NFIL3: Difference between revisions

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Revision as of 11:25, 2 January 2018

Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.^[1]

Function

Expression of interleukin-3 (IL3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.^[1]^[2]

References

↑ ^1.0 ^1.1 "Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated".
↑ Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. PMC 230857. PMID 7565758.

Cowell IG, Skinner A, Hurst HC (July 1992). "Transcriptional repression by a novel member of the bZIP family of transcription factors". Molecular and Cellular Biology. 12 (7): 3070–7. PMC 364521. PMID 1620116.
Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. PMC 230857. PMID 7565758.
Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (September 1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
Cowell IG, Hurst HC (September 1996). "Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1". Nucleic Acids Research. 24 (18): 3607–13. doi:10.1093/nar/24.18.3607. PMC 146135. PMID 8836190.
Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT (March 1997). "Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (6): 2609–14. doi:10.1073/pnas.94.6.2609. PMC 20136. PMID 9122243.
Hulme DJ, Blair IP, Dawkins JL, Nicholson GA (June 2000). "Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis". Human Genetics. 106 (6): 594–6. doi:10.1007/s004390050030. PMID 10942106.
Ozkurt IC, Tetradis S (July 2003). "Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts". The Journal of Biological Chemistry. 278 (29): 26803–9. doi:10.1074/jbc.M212652200. PMID 12743120.
Priceman SJ, Kirzner JD, Nary LJ, Morris D, Shankar DB, Sakamoto KM, Medh RD (June 2006). "Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells". Biochemical and Biophysical Research Communications. 344 (2): 491–9. doi:10.1016/j.bbrc.2006.03.169. PMC 2763529. PMID 16630563.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated".

[pmid7565758-2] Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. PMC 230857. PMID 7565758.

[1]

[2]

@@ Line 4: / Line 4: @@
 == Function ==
-Expression of interleukin-3 ([[Interleukin 3|IL3]]) is restricted to activated [[T cell]]s, natural killer ([[natural killer cell|NK]]) cells, and [[mast cell]] lines. [[Transcription (genetics)#Initiation|Transcription initiation]] depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.<ref name="entrez"/><ref name="pmid7565758">{{cite journal | vauthors = Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD | title = Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter | journal = Mol. Cell. Biol. | volume = 15 | issue = 11 | pages = 6055–63 |date=November 1995 | pmid = 7565758 | pmc = 230857 | doi = | url = }}</ref>
+Expression of interleukin-3 ([[Interleukin 3|IL3]]) is restricted to activated [[T cell]]s, natural killer ([[natural killer cell|NK]]) cells, and [[mast cell]] lines. [[Transcription (genetics)#Initiation|Transcription initiation]] depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.<ref name="entrez"/><ref name="pmid7565758">{{cite journal | vauthors = Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD | title = Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter | journal = Molecular and Cellular Biology | volume = 15 | issue = 11 | pages = 6055–63 | date = November 1995 | pmid = 7565758 | pmc = 230857 | doi =  }}</ref>
-==References==
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin|35em}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Cowell IG, Skinner A, Hurst HC | title = Transcriptional repression by a novel member of the bZIP family of transcription factors | journal = Molecular and Cellular Biology | volume = 12 | issue = 7 | pages = 3070–7 | date = July 1992 | pmid = 1620116 | pmc = 364521 | doi =  }}
-| citations =
+* {{cite journal | vauthors = Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD | title = Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter | journal = Molecular and Cellular Biology | volume = 15 | issue = 11 | pages = 6055–63 | date = November 1995 | pmid = 7565758 | pmc = 230857 | doi =  }}
-*{{cite journal  | vauthors=Cowell IG, Skinner A, Hurst HC |title=Transcriptional repression by a novel member of the bZIP family of transcription factors. |journal=Mol. Cell. Biol. |volume=12 |issue= 7 |pages= 3070–7 |year= 1992 |pmid= 1620116 |doi=  | pmc=364521  }}
+* {{cite journal | vauthors = Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K | title = The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression | journal = Gene | volume = 146 | issue = 2 | pages = 199–207 | date = September 1994 | pmid = 8076819 | doi = 10.1016/0378-1119(94)90293-3 }}
-*{{cite journal   |vauthors=Zhang W, Zhang J, Kornuc M, etal |title=Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter. |journal=Mol. Cell. Biol. |volume=15 |issue= 11 |pages= 6055–63 |year= 1995 |pmid= 7565758 |doi=  | pmc=230857  }}
+* {{cite journal | vauthors = Cowell IG, Hurst HC | title = Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1 | journal = Nucleic Acids Research | volume = 24 | issue = 18 | pages = 3607–13 | date = September 1996 | pmid = 8836190 | pmc = 146135 | doi = 10.1093/nar/24.18.3607 }}
-*{{cite journal   |vauthors=Matoba R, Okubo K, Hori N, etal |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=10.1016/0378-1119(94)90293-3  }}
+* {{cite journal | vauthors = Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT | title = Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 6 | pages = 2609–14 | date = March 1997 | pmid = 9122243 | pmc = 20136 | doi = 10.1073/pnas.94.6.2609 }}
-*{{cite journal  | vauthors=Cowell IG, Hurst HC |title=Protein–protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1. |journal=Nucleic Acids Res. |volume=24 |issue= 18 |pages= 3607–13 |year= 1996 |pmid= 8836190 |doi=10.1093/nar/24.18.3607  | pmc=146135  }}
+* {{cite journal | vauthors = Hulme DJ, Blair IP, Dawkins JL, Nicholson GA | title = Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis | journal = Human Genetics | volume = 106 | issue = 6 | pages = 594–6 | date = June 2000 | pmid = 10942106 | doi = 10.1007/s004390050030 }}
-*{{cite journal   |vauthors=Ikushima S, Inukai T, Inaba T, etal |title=Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2609–14 |year= 1997 |pmid= 9122243 |doi=10.1073/pnas.94.6.2609  | pmc=20136  }}
+* {{cite journal | vauthors = Ozkurt IC, Tetradis S | title = Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26803–9 | date = July 2003 | pmid = 12743120 | doi = 10.1074/jbc.M212652200 }}
-*{{cite journal  | vauthors=Hulme DJ, Blair IP, Dawkins JL, Nicholson GA |title=Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis. |journal=Hum. Genet. |volume=106 |issue= 6 |pages= 594–6 |year= 2000 |pmid= 10942106 |doi=10.1007/s004390050030  }}
+* {{cite journal | vauthors = Priceman SJ, Kirzner JD, Nary LJ, Morris D, Shankar DB, Sakamoto KM, Medh RD | title = Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells | journal = Biochemical and Biophysical Research Communications | volume = 344 | issue = 2 | pages = 491–9 | date = June 2006 | pmid = 16630563 | pmc = 2763529 | doi = 10.1016/j.bbrc.2006.03.169 }}
-*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | vauthors=Ozkurt IC, Tetradis S |title=Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26803–9 |year= 2003 |pmid= 12743120 |doi= 10.1074/jbc.M212652200 }}
-*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein–protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal   |vauthors=Priceman SJ, Kirzner JD, Nary LJ, etal |title=Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 2 |pages= 491–9 |year= 2006 |pmid= 16630563 |doi= 10.1016/j.bbrc.2006.03.169  | pmc=2763529 }}
-}}
 {{refend}}
 {{NLM content}}
 {{Transcription factors|g1}}
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 [[Category:Transcription factors]]
 {{gene-9-stub}}

NFIL3: Difference between revisions

Revision as of 11:25, 2 January 2018

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