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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''PR domain zinc finger protein 2''' is a [[protein]] that in humans is encoded by the ''PRDM2'' [[gene]].<ref name="pmid7538672">{{cite journal | vauthors = Buyse IM, Shao G, Huang S | title = The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 10 | pages = 4467–71 | date = May 1995 | pmid = 7538672 | pmc = 41965 | doi = 10.1073/pnas.92.10.4467 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7799| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = PR domain containing 2, with ZNF domain
| HGNCid = 9347
| Symbol = PRDM2
| AltSymbols =; HUMHOXY1; MTB-ZF; RIZ; RIZ1; RIZ2
| OMIM = 601196
| ECnumber = 
| Homologene = 40822
| MGIid = 107628
| GeneAtlas_image1 = PBB_GE_PRDM2_203056_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRDM2_216433_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRDM2_203057_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7799
    | Hs_Ensembl = ENSG00000116731
    | Hs_RefseqProtein = NP_001007258
    | Hs_RefseqmRNA = NM_001007257
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 13899322
    | Hs_GenLoc_end = 14024162
    | Hs_Uniprot = Q13029
    | Mm_EntrezGene = 110593
    | Mm_Ensembl = ENSMUSG00000057637
    | Mm_RefseqmRNA = XM_898822
    | Mm_RefseqProtein = XP_903915
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 142398399
    | Mm_GenLoc_end = 142447681
    | Mm_Uniprot = 
  }}
}}
'''PR domain containing 2, with ZNF domain''', also known as '''PRDM2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7799| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7799| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PRDM2 has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]]<ref name=pmid10706618>{{cite journal | vauthors = Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA | title = The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3130–5 | date = Mar 2000 | pmid = 10706618 | pmc = 16204 | doi = 10.1073/pnas.050015697 }}</ref> and [[Retinoblastoma protein]].<ref name=pmid7538672 />
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Shapiro VS, Lee P, Winoto A | title = Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3 | journal = Gene | volume = 163 | issue = 2 | pages = 329–30 | date = Oct 1995 | pmid = 7590293 | doi = 10.1016/0378-1119(95)00420-B }}
| citations =
* {{cite journal | vauthors = Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S | title = cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene | journal = European Journal of Biochemistry / FEBS | volume = 235 | issue = 3 | pages = 471–9 | date = Feb 1996 | pmid = 8654390 | doi = 10.1111/j.1432-1033.1996.00471.x }}
*{{cite journal | author=Buyse IM, Shao G, Huang S |title=The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 10 |pages= 4467-71 |year= 1995 |pmid= 7538672 |doi= }}
* {{cite journal | vauthors = Buyse IM, Takahashi EI, Huang S | title = Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36 | journal = Genomics | volume = 34 | issue = 1 | pages = 119–21 | date = May 1996 | pmid = 8661032 | doi = 10.1006/geno.1996.0249 }}
*{{cite journal | author=Shapiro VS, Lee P, Winoto A |title=Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3. |journal=Gene |volume=163 |issue= 2 |pages= 329-30 |year= 1995 |pmid= 7590293 |doi= }}
* {{cite journal | vauthors = Liu L, Shao G, Steele-Perkins G, Huang S | title = The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter | journal = The Journal of Biological Chemistry | volume = 272 | issue = 5 | pages = 2984–91 | date = Jan 1997 | pmid = 9006946 | doi = 10.1074/jbc.272.5.2984 }}
*{{cite journal | author=Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S |title=cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene. |journal=Eur. J. Biochem. |volume=235 |issue= 3 |pages= 471-9 |year= 1996 |pmid= 8654390 |doi= }}
* {{cite journal | vauthors = Xie M, Shao G, Buyse IM, Huang S | title = Transcriptional repression mediated by the PR domain zinc finger gene RIZ | journal = The Journal of Biological Chemistry | volume = 272 | issue = 42 | pages = 26360–6 | date = Oct 1997 | pmid = 9334209 | doi = 10.1074/jbc.272.42.26360 }}
*{{cite journal | author=Buyse IM, Takahashi EI, Huang S |title=Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36. |journal=Genomics |volume=34 |issue= 1 |pages= 119-21 |year= 1996 |pmid= 8661032 |doi= 10.1006/geno.1996.0249 }}
* {{cite journal | vauthors = He L, Yu JX, Liu L, Buyse IM, Wang MS, Yang QC, Nakagawara A, Brodeur GM, Shi YE, Huang S | title = RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis | journal = Cancer Research | volume = 58 | issue = 19 | pages = 4238–44 | date = Oct 1998 | pmid = 9766644 | doi =  }}
*{{cite journal | author=Liu L, Shao G, Steele-Perkins G, Huang S |title=The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2984-91 |year= 1997 |pmid= 9006946 |doi= }}
* {{cite journal | vauthors = Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA | title = The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3130–5 | date = Mar 2000 | pmid = 10706618 | pmc = 16204 | doi = 10.1073/pnas.050015697 }}
*{{cite journal | author=Xie M, Shao G, Buyse IM, Huang S |title=Transcriptional repression mediated by the PR domain zinc finger gene RIZ. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26360-6 |year= 1997 |pmid= 9334209 |doi=  }}
* {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 7 | pages = 3491–6 | date = Mar 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}
*{{cite journal | author=He L, Yu JX, Liu L, ''et al.'' |title=RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis. |journal=Cancer Res. |volume=58 |issue= 19 |pages= 4238-44 |year= 1998 |pmid= 9766644 |doi= }}
* {{cite journal | vauthors = Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S | title = Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily | journal = Cancer Research | volume = 61 | issue = 22 | pages = 8094–9 | date = Nov 2001 | pmid = 11719434 | doi =  }}
*{{cite journal | author=Abbondanza C, Medici N, Nigro V, ''et al.'' |title=The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3130-5 |year= 2000 |pmid= 10706618 |doi= 10.1073/pnas.050015697 }}
* {{cite journal | vauthors = Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T | title = Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia | journal = The Tohoku Journal of Experimental Medicine | volume = 196 | issue = 3 | pages = 193–201 | date = Mar 2002 | pmid = 12002276 | doi = 10.1620/tjem.196.193 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
* {{cite journal | vauthors = Poetsch M, Dittberner T, Woenckhaus C | title = Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36 | journal = Oncogene | volume = 21 | issue = 19 | pages = 3038–42 | date = May 2002 | pmid = 12082534 | doi = 10.1038/sj.onc.1205457 }}
*{{cite journal | author=Du Y, Carling T, Fang W, ''et al.'' |title=Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. |journal=Cancer Res. |volume=61 |issue= 22 |pages= 8094-9 |year= 2001 |pmid= 11719434 |doi= }}
* {{cite journal | vauthors = Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T | title = Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia | journal = British Journal of Haematology | volume = 119 | issue = 4 | pages = 940–8 | date = Dec 2002 | pmid = 12472571 | doi = 10.1046/j.1365-2141.2002.03972.x }}
*{{cite journal | author=Sasaki O, Meguro K, Tohmiya Y, ''et al.'' |title=Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia. |journal=Tohoku J. Exp. Med. |volume=196 |issue= 3 |pages= 193-201 |year= 2003 |pmid= 12002276 |doi= }}
* {{cite journal | vauthors = Tokumaru Y, Nomoto S, Jerónimo C, Henrique R, Harden S, Trink B, Sidransky D | title = Biallelic inactivation of the RIZ1 gene in human gastric cancer | journal = Oncogene | volume = 22 | issue = 44 | pages = 6954–8 | date = Oct 2003 | pmid = 14534544 | doi = 10.1038/sj.onc.1206403 }}
*{{cite journal | author=Poetsch M, Dittberner T, Woenckhaus C |title=Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36. |journal=Oncogene |volume=21 |issue= 19 |pages= 3038-42 |year= 2002 |pmid= 12082534 |doi= 10.1038/sj.onc.1205457 }}
* {{cite journal | vauthors = Kim KC, Geng L, Huang S | title = Inactivation of a histone methyltransferase by mutations in human cancers | journal = Cancer Research | volume = 63 | issue = 22 | pages = 7619–23 | date = Nov 2003 | pmid = 14633678 | doi = }}
*{{cite journal | author=Sasaki O, Meguro K, Tohmiya Y, ''et al.'' |title=Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia. |journal=Br. J. Haematol. |volume=119 |issue= 4 |pages= 940-8 |year= 2003 |pmid= 12472571 |doi= }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Pan KF, Lu YY, Liu WG, Zhang L, You WC | title = Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability | journal = World Journal of Gastroenterology | volume = 10 | issue = 18 | pages = 2719–22 | date = Sep 2004 | pmid = 15309726 | doi =  10.3748/wjg.v10.i18.2719}}
*{{cite journal | author=Tokumaru Y, Nomoto S, Jerónimo C, ''et al.'' |title=Biallelic inactivation of the RIZ1 gene in human gastric cancer. |journal=Oncogene |volume=22 |issue= 44 |pages= 6954-8 |year= 2003 |pmid= 14534544 |doi= 10.1038/sj.onc.1206403 }}
* {{cite journal | vauthors = Rossi M, Abbondanza C, D'Arcangelo A, Gazzerro P, Medici N, Moncharmont B, Puca GA | title = The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation | journal = Cancer Letters | volume = 215 | issue = 2 | pages = 229–37 | date = Nov 2004 | pmid = 15488642 | doi = 10.1016/j.canlet.2004.05.014 }}
*{{cite journal | author=Kim KC, Geng L, Huang S |title=Inactivation of a histone methyltransferase by mutations in human cancers. |journal=Cancer Res. |volume=63 |issue= 22 |pages= 7619-23 |year= 2004 |pmid= 14633678 |doi=  }}
* {{cite journal | vauthors = Grundberg E, Carling T, Brändström H, Huang S, Ribom EL, Ljunggren O, Mallmin H, Kindmark A | title = A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 89 | issue = 12 | pages = 6173–8 | date = Dec 2004 | pmid = 15579774 | doi = 10.1210/jc.2004-0403 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Pan KF, Lu YY, Liu WG, ''et al.'' |title=Detection of frameshift mutations of RIZ in gastric cancers with microsatellite instability. |journal=World J. Gastroenterol. |volume=10 |issue= 18 |pages= 2719-22 |year= 2004 |pmid= 15309726 |doi=  }}
*{{cite journal  | author=Rossi M, Abbondanza C, D'Arcangelo A, ''et al.'' |title=The Zn-finger domain of RIZ protein promotes MCF-7 cell proliferation. |journal=Cancer Lett. |volume=215 |issue= 2 |pages= 229-37 |year= 2004 |pmid= 15488642 |doi= 10.1016/j.canlet.2004.05.014 }}
*{{cite journal  | author=Grundberg E, Carling T, Brändström H, ''et al.'' |title=A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 12 |pages= 6173-8 |year= 2005 |pmid= 15579774 |doi= 10.1210/jc.2004-0403 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|PRDM2+protein,+human}}
* {{MeshName|PRDM2+protein,+human}}


{{protein-stub}}
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{{Transcription factors}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
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Latest revision as of 01:56, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.[1][2]

Function

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[2]

Interactions

PRDM2 has been shown to interact with Estrogen receptor alpha[3] and Retinoblastoma protein.[1]

References

  1. ↑ 1.0 1.1 Buyse IM, Shao G, Huang S (May 1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Proceedings of the National Academy of Sciences of the United States of America. 92 (10): 4467–71. doi:10.1073/pnas.92.10.4467. PMC 41965. PMID 7538672.
  2. ↑ 2.0 2.1 "Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain".
  3. ↑ Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA (Mar 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMC 16204. PMID 10706618.

Further reading

  • Shapiro VS, Lee P, Winoto A (Oct 1995). "Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3". Gene. 163 (2): 329–30. doi:10.1016/0378-1119(95)00420-B. PMID 7590293.
  • Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S (Feb 1996). "cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene". European Journal of Biochemistry / FEBS. 235 (3): 471–9. doi:10.1111/j.1432-1033.1996.00471.x. PMID 8654390.
  • Buyse IM, Takahashi EI, Huang S (May 1996). "Physical mapping of the retinoblastoma interacting zinc finger gene RIZ to D1S228 on chromosome 1p36". Genomics. 34 (1): 119–21. doi:10.1006/geno.1996.0249. PMID 8661032.
  • Liu L, Shao G, Steele-Perkins G, Huang S (Jan 1997). "The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter". The Journal of Biological Chemistry. 272 (5): 2984–91. doi:10.1074/jbc.272.5.2984. PMID 9006946.
  • Xie M, Shao G, Buyse IM, Huang S (Oct 1997). "Transcriptional repression mediated by the PR domain zinc finger gene RIZ". The Journal of Biological Chemistry. 272 (42): 26360–6. doi:10.1074/jbc.272.42.26360. PMID 9334209.
  • He L, Yu JX, Liu L, Buyse IM, Wang MS, Yang QC, Nakagawara A, Brodeur GM, Shi YE, Huang S (Oct 1998). "RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis". Cancer Research. 58 (19): 4238–44. PMID 9766644.
  • Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA (Mar 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3130–5. doi:10.1073/pnas.050015697. PMC 16204. PMID 10706618.
  • Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
  • Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S (Nov 2001). "Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily". Cancer Research. 61 (22): 8094–9. PMID 11719434.
  • Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T (Mar 2002). "Nucleotide alteration of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukemia". The Tohoku Journal of Experimental Medicine. 196 (3): 193–201. doi:10.1620/tjem.196.193. PMID 12002276.
  • Poetsch M, Dittberner T, Woenckhaus C (May 2002). "Frameshift mutations of RIZ, but no point mutations in RIZ1 exons in malignant melanomas with deletions in 1p36". Oncogene. 21 (19): 3038–42. doi:10.1038/sj.onc.1205457. PMID 12082534.
  • Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T (Dec 2002). "Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia". British Journal of Haematology. 119 (4): 940–8. doi:10.1046/j.1365-2141.2002.03972.x. PMID 12472571.
  • Tokumaru Y, Nomoto S, Jerónimo C, Henrique R, Harden S, Trink B, Sidransky D (Oct 2003). "Biallelic inactivation of the RIZ1 gene in human gastric cancer". Oncogene. 22 (44): 6954–8. doi:10.1038/sj.onc.1206403. PMID 14534544.
  • Kim KC, Geng L, Huang S (Nov 2003). "Inactivation of a histone methyltransferase by mutations in human cancers". Cancer Research. 63 (22): 7619–23. PMID 14633678.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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