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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''PR domain zinc finger protein 1''' also known as '''BLIMP-1''' is a [[protein]] that in humans is encoded by the ''PRDM1'' [[gene]].<ref name="pmid1851123">{{cite journal | vauthors = Keller AD, Maniatis T | title = Identification and characterization of a novel repressor of beta-interferon gene expression | journal = Genes & Development | volume = 5 | issue = 5 | pages = 868–79 | date = May 1991 | pmid = 1851123 | pmc = | doi = 10.1101/gad.5.5.868 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRDM1 PR domain containing 1, with ZNF domain| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=639| accessdate = }}</ref> BLIMP-1 acts as a [[repressor]] of [[interferon type I|beta-interferon]] (β-IFN) gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the β-IFN gene promoter. Transcription of this gene increases upon virus induction.<ref name="entrez"/>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PR domain containing 1, with ZNF domain
| HGNCid = 9346
| Symbol = PRDM1
| AltSymbols =; BLIMP1; MGC118922; MGC118923; MGC118924; MGC118925; PRDI-BF1
| OMIM = 603423
| ECnumber = 
| Homologene = 925
| MGIid = 99655
| GeneAtlas_image1 = PBB_GE_PRDM1_217192_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001892 |text = embryonic placenta development}} {{GNF_GO|id=GO:0001893 |text = maternal placenta development}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0045165 |text = cell fate commitment}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 639
    | Hs_Ensembl = ENSG00000057657
    | Hs_RefseqProtein = NP_001189
    | Hs_RefseqmRNA = NM_001198
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 106640888
    | Hs_GenLoc_end = 106664507
    | Hs_Uniprot = O75626
    | Mm_EntrezGene = 12142
    | Mm_Ensembl = ENSMUSG00000038151
    | Mm_RefseqmRNA = NM_007548
    | Mm_RefseqProtein = NP_031574
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 44125592
    | Mm_GenLoc_end = 44147163
    | Mm_Uniprot = Q3UET9
  }}
}}
'''PR domain containing 1, with ZNF domain''', also known as '''PRDM1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRDM1 PR domain containing 1, with ZNF domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=639| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
The increased expression of the Blimp-1 protein in [[B lymphocyte]]s, [[T lymphocyte]]s, [[NK cell]] and other immune system cells leads to an immune response through proliferation and differentiation of antibody secreting [[plasma cell]]s.  Blimp-1 is also considered a 'master regulator' of [[hematopoietic stem cell]]s.<ref name="pmid8168136">{{cite journal | vauthors = Turner CA, Mack DH, Davis MM | title = Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells | journal = Cell | volume = 77 | issue = 2 | pages = 297–306 | date = Apr 1994 | pmid = 8168136 | doi = 10.1016/0092-8674(94)90321-2 }}</ref><ref name="pmid15100284">{{cite journal | vauthors = Sciammas R, Davis MM | title = Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation | journal = Journal of Immunology | volume = 172 | issue = 9 | pages = 5427–40 | date = May 2004 | pmid = 15100284 | doi = 10.4049/jimmunol.172.9.5427 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: PRDM1 PR domain containing 1, with ZNF domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=639| accessdate = }}</ref>
}}


==References==
Blimp1 (also known as Prdm1), a known transcriptional [[repressor]], has a critical role in the foundation of the mouse [[germ cell]] lineage, as its disruption causes a block early in the process of primordial germ cell formation. Blimp1-deficient mutant embryos form a tight cluster of about 20 primordial germ cell-like cells, which fail to show the characteristic migration, proliferation and consistent repression of [[homeobox]] genes that normally accompany specification of primordial germ cells. The genetic lineage-tracing experiments indicate that the Blimp1-positive cells originating from the proximal posterior [[epiblast]] cells are indeed the lineage-restricted primordial germ cell precursors.<ref>{{cite journal | vauthors = Ohinata Y, Payer B, O'Carroll D, Ancelin K, Ono Y, Sano M, Barton SC, Obukhanych T, Nussenzweig M, Tarakhovsky A, Saitou M, Surani MA | title = Blimp1 is a critical determinant of the germ cell lineage in mice | journal = Nature | volume = 436 | issue = 7048 | date = Jul 2005 | pmid = 15937476 | doi = 10.1038/nature03813 }}</ref>
{{reflist|2}}
 
==Further reading==
== Second cancers after radiation treatment ==
{{refbegin | 2}}
 
{{PBB_Further_reading
A [[genome-wide association study]] has identified two genetic variations near the PRDM1 gene that predict an increased likelihood of developing a second cancer after radiation treatment for [[Hodgkin lymphoma]].<ref name="pmid21785431">{{cite journal | vauthors = Best T, Li D, Skol AD, Kirchhoff T, Jackson SA, Yasui Y, Bhatia S, Strong LC, Domchek SM, Nathanson KL, Olopade OI, Huang RS, Mack TM, Conti DV, Offit K, Cozen W, Robison LL, Onel K | title = Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma | journal = Nature Medicine | volume = 17 | issue = 8 | pages = 941–3 | date = Aug 2011 | pmid = 21785431 | pmc = 3229923 | doi = 10.1038/nm.2407 | laysummary = http://www.uchospitals.edu/news/2011/20110725-lymphoma.html | laysource = University of Chicago Medical Center }}</ref>
| citations =
{{Clear}}
*{{cite journal  | author=Keller AD, Maniatis T |title=Identification and characterization of a novel repressor of beta-interferon gene expression. |journal=Genes Dev. |volume=5 |issue= 5 |pages= 868-79 |year= 1991 |pmid= 1851123 |doi= }}
 
*{{cite journal  | author=Huang S |title=Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1. |journal=Cell |volume=78 |issue= 1 |pages= 9 |year= 1994 |pmid= 8033216 |doi= }}
== References ==
*{{cite journal  | author=Turner CA, Mack DH, Davis MM |title=Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells. |journal=Cell |volume=77 |issue= 2 |pages= 297-306 |year= 1994 |pmid= 8168136 |doi=  }}
{{reflist|33em}}
*{{cite journal  | author=Mock BA, Liu L, LePaslier D, Huang S |title=The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10. |journal=Genomics |volume=37 |issue= 1 |pages= 24-8 |year= 1997 |pmid= 8921366 |doi= }}
 
*{{cite journal | author=Ren B, Chee KJ, Kim TH, Maniatis T |title=PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 125-37 |year= 1999 |pmid= 9887105 |doi= }}
== Further reading ==
*{{cite journal | author=Angelin-Duclos C, Cattoretti G, Lin KI, Calame K |title=Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo. |journal=J. Immunol. |volume=165 |issue= 10 |pages= 5462-71 |year= 2000 |pmid= 11067898 |doi= }}
{{refbegin|33em}}
*{{cite journal | author=Gupta S, Anthony A, Pernis AB |title=Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins. |journal=J. Immunol. |volume=166 |issue= 10 |pages= 6104-11 |year= 2001 |pmid= 11342629 |doi= }}
* {{cite journal | vauthors = Huang S | title = Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1 | journal = Cell | volume = 78 | issue = 1 | pages = 9 | date = Jul 1994 | pmid = 8033216 | doi = 10.1016/0092-8674(94)90565-7 }}
*{{cite journal | author=Medina F, Segundo C, Campos-Caro A, ''et al.'' |title=The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression. |journal=Blood |volume=99 |issue= 6 |pages= 2154-61 |year= 2002 |pmid= 11877292 |doi= }}
* {{cite journal | vauthors = Mock BA, Liu L, LePaslier D, Huang S | title = The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10 | journal = Genomics | volume = 37 | issue = 1 | pages = 24–8 | date = Oct 1996 | pmid = 8921366 | doi = 10.1006/geno.1996.0516 }}
*{{cite journal | author=Shaffer AL, Lin KI, Kuo TC, ''et al.'' |title=Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program. |journal=Immunity |volume=17 |issue= 1 |pages= 51-62 |year= 2002 |pmid= 12150891 |doi= }}
* {{cite journal | vauthors = Ren B, Chee KJ, Kim TH, Maniatis T | title = PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins | journal = Genes & Development | volume = 13 | issue = 1 | pages = 125–37 | date = Jan 1999 | pmid = 9887105 | pmc = 316372 | doi = 10.1101/gad.13.1.125 }}
*{{cite journal | author=Vasanwala FH, Kusam S, Toney LM, Dent AL |title=Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene. |journal=J. Immunol. |volume=169 |issue= 4 |pages= 1922-9 |year= 2002 |pmid= 12165517 |doi= }}
* {{cite journal | vauthors = Angelin-Duclos C, Cattoretti G, Lin KI, Calame K | title = Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo | journal = Journal of Immunology | volume = 165 | issue = 10 | pages = 5462–71 | date = Nov 2000 | pmid = 11067898 | doi = 10.4049/jimmunol.165.10.5462 }}
*{{cite journal | author=Borson ND, Lacy MQ, Wettstein PJ |title=Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma. |journal=Blood |volume=100 |issue= 13 |pages= 4629-39 |year= 2003 |pmid= 12453881 |doi= 10.1182/blood.V100.13.4629 }}
* {{cite journal | vauthors = Gupta S, Anthony A, Pernis AB | title = Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins | journal = Journal of Immunology | volume = 166 | issue = 10 | pages = 6104–11 | date = May 2001 | pmid = 11342629 | doi = 10.4049/jimmunol.166.10.6104 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Medina F, Segundo C, Campos-Caro A, González-García I, Brieva JA | title = The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression | journal = Blood | volume = 99 | issue = 6 | pages = 2154–61 | date = Mar 2002 | pmid = 11877292 | doi = 10.1182/blood.V99.6.2154 }}
*{{cite journal | author=Györy I, Fejér G, Ghosh N, ''et al.'' |title=Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. |journal=J. Immunol. |volume=170 |issue= 6 |pages= 3125-33 |year= 2003 |pmid= 12626569 |doi= }}
* {{cite journal | vauthors = Shaffer AL, Lin KI, Kuo TC, Yu X, Hurt EM, Rosenwald A, Giltnane JM, Yang L, Zhao H, Calame K, Staudt LM | title = Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program | journal = Immunity | volume = 17 | issue = 1 | pages = 51–62 | date = Jul 2002 | pmid = 12150891 | doi = 10.1016/S1074-7613(02)00335-7 }}
*{{cite journal | author=Gyory I, Wu J, Fejér G, ''et al.'' |title=PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing. |journal=Nat. Immunol. |volume=5 |issue= 3 |pages= 299-308 |year= 2004 |pmid= 14985713 |doi= 10.1038/ni1046 }}
* {{cite journal | vauthors = Vasanwala FH, Kusam S, Toney LM, Dent AL | title = Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene | journal = Journal of Immunology | volume = 169 | issue = 4 | pages = 1922–9 | date = Aug 2002 | pmid = 12165517 | doi = 10.4049/jimmunol.169.4.1922 }}
*{{cite journal | author=Lotz C, Mutallib SA, Oehlrich N, ''et al.'' |title=Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL. |journal=J. Immunol. |volume=175 |issue= 2 |pages= 1301-9 |year= 2005 |pmid= 16002735 |doi= }}
* {{cite journal | vauthors = Borson ND, Lacy MQ, Wettstein PJ | title = Altered mRNA expression of Pax5 and Blimp-1 in B cells in multiple myeloma | journal = Blood | volume = 100 | issue = 13 | pages = 4629–39 | date = Dec 2002 | pmid = 12453881 | doi = 10.1182/blood.V100.13.4629 }}
*{{cite journal | author=Tam W, Gomez M, Chadburn A, ''et al.'' |title=Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. |journal=Blood |volume=107 |issue= 10 |pages= 4090-100 |year= 2006 |pmid= 16424392 |doi= 10.1182/blood-2005-09-3778 }}
* {{cite journal | vauthors = Györy I, Fejér G, Ghosh N, Seto E, Wright KL | title = Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines | journal = Journal of Immunology | volume = 170 | issue = 6 | pages = 3125–33 | date = Mar 2003 | pmid = 12626569 | doi = 10.4049/jimmunol.170.6.3125 }}
*{{cite journal | author=Pasqualucci L, Compagno M, Houldsworth J, ''et al.'' |title=Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma. |journal=J. Exp. Med. |volume=203 |issue= 2 |pages= 311-7 |year= 2006 |pmid= 16492805 |doi= 10.1084/jem.20052204 }}
* {{cite journal | vauthors = Gyory I, Wu J, Fejér G, Seto E, Wright KL | title = PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing | journal = Nature Immunology | volume = 5 | issue = 3 | pages = 299–308 | date = Mar 2004 | pmid = 14985713 | doi = 10.1038/ni1046 }}
*{{cite journal | author=González-García I, Ocaña E, Jiménez-Gómez G, ''et al.'' |title=Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells. |journal=J. Immunol. |volume=176 |issue= 7 |pages= 4042-50 |year= 2006 |pmid= 16547239 |doi= }}
* {{cite journal | vauthors = Lotz C, Mutallib SA, Oehlrich N, Liewer U, Ferreira EA, Moos M, Hundemer M, Schneider S, Strand S, Huber C, Goldschmidt H, Theobald M | title = Targeting positive regulatory domain I-binding factor 1 and X box-binding protein 1 transcription factors by multiple myeloma-reactive CTL | journal = Journal of Immunology | volume = 175 | issue = 2 | pages = 1301–9 | date = Jul 2005 | pmid = 16002735 | doi = 10.4049/jimmunol.175.2.1301 }}
*{{cite journal | author=Garcia JF, Roncador G, García JF, ''et al.'' |title=PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma. |journal=Haematologica |volume=91 |issue= 4 |pages= 467-74 |year= 2006 |pmid= 16585013 |doi=  }}
* {{cite journal | vauthors = Tam W, Gomez M, Chadburn A, Lee JW, Chan WC, Knowles DM | title = Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas | journal = Blood | volume = 107 | issue = 10 | pages = 4090–100 | date = May 2006 | pmid = 16424392 | doi = 10.1182/blood-2005-09-3778 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
* {{cite journal | vauthors = Pasqualucci L, Compagno M, Houldsworth J, Monti S, Grunn A, Nandula SV, Aster JC, Murty VV, Shipp MA, Dalla-Favera R | title = Inactivation of the PRDM1/BLIMP1 gene in diffuse large B cell lymphoma | journal = The Journal of Experimental Medicine | volume = 203 | issue = 2 | pages = 311–7 | date = Feb 2006 | pmid = 16492805 | pmc = 2118216 | doi = 10.1084/jem.20052204 }}
}}
* {{cite journal | vauthors = González-García I, Ocaña E, Jiménez-Gómez G, Campos-Caro A, Brieva JA | title = Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells | journal = Journal of Immunology | volume = 176 | issue = 7 | pages = 4042–50 | date = Apr 2006 | pmid = 16547239 | doi = 10.4049/jimmunol.176.7.4042 }}
* {{cite journal | vauthors = Garcia JF, Roncador G, García JF, Sánz AI, Maestre L, Lucas E, Montes-Moreno S, Fernandez Victoria R, Martinez-Torrecuadrara JL, Marafioti T, Mason DY, Piris MA | title = PRDM1/BLIMP-1 expression in multiple B and T-cell lymphoma | journal = Haematologica | volume = 91 | issue = 4 | pages = 467–74 | date = Apr 2006 | pmid = 16585013 | doi =  }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|PRDM1+protein,+human}}
* {{MeshName|PRDM1+protein,+human}}
* {{FactorBook|PRDM1}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 11:51, 30 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

PR domain zinc finger protein 1 also known as BLIMP-1 is a protein that in humans is encoded by the PRDM1 gene.[1][2] BLIMP-1 acts as a repressor of beta-interferon (β-IFN) gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the β-IFN gene promoter. Transcription of this gene increases upon virus induction.[2]

Function

The increased expression of the Blimp-1 protein in B lymphocytes, T lymphocytes, NK cell and other immune system cells leads to an immune response through proliferation and differentiation of antibody secreting plasma cells. Blimp-1 is also considered a 'master regulator' of hematopoietic stem cells.[3][4]

Blimp1 (also known as Prdm1), a known transcriptional repressor, has a critical role in the foundation of the mouse germ cell lineage, as its disruption causes a block early in the process of primordial germ cell formation. Blimp1-deficient mutant embryos form a tight cluster of about 20 primordial germ cell-like cells, which fail to show the characteristic migration, proliferation and consistent repression of homeobox genes that normally accompany specification of primordial germ cells. The genetic lineage-tracing experiments indicate that the Blimp1-positive cells originating from the proximal posterior epiblast cells are indeed the lineage-restricted primordial germ cell precursors.[5]

Second cancers after radiation treatment

A genome-wide association study has identified two genetic variations near the PRDM1 gene that predict an increased likelihood of developing a second cancer after radiation treatment for Hodgkin lymphoma.[6]

References

  1. ↑ Keller AD, Maniatis T (May 1991). "Identification and characterization of a novel repressor of beta-interferon gene expression". Genes & Development. 5 (5): 868–79. doi:10.1101/gad.5.5.868. PMID 1851123.
  2. ↑ 2.0 2.1 "Entrez Gene: PRDM1 PR domain containing 1, with ZNF domain".
  3. ↑ Turner CA, Mack DH, Davis MM (Apr 1994). "Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells". Cell. 77 (2): 297–306. doi:10.1016/0092-8674(94)90321-2. PMID 8168136.
  4. ↑ Sciammas R, Davis MM (May 2004). "Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation". Journal of Immunology. 172 (9): 5427–40. doi:10.4049/jimmunol.172.9.5427. PMID 15100284.
  5. ↑ Ohinata Y, Payer B, O'Carroll D, Ancelin K, Ono Y, Sano M, Barton SC, Obukhanych T, Nussenzweig M, Tarakhovsky A, Saitou M, Surani MA (Jul 2005). "Blimp1 is a critical determinant of the germ cell lineage in mice". Nature. 436 (7048). doi:10.1038/nature03813. PMID 15937476.
  6. ↑ Best T, Li D, Skol AD, Kirchhoff T, Jackson SA, Yasui Y, Bhatia S, Strong LC, Domchek SM, Nathanson KL, Olopade OI, Huang RS, Mack TM, Conti DV, Offit K, Cozen W, Robison LL, Onel K (Aug 2011). "Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma". Nature Medicine. 17 (8): 941–3. doi:10.1038/nm.2407. PMC 3229923. PMID 21785431. Lay summary – University of Chicago Medical Center.

Further reading

  • Huang S (Jul 1994). "Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1". Cell. 78 (1): 9. doi:10.1016/0092-8674(94)90565-7. PMID 8033216.
  • Mock BA, Liu L, LePaslier D, Huang S (Oct 1996). "The B-lymphocyte maturation promoting transcription factor BLIMP1/PRDI-BF1 maps to D6S447 on human chromosome 6q21-q22.1 and the syntenic region of mouse chromosome 10". Genomics. 37 (1): 24–8. doi:10.1006/geno.1996.0516. PMID 8921366.
  • Ren B, Chee KJ, Kim TH, Maniatis T (Jan 1999). "PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins". Genes & Development. 13 (1): 125–37. doi:10.1101/gad.13.1.125. PMC 316372. PMID 9887105.
  • Angelin-Duclos C, Cattoretti G, Lin KI, Calame K (Nov 2000). "Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo". Journal of Immunology. 165 (10): 5462–71. doi:10.4049/jimmunol.165.10.5462. PMID 11067898.
  • Gupta S, Anthony A, Pernis AB (May 2001). "Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins". Journal of Immunology. 166 (10): 6104–11. doi:10.4049/jimmunol.166.10.6104. PMID 11342629.
  • Medina F, Segundo C, Campos-Caro A, González-García I, Brieva JA (Mar 2002). "The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression". Blood. 99 (6): 2154–61. doi:10.1182/blood.V99.6.2154. PMID 11877292.
  • Shaffer AL, Lin KI, Kuo TC, Yu X, Hurt EM, Rosenwald A, Giltnane JM, Yang L, Zhao H, Calame K, Staudt LM (Jul 2002). "Blimp-1 orchestrates plasma cell differentiation by extinguishing the mature B cell gene expression program". Immunity. 17 (1): 51–62. doi:10.1016/S1074-7613(02)00335-7. PMID 12150891.
  • Vasanwala FH, Kusam S, Toney LM, Dent AL (Aug 2002). "Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene". Journal of Immunology. 169 (4): 1922–9. doi:10.4049/jimmunol.169.4.1922. PMID 12165517.
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