SIX5: Difference between revisions

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Latest revision as of 15:45, 8 October 2017

Homeobox protein SIX5 is a protein that in humans is encoded by the SIX5 gene.^[1]^[2]

References

↑ Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL (Apr 1996). "A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat". Hum Mol Genet. 4 (10): 1919–25. doi:10.1093/hmg/4.10.1919. PMID 8595416.
↑ "Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)".

Murakami Y, Ohto H, Ikeda U, Shimada K, Momoi T, Kawakami K (1999). "Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements". Hum. Mol. Genet. 7 (13): 2103–12. doi:10.1093/hmg/7.13.2103. PMID 9817928.
Winchester CL, Ferrier RK, Sermoni A, Clark BJ, Johnson KJ (1999). "Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy". Hum. Mol. Genet. 8 (3): 481–92. doi:10.1093/hmg/8.3.481. PMID 9949207.
Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K (2000). "Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya". Mol. Cell. Biol. 19 (10): 6815–24. doi:10.1128/mcb.19.10.6815. PMC 84678. PMID 10490620.
Harris SE, Winchester CL, Johnson KJ (2000). "Functional analysis of the homeodomain protein SIX5". Nucleic Acids Res. 28 (9): 1871–8. doi:10.1093/nar/28.9.1871. PMC 103302. PMID 10756185.
Winchester C, Robertson S, MacLeod T, Johnson K, Thomas M (2000). "Expression of a homeobox gene (SIX5) in borderline ovarian tumours". J. Clin. Pathol. 53 (3): 212–7. doi:10.1136/jcp.53.3.212. PMC 1731149. PMID 10823141.
Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences". J. Biol. Chem. 277 (9): 7021–8. doi:10.1074/jbc.M108417200. PMID 11748221.
Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K (2002). "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1". Hum. Mol. Genet. 11 (9): 1045–58. doi:10.1093/hmg/11.9.1045. PMID 11978764.
Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P (2003). "Six and Eya expression during human somitogenesis and MyoD gene family activation". J. Muscle Res. Cell. Motil. 23 (3): 255–64. doi:10.1023/A:1020990825644. PMID 12500905.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F (2007). "Transcription Factor SIX5 Is Mutated in Patients with Branchio-Oto-Renal Syndrome". Am. J. Hum. Genet. 80 (4): 800–4. doi:10.1086/513322. PMC 1852719. PMID 17357085.

External links

FactorBook SIX5

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid8595416-1] Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL (Apr 1996). "A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat". Hum Mol Genet. 4 (10): 1919–25. doi:10.1093/hmg/4.10.1919. PMID 8595416.

[entrez-2] "Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Homeobox protein SIX5''' is a [[protein]] that in humans is encoded by the ''SIX5'' [[gene]].<ref name="pmid8595416">{{cite journal | vauthors = Boucher CA, King SK, Carey N, Krahe R, Winchester CL, Rahman S, Creavin T, Meghji P, Bailey ME, Chartier FL | title = A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat | journal = Hum Mol Genet | volume = 4 | issue = 10 | pages = 1919–25 | date = Apr 1996 | pmid = 8595416 | pmc =  | doi = 10.1093/hmg/4.10.1919 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147912| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== References ==
-{{GNF_Protein_box
+{{reflist}}
- | image =
- | image_source =
- | PDB =
- | Name = Sine oculis homeobox homolog 5 (Drosophila)
- | HGNCid = 10891
- | Symbol = SIX5
- | AltSymbols =; DMAHP
- | OMIM = 600963
- | ECnumber =
- | Homologene = 72248
- | MGIid = 106220
- | GeneAtlas_image1 = PBB_GE_SIX5_217661_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 147912
-    | Hs_Ensembl = ENSG00000177045
-    | Hs_RefseqProtein = NP_787071
-    | Hs_RefseqmRNA = NM_175875
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 50959884
-    | Hs_GenLoc_end = 50964152
-    | Hs_Uniprot = Q8N196
-    | Mm_EntrezGene = 20475
-    | Mm_Ensembl = ENSMUSG00000040841
-    | Mm_RefseqmRNA = NM_011383
-    | Mm_RefseqProtein = NP_035513
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 7
-    | Mm_GenLoc_start = 18253066
-    | Mm_GenLoc_end = 18256867
-    | Mm_Uniprot = P70178
-  }}
-}}
-'''Sine oculis homeobox homolog 5 (Drosophila)''', also known as '''SIX5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SIX5 sine oculis homeobox homolog 5 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147912| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Further reading ==
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
-{{reflist|2}}
-==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Murakami Y, Ohto H, Ikeda U, Shimada K, Momoi T, Kawakami K | title = Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements | journal = Hum. Mol. Genet. | volume = 7 | issue = 13 | pages = 2103–12 | year = 1999 | pmid = 9817928 | doi = 10.1093/hmg/7.13.2103 }}
-| citations =
+* {{cite journal | vauthors = Winchester CL, Ferrier RK, Sermoni A, Clark BJ, Johnson KJ | title = Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy | journal = Hum. Mol. Genet. | volume = 8 | issue = 3 | pages = 481–92 | year = 1999 | pmid = 9949207 | doi = 10.1093/hmg/8.3.481 }}
-*{{cite journal  | author=Boucher CA, King SK, Carey N, ''et al.'' |title=A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. |journal=Hum. Mol. Genet. |volume=4 |issue= 10 |pages= 1919-25 |year= 1996 |pmid= 8595416 |doi=  }}
+* {{cite journal | vauthors = Ohto H, Kamada S, Tago K, Tominaga SI, Ozaki H, Sato S, Kawakami K | title = Cooperation of Six and Eya in Activation of Their Target Genes through Nuclear Translocation of Eya | journal = Mol. Cell. Biol. | volume = 19 | issue = 10 | pages = 6815–24 | year = 2000 | pmid = 10490620 | pmc = 84678 | doi =  10.1128/mcb.19.10.6815}}
-*{{cite journal  | author=Murakami Y, Ohto H, Ikeda U, ''et al.'' |title=Promoter of mDMAHP/Six5: differential utilization of multiple transcription initiation sites and positive/negative regulatory elements. |journal=Hum. Mol. Genet. |volume=7 |issue= 13 |pages= 2103-12 |year= 1999 |pmid= 9817928 |doi=  }}
+* {{cite journal | vauthors = Harris SE, Winchester CL, Johnson KJ | title = Functional analysis of the homeodomain protein SIX5 | journal = Nucleic Acids Res. | volume = 28 | issue = 9 | pages = 1871–8 | year = 2000 | pmid = 10756185 | pmc = 103302 | doi = 10.1093/nar/28.9.1871 }}
-*{{cite journal  | author=Winchester CL, Ferrier RK, Sermoni A, ''et al.'' |title=Characterization of the expression of DMPK and SIX5 in the human eye and implications for pathogenesis in myotonic dystrophy. |journal=Hum. Mol. Genet. |volume=8 |issue= 3 |pages= 481-92 |year= 1999 |pmid= 9949207 |doi=  }}
+* {{cite journal | vauthors = Winchester C, Robertson S, MacLeod T, Johnson K, Thomas M | title = Expression of a homeobox gene (SIX5) in borderline ovarian tumours | journal = J. Clin. Pathol. | volume = 53 | issue = 3 | pages = 212–7 | year = 2000 | pmid = 10823141 | pmc = 1731149 | doi = 10.1136/jcp.53.3.212 }}
-*{{cite journal  | author=Ohto H, Kamada S, Tago K, ''et al.'' |title=Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6815-24 |year= 2000 |pmid= 10490620 |doi=  }}
+* {{cite journal | vauthors = Dintilhac A, Bernués J | title = HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences | journal = J. Biol. Chem. | volume = 277 | issue = 9 | pages = 7021–8 | year = 2002 | pmid = 11748221 | doi = 10.1074/jbc.M108417200 }}
-*{{cite journal  | author=Harris SE, Winchester CL, Johnson KJ |title=Functional analysis of the homeodomain protein SIX5. |journal=Nucleic Acids Res. |volume=28 |issue= 9 |pages= 1871-8 |year= 2000 |pmid= 10756185 |doi=  }}
+* {{cite journal | vauthors = Sato S, Nakamura M, Cho DH, Tapscott SJ, Ozaki H, Kawakami K | title = Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1 | journal = Hum. Mol. Genet. | volume = 11 | issue = 9 | pages = 1045–58 | year = 2002 | pmid = 11978764 | doi = 10.1093/hmg/11.9.1045 }}
-*{{cite journal  | author=Winchester C, Robertson S, MacLeod T, ''et al.'' |title=Expression of a homeobox gene (SIX5) in borderline ovarian tumours. |journal=J. Clin. Pathol. |volume=53 |issue= 3 |pages= 212-7 |year= 2000 |pmid= 10823141 |doi=  }}
+* {{cite journal | vauthors = Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P | title = Six and Eya expression during human somitogenesis and MyoD gene family activation | journal = J. Muscle Res. Cell. Motil. | volume = 23 | issue = 3 | pages = 255–64 | year = 2003 | pmid = 12500905 | doi = 10.1023/A:1020990825644 }}
-*{{cite journal  | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021-8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
+* {{cite journal|authorlink13=Huda Zoghbi | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Sato S, Nakamura M, Cho DH, ''et al.'' |title=Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1. |journal=Hum. Mol. Genet. |volume=11 |issue= 9 |pages= 1045-58 |year= 2002 |pmid= 11978764 |doi=  }}
+* {{cite journal | vauthors = Hoskins BE, Cramer CH, Silvius D, Zou D, Raymond RM, Orten DJ, Kimberling WJ, Smith RJ, Weil D, Petit C, Otto EA, Xu PX, Hildebrandt F | title = Transcription Factor SIX5 Is Mutated in Patients with Branchio-Oto-Renal Syndrome | journal = Am. J. Hum. Genet. | volume = 80 | issue = 4 | pages = 800–4 | year = 2007 | pmid = 17357085 | pmc = 1852719 | doi = 10.1086/513322 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Fougerousse F, Durand M, Lopez S, ''et al.'' |title=Six and Eya expression during human somitogenesis and MyoD gene family activation. |journal=J. Muscle Res. Cell. Motil. |volume=23 |issue= 3 |pages= 255-64 |year= 2003 |pmid= 12500905 |doi=  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
-*{{cite journal  | author=Hoskins BE, Cramer CH, Silvius D, ''et al.'' |title=Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome. |journal=Am. J. Hum. Genet. |volume=80 |issue= 4 |pages= 800-4 |year= 2007 |pmid= 17357085 |doi= 10.1086/513322 }}
-}}
 {{refend}}
-{{protein-stub}}
+== External links ==
-{{WikiDoc Sources}}
+* {{FactorBook|SIX5}}
+{{Transcription factors|g3}}
+[[Category:Transcription factors]]
+{{gene-19-stub}}

SIX5: Difference between revisions

Latest revision as of 15:45, 8 October 2017

References

Further reading

External links

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