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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{DISPLAYTITLE:''EHF'' (gene)}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''ETS homologous factor''' is a [[protein]] that in humans is encoded by the ''EHF'' [[gene]].<ref name="pmid10527851">{{cite journal | vauthors = Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH | title = Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF | journal = Biochem Biophys Res Commun | volume = 264 | issue = 1 | pages = 119–26 |date=Nov 1999 | pmid = 10527851 | pmc =  | doi = 10.1006/bbrc.1999.1493 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EHF ets homologous factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26298| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Ets homologous factor
| HGNCid = 3246
| Symbol = EHF
| AltSymbols =; ESE3; ESEJ
| OMIM = 605439
| ECnumber = 
| Homologene = 7301
| MGIid = 1270840
| GeneAtlas_image1 = PBB_GE_EHF_219850_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0030855 |text = epithelial cell differentiation}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26298
    | Hs_Ensembl = ENSG00000135373
    | Hs_RefseqProtein = NP_036285
    | Hs_RefseqmRNA = NM_012153
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 34599244
    | Hs_GenLoc_end = 34639657
    | Hs_Uniprot = Q9NZC4
    | Mm_EntrezGene = 13661
    | Mm_Ensembl = ENSMUSG00000012350
    | Mm_RefseqmRNA = NM_007914
    | Mm_RefseqProtein = NP_031940
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 103064272
    | Mm_GenLoc_end = 103104035
    | Mm_Uniprot = O70273
  }}
}}
'''Ets homologous factor''', also known as '''EHF''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EHF ets homologous factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26298| accessdate = }}</ref>
 
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: EHF ets homologous factor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26298| accessdate = }}</ref>
| summary_text = This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with [[asthma]] susceptibility. This protein may be involved in epithelial differentiation and [[carcinogenesis]].<ref name="entrez" />
}}
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading}}
| citations =  
Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).
*{{cite journal  | author=Fujikawa M, Katagiri T, Tugores A, ''et al.'' |title=ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. |journal=Cancer Sci. |volume=98 |issue= 9 |pages= 1468-75 |year= 2007 |pmid= 17627613 |doi= 10.1111/j.1349-7006.2007.00543.x }}
 
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.
*{{cite journal  | author=Park C, Lee I, Kang WK |title=Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis. |journal=Mol. Cancer Ther. |volume=5 |issue= 12 |pages= 3191-6 |year= 2007 |pmid= 17172423 |doi= 10.1158/1535-7163.MCT-06-0570 }}
 
*{{cite journal  | author=Lim JH, Cho JY, Park YB, ''et al.'' |title=ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites. |journal=Biochem. Biophys. Res. Commun. |volume=350 |issue= 3 |pages= 736-41 |year= 2006 |pmid= 17027647 |doi= 10.1016/j.bbrc.2006.09.102 }}
Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).
*{{cite journal  | author=Taylor TD, Noguchi H, Totoki Y, ''et al.'' |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497-500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 }}
 
*{{cite journal  | author=Appel S, Bringmann A, Grünebach F, ''et al.'' |title=Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. |journal=Blood |volume=107 |issue= 8 |pages= 3265-70 |year= 2006 |pmid= 16380452 |doi= 10.1182/blood-2005-06-2480 }}
==References==
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
{{reflist}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Fujikawa M, Katagiri T, Tugores A |title=ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence. |journal=Cancer Sci. |volume=98 |issue= 9 |pages= 1468–75 |year= 2007 |pmid= 17627613 |doi= 10.1111/j.1349-7006.2007.00543.x |display-authors=etal}}
*{{cite journal  | author=Silverman ES, Baron RM, Palmer LJ, ''et al.'' |title=Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. |journal=Am. J. Respir. Cell Mol. Biol. |volume=27 |issue= 6 |pages= 697-704 |year= 2003 |pmid= 12444029 |doi=  }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Tugores A, Le J, Sorokina I, ''et al.'' |title=The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20397-406 |year= 2001 |pmid= 11259407 |doi= 10.1074/jbc.M010930200 }}
*{{cite journal  | vauthors=Park C, Lee I, Kang WK |title=Influence of small interfering RNA corresponding to ets homologous factor on senescence-associated modulation of prostate carcinogenesis. |journal=Mol. Cancer Ther. |volume=5 |issue= 12 |pages= 3191–6 |year= 2007 |pmid= 17172423 |doi= 10.1158/1535-7163.MCT-06-0570 }}
*{{cite journal  | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal  | vauthors=Lim JH, Cho JY, Park YB |title=ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites. |journal=Biochem. Biophys. Res. Commun. |volume=350 |issue= 3 |pages= 736–41 |year= 2006 |pmid= 17027647 |doi= 10.1016/j.bbrc.2006.09.102 |display-authors=etal}}
*{{cite journal  | author=Kas K, Finger E, Grall F, ''et al.'' |title=ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2986-98 |year= 2000 |pmid= 10644770 |doi= }}
*{{cite journal  | vauthors=Taylor TD, Noguchi H, Totoki Y |title=Human chromosome 11 DNA sequence and analysis including novel gene identification. |journal=Nature |volume=440 |issue= 7083 |pages= 497–500 |year= 2006 |pmid= 16554811 |doi= 10.1038/nature04632 |display-authors=etal}}
*{{cite journal  | author=Kleinbaum LA, Duggan C, Ferreira E, ''et al.'' |title=Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 119-26 |year= 1999 |pmid= 10527851 |doi= 10.1006/bbrc.1999.1493 }}
*{{cite journal  | vauthors=Appel S, Bringmann A, Grünebach F |title=Epithelial-specific transcription factor ESE-3 is involved in the development of monocyte-derived DCs. |journal=Blood |volume=107 |issue= 8 |pages= 3265–70 |year= 2006 |pmid= 16380452 |doi= 10.1182/blood-2005-06-2480 |display-authors=etal}}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Silverman ES, Baron RM, Palmer LJ |title=Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. |journal=Am. J. Respir. Cell Mol. Biol. |volume=27 |issue= 6 |pages= 697–704 |year= 2003 |pmid= 12444029 |doi=  10.1165/rcmb.2002-0011oc|display-authors=etal}}
*{{cite journal  | vauthors=Tugores A, Le J, Sorokina I |title=The epithelium-specific ETS protein EHF/ESE-3 is a context-dependent transcriptional repressor downstream of MAPK signaling cascades. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 20397–406 |year= 2001 |pmid= 11259407 |doi= 10.1074/jbc.M010930200 |display-authors=etal}}
*{{cite journal  | vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267 |display-authors=etal}}
*{{cite journal  | vauthors=Kas K, Finger E, Grall F |title=ESE-3, a novel member of an epithelium-specific ets transcription factor subfamily, demonstrates different target gene specificity from ESE-1. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2986–98 |year= 2000 |pmid= 10644770 |doi=10.1074/jbc.275.4.2986  |display-authors=etal}}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
{{refend}}
{{refend}}


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* {{MeshName|EHF+protein,+human}}
* {{MeshName|EHF+protein,+human}}


{{NLM content}}
{{Transcription factors|g3}}
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[[Category:Transcription factors]]
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{{gene-11-stub}}

Latest revision as of 00:22, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ETS homologous factor is a protein that in humans is encoded by the EHF gene.[1][2] This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.[2]

Further reading

Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.

Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).

References

  1. ↑ Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH (Nov 1999). "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF". Biochem Biophys Res Commun. 264 (1): 119–26. doi:10.1006/bbrc.1999.1493. PMID 10527851.
  2. ↑ 2.0 2.1 "Entrez Gene: EHF ets homologous factor".

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=EHF_(gene)&oldid=1415425"