EMX2: Difference between revisions

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Revision as of 00:29, 31 August 2017

Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.^[1]^[2]

Function

The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. EMX1 (MIM 600034) and EMX2 are related to the 'empty spiracles' gene expressed in the developing Drosophila head.[supplied by OMIM]^[2]

References

↑ Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (Dec 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790.
↑ ^2.0 ^2.1 "Entrez Gene: EMX2 empty spiracles homeobox 2".

Guerrini R, Carrozzo R (2002). "Epileptogenic brain malformations: clinical presentation, malformative patterns and indications for genetic testing". Seizure : the journal of the British Epilepsy Association. 11 Suppl A: 532–43, quiz 544–7. doi:10.1053/seiz.2001.0650. PMID 12185771.
Simeone A, Gulisano M, Acampora D, et al. (1992). "Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex". EMBO J. 11 (7): 2541–50. PMC 556729. PMID 1352754.
Brunelli S, Faiella A, Capra V, et al. (1996). "Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly". Nat. Genet. 12 (1): 94–6. doi:10.1038/ng0196-94. PMID 8528262.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Noonan FC, Mutch DG, Ann Mallon M, Goodfellow PJ (2001). "Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis, and a search for mutations in endometrial cancers". Genomics. 76 (1–3): 37–44. doi:10.1006/geno.2001.6590. PMID 11549315.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Troy PJ, Daftary GS, Bagot CN, Taylor HS (2003). "Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10". Mol. Cell. Biol. 23 (1): 1–13. doi:10.1128/MCB.23.1.1-13.2003. PMC 140663. PMID 12482956.
Noonan FC, Goodfellow PJ, Staloch LJ, et al. (2003). "Antisense transcripts at the EMX2 locus in human and mouse". Genomics. 81 (1): 58–66. doi:10.1016/S0888-7543(02)00023-X. PMID 12573261.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Daftary GS, Taylor HS (2004). "EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis". J. Clin. Endocrinol. Metab. 89 (5): 2390–6. doi:10.1210/jc.2003-031389. PMID 15126568.
Nédélec S, Foucher I, Brunet I, et al. (2004). "Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons". Proc. Natl. Acad. Sci. U.S.A. 101 (29): 10815–20. doi:10.1073/pnas.0403824101. PMC 490017. PMID 15247416.
Hamasaki T, Leingärtner A, Ringstedt T, O'Leary DD (2004). "EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors". Neuron. 43 (3): 359–72. doi:10.1016/j.neuron.2004.07.016. PMID 15294144.
Treloar SA, Zhao ZZ, Le L, et al. (2007). "Variants in EMX2 and PTEN do not contribute to risk of endometriosis". Mol. Hum. Reprod. 13 (8): 587–94. doi:10.1093/molehr/gam023. PMID 17563403.

External links

EMX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[pmid7959790-1] Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E (Dec 1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790.

[entrez-2] 2.0 ^2.1 "Entrez Gene: EMX2 empty spiracles homeobox 2".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Homeobox protein Emx2''' is a [[protein]] that in humans is encoded by the ''EMX2'' [[gene]].<ref name="pmid7959790">{{cite journal | vauthors = Kastury K, Druck T, Huebner K, Barletta C, Acampora D, Simeone A, Faiella A, Boncinelli E | title = Chromosome locations of human EMX and OTX genes | journal = Genomics | volume = 22 | issue = 1 | pages = 41–5 |date=Dec 1994 | pmid = 7959790 | pmc =  | doi = 10.1006/geno.1994.1343 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EMX2 empty spiracles homeobox 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2018| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
+The [[homeodomain]] [[transcription factor]] EMX2 is critical for central nervous system and urogenital development. [[EMX1]] (MIM 600034) and EMX2 are related to the 'empty spiracles' gene expressed in the developing ''[[Drosophila]]'' head.[supplied by OMIM]<ref name="entrez" />
- | image =
- | image_source =
- | PDB =
- | Name = Empty spiracles homeobox 2
- | HGNCid = 3341
- | Symbol = EMX2
- | AltSymbols =;
- | OMIM = 600035
- | ECnumber =
- | Homologene = 3023
- | MGIid = 95388
- | GeneAtlas_image1 = PBB_GE_EMX2_221950_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0030182 |text = neuron differentiation}} {{GNF_GO|id=GO:0030900 |text = forebrain development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 2018
-    | Hs_Ensembl = ENSG00000170370
-    | Hs_RefseqProtein = NP_004089
-    | Hs_RefseqmRNA = NM_004098
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 10
-    | Hs_GenLoc_start = 119291946
-    | Hs_GenLoc_end = 119299047
-    | Hs_Uniprot = Q04743
-    | Mm_EntrezGene = 13797
-    | Mm_Ensembl = ENSMUSG00000043969
-    | Mm_RefseqmRNA = NM_010132
-    | Mm_RefseqProtein = NP_034262
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 19
-    | Mm_GenLoc_start = 59512466
-    | Mm_GenLoc_end = 59517297
-    | Mm_Uniprot = Q04744
-  }}
-}}
-'''Empty spiracles homeobox 2''', also known as '''EMX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EMX2 empty spiracles homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2018| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== See also ==
-{{PBB_Summary
+* [[EMX1]]
-| section_title =
-| summary_text = The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. EMX1 (MIM 600034) and EMX2 are related to the 'empty spiracles' gene expressed in the developing Drosophila head.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: EMX2 empty spiracles homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2018| accessdate = }}</ref>
-}}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Guerrini R, Carrozzo R |title=Epileptogenic brain malformations: clinical presentation, malformative patterns and indications for genetic testing |journal=Seizure : the journal of the British Epilepsy Association |volume=11 Suppl A |issue=  |pages= 532–43; quiz 544–7 |year= 2002 |pmid= 12185771 |doi=  10.1053/seiz.2001.0650}}
-| citations =
+*{{cite journal  | vauthors=Simeone A, Gulisano M, Acampora D |title=Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex |journal=EMBO J. |volume=11 |issue= 7 |pages= 2541–50 |year= 1992 |pmid= 1352754 |doi=  | pmc=556729  |display-authors=etal}}
-*{{cite journal  | author=Guerrini R, Carrozzo R |title=Epileptogenic brain malformations: clinical presentation, malformative patterns and indications for genetic testing. |journal=Seizure : the journal of the British Epilepsy Association |volume=11 Suppl A |issue=  |pages= 532-43; quiz 544-7 |year= 2002 |pmid= 12185771 |doi=  }}
+*{{cite journal  | vauthors=Brunelli S, Faiella A, Capra V |title=Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly |journal=Nat. Genet. |volume=12 |issue= 1 |pages= 94–6 |year= 1996 |pmid= 8528262 |doi= 10.1038/ng0196-94 |display-authors=etal}}
-*{{cite journal  | author=Simeone A, Gulisano M, Acampora D, ''et al.'' |title=Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. |journal=EMBO J. |volume=11 |issue= 7 |pages= 2541-50 |year= 1992 |pmid= 1352754 |doi=  }}
+*{{cite journal  | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 |display-authors=etal}}
-*{{cite journal  | author=Kastury K, Druck T, Huebner K, ''et al.'' |title=Chromosome locations of human EMX and OTX genes. |journal=Genomics |volume=22 |issue= 1 |pages= 41-5 |year= 1994 |pmid= 7959790 |doi= 10.1006/geno.1994.1343 }}
+*{{cite journal  | vauthors=Noonan FC, Mutch DG, Ann Mallon M, Goodfellow PJ |title=Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis, and a search for mutations in endometrial cancers |journal=Genomics |volume=76 |issue= 1–3 |pages= 37–44 |year= 2001 |pmid= 11549315 |doi= 10.1006/geno.2001.6590 }}
-*{{cite journal  | author=Brunelli S, Faiella A, Capra V, ''et al.'' |title=Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly. |journal=Nat. Genet. |volume=12 |issue= 1 |pages= 94-6 |year= 1996 |pmid= 8528262 |doi= 10.1038/ng0196-94 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
+*{{cite journal  | vauthors=Troy PJ, Daftary GS, Bagot CN, Taylor HS |title=Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10 |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 1–13 |year= 2003 |pmid= 12482956 |doi=10.1128/MCB.23.1.1-13.2003  | pmc=140663  }}
-*{{cite journal  | author=Noonan FC, Mutch DG, Ann Mallon M, Goodfellow PJ |title=Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis, and a search for mutations in endometrial cancers. |journal=Genomics |volume=76 |issue= 1-3 |pages= 37-44 |year= 2001 |pmid= 11549315 |doi= 10.1006/geno.2001.6590 }}
+*{{cite journal  | vauthors=Noonan FC, Goodfellow PJ, Staloch LJ |title=Antisense transcripts at the EMX2 locus in human and mouse |journal=Genomics |volume=81 |issue= 1 |pages= 58–66 |year= 2003 |pmid= 12573261 |doi=10.1016/S0888-7543(02)00023-X  |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Troy PJ, Daftary GS, Bagot CN, Taylor HS |title=Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 1-13 |year= 2003 |pmid= 12482956 |doi=  }}
+*{{cite journal  | vauthors=Daftary GS, Taylor HS |title=EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 5 |pages= 2390–6 |year= 2004 |pmid= 15126568 |doi=10.1210/jc.2003-031389  }}
-*{{cite journal  | author=Noonan FC, Goodfellow PJ, Staloch LJ, ''et al.'' |title=Antisense transcripts at the EMX2 locus in human and mouse. |journal=Genomics |volume=81 |issue= 1 |pages= 58-66 |year= 2003 |pmid= 12573261 |doi=  }}
+*{{cite journal  | vauthors=Nédélec S, Foucher I, Brunet I |title=Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 29 |pages= 10815–20 |year= 2004 |pmid= 15247416 |doi= 10.1073/pnas.0403824101  | pmc=490017 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Hamasaki T, Leingärtner A, Ringstedt T, O'Leary DD |title=EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors |journal=Neuron |volume=43 |issue= 3 |pages= 359–72 |year= 2004 |pmid= 15294144 |doi= 10.1016/j.neuron.2004.07.016 }}
-*{{cite journal  | author=Daftary GS, Taylor HS |title=EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 5 |pages= 2390-6 |year= 2004 |pmid= 15126568 |doi=  }}
+*{{cite journal  | vauthors=Treloar SA, Zhao ZZ, Le L |title=Variants in EMX2 and PTEN do not contribute to risk of endometriosis |journal=Mol. Hum. Reprod. |volume=13 |issue= 8 |pages= 587–94 |year= 2007 |pmid= 17563403 |doi= 10.1093/molehr/gam023 |display-authors=etal}}
-*{{cite journal  | author=Nédélec S, Foucher I, Brunet I, ''et al.'' |title=Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 29 |pages= 10815-20 |year= 2004 |pmid= 15247416 |doi= 10.1073/pnas.0403824101 }}
-*{{cite journal  | author=Hamasaki T, Leingärtner A, Ringstedt T, O'Leary DD |title=EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors. |journal=Neuron |volume=43 |issue= 3 |pages= 359-72 |year= 2004 |pmid= 15294144 |doi= 10.1016/j.neuron.2004.07.016 }}
-*{{cite journal  | author=Treloar SA, Zhao ZZ, Le L, ''et al.'' |title=Variants in EMX2 and PTEN do not contribute to risk of endometriosis. |journal=Mol. Hum. Reprod. |volume=13 |issue= 8 |pages= 587-94 |year= 2007 |pmid= 17563403 |doi= 10.1093/molehr/gam023 }}
-}}
 {{refend}}
@@ Line 80: / Line 31: @@
 * {{MeshName|EMX2+protein,+human}}
+{{NLM content}}
+{{Transcription factors|g3}}
-{{protein-stub}}
-{{NLM content}}
-{{Transcription factors}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-10-stub}}

EMX2: Difference between revisions

Revision as of 00:29, 31 August 2017

Contents

Function

See also

References

Further reading

External links

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