Mesenchyme homeobox 2''', also known as '''MEOX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MEOX2 mesenchyme homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4223| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.<ref name="entrez">{{cite web | title = Entrez Gene: MEOX2 mesenchyme homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4223| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MEOX2 has been shown to [[Protein-protein interaction|interact]] with [[PAX1]]<ref name=pmid11423130>{{cite journal | vauthors = Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D | title = Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors | journal = FEBS Lett. | volume = 499 | issue = 3 | pages = 274–8 | date = Jun 2001 | pmid = 11423130 | doi = 10.1016/S0014-5793(01)02556-X }}</ref> and [[PAX3]].<ref name=pmid11423130/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Grigoriou M, Kastrinaki MC, Modi WS, Theodorakis K, Mankoo B, Pachnis V, Karagogeos D | title = Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3 | journal = Genomics | volume = 26 | issue = 3 | pages = 550–5 | year = 1995 | pmid = 7607679 | doi = 10.1016/0888-7543(95)80174-K }}
| citations =
* {{cite journal | vauthors = Reardon W, McManus SP, Summers D, Winter RM | title = Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2 | journal = Am. J. Med. Genet. | volume = 47 | issue = 5 | pages = 633–6 | year = 1994 | pmid = 8266988 | doi = 10.1002/ajmg.1320470510 }}
*{{cite journal | author=Grigoriou M, Kastrinaki MC, Modi WS, ''et al.'' |title=Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. |journal=Genomics |volume=26 |issue= 3 |pages= 550-5 |year= 1995 |pmid= 7607679 |doi=  }}
* {{cite journal | vauthors = Quinn LM, Latham SE, Kalionis B | title = The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta | journal = Placenta | volume = 21 Suppl A | issue =  | pages = S50–4 | year = 2000 | pmid = 10831122 | doi = 10.1053/plac.1999.0514 }}
*{{cite journal  | author=LePage DF, Altomare DA, Testa JR, Walsh K |title=Molecular cloning and localization of the human GAX gene to 7p21. |journal=Genomics |volume=24 |issue= 3 |pages= 535-40 |year= 1995 |pmid= 7713505 |doi= 10.1006/geno.1994.1663 }}
* {{cite journal | vauthors = Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D | title = Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors | journal = FEBS Lett. | volume = 499 | issue = 3 | pages = 274–8 | year = 2001 | pmid = 11423130 | doi = 10.1016/S0014-5793(01)02556-X }}
*{{cite journal | author=Reardon W, McManus SP, Summers D, Winter RM |title=Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2. |journal=Am. J. Med. Genet. |volume=47 |issue= 5 |pages= 633-6 |year= 1994 |pmid= 8266988 |doi= 10.1002/ajmg.1320470510 }}
* {{cite journal | vauthors = Gorski DH, Leal AJ | title = Inhibition of endothelial cell activation by the homeobox gene Gax | journal = J. Surg. Res. | volume = 111 | issue = 1 | pages = 91–9 | year = 2003 | pmid = 12842453 | doi = 10.1016/S0022-4804(03)00042-8 }}
*{{cite journal | author=Quinn LM, Latham SE, Kalionis B |title=The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta. |journal=Placenta |volume=21 Suppl A |issue=  |pages= S50-4 |year= 2000 |pmid= 10831122 |doi= }}
* {{cite journal | vauthors = Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV | title = Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease | journal = Nat. Med. | volume = 11 | issue = 9 | pages = 959–65 | year = 2005 | pmid = 16116430 | doi = 10.1038/nm1287 }}
*{{cite journal | author=Stamataki D, Kastrinaki M, Mankoo BS, ''et al.'' |title=Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors. |journal=FEBS Lett. |volume=499 |issue= 3 |pages= 274-8 |year= 2001 |pmid= 11423130 |doi=  }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT | title = Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10 | journal = Mol. Cell. Biochem. | volume = 275 | issue = 1–2 | pages = 75–84 | year = 2006 | pmid = 16335786 | doi = 10.1007/s11010-005-0823-3 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Gorski DH, Leal AJ |title=Inhibition of endothelial cell activation by the homeobox gene Gax. |journal=J. Surg. Res. |volume=111 |issue= 1 |pages= 91-9 |year= 2003 |pmid= 12842453 |doi=  }}
* {{cite journal | vauthors = Chen Y, Leal AD, Patel S, Gorski DH | title = The homeobox gene Gax activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences | journal = J. Biol. Chem. | volume = 282 | issue = 1 | pages = 507–17 | year = 2007 | pmid = 17074759 | pmc = 1865102 | doi = 10.1074/jbc.M606604200 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Wu Z, Guo H, Chow N, ''et al.'' |title=Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. |journal=Nat. Med. |volume=11 |issue= 9 |pages= 959-65 |year= 2005 |pmid= 16116430 |doi= 10.1038/nm1287 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Lin J, Friesen MT, Bocangel P, ''et al.'' |title=Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. |journal=Mol. Cell. Biochem. |volume=275 |issue= 1-2 |pages= 75-84 |year= 2006 |pmid= 16335786 |doi= }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Chen Y, Leal AD, Patel S, Gorski DH |title=The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences. |journal=J. Biol. Chem. |volume=282 |issue= 1 |pages= 507-17 |year= 2007 |pmid= 17074759 |doi= 10.1074/jbc.M606604200 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|MEOX2+protein,+human}}
* {{MeshName|MEOX2+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-7-stub}}

Latest revision as of 15:36, 8 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[1][2]

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[2]

Interactions

MEOX2 has been shown to interact with PAX1[3] and PAX3.[3]

References

  1. ↑ LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505.
  2. ↑ 2.0 2.1 "Entrez Gene: MEOX2 mesenchyme homeobox 2".
  3. ↑ 3.0 3.1 Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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