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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''POU domain, class 4, transcription factor 2''' is a [[protein]] that in humans is encoded by the ''POU4F2'' [[gene]].<ref name="pmid8332509">{{cite journal | vauthors = Ring CJ, Latchman DS | title = The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain | journal = Nucleic Acids Research | volume = 21 | issue = 12 | pages = 2946 | date = Jun 1993 | pmid = 8332509 | pmc = 309696 | doi = 10.1093/nar/21.12.2946 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5458| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = POU domain, class 4, transcription factor 2
| HGNCid = 9219
| Symbol = POU4F2
| AltSymbols =; BRN3.2; BRN3B; Brn-3b
| OMIM = 113725
| ECnumber = 
| Homologene = 20959
| MGIid = 102524
| GeneAtlas_image1 = PBB_GE_POU4F2_207725_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5458
    | Hs_Ensembl = ENSG00000151615
    | Hs_RefseqProtein = NP_004566
    | Hs_RefseqmRNA = NM_004575
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 147779538
    | Hs_GenLoc_end = 147783073
    | Hs_Uniprot = Q12837
    | Mm_EntrezGene = 18997
    | Mm_Ensembl = ENSMUSG00000031688
    | Mm_RefseqmRNA = NM_138944
    | Mm_RefseqProtein = NP_620394
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 81329081
    | Mm_GenLoc_end = 81332724
    | Mm_Uniprot = Q62091
  }}
}}
'''POU domain, class 4, transcription factor 2''', also known as '''POU4F2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5458| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5458| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
POU4F2 has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]].<ref name=pmid9448000>{{cite journal | vauthors = Budhram-Mahadeo V, Parker M, Latchman DS | title = POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element | journal = Molecular and Cellular Biology | volume = 18 | issue = 2 | pages = 1029–41 | date = Feb 1998 | pmid = 9448000 | pmc = 108815 | doi=10.1128/mcb.18.2.1029}}</ref>
 
== See also ==
* [[BRN-3]]
* [[BRN-3]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Xiang M, Zhou L, Macke JP, Yoshioka T, Hendry SH, Eddy RL, Shows TB, Nathans J | title = The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons | journal = The Journal of Neuroscience | volume = 15 | issue = 7 Pt 1 | pages = 4762–85 | date = Jul 1995 | pmid = 7623109 | doi =  }}
| citations =
* {{cite journal | vauthors = Xiang M, Zhou L, Peng YW, Eddy RL, Shows TB, Nathans J | title = Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells | journal = Neuron | volume = 11 | issue = 4 | pages = 689–701 | date = Oct 1993 | pmid = 7691107 | doi = 10.1016/0896-6273(93)90079-7 }}
*{{cite journal | author=Xiang M, Zhou L, Macke JP, ''et al.'' |title=The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. |journal=J. Neurosci. |volume=15 |issue= 7 Pt 1 |pages= 4762-85 |year= 1995 |pmid= 7623109 |doi=  }}
* {{cite journal | vauthors = Bhargava AK, Li Z, Weissman SM | title = Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 21 | pages = 10260–4 | date = Nov 1993 | pmid = 8234287 | pmc = 47754 | doi = 10.1073/pnas.90.21.10260 }}
*{{cite journal | author=Xiang M, Zhou L, Peng YW, ''et al.'' |title=Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. |journal=Neuron |volume=11 |issue= 4 |pages= 689-701 |year= 1993 |pmid= 7691107 |doi= }}
* {{cite journal | vauthors = Smith MD, Dawson SJ, Latchman DS | title = Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 2 | pages = 1382–8 | date = Jan 1997 | pmid = 8995448 | doi = 10.1074/jbc.272.2.1382 }}
*{{cite journal | author=Bhargava AK, Li Z, Weissman SM |title=Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 21 |pages= 10260-4 |year= 1993 |pmid= 8234287 |doi=  }}
* {{cite journal | vauthors = Budhram-Mahadeo V, Parker M, Latchman DS | title = POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element | journal = Molecular and Cellular Biology | volume = 18 | issue = 2 | pages = 1029–41 | date = Feb 1998 | pmid = 9448000 | pmc = 108815 | doi =  10.1128/mcb.18.2.1029}}
*{{cite journal  | author=Ring CJ, Latchman DS |title=The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. |journal=Nucleic Acids Res. |volume=21 |issue= 12 |pages= 2946 |year= 1993 |pmid= 8332509 |doi=  }}
* {{cite journal | vauthors = Dennis JH, Budhram-Mahadeo V, Latchman DS | title = The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells | journal = Oncogene | volume = 20 | issue = 36 | pages = 4961–71 | date = Aug 2001 | pmid = 11526481 | doi = 10.1038/sj.onc.1204491 }}
*{{cite journal | author=Smith MD, Dawson SJ, Latchman DS |title=Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1382-8 |year= 1997 |pmid= 8995448 |doi= }}
* {{cite journal | vauthors = de Melo J, Qiu X, Du G, Cristante L, Eisenstat DD | title = Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina | journal = The Journal of Comparative Neurology | volume = 461 | issue = 2 | pages = 187–204 | date = Jun 2003 | pmid = 12724837 | doi = 10.1002/cne.10674 }}
*{{cite journal | author=Budhram-Mahadeo V, Parker M, Latchman DS |title=POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 1029-41 |year= 1998 |pmid= 9448000 |doi=  }}
* {{cite journal | vauthors = Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS | title = Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor | journal = Cancer Biology & Therapy | volume = 3 | issue = 3 | pages = 317–23 | date = Mar 2004 | pmid = 14726699 | doi = 10.4161/cbt.3.3.698 }}
*{{cite journal | author=Dennis JH, Budhram-Mahadeo V, Latchman DS |title=The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. |journal=Oncogene |volume=20 |issue= 36 |pages= 4961-71 |year= 2001 |pmid= 11526481 |doi= 10.1038/sj.onc.1204491 }}
* {{cite journal | vauthors = Irshad S, Pedley RB, Anderson J, Latchman DS, Budhram-Mahadeo V | title = The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo | journal = The Journal of Biological Chemistry | volume = 279 | issue = 20 | pages = 21617–27 | date = May 2004 | pmid = 14970234 | doi = 10.1074/jbc.M312506200 | pmc = 4294515 }}
*{{cite journal | author=de Melo J, Qiu X, Du G, ''et al.'' |title=Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina. |journal=J. Comp. Neurol. |volume=461 |issue= 2 |pages= 187-204 |year= 2003 |pmid= 12724837 |doi= 10.1002/cne.10674 }}
* {{cite journal | vauthors = Lee SA, Ndisang D, Patel C, Dennis JH, Faulkes DJ, D'Arrigo C, Samady L, Farooqui-Kabir S, Heads RJ, Latchman DS, Budhram-Mahadeo VS | title = Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter | journal = Cancer Research | volume = 65 | issue = 8 | pages = 3072–80 | date = Apr 2005 | pmid = 15833836 | doi = 10.1158/0008-5472.CAN-04-2865 }}
*{{cite journal | author=Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS |title=Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. |journal=Cancer Biol. Ther. |volume=3 |issue= 3 |pages= 317-23 |year= 2004 |pmid= 14726699 |doi= }}
* {{cite journal | vauthors = Weishaupt JH, Klöcker N, Bähr M | title = Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells | journal = Journal of Molecular Neuroscience | volume = 26 | issue = 1 | pages = 17–25 | year = 2005 | pmid = 15968082 | doi = 10.1385/JMN:26:1:017 }}
*{{cite journal | author=Irshad S, Pedley RB, Anderson J, ''et al.'' |title=The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 21617-27 |year= 2004 |pmid= 14970234 |doi= 10.1074/jbc.M312506200 }}
* {{cite journal | vauthors = Samady L, Faulkes DJ, Budhram-Mahadeo V, Ndisang D, Potter E, Brabant G, Latchman DS | title = The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells | journal = International Journal of Cancer | volume = 118 | issue = 4 | pages = 869–78 | date = Feb 2006 | pmid = 16152597 | doi = 10.1002/ijc.21435 }}
*{{cite journal | author=Lee SA, Ndisang D, Patel C, ''et al.'' |title=Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. |journal=Cancer Res. |volume=65 |issue= 8 |pages= 3072-80 |year= 2005 |pmid= 15833836 |doi= 10.1158/0008-5472.CAN-04-2865 }}
* {{cite journal | vauthors = Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP | title = Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes | journal = Physiological Genomics | volume = 25 | issue = 1 | pages = 9–15 | date = Mar 2006 | pmid = 16368877 | doi = 10.1152/physiolgenomics.00121.2005 }}
*{{cite journal | author=Weishaupt JH, Klöcker N, Bähr M |title=Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. |journal=J. Mol. Neurosci. |volume=26 |issue= 1 |pages= 17-25 |year= 2005 |pmid= 15968082 |doi= }}
* {{cite journal | vauthors = Calissano M, Diss JK, Latchman DS | title = Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells | journal = FEBS Letters | volume = 581 | issue = 13 | pages = 2490–6 | date = May 2007 | pmid = 17490655 | doi = 10.1016/j.febslet.2007.04.066 }}
*{{cite journal | author=Samady L, Faulkes DJ, Budhram-Mahadeo V, ''et al.'' |title=The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. |journal=Int. J. Cancer |volume=118 |issue= 4 |pages= 869-78 |year= 2006 |pmid= 16152597 |doi= 10.1002/ijc.21435 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Choy KW, Wang CC, Ogura A, ''et al.'' |title=Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. |journal=Physiol. Genomics |volume=25 |issue= 1 |pages= 9-15 |year= 2007 |pmid= 16368877 |doi= 10.1152/physiolgenomics.00121.2005 }}
*{{cite journal | author=Calissano M, Diss JK, Latchman DS |title=Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. |journal=FEBS Lett. |volume=581 |issue= 13 |pages= 2490-6 |year= 2007 |pmid= 17490655 |doi= 10.1016/j.febslet.2007.04.066 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|POU4F2+protein,+human}}
* {{MeshName|POU4F2+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}
[[Category:POU-domain proteins]]


{{protein-stub}}
 
{{NLM content}}
{{gene-4-stub}}
{{Transcription factors}}
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 12:06, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.[1][2]

Function

POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM][2]

Interactions

POU4F2 has been shown to interact with Estrogen receptor alpha.[3]

See also

References

  1. ↑ Ring CJ, Latchman DS (Jun 1993). "The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain". Nucleic Acids Research. 21 (12): 2946. doi:10.1093/nar/21.12.2946. PMC 309696. PMID 8332509.
  2. ↑ 2.0 2.1 "Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2".
  3. ↑ Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology. 18 (2): 1029–41. doi:10.1128/mcb.18.2.1029. PMC 108815. PMID 9448000.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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