MLLT1: Difference between revisions

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'''Protein ENL''' is a [[protein]] that in humans is encoded by the ''MLLT1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4298| accessdate = }}</ref>
'''Protein ENL''' is a [[protein]] that in humans is encoded by the ''MLLT1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4298| accessdate = }}</ref>


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==Interactions==
== Interactions ==
MLLT1 has been shown to [[Protein-protein interaction|interact]] with [[CBX8]].<ref name=pmid11313972>{{cite journal |last=García-Cuéllar |first=M P |authorlink= |author2=Zilles O |author3=Schreiner S A |author4=Birke M |author5=Winkler T H |author6=Slany R K  |date=Jan 2001 |title=The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 |journal=Oncogene |volume=20 |issue=4 |pages=411–419 |publisher= |location = England| issn = 0950-9232| pmid = 11313972 |doi = 10.1038/sj.onc.1204108 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
MLLT1 has been shown to [[Protein-protein interaction|interact]] with [[CBX8]].<ref name=pmid11313972>{{cite journal | vauthors = García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK | title = The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 | journal = Oncogene | volume = 20 | issue = 4 | pages = 411–9 | date = January 2001 | pmid = 11313972 | doi = 10.1038/sj.onc.1204108 }}</ref>
 
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tkachuk DC, Kohler S, Cleary ML | title = Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias | journal = Cell | volume = 71 | issue = 4 | pages = 691–700 | date = November 1992 | pmid = 1423624 | doi = 10.1016/0092-8674(92)90602-9 }}
| citations =
* {{cite journal | vauthors = Thirman MJ, Levitan DA, Kobayashi H, Simon MC, Rowley JD | title = Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 25 | pages = 12110–4 | date = December 1994 | pmid = 7991593 | pmc = 45386 | doi = 10.1073/pnas.91.25.12110 }}
*{{cite journal |vauthors=Tkachuk DC, Kohler S, Cleary ML |title=Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias |journal=Cell |volume=71 |issue= 4 |pages= 691–700 |year= 1992 |pmid= 1423624 |doi=10.1016/0092-8674(92)90602-9 }}
* {{cite journal | vauthors = Rubnitz JE, Morrissey J, Savage PA, Cleary ML | title = ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells | journal = Blood | volume = 84 | issue = 6 | pages = 1747–52 | date = September 1994 | pmid = 8080983 | doi =  }}
*{{cite journal | author=Thirman MJ |title=Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 25 |pages= 12110–12114 |year= 1995 |pmid= 7991593 |doi=10.1073/pnas.91.25.12110 | pmc=45386  |name-list-format=vanc| author2=Levitan DA  | author3=Kobayashi H  | display-authors=3  | last4=Simon  | first4=MC  | last5=Rowley  | first5=JD  }}
* {{cite journal | vauthors = Yamamoto K, Seto M, Komatsu H, Iida S, Akao Y, Kojima S, Kodera Y, Nakazawa S, Ariyoshi Y, Takahashi T | title = Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia | journal = Oncogene | volume = 8 | issue = 10 | pages = 2617–25 | date = October 1993 | pmid = 8378076 | doi =  }}
*{{cite journal |vauthors=Rubnitz JE, Morrissey J, Savage PA, Cleary ML |title=ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells |journal=Blood |volume=84 |issue= 6 |pages= 1747–52 |year= 1994 |pmid= 8080983 |doi=  }}
* {{cite journal | vauthors = Lavau C, Luo RT, Du C, Thirman MJ | title = Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 20 | pages = 10984–9 | date = September 2000 | pmid = 10995463 | pmc = 27135 | doi = 10.1073/pnas.190167297 }}
*{{cite journal | author=Yamamoto K |title=Two distinct portions of LTG19/ENL at 19p13 are involved in t(11;19) leukemia |journal=Oncogene |volume=8 |issue= 10 |pages= 2617–25 |year= 1993 |pmid= 8378076 |doi= |name-list-format=vanc| author2=Seto M  | author3=Komatsu H  | display-authors=3  | last4=Iida  | first4=S  | last5=Akao  | first5=Y  | last6=Kojima  | first6=S  | last7=Kodera  | first7=Y  | last8=Nakazawa  | first8=S  | last9=Ariyoshi  | first9=Y }}
* {{cite journal | vauthors = García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK | title = The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 | journal = Oncogene | volume = 20 | issue = 4 | pages = 411–9 | date = January 2001 | pmid = 11313972 | doi = 10.1038/sj.onc.1204108 }}
*{{cite journal |vauthors=Lavau C, Luo RT, Du C, Thirman MJ |title=Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 20 |pages= 10984–10989 |year= 2000 |pmid= 10995463 |doi= 10.1073/pnas.190167297 | pmc=27135 }}
* {{cite journal | vauthors = Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, Xue Y, Yang D, Murray D, Kanakubo E, Cleary ML, Wang W | title = Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner | journal = Molecular and Cellular Biology | volume = 23 | issue = 8 | pages = 2942–52 | date = April 2003 | pmid = 12665591 | pmc = 152562 | doi = 10.1128/MCB.23.8.2942-2952.2003 }}
*{{cite journal | author=García-Cuéllar MP |title=The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3 |journal=Oncogene |volume=20 |issue= 4 |pages= 411–419 |year= 2001 |pmid= 11313972 |doi= 10.1038/sj.onc.1204108 |name-list-format=vanc| author2=Zilles O  | author3=Schreiner SA  | display-authors=3  | last4=Birke  | first4=M  | last5=Winkler  | first5=T H  | last6=Slany  | first6=R K }}
* {{cite journal | vauthors = Gué M, Sun JS, Boudier T | title = Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited | journal = BMC Cancer | volume = 6 | pages = 20 | date = January 2006 | pmid = 16433901 | pmc = 1388228 | doi = 10.1186/1471-2407-6-20 }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Nie Z |title=Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2942–2952 |year= 2003 |pmid= 12665591 |doi=10.1128/MCB.23.8.2942-2952.2003 | pmc=152562  |name-list-format=vanc| author2=Yan Z  | author3=Chen EH  | display-authors=3  | last4=Sechi  | first4=S.  | last5=Ling  | first5=C.  | last6=Zhou  | first6=S.  | last7=Xue  | first7=Y.  | last8=Yang  | first8=D.  | last9=Murray  | first9=D.  }}
* {{cite journal | vauthors = Meyer C, Burmeister T, Strehl S, Schneider B, Hubert D, Zach O, Haas O, Klingebiel T, Dingermann T, Marschalek R | title = Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia | journal = Leukemia | volume = 21 | issue = 3 | pages = 588–90 | date = March 2007 | pmid = 17252016 | doi = 10.1038/sj.leu.2404542 }}
*{{cite journal |vauthors=Gué M, Sun JS, Boudier T |title=Simultaneous localization of MLL, AF4 and ENL genes in interphase nuclei by 3D-FISH: MLL translocation revisited |journal=BMC Cancer |volume=6|pages= 20 |year= 2006 |pmid= 16433901 |doi= 10.1186/1471-2407-6-20 | pmc=1388228 }}
*{{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–648 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal | author=Meyer C |title=Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia |journal=Leukemia |volume=21 |issue= 3 |pages= 588–590 |year= 2007 |pmid= 17252016 |doi= 10.1038/sj.leu.2404542 |name-list-format=vanc| author2=Burmeister T  | author3=Strehl S  | display-authors=3  | last4=Schneider  | first4=B  | last5=Hubert  | first5=D  | last6=Zach  | first6=O  | last7=Haas  | first7=O  | last8=Klingebiel  | first8=T  | last9=Dingermann  | first9=T }}
}}
{{refend}}
{{refend}}


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{{NLM content}}
{{NLM content}}
{{Transcription factors|g0}}
{{Transcription factors|g0}}
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[[Category:Transcription factors]]
[[Category:Transcription factors]]


{{gene-19-stub}}
{{gene-19-stub}}

Latest revision as of 11:22, 2 January 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein ENL is a protein that in humans is encoded by the MLLT1 gene.[1]


Interactions

MLLT1 has been shown to interact with CBX8.[2]

References

  1. ↑ "Entrez Gene: MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1".
  2. ↑ García-Cuéllar MP, Zilles O, Schreiner SA, Birke M, Winkler TH, Slany RK (January 2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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