PEG3: Difference between revisions
Jump to navigation
Jump to search
m (Bot: HTTP→HTTPS) |
No edit summary |
||
| Line 1: | Line 1: | ||
{{Infobox_gene}} | {{Infobox_gene}} | ||
'''Paternally-expressed gene 3 protein''' is a [[protein]] that in humans is encoded by the '' | '''Paternally-expressed gene 3 protein''' is a [[protein]] that in humans is encoded by the ''PEG3'' [[gene]].<ref name="pmid9149948">{{cite journal |vauthors=Kim J, Ashworth L, Branscomb E, Stubbs L | title = The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4 | journal = Genome Res | volume = 7 | issue = 5 | pages = 532–40 |date=August 1997 | pmid = 9149948 | pmc = 310658 | doi = 10.1101/gr.7.5.532}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PEG3 paternally expressed 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5178| accessdate = }}</ref> PEG3 is an [[imprinted gene]] expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.<ref>{{cite web|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0083359|| volume = 8 | issue = 12 |author1=Michelle M. Thiaville |author2=Jennifer M. Huang |author3=Hana Kim |author4=Muhammad B. Ekram |author5=Arundhati Bakshi |author6=Tae-Young Roh |author7=Joomyeong Kim |date=December 31, 2013|| accessdate = May 22, 2014|title=Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families}}</ref> PEG3 is a transcription factor that binds to DNA [11-13] via the [[sequence motif]] AGTnnCnnnTGGCT, which it binds to using multiple [[Kruppel-like factors]]. It also regulate the expression of Pgm2l1 through the binding of the motif.<ref name="pmid23078764 ">{{cite journal |vauthors=Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J | title = DNA-binding motif and target genes of the imprinted transcription factor PEG3 | journal = Gene | volume = 512 | issue = 2 | pages = 314–320 |date=January 2013 | pmid = 23078764 | pmc = 3513644 | doi = 10.1016/j.gene.2012.10.005}}</ref> | ||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
| Line 9: | Line 9: | ||
==Interactions== | ==Interactions== | ||
PEG3 has been shown to [[Protein-protein interaction|interact]] with [[SIAH2]]<ref name=pmid10681424>{{cite journal |last=Relaix |first=F |authorlink= |author2=Wei X j |author3=Li W |author4=Pan J |author5=Lin Y |author6=Bowtell D D |author7=Sassoon D A |author8=Wu X |date=February 2000 |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=5 |pages=2105–10 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10681424 |doi = 10.1073/pnas.040378897 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=15761 }}</ref> and [[SIAH1]].<ref name=pmid10681424/> | PEG3 has been shown to [[Protein-protein interaction|interact]] with [[SIAH2]]<ref name=pmid10681424>{{cite journal |last=Relaix |first=F |authorlink= |author2=Wei X j |author3=Li W |author4=Pan J |author5=Lin Y |author6=Bowtell D D |author7=Sassoon D A |author8=Wu X |date=February 2000 |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=5 |pages=2105–10 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10681424 |doi = 10.1073/pnas.040378897 | bibcode =2000PNAS...97.2105R | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=15761 }}</ref> and [[SIAH1]].<ref name=pmid10681424/> | ||
==References== | ==References== | ||
| Line 19: | Line 19: | ||
| citations = | | citations = | ||
*{{cite journal |vauthors=Relaix F, Wei XJ, Wu X, Sassoon DA |title=Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 287–91 |year= 1998 |pmid= 9500555 |doi= 10.1038/ng0398-287 }} | *{{cite journal |vauthors=Relaix F, Wei XJ, Wu X, Sassoon DA |title=Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 287–91 |year= 1998 |pmid= 9500555 |doi= 10.1038/ng0398-287 }} | ||
*{{cite journal |vauthors=Relaix F, Wei X, Li W, etal |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2105–10 |year= 2000 |pmid= 10681424 |doi= 10.1073/pnas.040378897 | pmc=15761 }} | *{{cite journal |vauthors=Relaix F, Wei X, Li W, etal |title=Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 5 |pages= 2105–10 |year= 2000 |pmid= 10681424 |doi= 10.1073/pnas.040378897 | pmc=15761 |bibcode=2000PNAS...97.2105R }} | ||
*{{cite journal |vauthors=Kim J, Bergmann A, Stubbs L |title=Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). |journal=Genomics |volume=64 |issue= 1 |pages= 114–8 |year= 2000 |pmid= 10708526 |doi= 10.1006/geno.1999.6112 }} | *{{cite journal |vauthors=Kim J, Bergmann A, Stubbs L |title=Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). |journal=Genomics |volume=64 |issue= 1 |pages= 114–8 |year= 2000 |pmid= 10708526 |doi= 10.1006/geno.1999.6112 }} | ||
*{{cite journal |vauthors=Kohda T, Asai A, Kuroiwa Y, etal |title=Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. |journal=Genes Cells |volume=6 |issue= 3 |pages= 237–47 |year= 2001 |pmid= 11260267 |doi=10.1046/j.1365-2443.2001.00412.x }} | *{{cite journal |vauthors=Kohda T, Asai A, Kuroiwa Y, etal |title=Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line. |journal=Genes Cells |volume=6 |issue= 3 |pages= 237–47 |year= 2001 |pmid= 11260267 |doi=10.1046/j.1365-2443.2001.00412.x }} | ||
| Line 25: | Line 25: | ||
*{{cite journal |vauthors=Yarden RI, Brody LC |title=Identification of proteins that interact with BRCA1 by Far-Western library screening. |journal=J. Cell. Biochem. |volume=83 |issue= 4 |pages= 521–31 |year= 2002 |pmid= 11746496 |doi=10.1002/jcb.1257 }} | *{{cite journal |vauthors=Yarden RI, Brody LC |title=Identification of proteins that interact with BRCA1 by Far-Western library screening. |journal=J. Cell. Biochem. |volume=83 |issue= 4 |pages= 521–31 |year= 2002 |pmid= 11746496 |doi=10.1002/jcb.1257 }} | ||
*{{cite journal |vauthors=Johnson MD, Wu X, Aithmitti N, Morrison RS |title=Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23000–7 |year= 2002 |pmid= 11943780 |doi= 10.1074/jbc.M201907200 }} | *{{cite journal |vauthors=Johnson MD, Wu X, Aithmitti N, Morrison RS |title=Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 23000–7 |year= 2002 |pmid= 11943780 |doi= 10.1074/jbc.M201907200 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Mirey G, Chartrain I, Froment C, etal |title=CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. |journal=Cell Cycle |volume=4 |issue= 6 |pages= 806–11 |year= 2006 |pmid= 15908796 |doi= 10.4161/cc.4.6.1716}} | *{{cite journal |vauthors=Mirey G, Chartrain I, Froment C, etal |title=CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis. |journal=Cell Cycle |volume=4 |issue= 6 |pages= 806–11 |year= 2006 |pmid= 15908796 |doi= 10.4161/cc.4.6.1716}} | ||
Latest revision as of 14:08, 6 August 2018
| VALUE_ERROR (nil) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Aliases | |||||||
| External IDs | GeneCards: [1] | ||||||
| Orthologs | |||||||
| Species | Human | Mouse | |||||
| Entrez |
|
| |||||
| Ensembl |
|
| |||||
| UniProt |
|
| |||||
| RefSeq (mRNA) |
|
| |||||
| RefSeq (protein) |
|
| |||||
| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
| |||||||
Paternally-expressed gene 3 protein is a protein that in humans is encoded by the PEG3 gene.[1][2] PEG3 is an imprinted gene expressed exclusively from the paternal allele and plays important roles in controlling fetal growth rates and nurturing behaviors as has potential roles in mammalian reproduction.[3] PEG3 is a transcription factor that binds to DNA [11-13] via the sequence motif AGTnnCnnnTGGCT, which it binds to using multiple Kruppel-like factors. It also regulate the expression of Pgm2l1 through the binding of the motif.[4]
Interactions
PEG3 has been shown to interact with SIAH2[5] and SIAH1.[5]
References
- ↑ Kim J, Ashworth L, Branscomb E, Stubbs L (August 1997). "The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4". Genome Res. 7 (5): 532–40. doi:10.1101/gr.7.5.532. PMC 310658. PMID 9149948.
- ↑ "Entrez Gene: PEG3 paternally expressed 3".
- ↑ Michelle M. Thiaville; Jennifer M. Huang; Hana Kim; Muhammad B. Ekram; Arundhati Bakshi; Tae-Young Roh; Joomyeong Kim (December 31, 2013). "Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families". Retrieved May 22, 2014.
- ↑ Thiaville MM, Huang JM, Kim H, Ekram MB, Roh TY, Kim J (January 2013). "DNA-binding motif and target genes of the imprinted transcription factor PEG3". Gene. 512 (2): 314–320. doi:10.1016/j.gene.2012.10.005. PMC 3513644. PMID 23078764.
- ↑ 5.0 5.1 Relaix, F; Wei X j; Li W; Pan J; Lin Y; Bowtell D D; Sassoon D A; Wu X (February 2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi:10.1073/pnas.040378897. ISSN 0027-8424. PMC 15761. PMID 10681424.
Further reading
- Relaix F, Wei XJ, Wu X, Sassoon DA (1998). "Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway". Nat. Genet. 18 (3): 287–91. doi:10.1038/ng0398-287. PMID 9500555.
- Relaix F, Wei X, Li W, et al. (2000). "Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis". Proc. Natl. Acad. Sci. U.S.A. 97 (5): 2105–10. Bibcode:2000PNAS...97.2105R. doi:10.1073/pnas.040378897. PMC 15761. PMID 10681424.
- Kim J, Bergmann A, Stubbs L (2000). "Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3)". Genomics. 64 (1): 114–8. doi:10.1006/geno.1999.6112. PMID 10708526.
- Kohda T, Asai A, Kuroiwa Y, et al. (2001). "Tumour suppressor activity of human imprinted gene PEG3 in a glioma cell line". Genes Cells. 6 (3): 237–47. doi:10.1046/j.1365-2443.2001.00412.x. PMID 11260267.
- Hiby SE, Lough M, Keverne EB, et al. (2001). "Paternal monoallelic expression of PEG3 in the human placenta". Hum. Mol. Genet. 10 (10): 1093–100. doi:10.1093/hmg/10.10.1093. PMID 11331620.
- Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496.
- Johnson MD, Wu X, Aithmitti N, Morrison RS (2002). "Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death". J. Biol. Chem. 277 (25): 23000–7. doi:10.1074/jbc.M201907200. PMID 11943780.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles at mitosis". Cell Cycle. 4 (6): 806–11. doi:10.4161/cc.4.6.1716. PMID 15908796.
- Dowdy SC, Gostout BS, Shridhar V, et al. (2005). "Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines". Gynecol. Oncol. 99 (1): 126–34. doi:10.1016/j.ygyno.2005.05.036. PMID 16023706.
- Chartrain I, Couturier A, Tassan JP (2006). "Cell-cycle-dependent cortical localization of pEg3 protein kinase in Xenopus and human cells". Biol. Cell. 98 (4): 253–63. doi:10.1042/BC20050041. PMID 16159311.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |