NFYC: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Nuclear transcription factor Y subunit gamma''' is a [[protein]] that in humans is encoded by the ''NFYC'' [[gene]].<ref name="pmid8921405">{{cite journal | vauthors = Sinha S, Maity SN, Seldin MF, de Crombrugghe B | title = Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor | journal = Genomics | volume = 37 | issue = 2 | pages = 260–3 | date = Feb 1997 | pmid = 8921405 | pmc =  | doi = 10.1006/geno.1996.0555 }}</ref><ref name="pmid9249075">{{cite journal | vauthors = Bellorini M, Zemzoumi K, Farina A, Berthelsen J, Piaggio G, Mantovani R | title = Cloning and expression of human NF-YC | journal = Gene | volume = 193 | issue = 1 | pages = 119–25 | date = Aug 1997 | pmid = 9249075 | pmc = | doi = 10.1016/S0378-1119(97)00109-1 }}</ref><ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_NFYC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n1j.
| PDB = {{PDB2|1n1j}}
| Name = Nuclear transcription factor Y, gamma
| HGNCid = 7806
| Symbol = NFYC
| AltSymbols =; CBF-C; CBFC; DKFZp667G242; FLJ45775; H1TF2A; HAP5; HSM; NF-YC; hCBF-C
| OMIM = 605344
| ECnumber = 
| Homologene = 7440
| MGIid = 107901
| GeneAtlas_image1 = PBB_GE_NFYC_202215_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NFYC_202216_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_NFYC_211251_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016602 |text = CCAAT-binding factor complex}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006457 |text = protein folding}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4802
    | Hs_Ensembl = ENSG00000066136
    | Hs_RefseqProtein = NP_055038
    | Hs_RefseqmRNA = NM_014223
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 40929829
    | Hs_GenLoc_end = 41009864
    | Hs_Uniprot = Q13952
    | Mm_EntrezGene = 18046
    | Mm_Ensembl = ENSMUSG00000032897
    | Mm_RefseqmRNA = NM_001048168
    | Mm_RefseqProtein = NP_001041633
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 120255074
    | Mm_GenLoc_end = 120323331
    | Mm_Uniprot = Q7TPS7
  }}
}}
'''Nuclear transcription factor Y, gamma''', also known as '''NFYC''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NFYC nuclear transcription factor Y, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4802| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved [[transcription factor]] that binds with high specificity to [[CAAT box|CCAAT]] motifs in the [[promoter (biology)|promoter]] regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit ([[NFYB]]), a prerequisite for subunit A ([[NFYA]]) association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a [[histone]]-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.<ref name="entrez">{{cite web | title = Entrez Gene: NFYC nuclear transcription factor Y, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4802| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.<ref name="entrez">{{cite web | title = Entrez Gene: NFYC nuclear transcription factor Y, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4802| accessdate = }}</ref>
}}


==References==
Two [[microRNA]]s; miR-30c and miR-30e are located within [[intron]]s of the ''nfyc'' gene.  These microRNAs are actively transcribed in human insulin-producing [[beta cell]]s in the [[Islets of Langerhans|pancreatic islets]] that also show high expression of nfyc and [[CDH1 (gene)|CDH1]] genes.  The expression of these intronic microRNAs is essential for maintaining the differentiated phenotype of human islet beta cells.  Inhibition of miR-30 family microRNAs induces [[epithelial-mesenchymal transition]] of human pancreatic islet cells.<ref name="Joglekar_2009">{{cite journal | vauthors = Joglekar MV, Patil D, Joglekar VM, Rao GV, Reddy DN, Mitnala S, Shouche Y, Hardikar AA | title = The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells | journal = Islets | volume = 1 | issue = 2 | pages = 137–147 | date = September–October 2009 | pmid = 21099261 | doi = 10.4161/isl.1.2.9578 }}</ref>
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
NFYC has been shown to [[Protein-protein interaction|interact]] with [[Myc]].<ref name="pmid10446203">{{cite journal | vauthors = Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H | title = Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y | journal = J. Biol. Chem. | volume = 274 | issue = 34 | pages = 24270–9 | date = August 1999 | pmid = 10446203 | doi = 10.1074/jbc.274.34.24270 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Mantovani R | title = The molecular biology of the CCAAT-binding factor NF-Y. | journal = Gene | volume = 239 | issue = 1 | pages = 15–27 | year = 1999 | pmid = 10571030 | doi = 10.1016/S0378-1119(99)00368-6 }}
| citations =
* {{cite journal | vauthors = Martinelli R, Heintz N | title = H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor involved in histone H1 cell cycle regulation. | journal = Mol. Cell. Biol. | volume = 14 | issue = 12 | pages = 8322–32 | year = 1994 | pmid = 7969168 | pmc = 359371 | doi =  }}
*{{cite journal | author=Mantovani R |title=The molecular biology of the CCAAT-binding factor NF-Y. |journal=Gene |volume=239 |issue= 1 |pages= 15-27 |year= 1999 |pmid= 10571030 |doi= }}
* {{cite journal | vauthors = Nakshatri H, Bhat-Nakshatri P, Currie RA | title = Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox. | journal = J. Biol. Chem. | volume = 271 | issue = 46 | pages = 28784–91 | year = 1997 | pmid = 8910521 | doi = 10.1074/jbc.271.46.28784 }}
*{{cite journal | author=Martinelli R, Heintz N |title=H1TF2A, the large subunit of a heterodimeric, glutamine-rich CCAAT-binding transcription factor involved in histone H1 cell cycle regulation. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8322-32 |year= 1994 |pmid= 7969168 |doi=  }}
* {{cite journal | vauthors = Dmitrenko V, Garifulin O, Kavsan V | title = Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. | journal = Gene | volume = 197 | issue = 1-2 | pages = 161–3 | year = 1997 | pmid = 9332362 | doi = 10.1016/S0378-1119(97)00255-2 }}
*{{cite journal | author=Nakshatri H, Bhat-Nakshatri P, Currie RA |title=Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox. |journal=J. Biol. Chem. |volume=271 |issue= 46 |pages= 28784-91 |year= 1997 |pmid= 8910521 |doi=  }}
* {{cite journal | vauthors = Currie RA | title = Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y). | journal = J. Biol. Chem. | volume = 272 | issue = 49 | pages = 30880–8 | year = 1998 | pmid = 9388234 | doi = 10.1074/jbc.272.49.30880 }}
*{{cite journal  | author=Sinha S, Maity SN, Seldin MF, de Crombrugghe B |title=Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. |journal=Genomics |volume=37 |issue= 2 |pages= 260-3 |year= 1997 |pmid= 8921405 |doi= 10.1006/geno.1996.0555 }}
* {{cite journal | vauthors = Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H | title = Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. | journal = J. Biol. Chem. | volume = 274 | issue = 34 | pages = 24270–9 | year = 1999 | pmid = 10446203 | doi = 10.1074/jbc.274.34.24270 }}
*{{cite journal  | author=Bellorini M, Zemzoumi K, Farina A, ''et al.'' |title=Cloning and expression of human NF-YC. |journal=Gene |volume=193 |issue= 1 |pages= 119-25 |year= 1997 |pmid= 9249075 |doi=  }}
* {{cite journal | vauthors = Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K | title = Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. | journal = Mol. Cell. Biol. | volume = 21 | issue = 4 | pages = 1239–48 | year = 2001 | pmid = 11158310 | pmc = 99577 | doi = 10.1128/MCB.21.4.1239-1248.2001 }}
*{{cite journal | author=Dmitrenko V, Garifulin O, Kavsan V |title=Isolation and sequence analysis of the cDNA encoding subunit C of human CCAAT-binding transcription factor. |journal=Gene |volume=197 |issue= 1-2 |pages= 161-3 |year= 1997 |pmid= 9332362 |doi= }}
* {{cite journal | vauthors = Izumi H, Molander C, Penn LZ, Ishisaki A, Kohno K, Funa K | title = Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. | journal = J. Cell Sci. | volume = 114 | issue = Pt 8 | pages = 1533–44 | year = 2001 | pmid = 11282029 | doi =  }}
*{{cite journal | author=Currie RA |title=Functional interaction between the DNA binding subunit trimerization domain of NF-Y and the high mobility group protein HMG-I(Y). |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30880-8 |year= 1998 |pmid= 9388234 |doi= }}
* {{cite journal | vauthors = Chen F, Ogawa K, Liu X, Stringfield TM, Chen Y | title = Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit. | journal = Biochem. J. | volume = 364 | issue = Pt 2 | pages = 571–7 | year = 2002 | pmid = 12023901 | pmc = 1222603 | doi = 10.1042/BJ20011703 }}
*{{cite journal | author=Taira T, Sawai M, Ikeda M, ''et al.'' |title=Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24270-9 |year= 1999 |pmid= 10446203 |doi= }}
* {{cite journal | vauthors = Romier C, Cocchiarella F, Mantovani R, Moras D | title = The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. | journal = J. Biol. Chem. | volume = 278 | issue = 2 | pages = 1336–45 | year = 2003 | pmid = 12401788 | doi = 10.1074/jbc.M209635200 }}
*{{cite journal | author=Yoshida H, Okada T, Haze K, ''et al.'' |title=Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1239-48 |year= 2001 |pmid= 11158310 |doi= 10.1128/MCB.21.4.1239-1248.2001 }}
* {{cite journal | vauthors = Salsi V, Caretti G, Wasner M, Reinhard W, Haugwitz U, Engeland K, Mantovani R | title = Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function. | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 6642–50 | year = 2003 | pmid = 12482752 | doi = 10.1074/jbc.M210065200 }}
*{{cite journal | author=Izumi H, Molander C, Penn LZ, ''et al.'' |title=Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor. |journal=J. Cell. Sci. |volume=114 |issue= Pt 8 |pages= 1533-44 |year= 2001 |pmid= 11282029 |doi=  }}
* {{cite journal | vauthors = Hirose T, Sowa Y, Takahashi S, Saito S, Yasuda C, Shindo N, Furuichi K, Sakai T | title = p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. | journal = Oncogene | volume = 22 | issue = 49 | pages = 7762–73 | year = 2003 | pmid = 14586402 | doi = 10.1038/sj.onc.1207091 }}
*{{cite journal | author=Chen F, Ogawa K, Liu X, ''et al.'' |title=Repression of Smad2 and Smad3 transactivating activity by association with a novel splice variant of CCAAT-binding factor C subunit. |journal=Biochem. J. |volume=364 |issue= Pt 2 |pages= 571-7 |year= 2002 |pmid= 12023901 |doi= 10.1042/BJ20011703 }}
* {{cite journal | vauthors = Chattopadhyay C, Hawke D, Kobayashi R, Maity SN | title = Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. | journal = Nucleic Acids Res. | volume = 32 | issue = 12 | pages = 3632–41 | year = 2004 | pmid = 15243141 | pmc = 484179 | doi = 10.1093/nar/gkh692 }}
*{{cite journal | author=Romier C, Cocchiarella F, Mantovani R, Moras D |title=The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y. |journal=J. Biol. Chem. |volume=278 |issue= 2 |pages= 1336-45 |year= 2003 |pmid= 12401788 |doi= 10.1074/jbc.M209635200 }}
* {{cite journal | vauthors = Wang B, Gao C, Ponder KP | title = C/EBPbeta contributes to hepatocyte growth factor-induced replication of rodent hepatocytes. | journal = J. Hepatol. | volume = 43 | issue = 2 | pages = 294–302 | year = 2005 | pmid = 15922473 | doi = 10.1016/j.jhep.2005.02.029 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Salsi V, Caretti G, Wasner M, ''et al.'' |title=Interactions between p300 and multiple NF-Y trimers govern cyclin B2 promoter function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 6642-50 |year= 2003 |pmid= 12482752 |doi= 10.1074/jbc.M210065200 }}
*{{cite journal | author=Hirose T, Sowa Y, Takahashi S, ''et al.'' |title=p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y. |journal=Oncogene |volume=22 |issue= 49 |pages= 7762-73 |year= 2003 |pmid= 14586402 |doi= 10.1038/sj.onc.1207091 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Chattopadhyay C, Hawke D, Kobayashi R, Maity SN |title=Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. |journal=Nucleic Acids Res. |volume=32 |issue= 12 |pages= 3632-41 |year= 2004 |pmid= 15243141 |doi= 10.1093/nar/gkh692 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wang B, Gao C, Ponder KP |title=C/EBPbeta contributes to hepatocyte growth factor-induced replication of rodent hepatocytes. |journal=J. Hepatol. |volume=43 |issue= 2 |pages= 294-302 |year= 2005 |pmid= 15922473 |doi= 10.1016/j.jhep.2005.02.029 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|NFYC+protein,+human}}
* {{MeshName|NFYC+protein,+human}}


{{NLM content}}
{{PDB Gallery|geneid=4802}}
{{Transcription factors|g0}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-1-stub}}

Latest revision as of 20:27, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.[1][2][3]

Function

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit (NFYB), a prerequisite for subunit A (NFYA) association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. Additional regulation, preliminarily supported by the EST database, may be represented by alternative splicing in this subunit.[3]

Two microRNAs; miR-30c and miR-30e are located within introns of the nfyc gene. These microRNAs are actively transcribed in human insulin-producing beta cells in the pancreatic islets that also show high expression of nfyc and CDH1 genes. The expression of these intronic microRNAs is essential for maintaining the differentiated phenotype of human islet beta cells. Inhibition of miR-30 family microRNAs induces epithelial-mesenchymal transition of human pancreatic islet cells.[4]

Interactions

NFYC has been shown to interact with Myc.[5]

References

  1. ↑ Sinha S, Maity SN, Seldin MF, de Crombrugghe B (Feb 1997). "Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor". Genomics. 37 (2): 260–3. doi:10.1006/geno.1996.0555. PMID 8921405.
  2. ↑ Bellorini M, Zemzoumi K, Farina A, Berthelsen J, Piaggio G, Mantovani R (Aug 1997). "Cloning and expression of human NF-YC". Gene. 193 (1): 119–25. doi:10.1016/S0378-1119(97)00109-1. PMID 9249075.
  3. ↑ 3.0 3.1 "Entrez Gene: NFYC nuclear transcription factor Y, gamma".
  4. ↑ Joglekar MV, Patil D, Joglekar VM, Rao GV, Reddy DN, Mitnala S, Shouche Y, Hardikar AA (September–October 2009). "The miR-30 family microRNAs confer epithelial phenotype to human pancreatic cells". Islets. 1 (2): 137–147. doi:10.4161/isl.1.2.9578. PMID 21099261.
  5. ↑ Taira T, Sawai M, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (August 1999). "Cell cycle-dependent switch of up-and down-regulation of human hsp70 gene expression by interaction between c-Myc and CBF/NF-Y". J. Biol. Chem. 274 (34): 24270–9. doi:10.1074/jbc.274.34.24270. PMID 10446203.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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