FOSB

FBJ murine osteosarcoma viral oncogene homolog B
Identifiers
Symbols	FOSB ; DKFZp686C0818; G0S3; GOS3; GOSB; MGC42291
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31403
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Overview

FBJ murine osteosarcoma viral oncogene homolog B (also known as FOSB or FosB) is a human gene.

The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

Delta FosB

Delta FosB is a truncated splice variant of FosB. Delta FosB has been implicated in the development of drug addiction and control of the reward system in the brain.

See also

• AP-1 (transcription factor)

Further reading

• Martin-Gallardo A, McCombie WR, Gocayne JD; et al. (1993). "Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3". Nat. Genet. 1 (1): 34–9. doi:10.1038/ng0492-34. PMID 1301997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR (1991). "A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes". DNA Cell Biol. 9 (8): 579–87. PMID 1702972.CS1 maint: Multiple names: authors list (link)
• Nakabeppu Y, Nathans D (1991). "A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity". Cell. 64 (4): 751–9. PMID 1900040.
• Schuermann M, Jooss K, Müller R (1991). "fosB is a transforming gene encoding a transcriptional activator". Oncogene. 6 (4): 567–76. PMID 1903195.CS1 maint: Multiple names: authors list (link)
• Brown JR, Ye H, Bronson RT; et al. (1996). "A defect in nurturing in mice lacking the immediate early gene fosB". Cell. 86 (2): 297–309. PMID 8706134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heximer SP, Cristillo AD, Russell L, Forsdyke DR (1997). "Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3)". DNA Cell Biol. 15 (12): 1025–38. PMID 8985116.CS1 maint: Multiple names: authors list (link)
• Liberati NT, Datto MB, Frederick JP; et al. (1999). "Smads bind directly to the Jun family of AP-1 transcription factors". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 4844–9. PMID 10220381.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yamamura Y, Hua X, Bergelson S, Lodish HF (2000). "Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis". J. Biol. Chem. 275 (46): 36295–302. doi:10.1074/jbc.M006023200. PMID 10942775.CS1 maint: Multiple names: authors list (link)
• Bergman MR, Cheng S, Honbo N; et al. (2003). "A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers". Biochem. J. 369 (Pt 3): 485–96. doi:10.1042/BJ20020707. PMID 12371906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Milde-Langosch K, Kappes H, Riethdorf S; et al. (2003). "FosB is highly expressed in normal mammary epithelia, but down-regulated in poorly differentiated breast carcinomas". Breast Cancer Res. Treat. 77 (3): 265–75. PMID 12602926.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baumann S, Hess J, Eichhorst ST; et al. (2003). "An unexpected role for FosB in activation-induced cell death of T cells". Oncogene. 22 (9): 1333–9. doi:10.1038/sj.onc.1206126. PMID 12618758.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holmes DI, Zachary I (2004). "Placental growth factor induces FosB and c-Fos gene expression via Flt-1 receptors". FEBS Lett. 557 (1–3): 93–8. PMID 14741347.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Konsman JP, Blomqvist A (2005). "Forebrain patterns of c-Fos and FosB induction during cancer-associated anorexia-cachexia in rat". Eur. J. Neurosci. 21 (10): 2752–66. doi:10.1111/j.1460-9568.2005.04102.x. PMID 15926923.

External links

• FOSB+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.