E4F1: Difference between revisions

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Latest revision as of 02:25, 27 October 2017

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.^[1]^[2]^[3]

Function

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.^[3]

Interactions

E4F1 has been shown to interact with:

P16,^[4]
P53,^[4]^[5] and
RB1^[6]

References

↑ Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet. 82 (1–2): 99–100. doi:10.1159/000015075. PMID 9763670.
↑ Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res. 6 (6): 525–37. doi:10.1101/gr.6.6.525. PMID 8828041.
↑ ^3.0 ^3.1 "Entrez Gene: E4F1 E4F transcription factor 1".
↑ ^4.0 ^4.1 Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–9. doi:10.1074/jbc.M210978200. PMID 12446718.
↑ Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (January 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–99. doi:10.1038/sj.onc.1203250. PMID 10644996.
↑ Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (July 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–43. doi:10.1073/pnas.130198397. PMC 16614. PMID 10869426.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Fernandes ER, Rooney RJ (1997). "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3". Mol. Cell. Biol. 17 (4): 1890–903. PMC 232036. PMID 9121437.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Rooney RJ, Daniels RR, Jenkins NA, Gilbert DJ, Rothammer K, Morris SW, Higgs DR, Copeland NG (1998). "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice". Mamm. Genome. 9 (4): 320–3. doi:10.1007/s003359900758. PMID 9530632.
Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–99. doi:10.1038/sj.onc.1203250. PMID 10644996.
Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–43. doi:10.1073/pnas.130198397. PMC 16614. PMID 10869426.
Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–9. doi:10.1074/jbc.M210978200. PMID 12446718.
Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F (2004). "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene". Cancer Res. 64 (1): 102–7. doi:10.1158/0008-5472.CAN-03-2622. PMID 14729613.
Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H (2005). "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis". Am. J. Pathol. 165 (6): 2019–31. doi:10.1016/s0002-9440(10)63253-1. PMC 1618705. PMID 15579445.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Paul C, Lacroix M, Iankova I, Julien E, Schäfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C (2006). "The LIM-only protein FHL2 is a negative regulator of E4F1". Oncogene. 25 (40): 5475–84. doi:10.1038/sj.onc.1209567. PMID 16652157.
Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C (2006). "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation". Cell. 127 (4): 775–88. doi:10.1016/j.cell.2006.09.031. PMID 17110336.
Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P (2007). "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression". EMBO Rep. 8 (7): 671–7. doi:10.1038/sj.embor.7400983. PMC 1905893. PMID 17557114.

External links

E4F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[pmid9763670-1] Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet. 82 (1–2): 99–100. doi:10.1159/000015075. PMID 9763670.

[pmid8828041-2] Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res. 6 (6): 525–37. doi:10.1101/gr.6.6.525. PMID 8828041.

[entrez-3] 3.0 ^3.1 "Entrez Gene: E4F1 E4F transcription factor 1".

[pmid12446718-4] 4.0 ^4.1 Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–9. doi:10.1074/jbc.M210978200. PMID 12446718.

[pmid10644996-5] Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (January 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–99. doi:10.1038/sj.onc.1203250. PMID 10644996.

[pmid10869426-6] Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (July 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–43. doi:10.1073/pnas.130198397. PMC 16614. PMID 10869426.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Transcription factor E4F1''' is a [[protein]] that in humans is encoded by the ''E4F1'' [[gene]].<ref name="pmid9763670">{{cite journal | vauthors = Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G | title = Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids | journal = Cytogenet Cell Genet | volume = 82 | issue = 1-2 | pages = 99–100 | date = November 1998 | pmid = 9763670 | pmc =  | doi = 10.1159/000015075 }}</ref><ref name="pmid8828041">{{cite journal | vauthors = Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM | title = Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3 | journal = Genome Res | volume = 6 | issue = 6 | pages = 525–37 | date = December 1996 | pmid = 8828041 | pmc =  | doi = 10.1101/gr.6.6.525 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: E4F1 E4F transcription factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1877| accessdate = }}</ref>
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-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = E4F transcription factor 1
- | HGNCid = 3121
- | Symbol = E4F1
- | AltSymbols =; E4F; MGC99614
- | OMIM = 603022
- | ECnumber =
- | Homologene = 3259
- | MGIid = 109530
- | GeneAtlas_image1 = PBB_GE_E4F1_218524_at_tn.png
- | Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
- | Process = {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1877
-    | Hs_Ensembl = ENSG00000167967
-    | Hs_RefseqProtein = NP_004415
-    | Hs_RefseqmRNA = NM_004424
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 16
-    | Hs_GenLoc_start = 2213568
-    | Hs_GenLoc_end = 2225744
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 13560
-    | Mm_Ensembl = ENSMUSG00000024137
-    | Mm_RefseqmRNA = NM_007893
-    | Mm_RefseqProtein = NP_031919
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 24171379
-    | Mm_GenLoc_end = 24182911
-    | Mm_Uniprot =
-  }}
-}}
-'''E4F transcription factor 1''', also known as '''E4F1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: E4F1 E4F transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1877| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The [[zinc finger protein]] encoded by this gene is one of several cellular transcription factors whose [[DNA-binding]] activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
-| summary_text = The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.<ref name="entrez">{{cite web | title = Entrez Gene: E4F1 E4F transcription factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1877| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+E4F1 has been shown to [[Protein-protein interaction|interact]] with:
+* [[P16 (gene)|P16]],<ref name = pmid12446718>{{cite journal | vauthors = Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF | title = Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition | journal = J. Biol. Chem. | volume = 278 | issue = 7 | pages = 4981–9 | date = February 2003 | pmid = 12446718 | doi = 10.1074/jbc.M210978200 }}</ref>
+* [[P53]],<ref name = pmid12446718/><ref name = pmid10644996>{{cite journal | vauthors = Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G | title = p53 is involved in the p120E4F-mediated growth arrest | journal = Oncogene | volume = 19 | issue = 2 | pages = 188–99 | date = January 2000 | pmid = 10644996 | doi = 10.1038/sj.onc.1203250 }}</ref> and
+* [[Retinoblastoma protein|RB1]]<ref name = pmid10869426>{{cite journal | vauthors = Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C | title = pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 14 | pages = 7738–43 | date = July 2000 | pmid = 10869426 | pmc = 16614 | doi = 10.1073/pnas.130198397 }}</ref>
+== References ==
+{{reflist}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
-| citations =
+* {{cite journal | vauthors = Fernandes ER, Rooney RJ | title = The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 1890–903 | year = 1997 | pmid = 9121437 | pmc = 232036 | doi =  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
-*{{cite journal  | author=Burn TC, Connors TD, Van Raay TJ, ''et al.'' |title=Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3. |journal=Genome Res. |volume=6 |issue= 6 |pages= 525-37 |year= 1996 |pmid= 8828041 |doi=  }}
+* {{cite journal | vauthors = Rooney RJ, Daniels RR, Jenkins NA, Gilbert DJ, Rothammer K, Morris SW, Higgs DR, Copeland NG | title = Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice. | journal = Mamm. Genome | volume = 9 | issue = 4 | pages = 320–3 | year = 1998 | pmid = 9530632 | doi = 10.1007/s003359900758 }}
-*{{cite journal  | author=Fernandes ER, Rooney RJ |title=The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1890-903 |year= 1997 |pmid= 9121437 |doi=  }}
+* {{cite journal | vauthors = Kim ST, Lim DS, Canman CE, Kastan MB | title = Substrate specificities and identification of putative substrates of ATM kinase family members. | journal = J. Biol. Chem. | volume = 274 | issue = 53 | pages = 37538–43 | year = 2000 | pmid = 10608806 | doi = 10.1074/jbc.274.53.37538 }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+* {{cite journal | vauthors = Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G | title = p53 is involved in the p120E4F-mediated growth arrest. | journal = Oncogene | volume = 19 | issue = 2 | pages = 188–99 | year = 2000 | pmid = 10644996 | doi = 10.1038/sj.onc.1203250 }}
-*{{cite journal  | author=Rooney RJ, Daniels RR, Jenkins NA, ''et al.'' |title=Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice. |journal=Mamm. Genome |volume=9 |issue= 4 |pages= 320-3 |year= 1998 |pmid= 9530632 |doi=  }}
+* {{cite journal | vauthors = Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C | title = pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 14 | pages = 7738–43 | year = 2000 | pmid = 10869426 | pmc = 16614 | doi = 10.1073/pnas.130198397 }}
-*{{cite journal  | author=Saccone S, Sandy P, Meroni G, ''et al.'' |title=Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids. |journal=Cytogenet. Cell Genet. |volume=82 |issue= 1-2 |pages= 99-100 |year= 1998 |pmid= 9763670 |doi=  }}
+* {{cite journal | vauthors = Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF | title = Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. | journal = J. Biol. Chem. | volume = 278 | issue = 7 | pages = 4981–9 | year = 2003 | pmid = 12446718 | doi = 10.1074/jbc.M210978200 }}
-*{{cite journal  | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538-43 |year= 2000 |pmid= 10608806 |doi=  }}
+* {{cite journal | vauthors = Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F | title = Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. | journal = Cancer Res. | volume = 64 | issue = 1 | pages = 102–7 | year = 2004 | pmid = 14729613 | doi = 10.1158/0008-5472.CAN-03-2622 }}
-*{{cite journal  | author=Sandy P, Gostissa M, Fogal V, ''et al.'' |title=p53 is involved in the p120E4F-mediated growth arrest. |journal=Oncogene |volume=19 |issue= 2 |pages= 188-99 |year= 2000 |pmid= 10644996 |doi= 10.1038/sj.onc.1203250 }}
+* {{cite journal | vauthors = Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H | title = E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. | journal = Am. J. Pathol. | volume = 165 | issue = 6 | pages = 2019–31 | year = 2005 | pmid = 15579445 | pmc = 1618705 | doi = 10.1016/s0002-9440(10)63253-1 }}
-*{{cite journal  | author=Fajas L, Paul C, Zugasti O, ''et al.'' |title=pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7738-43 |year= 2000 |pmid= 10869426 |doi= 10.1073/pnas.130198397 }}
+* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network. | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
-*{{cite journal  | author=Rizos H, Diefenbach E, Badhwar P, ''et al.'' |title=Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 4981-9 |year= 2003 |pmid= 12446718 |doi= 10.1074/jbc.M210978200 }}
+* {{cite journal | vauthors = Paul C, Lacroix M, Iankova I, Julien E, Schäfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C | title = The LIM-only protein FHL2 is a negative regulator of E4F1. | journal = Oncogene | volume = 25 | issue = 40 | pages = 5475–84 | year = 2006 | pmid = 16652157 | doi = 10.1038/sj.onc.1209567 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C | title = E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. | journal = Cell | volume = 127 | issue = 4 | pages = 775–88 | year = 2006 | pmid = 17110336 | doi = 10.1016/j.cell.2006.09.031 }}
-*{{cite journal  | author=Fenton SL, Dallol A, Agathanggelou A, ''et al.'' |title=Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene. |journal=Cancer Res. |volume=64 |issue= 1 |pages= 102-7 |year= 2004 |pmid= 14729613 |doi=  }}
+* {{cite journal | vauthors = Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P | title = The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. | journal = EMBO Rep. | volume = 8 | issue = 7 | pages = 671–7 | year = 2007 | pmid = 17557114 | pmc = 1905893 | doi = 10.1038/sj.embor.7400983 }}
-*{{cite journal  | author=Nakamura Y, Igarashi K, Suzuki T, ''et al.'' |title=E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis. |journal=Am. J. Pathol. |volume=165 |issue= 6 |pages= 2019-31 |year= 2005 |pmid= 15579445 |doi=  }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
-*{{cite journal  | author=Paul C, Lacroix M, Iankova I, ''et al.'' |title=The LIM-only protein FHL2 is a negative regulator of E4F1. |journal=Oncogene |volume=25 |issue= 40 |pages= 5475-84 |year= 2006 |pmid= 16652157 |doi= 10.1038/sj.onc.1209567 }}
-*{{cite journal  | author=Le Cam L, Linares LK, Paul C, ''et al.'' |title=E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. |journal=Cell |volume=127 |issue= 4 |pages= 775-88 |year= 2006 |pmid= 17110336 |doi= 10.1016/j.cell.2006.09.031 }}
-*{{cite journal  | author=Cvetanovic M, Rooney RJ, Garcia JJ, ''et al.'' |title=The role of LANP and ataxin 1 in E4F-mediated transcriptional repression. |journal=EMBO Rep. |volume=8 |issue= 7 |pages= 671-7 |year= 2007 |pmid= 17557114 |doi= 10.1038/sj.embor.7400983 }}
-}}
 {{refend}}
@@ Line 83: / Line 37: @@
 * {{MeshName|E4F1+protein,+human}}
+{{NLM content}}
+{{Transcription factors|g2}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-16-stub}}

E4F1: Difference between revisions

Latest revision as of 02:25, 27 October 2017

Contents

Function

Interactions

References

Further reading

External links

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