PEG3: Difference between revisions

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Latest revision as of 14:08, 6 August 2018

Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.^[1]^[2] PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.^[3] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.^[4]

Interactions

PEG3 has been shown to interact with SIAH2^[5] and SIAH1.^[5]

References

↑ Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658. PMID 9149948.
↑ "Entrez Gene: PEG3 paternally expressed 3".
↑ Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". Retrieved May 22, 2014.
↑ Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.
↑ ^5.0 ^5.1 Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424.

Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway". Nat. Genet. 18 (3): 287–91. doi:10.1038/ng0398-287. PMID 9500555.
Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi:10.1073/pnas.040378897. PMC 15761. PMID 10681424.
Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3)". Genomics. 64 (1): 114–8. doi:10.1006/geno.1999.6112. PMID 10708526.
Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line". Genes Cells. 6 (3): 237–47. doi:10.1046/j.1365-2443.2001.00412.x. PMID 11260267.
Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta". Hum. Mol. Genet. 10 (10): 1093–100. doi:10.1093/hmg/10.10.1093. PMID 11331620.
Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496.
Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death". J. Biol. Chem. 277 (25): 23000–7. doi:10.1074/jbc.M201907200. PMID 11943780.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis". Cell Cycle. 4 (6): 806–11. doi:10.4161/cc.4.6.1716. PMID 15908796.
Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines". Gynecol. Oncol. 99 (1): 126–34. doi:10.1016/j.ygyno.2005.05.036. PMID 16023706.
Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells". Biol. Cell. 98 (4): 253–63. doi:10.1042/BC20050041. PMID 16159311.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[pmid9149948-1] Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658. PMID 9149948.

[entrez-2] "Entrez Gene: PEG3 paternally expressed 3".

[3] Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". Retrieved May 22, 2014.

[pmid23078764-4] Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.

[pmid10681424-5] 5.0 ^5.1 Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424.

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[5]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Paternally-expressed gene 3 protein''' is a [[protein]] that in humans is encoded by the ''PEG3'' [[gene]].<ref name="pmid9149948">{{cite journal |vauthors=Kim J, Ashworth L, Branscomb E, Stubbs L | title = The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4 | journal = Genome Res | volume = 7 | issue = 5 | pages = 532–40 |date=August 1997 | pmid = 9149948 | pmc = 310658 | doi =  10.1101/gr.7.5.532}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PEG3 paternally expressed 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178| accessdate = }}</ref> PEG3 is an [[imprinted gene]] expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.<ref>{{cite web|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0083359|| volume = 8 | issue = 12 |author1=Michelle M. Thiaville |author2=Jennifer M. Huang |author3=Hana Kim |author4=Muhammad B. Ekram |author5=Arundhati Bakshi |author6=Tae-Young Roh |author7=Joomyeong Kim |date=December 31, 2013|| accessdate = May 22, 2014|title=Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families}}</ref>  PEG3 is a transcription factor that binds to DNA [11-13] via the [[sequence motif]] AGTnnCnnnTGGCT, which it binds to using multiple [[Kruppel-like factors]]. It also regulate the expression of Pgm2l1 through the binding of the motif.<ref name="pmid23078764 ">{{cite journal |vauthors=Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J | title = DNA-binding motif and target genes of the imprinted transcription factor PEG3 | journal = Gene | volume = 512 | issue = 2 | pages = 314–320 |date=January 2013 | pmid = 23078764 | pmc = 3513644 | doi =  10.1016/j.gene.2012.10.005}}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Paternally expressed 3
- | HGNCid = 8826
- | Symbol = PEG3
- | AltSymbols =; DKFZp781A095; KIAA0287; PW1; ZSCAN24
- | OMIM = 601483
- | ECnumber =
- | Homologene = 31363
- | MGIid = 104748
-  | Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006915 |text = apoptosis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5178
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = NP_006201
-    | Hs_RefseqmRNA = NM_006210
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 18616
-    | Mm_Ensembl = ENSMUSG00000002265
-    | Mm_RefseqmRNA = NM_001010988
-    | Mm_RefseqProtein = NP_001010988
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 6310046
-    | Mm_GenLoc_end = 6334505
-    | Mm_Uniprot = Q0P5Y8
-  }}
-}}
-'''Paternally expressed 3''', also known as '''PEG3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PEG3 paternally expressed 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 52: / Line 7: @@
 | summary_text =
 }}
+==Interactions==
+PEG3 has been shown to [[Protein-protein interaction|interact]] with [[SIAH2]]<ref name=pmid10681424>{{cite journal |last=Relaix |first=F |authorlink= |author2=Wei X j |author3=Li W |author4=Pan J |author5=Lin Y |author6=Bowtell D D |author7=Sassoon D A |author8=Wu X  |date=February 2000  |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=5 |pages=2105–10 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10681424 |doi = 10.1073/pnas.040378897 | bibcode =2000PNAS...97.2105R | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=15761 }}</ref> and [[SIAH1]].<ref name=pmid10681424/>
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Kim J, Ashworth L, Branscomb E, Stubbs L |title=The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4. |journal=Genome Res. |volume=7 |issue= 5 |pages= 532-40 |year= 1997 |pmid= 9149948 |doi=  }}
+*{{cite journal  |vauthors=Relaix F, Wei XJ, Wu X, Sassoon DA |title=Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 287–91 |year= 1998 |pmid= 9500555 |doi= 10.1038/ng0398-287 }}
-*{{cite journal  | author=Relaix F, Wei XJ, Wu X, Sassoon DA |title=Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 287-91 |year= 1998 |pmid= 9500555 |doi= 10.1038/ng0398-287 }}
+*{{cite journal   |vauthors=Relaix F, Wei X, Li W, etal |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2105–10 |year= 2000 |pmid= 10681424 |doi= 10.1073/pnas.040378897  | pmc=15761 |bibcode=2000PNAS...97.2105R }}
-*{{cite journal  | author=Relaix F, Wei X, Li W, ''et al.'' |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2105-10 |year= 2000 |pmid= 10681424 |doi= 10.1073/pnas.040378897 }}
+*{{cite journal  |vauthors=Kim J, Bergmann A, Stubbs L |title=Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). |journal=Genomics |volume=64 |issue= 1 |pages= 114–8 |year= 2000 |pmid= 10708526 |doi= 10.1006/geno.1999.6112 }}
-*{{cite journal  | author=Kim J, Bergmann A, Stubbs L |title=Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). |journal=Genomics |volume=64 |issue= 1 |pages= 114-8 |year= 2000 |pmid= 10708526 |doi= 10.1006/geno.1999.6112 }}
+*{{cite journal   |vauthors=Kohda T, Asai A, Kuroiwa Y, etal |title=Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. |journal=Genes Cells |volume=6 |issue= 3 |pages= 237–47 |year= 2001 |pmid= 11260267 |doi=10.1046/j.1365-2443.2001.00412.x  }}
-*{{cite journal  | author=Kohda T, Asai A, Kuroiwa Y, ''et al.'' |title=Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. |journal=Genes Cells |volume=6 |issue= 3 |pages= 237-47 |year= 2001 |pmid= 11260267 |doi=  }}
+*{{cite journal   |vauthors=Hiby SE, Lough M, Keverne EB, etal |title=Paternal monoallelic expression of PEG3 in the human placenta. |journal=Hum. Mol. Genet. |volume=10 |issue= 10 |pages= 1093–100 |year= 2001 |pmid= 11331620 |doi=10.1093/hmg/10.10.1093  }}
-*{{cite journal  | author=Hiby SE, Lough M, Keverne EB, ''et al.'' |title=Paternal monoallelic expression of PEG3 in the human placenta. |journal=Hum. Mol. Genet. |volume=10 |issue= 10 |pages= 1093-100 |year= 2001 |pmid= 11331620 |doi=  }}
+*{{cite journal  |vauthors=Yarden RI, Brody LC |title=Identification of proteins that interact with BRCA1 by Far-Western library screening. |journal=J. Cell. Biochem. |volume=83 |issue= 4 |pages= 521–31 |year= 2002 |pmid= 11746496 |doi=10.1002/jcb.1257  }}
-*{{cite journal  | author=Yarden RI, Brody LC |title=Identification of proteins that interact with BRCA1 by Far-Western library screening. |journal=J. Cell. Biochem. |volume=83 |issue= 4 |pages= 521-31 |year= 2002 |pmid= 11746496 |doi=  }}
+*{{cite journal  |vauthors=Johnson MD, Wu X, Aithmitti N, Morrison RS |title=Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23000–7 |year= 2002 |pmid= 11943780 |doi= 10.1074/jbc.M201907200 }}
-*{{cite journal  | author=Johnson MD, Wu X, Aithmitti N, Morrison RS |title=Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23000-7 |year= 2002 |pmid= 11943780 |doi= 10.1074/jbc.M201907200 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Mirey G, Chartrain I, Froment C, etal |title=CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. |journal=Cell Cycle |volume=4 |issue= 6 |pages= 806–11 |year= 2006 |pmid= 15908796 |doi=  10.4161/cc.4.6.1716}}
-*{{cite journal  | author=Mirey G, Chartrain I, Froment C, ''et al.'' |title=CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. |journal=Cell Cycle |volume=4 |issue= 6 |pages= 806-11 |year= 2006 |pmid= 15908796 |doi=  }}
+*{{cite journal   |vauthors=Dowdy SC, Gostout BS, Shridhar V, etal |title=Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. |journal=Gynecol. Oncol. |volume=99 |issue= 1 |pages= 126–34 |year= 2005 |pmid= 16023706 |doi= 10.1016/j.ygyno.2005.05.036 }}
-*{{cite journal  | author=Dowdy SC, Gostout BS, Shridhar V, ''et al.'' |title=Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. |journal=Gynecol. Oncol. |volume=99 |issue= 1 |pages= 126-34 |year= 2005 |pmid= 16023706 |doi= 10.1016/j.ygyno.2005.05.036 }}
+*{{cite journal  |vauthors=Chartrain I, Couturier A, Tassan JP |title=Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. |journal=Biol. Cell |volume=98 |issue= 4 |pages= 253–63 |year= 2006 |pmid= 16159311 |doi= 10.1042/BC20050041 }}
-*{{cite journal  | author=Chartrain I, Couturier A, Tassan JP |title=Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells. |journal=Biol. Cell |volume=98 |issue= 4 |pages= 253-63 |year= 2006 |pmid= 16159311 |doi= 10.1042/BC20050041 }}
+*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
 }}
 {{refend}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{Transcription factors|g2}}
 {{protein-stub}}
-{{WikiDoc Sources}}

PEG3: Difference between revisions

Latest revision as of 14:08, 6 August 2018

Interactions

References

Further reading

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