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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''MAX-interacting protein 1''' is a [[protein]] that in humans is encoded by the ''MXI1'' [[gene]].<ref name="pmid7959753">{{cite journal | vauthors = Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV | title = Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25 | journal = Genomics | volume = 21 | issue = 3 | pages = 669–72 | date = Nov 1994 | pmid = 7959753 | pmc = | doi = 10.1006/geno.1994.1336 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MXI1 MAX interactor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4601| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MAX interactor 1
| HGNCid = 7534
| Symbol = MXI1
| AltSymbols =; MAD2; MGC43220; MXD2; MXI
| OMIM = 600020
| ECnumber = 
| Homologene = 4351
| MGIid = 97245
| GeneAtlas_image1 = PBB_GE_MXI1_202364_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0042994 |text = cytoplasmic sequestering of transcription factor}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4601
    | Hs_Ensembl = ENSG00000119950
    | Hs_RefseqProtein = NP_001008541
    | Hs_RefseqmRNA = NM_001008541
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 111957353
    | Hs_GenLoc_end = 112037113
    | Hs_Uniprot = P50539
    | Mm_EntrezGene = 17859
    | Mm_Ensembl = ENSMUSG00000025025
    | Mm_RefseqmRNA = NM_001008542
    | Mm_RefseqProtein = NP_001008542
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 53363833
    | Mm_GenLoc_end = 53426600
    | Mm_Uniprot = Q3USD3
  }}
}}
'''MAX interactor 1''', also known as '''MXI1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MXI1 MAX interactor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4601| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.<ref name="entrez">{{cite web | title = Entrez Gene: MXI1 MAX interactor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4601| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MXI1 has been shown to [[Protein-protein interaction|interact]] with [[SMC3 (gene)|SMC3]]<ref name=pmid9528857>{{cite journal | vauthors = Gupta K, Anand G, Yin X, Grove L, Prochownik EV | title = Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc  | journal = Oncogene | volume = 16 | issue = 9 | pages = 1149–59 | date = Mar 1998 | pmid = 9528857 | doi = 10.1038/sj.onc.1201634 }}</ref> and [[MAX (gene)|MAX]].<ref name=pmid9528857/><ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network  | journal = [[Nature (journal)|Nature]] | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid10593926>{{cite journal | vauthors = Billin AN, Eilers AL, Queva C, Ayer DE | title = Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors  | journal = J. Biol. Chem. | volume = 274 | issue = 51 | pages = 36344–50 | date = Dec 1999 | pmid = 10593926 | doi = 10.1074/jbc.274.51.36344 }}</ref><ref name=pmid9184233>{{cite journal | vauthors = Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R | title = Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor  | journal = EMBO J. | volume = 16 | issue = 10 | pages = 2892–906 | date = May 1997 | pmid = 9184233 | pmc = 1169897 | doi = 10.1093/emboj/16.10.2892 }}</ref><ref name=pmid10229200>{{cite journal | vauthors = FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE | title = Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc  | journal = Oncogene | volume = 18 | issue = 15 | pages = 2489–98 | date = Apr 1999 | pmid = 10229200 | doi = 10.1038/sj.onc.1202611 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zervos AS, Gyuris J, Brent R | title = Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites | journal = Cell | volume = 72 | issue = 2 | pages = 223–32 | year = 1993 | pmid = 8425219 | doi = 10.1016/0092-8674(93)90662-A }}
| citations =
* {{cite journal | vauthors = Zervos AS, Gyuris J, Brent R | title = Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites | journal = Cell | volume = 79 | issue = 2 | pages = following 388 | year = 1994 | pmid = 7954804 | doi = <!-- none--> | url = http://download.cell.com/pdf/PII0092867494902062.pdf?intermediate=true | format = PDF | deadurl = yes | archiveurl = https://web.archive.org/web/20110928102226/http://download.cell.com/pdf/PII0092867494902062.pdf?intermediate=true | archivedate = 2011-09-28 | df = }}
*{{cite journal | author=Eagle LR, Yin X, Brothman AR, ''et al.'' |title=Mutation of the MXI1 gene in prostate cancer. |journal=Nat. Genet. |volume=9 |issue= 3 |pages= 249-55 |year= 1995 |pmid= 7773287 |doi= 10.1038/ng0395-249 }}
* {{cite journal | vauthors = Schreiber-Agus N, Meng Y, Hoang T, Hou H, Chen K, Greenberg R, Cordon-Cardo C, Lee HW, DePinho RA | title = Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth | journal = Nature | volume = 393 | issue = 6684 | pages = 483–7 | year = 1998 | pmid = 9624006 | doi = 10.1038/31008 | authorlink7 = Carlos Cordon-Cardo }}
*{{cite journal | author=Albarosa R, DiDonato S, Finocchiaro G |title=Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. |journal=Hum. Genet. |volume=95 |issue= 6 |pages= 709-11 |year= 1995 |pmid= 7789959 |doi= }}
* {{cite journal | vauthors = Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV | title = Mutation of the MXI1 gene in prostate cancer | journal = Nat. Genet. | volume = 9 | issue = 3 | pages = 249–55 | year = 1995 | pmid = 7773287 | doi = 10.1038/ng0395-249 }}
*{{cite journal  | author=Schreiber-Agus N, Chin L, Chen K, ''et al.'' |title=An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. |journal=Cell |volume=80 |issue= 5 |pages= 777-86 |year= 1995 |pmid= 7889571 |doi= }}
* {{cite journal | vauthors = Albarosa R, DiDonato S, Finocchiaro G | title = Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas | journal = Hum. Genet. | volume = 95 | issue = 6 | pages = 709–11 | year = 1995 | pmid = 7789959 | doi = 10.1007/BF00209493 }}
*{{cite journal | author=Zervos AS, Gyuris J, Brent R |title=Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. |journal=Cell |volume=79 |issue= 2 |pages= following 388 |year= 1994 |pmid= 7954804 |doi= }}
* {{cite journal | vauthors = Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, Guida P, Skoultchi AI, DePinho RA | title = An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3 | journal = Cell | volume = 80 | issue = 5 | pages = 777–86 | year = 1995 | pmid = 7889571 | doi = 10.1016/0092-8674(95)90356-9 }}
*{{cite journal | author=Wechsler DS, Hawkins AL, Li X, ''et al.'' |title=Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25. |journal=Genomics |volume=21 |issue= 3 |pages= 669-72 |year= 1994 |pmid= 7959753 |doi= 10.1006/geno.1994.1336 }}
* {{cite journal | vauthors = Edelhoff S, Ayer DE, Zervos AS, Steingrímsson E, Jenkins NA, Copeland NG, Eisenman RN, Brent R, Disteche CM | title = Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19 | journal = Oncogene | volume = 9 | issue = 2 | pages = 665–8 | year = 1994 | pmid = 8290278 | doi =  }}
*{{cite journal | author=Edelhoff S, Ayer DE, Zervos AS, ''et al.'' |title=Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19. |journal=Oncogene |volume=9 |issue= 2 |pages= 665-8 |year= 1994 |pmid= 8290278 |doi= }}
* {{cite journal | vauthors = Wechsler DS, Shelly CA, Dang CV | title = Genomic organization of human MXI1, a putative tumor suppressor gene | journal = Genomics | volume = 32 | issue = 3 | pages = 466–70 | year = 1997 | pmid = 8838813 | doi = 10.1006/geno.1996.0144 }}
*{{cite journal | author=Zervos AS, Gyuris J, Brent R |title=Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. |journal=Cell |volume=72 |issue= 2 |pages= 223-32 |year= 1993 |pmid= 8425219 |doi=  }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Res. | volume = 6 | issue = 9 | pages = 791–806 | year = 1997 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Wechsler DS, Shelly CA, Dang CV |title=Genomic organization of human MXI1, a putative tumor suppressor gene. |journal=Genomics |volume=32 |issue= 3 |pages= 466-70 |year= 1997 |pmid= 8838813 |doi= 10.1006/geno.1996.0144 }}
* {{cite journal | vauthors = Shimizu E, Shirasawa H, Kodama K, Sato T, Simizu B | title = Expression, regulation and polymorphism of the mxi1 genes | journal = Gene | volume = 176 | issue = 1–2 | pages = 45–8 | year = 1997 | pmid = 8918230 | doi = 10.1016/0378-1119(96)00206-5 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Gupta K, Anand G, Yin X, Grove L, Prochownik EV | title = Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc | journal = Oncogene | volume = 16 | issue = 9 | pages = 1149–59 | year = 1998 | pmid = 9528857 | doi = 10.1038/sj.onc.1201634 }}
*{{cite journal | author=Shimizu E, Shirasawa H, Kodama K, ''et al.'' |title=Expression, regulation and polymorphism of the mxi1 genes. |journal=Gene |volume=176 |issue= 1-2 |pages= 45-8 |year= 1997 |pmid= 8918230 |doi= }}
* {{cite journal | vauthors = Prochownik EV, Eagle Grove L, Deubler D, Zhu XL, Stephenson RA, Rohr LR, Yin X, Brothman AR | title = Commonly occurring loss and mutation of the MXI1 gene in prostate cancer | journal = Genes Chromosomes Cancer | volume = 22 | issue = 4 | pages = 295–304 | year = 1999 | pmid = 9669667 | doi = 10.1002/(SICI)1098-2264(199808)22:4<295::AID-GCC5>3.0.CO;2-Q }}
*{{cite journal | author=Gupta K, Anand G, Yin X, ''et al.'' |title=Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. |journal=Oncogene |volume=16 |issue= 9 |pages= 1149-59 |year= 1998 |pmid= 9528857 |doi= 10.1038/sj.onc.1201634 }}
* {{cite journal | vauthors = Li XJ, Wang DY, Zhu Y, Guo RJ, Wang XD, Lubomir K, Mukai K, Sasaki H, Yoshida H, Oka T, Machinami R, Shinmura K, Tanaka M, Sugimura H | title = Mxi1 mutations in human neurofibrosarcomas | journal = Jpn. J. Cancer Res. | volume = 90 | issue = 7 | pages = 740–6 | year = 1999 | pmid = 10470286 | doi = 10.1111/j.1349-7006.1999.tb00809.x }}
*{{cite journal | author=Schreiber-Agus N, Meng Y, Hoang T, ''et al.'' |title=Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. |journal=Nature |volume=393 |issue= 6684 |pages= 483-7 |year= 1998 |pmid= 9624006 |doi= 10.1038/31008 }}
* {{cite journal | vauthors = Benson LQ, Coon MR, Krueger LM, Han GC, Sarnaik AA, Wechsler DS | title = Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2 | journal = J. Biol. Chem. | volume = 274 | issue = 40 | pages = 28794–802 | year = 1999 | pmid = 10497252 | doi = 10.1074/jbc.274.40.28794 }}
*{{cite journal | author=Prochownik EV, Eagle Grove L, Deubler D, ''et al.'' |title=Commonly occurring loss and mutation of the MXI1 gene in prostate cancer. |journal=Genes Chromosomes Cancer |volume=22 |issue= 4 |pages= 295-304 |year= 1999 |pmid= 9669667 |doi= }}
* {{cite journal | vauthors = Taj MM, Tawil RJ, Engstrom LD, Zeng Z, Hwang C, Sanda MG, Wechsler DS | title = Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells | journal = Prostate | volume = 47 | issue = 3 | pages = 194–204 | year = 2001 | pmid = 11351349 | doi = 10.1002/pros.1063 }}
*{{cite journal | author=Li XJ, Wang DY, Zhu Y, ''et al.'' |title=Mxi1 mutations in human neurofibrosarcomas. |journal=Jpn. J. Cancer Res. |volume=90 |issue= 7 |pages= 740-6 |year= 1999 |pmid= 10470286 |doi= }}
* {{cite journal | vauthors = Yin X, Landay MF, Han W, Levitan ES, Watkins SC, Levenson RM, Farkas DL, Prochownik EV | title = Dynamic in vivo interactions among Myc network members | journal = Oncogene | volume = 20 | issue = 34 | pages = 4650–64 | year = 2001 | pmid = 11498788 | doi = 10.1038/sj.onc.1204606 }}
*{{cite journal | author=Benson LQ, Coon MR, Krueger LM, ''et al.'' |title=Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28794-802 |year= 1999 |pmid= 10497252 |doi= }}
* {{cite journal | vauthors = Manni I, Tunici P, Cirenei N, Albarosa R, Colombo BM, Roz L, Sacchi A, Piaggio G, Finocchiaro G | title = Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression | journal = Br. J. Cancer | volume = 86 | issue = 3 | pages = 477–84 | year = 2002 | pmid = 11875718 | pmc = 2375210 | doi = 10.1038/sj.bjc.6600065 }}
*{{cite journal | author=Taj MM, Tawil RJ, Engstrom LD, ''et al.'' |title=Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells. |journal=Prostate |volume=47 |issue= 3 |pages= 194-204 |year= 2001 |pmid= 11351349 |doi= 10.1002/pros.1063 }}
* {{cite journal | vauthors = Ariyanayagam-Baksh SM, Baksh FK, Swalsky PA, Finkelstein SD | title = Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma | journal = Mod. Pathol. | volume = 16 | issue = 10 | pages = 992–5 | year = 2004 | pmid = 14559981 | doi = 10.1097/01.MP.0000087421.44975.1C }}
*{{cite journal | author=Yin  X, Landay MF, Han W, ''et al.'' |title=Dynamic in vivo interactions among Myc network members. |journal=Oncogene |volume=20 |issue= 34 |pages= 4650-64 |year= 2001 |pmid= 11498788 |doi= 10.1038/sj.onc.1204606 }}
*{{cite journal  | author=Manni I, Tunici P, Cirenei N, ''et al.'' |title=Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression. |journal=Br. J. Cancer |volume=86 |issue= 3 |pages= 477-84 |year= 2002 |pmid= 11875718 |doi= 10.1038/sj.bjc.6600065 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Ariyanayagam-Baksh SM, Baksh FK, Swalsky PA, Finkelstein SD |title=Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma. |journal=Mod. Pathol. |volume=16 |issue= 10 |pages= 992-5 |year= 2004 |pmid= 14559981 |doi= 10.1097/01.MP.0000087421.44975.1C }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|MXI1+protein,+human}}
* {{MeshName|MXI1+protein,+human}}
* {{FactorBook|Mxi1}}


{{NLM content}}
{{Transcription factors|g1}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{Gene-10-stub}}

Latest revision as of 03:22, 11 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.[1][2]

Function

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.[2]

Interactions

MXI1 has been shown to interact with SMC3[3] and MAX.[3][4][5][6][7]

References

  1. ↑ Wechsler DS, Hawkins AL, Li X, Jabs EW, Griffin CA, Dang CV (Nov 1994). "Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25". Genomics. 21 (3): 669–72. doi:10.1006/geno.1994.1336. PMID 7959753.
  2. ↑ 2.0 2.1 "Entrez Gene: MXI1 MAX interactor 1".
  3. ↑ 3.0 3.1 Gupta K, Anand G, Yin X, Grove L, Prochownik EV (Mar 1998). "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene. 16 (9): 1149–59. doi:10.1038/sj.onc.1201634. PMID 9528857.
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  5. ↑ Billin AN, Eilers AL, Queva C, Ayer DE (Dec 1999). "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. 274 (51): 36344–50. doi:10.1074/jbc.274.51.36344. PMID 10593926.
  6. ↑ Meroni G, Reymond A, Alcalay M, Borsani G, Tanigami A, Tonlorenzi R, Lo Nigro C, Messali S, Zollo M, Ledbetter DH, Brent R, Ballabio A, Carrozzo R (May 1997). "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–906. doi:10.1093/emboj/16.10.2892. PMC 1169897. PMID 9184233.
  7. ↑ FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE (Apr 1999). "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene. 18 (15): 2489–98. doi:10.1038/sj.onc.1202611. PMID 10229200.

Further reading

  • Zervos AS, Gyuris J, Brent R (1993). "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites". Cell. 72 (2): 223–32. doi:10.1016/0092-8674(93)90662-A. PMID 8425219.
  • Zervos AS, Gyuris J, Brent R (1994). "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites" (PDF). Cell. 79 (2): following 388. PMID 7954804. Archived from the original (PDF) on 2011-09-28.
  • Schreiber-Agus N, Meng Y, Hoang T, Hou H, Chen K, Greenberg R, Cordon-Cardo C, Lee HW, DePinho RA (1998). "Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth". Nature. 393 (6684): 483–7. doi:10.1038/31008. PMID 9624006.
  • Eagle LR, Yin X, Brothman AR, Williams BJ, Atkin NB, Prochownik EV (1995). "Mutation of the MXI1 gene in prostate cancer". Nat. Genet. 9 (3): 249–55. doi:10.1038/ng0395-249. PMID 7773287.
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