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{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein 638''' is a [[protein]] that in humans is encoded by the ''ZNF638'' [[gene]].<ref name="pmid8647861">{{cite journal |vauthors=Inagaki H, Matsushima Y, Nakamura K, Ohshima M, Kadowaki T, Kitagawa Y | title = A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain | journal = J Biol Chem | volume = 271 | issue = 21 | pages = 12525–31 |date=Jul 1996 | pmid = 8647861 | pmc =  | doi =10.1074/jbc.271.21.12525 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ZNF638 zinc finger protein 638| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27332| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Zinc finger protein 638
| HGNCid = 17894
| Symbol = ZNF638
| AltSymbols =; DKFZp686P1231; MGC26130; MGC90196; NP220; ZFML; Zfp638
| OMIM = 
| ECnumber = 
| Homologene = 7447
| MGIid = 1203484
| GeneAtlas_image1 = PBB_GE_ZNF638_213775_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_ZNF638_211257_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003690 |text = double-stranded DNA binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27332
    | Hs_Ensembl = ENSG00000075292
    | Hs_RefseqProtein = NP_001014972
    | Hs_RefseqmRNA = NM_001014972
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 71412397
    | Hs_GenLoc_end = 71515695
    | Hs_Uniprot = Q14966
    | Mm_EntrezGene = 18139
    | Mm_Ensembl = ENSMUSG00000030016
    | Mm_RefseqmRNA = NM_008717
    | Mm_RefseqProtein = NP_032743
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 83880025
    | Mm_GenLoc_end = 83952527
    | Mm_Uniprot = Q3TNM0
  }}
}}
'''Zinc finger protein 638''', also known as '''ZNF638''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ZNF638 zinc finger protein 638| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27332| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: ZNF638 zinc finger protein 638| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27332| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: ZNF638 zinc finger protein 638| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27332| accessdate = }}</ref>
}}
}}
==Interactions==
ZNF638 has been shown to [[Protein-protein interaction|interact]] with [[FHL2]].<ref name=pmid11813260>{{cite journal |last=Ng |first=Enders Kai On |authorlink= |author2=Chan Kwok Keung |author3=Wong Chi Hang |author4=Tsui Stephen Kwok Wing |author5=Ngai Sai Ming |author6=Lee Simon Ming Yuen |author7=Kotaka Masayo |author8=Lee Cheuk Yu |author9=Waye Mary Miu Yee |author10=Fung Kwok Pui  |year=2002|title=Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220 |journal=J. Cell. Biochem. |volume=84 |issue=3 |pages=556–66 |publisher= |location = United States| issn = 0730-2312| pmid = 11813260 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1002/jcb.10041 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Inagaki H, Matsushima Y, Nakamura K, ''et al.'' |title=A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12525-31 |year= 1996 |pmid= 8647861 |doi=  }}
*{{cite journal   |vauthors=Okumara K, Nogami M, Matsushima Y, etal |title=Mapping of human DNA-binding nuclear protein (NP220) to chromosome band 2p13.1-p13.2 and its relation to matrin 3. |journal=Biosci. Biotechnol. Biochem. |volume=62 |issue= 8 |pages= 1640–2 |year= 1998 |pmid= 9757574 |doi=10.1271/bbb.62.1640 }}
*{{cite journal  | author=Okumara K, Nogami M, Matsushima Y, ''et al.'' |title=Mapping of human DNA-binding nuclear protein (NP220) to chromosome band 2p13.1-p13.2 and its relation to matrin 3. |journal=Biosci. Biotechnol. Biochem. |volume=62 |issue= 8 |pages= 1640-2 |year= 1998 |pmid= 9757574 |doi=  }}
*{{cite journal   |vauthors=Eichmuller S, Usener D, Dummer R, etal |title=Serological detection of cutaneous T-cell lymphoma-associated antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 629–34 |year= 2001 |pmid= 11149944 |doi= 10.1073/pnas.021386498 | pmc=14639 }}
*{{cite journal | author=Eichmuller S, Usener D, Dummer R, ''et al.'' |title=Serological detection of cutaneous T-cell lymphoma-associated antigens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 2 |pages= 629-34 |year= 2001 |pmid= 11149944 |doi= 10.1073/pnas.021386498 }}
*{{cite journal   |vauthors=Ng EK, Chan KK, Wong CH, etal |title=Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220. |journal=J. Cell. Biochem. |volume=84 |issue= 3 |pages= 556–66 |year= 2002 |pmid= 11813260 |doi=10.1002/jcb.10041 }}
*{{cite journal | author=Ng EK, Chan KK, Wong CH, ''et al.'' |title=Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220. |journal=J. Cell. Biochem. |volume=84 |issue= 3 |pages= 556-66 |year= 2002 |pmid= 11813260 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Benzinger A, Muster N, Koch HB, etal |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
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* {{MeshName|ZNF638+protein,+human}}
* {{MeshName|ZNF638+protein,+human}}


{{NLM content}}
{{Transcription factors|g2}}
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Latest revision as of 02:56, 27 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene.[1][2]

The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.[2]

Interactions

ZNF638 has been shown to interact with FHL2.[3]

References

  1. ↑ Inagaki H, Matsushima Y, Nakamura K, Ohshima M, Kadowaki T, Kitagawa Y (Jul 1996). "A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain". J Biol Chem. 271 (21): 12525–31. doi:10.1074/jbc.271.21.12525. PMID 8647861.
  2. ↑ 2.0 2.1 "Entrez Gene: ZNF638 zinc finger protein 638".
  3. ↑ Ng, Enders Kai On; Chan Kwok Keung; Wong Chi Hang; Tsui Stephen Kwok Wing; Ngai Sai Ming; Lee Simon Ming Yuen; Kotaka Masayo; Lee Cheuk Yu; Waye Mary Miu Yee; Fung Kwok Pui (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. United States. 84 (3): 556–66. doi:10.1002/jcb.10041. ISSN 0730-2312. PMID 11813260.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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