Retinoblastoma-like protein 1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Retinoblastoma-like 1''' ('''p107'''), also known as '''RBL1''', is a [[protein]] that in humans is encoded by the ''RBL1'' [[gene]].<ref name="entrez"/><ref name="pmid1833063">{{cite journal | vauthors = Ewen ME, Xing YG, Lawrence JB, Livingston DM | title = Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein | journal = Cell | volume = 66 | issue = 6 | pages = 1155–64 | date = Sep 1991 | pmid = 1833063 | doi = 10.1016/0092-8674(91)90038-Z }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Retinoblastoma-like 1 (p107)
| HGNCid = 9893
| Symbol = RBL1
| AltSymbols =; PRB1; CP107; MGC40006; p107
| OMIM = 116957
| ECnumber = 
| Homologene = 2172
| MGIid = 103300
| GeneAtlas_image1 = PBB_GE_RBL1_205296_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005667 |text = transcription factor complex}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0043550 |text = regulation of lipid kinase activity}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5933
    | Hs_Ensembl = ENSG00000080839
    | Hs_RefseqProtein = NP_002886
    | Hs_RefseqmRNA = NM_002895
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 35058166
    | Hs_GenLoc_end = 35157824
    | Hs_Uniprot = P28749
    | Mm_EntrezGene = 19650
    | Mm_Ensembl = ENSMUSG00000027641
    | Mm_RefseqmRNA = NM_011249
    | Mm_RefseqProtein = NP_035379
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 156837339
    | Mm_GenLoc_end = 156895960
    | Mm_Uniprot = Q3U1D4
  }}
}}
'''Retinoblastoma-like 1 (p107)''', also known as '''RBL1''', is a human [[gene]].<ref name="entrez" />


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is similar in sequence and possibly function to the product of the [[retinoblastoma]] 1 ([[RB1]]) gene. The RB1 gene product is a [[tumor suppressor gene|tumor suppressor protein]] that appears to be involved in [[cell cycle]] regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with [[adenovirus]] [[EP300|E1A protein]] and [[SV40 Large T-antigen]], with the [[SV40]] large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing [[E2F]] binding sites in their [[promotor (biology)|promoter]]s. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different [[isoform]]s have been found for this gene.<ref name="entrez">{{Cite web| title = Entrez Gene: RBL1 retinoblastoma-like 1 (p107)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5933| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: RBL1 retinoblastoma-like 1 (p107)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5933| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
Retinoblastoma-like protein 1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[BEGAIN]],<ref name = pmid16189514/>
* [[BRCA1]],<ref name = pmid11521194>{{cite journal | vauthors = Fan S, Yuan R, Ma YX, Xiong J, Meng Q, Erdos M, Zhao JN, Goldberg ID, Pestell RG, Rosen EM | title = Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding | journal = Oncogene | volume = 20 | issue = 35 | pages = 4827–41 | date = Aug 2001 | pmid = 11521194 | doi = 10.1038/sj.onc.1204666 }}</ref>
* [[BRF1 (gene) | BRF1]],<ref name = pmid10330166>{{cite journal | vauthors = Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ | title = RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130 | journal = Molecular and Cellular Biology | volume = 19 | issue = 6 | pages = 4255–61 | date = Jun 1999 | pmid = 10330166 | pmc = 104385 | doi =  10.1128/mcb.19.6.4255}}</ref>
* [[Cyclin A2]],<ref name = pmid8230483/><ref name = pmid12439743>{{cite journal | vauthors = Joaquin M, Bessa M, Saville MK, Watson RJ | title = B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107 | journal = Oncogene | volume = 21 | issue = 52 | pages = 7923–32 | date = Nov 2002 | pmid = 12439743 | doi = 10.1038/sj.onc.1206001 }}</ref>
* [[Cyclin-dependent kinase 2]],<ref name = pmid9891079>{{cite journal | vauthors = Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E | title = Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest | journal = Molecular and Cellular Biology | volume = 19 | issue = 2 | pages = 1460–9 | date = Feb 1999 | pmid = 9891079 | pmc = 116074 | doi =  10.1128/mcb.19.2.1460}}</ref><ref name = pmid11884610>{{cite journal | vauthors = Leng X, Noble M, Adams PD, Qin J, Harper JW | title = Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4 | journal = Molecular and Cellular Biology | volume = 22 | issue = 7 | pages = 2242–54 | date = Apr 2002 | pmid = 11884610 | pmc = 133692 | doi =  10.1128/mcb.22.7.2242-2254.2002}}</ref>
* [[E2F1]],<ref name = pmid8230483>{{cite journal | vauthors = Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K | title = Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1 | journal = Journal of Virology | volume = 67 | issue = 12 | pages = 7641–7 | date = Dec 1993 | pmid = 8230483 | pmc = 238233 | doi =  }}</ref>
* [[HDAC1]],<ref name = pmid10490602>{{cite journal | vauthors = Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE | title = RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins | journal = Molecular and Cellular Biology | volume = 19 | issue = 10 | pages = 6632–41 | date = Oct 1999 | pmid = 10490602 | pmc = 84642 | doi =  10.1128/mcb.19.10.6632}}</ref><ref name = pmid9724731>{{cite journal | vauthors = Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D | title = The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 18 | pages = 10493–8 | date = Sep 1998 | pmid = 9724731 | pmc = 27922 | doi =  10.1073/pnas.95.18.10493}}</ref>
* [[MYBL2]]<ref name = pmid12439743/><ref name = pmid12947099>{{cite journal | vauthors = Joaquin M, Watson RJ | title = The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 45 | pages = 44255–64 | date = Nov 2003 | pmid = 12947099 | doi = 10.1074/jbc.M308953200 }}</ref>
* [[Mothers against decapentaplegic homolog 3]],<ref name = pmid12150994>{{cite journal | vauthors = Chen CR, Kang Y, Siegel PM, Massagué J | title = E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression | journal = Cell | volume = 110 | issue = 1 | pages = 19–32 | date = Jul 2002 | pmid = 12150994 | doi =  10.1016/s0092-8674(02)00801-2}}</ref>
* [[Prohibitin]],<ref name = pmid10376528>{{cite journal | vauthors = Wang S, Nath N, Adlam M, Chellappan S | title = Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function | journal = Oncogene | volume = 18 | issue = 23 | pages = 3501–10 | date = Jun 1999 | pmid = 10376528 | doi = 10.1038/sj.onc.1202684 }}</ref>  and
* [[RBBP8]].<ref name = pmid9721205>{{cite journal | vauthors = Fusco C, Reymond A, Zervos AS | title = Molecular cloning and characterization of a novel retinoblastoma-binding protein | journal = Genomics | volume = 51 | issue = 3 | pages = 351–8 | date = Aug 1998 | pmid = 9721205 | doi = 10.1006/geno.1998.5368 }}</ref><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
{{Div col end}}
 
== See also ==
* [[Pocket protein family]]
* [[Pocket protein family]]


==References==
== References ==
{{reflist|2}}
{{Reflist|33em}}
{{NLM content}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{Refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E | title = Interaction between human cyclin A and adenovirus E1A-associated p107 protein | journal = Science | volume = 255 | issue = 5040 | pages = 87–90 | date = Jan 1992 | pmid = 1532458 | doi = 10.1126/science.1532458 }}
| citations =
* {{cite journal | vauthors = Ewen ME, Xing YG, Lawrence JB, Livingston DM | title = Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein | journal = Cell | volume = 66 | issue = 6 | pages = 1155–64 | date = Sep 1991 | pmid = 1833063 | doi = 10.1016/0092-8674(91)90038-Z }}
*{{cite journal | author=Faha B, Ewen ME, Tsai LH, ''et al.'' |title=Interaction between human cyclin A and adenovirus E1A-associated p107 protein. |journal=Science |volume=255 |issue= 5040 |pages= 87-90 |year= 1992 |pmid= 1532458 |doi= }}
* {{cite journal | vauthors = Datta PK, Raychaudhuri P, Bagchi S | title = Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription | journal = Molecular and Cellular Biology | volume = 15 | issue = 10 | pages = 5444–52 | date = Oct 1995 | pmid = 7565695 | pmc = 230794 | doi =  10.1128/mcb.15.10.5444}}
*{{cite journal | author=Ewen ME, Xing YG, Lawrence JB, Livingston DM |title=Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. |journal=Cell |volume=66 |issue= 6 |pages= 1155-64 |year= 1991 |pmid= 1833063 |doi= }}
* {{cite journal | vauthors = Zhu L, Zhu L, Xie E, Chang LS | title = Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins | journal = Molecular and Cellular Biology | volume = 15 | issue = 7 | pages = 3552–62 | date = Jul 1995 | pmid = 7791762 | pmc = 230592 | doi =  10.1128/mcb.15.7.3552}}
*{{cite journal | author=Datta PK, Raychaudhuri P, Bagchi S |title=Association of p107 with Sp1: genetically separable regions of p107 are involved in regulation of E2F- and Sp1-dependent transcription. |journal=Mol. Cell. Biol. |volume=15 |issue= 10 |pages= 5444-52 |year= 1995 |pmid= 7565695 |doi=  }}
* {{cite journal | vauthors = Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA | title = E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 6 | pages = 2403–7 | date = Mar 1995 | pmid = 7892279 | pmc = 42492 | doi = 10.1073/pnas.92.6.2403 }}
*{{cite journal | author=Zhu L, Zhu L, Xie E, Chang LS |title=Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 7 |pages= 3552-62 |year= 1995 |pmid= 7791762 |doi=  }}
* {{cite journal | vauthors = Kim YW, Otterson GA, Kratzke RA, Coxon AB, Kaye FJ | title = Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein | journal = Molecular and Cellular Biology | volume = 14 | issue = 11 | pages = 7256–64 | date = Nov 1994 | pmid = 7935440 | pmc = 359260 | doi =  10.1128/mcb.14.11.7256}}
*{{cite journal | author=Sardet C, Vidal M, Cobrinik D, ''et al.'' |title=E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 2403-7 |year= 1995 |pmid= 7892279 |doi= }}
* {{cite journal | vauthors = Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM | title = E2F-4, a new member of the E2F transcription factor family, interacts with p107 | journal = Genes & Development | volume = 8 | issue = 22 | pages = 2665–79 | date = Nov 1994 | pmid = 7958924 | doi = 10.1101/gad.8.22.2665 }}
*{{cite journal | author=Kim YW, Otterson GA, Kratzke RA, ''et al.'' |title=Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. |journal=Mol. Cell. Biol. |volume=14 |issue= 11 |pages= 7256-64 |year= 1994 |pmid= 7935440 |doi=  }}
* {{cite journal | vauthors = Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R | title = E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo | journal = Genes & Development | volume = 8 | issue = 22 | pages = 2680–90 | date = Nov 1994 | pmid = 7958925 | doi = 10.1101/gad.8.22.2680 }}
*{{cite journal | author=Ginsberg D, Vairo G, Chittenden T, ''et al.'' |title=E2F-4, a new member of the E2F transcription factor family, interacts with p107. |journal=Genes Dev. |volume=8 |issue= 22 |pages= 2665-79 |year= 1994 |pmid= 7958924 |doi= }}
* {{cite journal | vauthors = Beijersbergen RL, Hijmans EM, Zhu L, Bernards R | title = Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation | journal = The EMBO Journal | volume = 13 | issue = 17 | pages = 4080–6 | date = Sep 1994 | pmid = 8076603 | pmc = 395329 | doi =  }}
*{{cite journal | author=Beijersbergen RL, Kerkhoven RM, Zhu L, ''et al.'' |title=E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. |journal=Genes Dev. |volume=8 |issue= 22 |pages= 2680-90 |year= 1994 |pmid= 7958925 |doi= }}
* {{cite journal | vauthors = Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K | title = Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1 | journal = Journal of Virology | volume = 67 | issue = 12 | pages = 7641–7 | date = Dec 1993 | pmid = 8230483 | pmc = 238233 | doi =  }}
*{{cite journal | author=Beijersbergen RL, Hijmans EM, Zhu L, Bernards R |title=Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. |journal=EMBO J. |volume=13 |issue= 17 |pages= 4080-6 |year= 1994 |pmid= 8076603 |doi=  }}
* {{cite journal | vauthors = Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D, Dyson N, Harlow E | title = Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein | journal = Genes & Development | volume = 7 | issue = 7A | pages = 1111–25 | date = Jul 1993 | pmid = 8319904 | doi = 10.1101/gad.7.7a.1111 }}
*{{cite journal | author=Dyson N, Dembski M, Fattaey A, ''et al.'' |title=Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. |journal=J. Virol. |volume=67 |issue= 12 |pages= 7641-7 |year= 1993 |pmid= 8230483 |doi=  }}
* {{cite journal | vauthors = Ikeda MA, Jakoi L, Nevins JR | title = A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 8 | pages = 3215–20 | date = Apr 1996 | pmid = 8622916 | pmc = 39585 | doi = 10.1073/pnas.93.8.3215 }}
*{{cite journal | author=Zhu L, van den Heuvel S, Helin K, ''et al.'' |title=Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. |journal=Genes Dev. |volume=7 |issue= 7A |pages= 1111-25 |year= 1993 |pmid= 8319904 |doi= }}
* {{cite journal | vauthors = Xiao ZX, Ginsberg D, Ewen M, Livingston DM | title = Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 4633–7 | date = May 1996 | pmid = 8643455 | pmc = 39330 | doi = 10.1073/pnas.93.10.4633 }}
*{{cite journal | author=Ikeda MA, Jakoi L, Nevins JR |title=A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3215-20 |year= 1996 |pmid= 8622916 |doi= }}
* {{cite journal | vauthors = Vidal M, Brachmann RK, Fattaey A, Harlow E, Boeke JD | title = Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 19 | pages = 10315–20 | date = Sep 1996 | pmid = 8816797 | pmc = 38381 | doi = 10.1073/pnas.93.19.10315 }}
*{{cite journal | author=Xiao ZX, Ginsberg D, Ewen M, Livingston DM |title=Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 4633-7 |year= 1996 |pmid= 8643455 |doi= }}
* {{cite journal | vauthors = Shao Z, Siegert JL, Ruppert S, Robbins PD | title = Rb interacts with TAF(II)250/TFIID through multiple domains | journal = Oncogene | volume = 15 | issue = 4 | pages = 385–92 | date = Jul 1997 | pmid = 9242374 | doi = 10.1038/sj.onc.1201204 }}
*{{cite journal | author=Vidal M, Brachmann RK, Fattaey A, ''et al.'' |title=Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10315-20 |year= 1996 |pmid= 8816797 |doi= }}
* {{cite journal | vauthors = Verona R, Moberg K, Estes S, Starz M, Vernon JP, Lees JA | title = E2F activity is regulated by cell cycle-dependent changes in subcellular localization | journal = Molecular and Cellular Biology | volume = 17 | issue = 12 | pages = 7268–82 | date = Dec 1997 | pmid = 9372959 | pmc = 232584 | doi =  10.1128/mcb.17.12.7268}}
*{{cite journal | author=Shao Z, Siegert JL, Ruppert S, Robbins PD |title=Rb interacts with TAF(II)250/TFIID through multiple domains. |journal=Oncogene |volume=15 |issue= 4 |pages= 385-92 |year= 1997 |pmid= 9242374 |doi= 10.1038/sj.onc.1201204 }}
* {{cite journal | vauthors = Trimarchi JM, Fairchild B, Verona R, Moberg K, Andon N, Lees JA | title = E2F-6, a member of the E2F family that can behave as a transcriptional repressor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 6 | pages = 2850–5 | date = Mar 1998 | pmid = 9501179 | pmc = 19658 | doi = 10.1073/pnas.95.6.2850 }}
*{{cite journal | author=Verona R, Moberg K, Estes S, ''et al.'' |title=E2F activity is regulated by cell cycle-dependent changes in subcellular localization. |journal=Mol. Cell. Biol. |volume=17 |issue= 12 |pages= 7268-82 |year= 1997 |pmid= 9372959 |doi=  }}
* {{cite journal | vauthors = Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM | title = Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7 | journal = Molecular and Cellular Biology | volume = 18 | issue = 5 | pages = 2748–57 | date = May 1998 | pmid = 9566894 | pmc = 110654 | doi =  10.1128/mcb.18.5.2748}}
*{{cite journal | author=Trimarchi JM, Fairchild B, Verona R, ''et al.'' |title=E2F-6, a member of the E2F family that can behave as a transcriptional repressor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 6 |pages= 2850-5 |year= 1998 |pmid= 9501179 |doi= }}
* {{cite journal | vauthors = Woitach JT, Zhang M, Niu CH, Thorgeirsson SS | title = A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability | journal = Nature Genetics | volume = 19 | issue = 4 | pages = 371–4 | date = Aug 1998 | pmid = 9697699 | doi = 10.1038/1258 }}
*{{cite journal | author=Sterner JM, Dew-Knight S, Musahl C, ''et al.'' |title=Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2748-57 |year= 1998 |pmid= 9566894 |doi=  }}
* {{cite journal | vauthors = Veal E, Eisenstein M, Tseng ZH, Gill G | title = A cellular repressor of E1A-stimulated genes that inhibits activation by E2F | journal = Molecular and Cellular Biology | volume = 18 | issue = 9 | pages = 5032–41 | date = Sep 1998 | pmid = 9710587 | pmc = 109088 | doi =  10.1128/mcb.18.9.5032}}
*{{cite journal | author=Woitach JT, Zhang M, Niu CH, Thorgeirsson SS |title=A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. |journal=Nat. Genet. |volume=19 |issue= 4 |pages= 371-4 |year= 1998 |pmid= 9697699 |doi= 10.1038/1258 }}
{{Refend}}
*{{cite journal | author=Veal E, Eisenstein M, Tseng ZH, Gill G |title=A cellular repressor of E1A-stimulated genes that inhibits activation by E2F. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5032-41 |year= 1998 |pmid= 9710587 |doi=  }}
}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|RBL1+protein,+human}}
* {{MeshName|RBL1+protein,+human}}


{{Transcription factors|g0}}


{{protein-stub}}
{{DEFAULTSORT:Retinoblastoma-Like Protein 1}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]

Latest revision as of 16:56, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.[1][2]

Function

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.[1]

Interactions

Retinoblastoma-like protein 1 has been shown to interact with:

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: RBL1 retinoblastoma-like 1 (p107)".
  2. ↑ Ewen ME, Xing YG, Lawrence JB, Livingston DM (Sep 1991). "Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein". Cell. 66 (6): 1155–64. doi:10.1016/0092-8674(91)90038-Z. PMID 1833063.
  3. ↑ 3.0 3.1 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  4. ↑ Fan S, Yuan R, Ma YX, Xiong J, Meng Q, Erdos M, Zhao JN, Goldberg ID, Pestell RG, Rosen EM (Aug 2001). "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene. 20 (35): 4827–41. doi:10.1038/sj.onc.1204666. PMID 11521194.
  5. ↑ Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ (Jun 1999). "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Molecular and Cellular Biology. 19 (6): 4255–61. doi:10.1128/mcb.19.6.4255. PMC 104385. PMID 10330166.
  6. ↑ 6.0 6.1 Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (Dec 1993). "Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1". Journal of Virology. 67 (12): 7641–7. PMC 238233. PMID 8230483.
  7. ↑ 7.0 7.1 Joaquin M, Bessa M, Saville MK, Watson RJ (Nov 2002). "B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107". Oncogene. 21 (52): 7923–32. doi:10.1038/sj.onc.1206001. PMID 12439743.
  8. ↑ Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (Feb 1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Molecular and Cellular Biology. 19 (2): 1460–9. doi:10.1128/mcb.19.2.1460. PMC 116074. PMID 9891079.
  9. ↑ Leng X, Noble M, Adams PD, Qin J, Harper JW (Apr 2002). "Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4". Molecular and Cellular Biology. 22 (7): 2242–54. doi:10.1128/mcb.22.7.2242-2254.2002. PMC 133692. PMID 11884610.
  10. ↑ Lai A, Lee JM, Yang WM, DeCaprio JA, Kaelin WG, Seto E, Branton PE (Oct 1999). "RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins". Molecular and Cellular Biology. 19 (10): 6632–41. doi:10.1128/mcb.19.10.6632. PMC 84642. PMID 10490602.
  11. ↑ Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep 1998). "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United States of America. 95 (18): 10493–8. doi:10.1073/pnas.95.18.10493. PMC 27922. PMID 9724731.
  12. ↑ Joaquin M, Watson RJ (Nov 2003). "The cell cycle-regulated B-Myb transcription factor overcomes cyclin-dependent kinase inhibitory activity of p57(KIP2) by interacting with its cyclin-binding domain". The Journal of Biological Chemistry. 278 (45): 44255–64. doi:10.1074/jbc.M308953200. PMID 12947099.
  13. ↑ Chen CR, Kang Y, Siegel PM, Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell. 110 (1): 19–32. doi:10.1016/s0092-8674(02)00801-2. PMID 12150994.
  14. ↑ Wang S, Nath N, Adlam M, Chellappan S (Jun 1999). "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene. 18 (23): 3501–10. doi:10.1038/sj.onc.1202684. PMID 10376528.
  15. ↑ Fusco C, Reymond A, Zervos AS (Aug 1998). "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics. 51 (3): 351–8. doi:10.1006/geno.1998.5368. PMID 9721205.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Further reading

External links

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