Hepatocyte nuclear factor 4 gamma: Difference between revisions

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{{Infobox_gene}} __NOTOC__
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'''Hepatocyte nuclear factor 4 gamma''' ('''HNF4G''') also known as '''NR2A2''' (nuclear receptor subfamily 2, group A, member 2) is a [[nuclear receptor]] that in humans is encoded by the ''HNF4G'' ''gene''.<ref name="entrez">{{cite web | title = Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3174| accessdate = }}</ref><ref name="pmid8622695">{{cite journal |vauthors=Drewes T, Senkel S, Holewa B, Ryffel GU | title = Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 925–31 |date=March 1996 | pmid = 8622695 | pmc = 231074 | doi = 10.1128/mcb.16.3.925| url = | issn = }}</ref><ref name="pmid12220494">{{cite journal |vauthors=Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP | title = Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids | journal = Structure | volume = 10 | issue = 9 | pages = 1225–34 |date=September 2002 | pmid = 12220494 | doi = 10.1016/S0969-2126(02)00829-8 | url = | issn = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_HNF4G_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1lv2.
| PDB = {{PDB2|1lv2}}
| Name = Hepatocyte nuclear factor 4, gamma
| HGNCid = 5026
| Symbol = HNF4G
| AltSymbols =; NR2A2
| OMIM = 605966
| ECnumber = 
| Homologene = 37886
| MGIid = 1353604
| GeneAtlas_image1 = PBB_GE_HNF4G_207456_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3174
    | Hs_Ensembl = ENSG00000164749
    | Hs_RefseqProtein = NP_004124
    | Hs_RefseqmRNA = NM_004133
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 76482826
    | Hs_GenLoc_end = 76639117
    | Hs_Uniprot = Q14541
    | Mm_EntrezGene = 30942
    | Mm_Ensembl = ENSMUSG00000017688
    | Mm_RefseqmRNA = NM_013920
    | Mm_RefseqProtein = NP_038948
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 3493753
    | Mm_GenLoc_end = 3643025
    | Mm_Uniprot = Q059V1
  }}
}}
'''Hepatocyte nuclear factor 4 gamma''' ('''HNF4G''') also known as '''NR2A2''' (nuclear receptor subfamily 2, group A, member 2) is a [[nuclear receptor]] encoded by the {{gene|HNF4G}} gene.<ref name="entrez">{{cite web | title = Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3174| accessdate = }}</ref>
 
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}}


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Drewes T, Senkel S, Holewa B, Ryffel GU |title=Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 925-31 |year= 1996 |pmid= 8622695 |doi=  }}
*{{cite journal   |vauthors=Plengvidhya N, Antonellis A, Wogan LT, etal |title=Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. |journal=Diabetes |volume=48 |issue= 10 |pages= 2099–102 |year= 1999 |pmid= 10512380 |doi=10.2337/diabetes.48.10.2099 }}
*{{cite journal  | author=Plengvidhya N, Antonellis A, Wogan LT, ''et al.'' |title=Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. |journal=Diabetes |volume=48 |issue= 10 |pages= 2099-102 |year= 1999 |pmid= 10512380 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Wisely GB, Miller AB, Davis RG, ''et al.'' |title=Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. |journal=Structure |volume=10 |issue= 9 |pages= 1225-34 |year= 2003 |pmid= 12220494 |doi= }}
*{{cite journal   |vauthors=Ozeki T, Takahashi Y, Nakayama K, etal |title=Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. |journal=Pharmacogenetics |volume=13 |issue= 1 |pages= 49–53 |year= 2003 |pmid= 12544512 |doi=10.1097/00008571-200301000-00007 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Nusbaum C, Mikkelsen TS, Zody MC, etal |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331–5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 }}
*{{cite journal | author=Ozeki T, Takahashi Y, Nakayama K, ''et al.'' |title=Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers. |journal=Pharmacogenetics |volume=13 |issue= 1 |pages= 49-53 |year= 2003 |pmid= 12544512 |doi=  }}
*{{cite journal | author=Nusbaum C, Mikkelsen TS, Zody MC, ''et al.'' |title=DNA sequence and analysis of human chromosome 8. |journal=Nature |volume=439 |issue= 7074 |pages= 331-5 |year= 2006 |pmid= 16421571 |doi= 10.1038/nature04406 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{Transcription factors}}
* {{FactorBook|HNF4G}}
 
{{PDB Gallery|geneid=3174}}
{{Transcription factors|g2}}
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[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
 
{{gene-8-stub}}

Revision as of 16:11, 31 August 2017

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Orthologs
SpeciesHumanMouse
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Ensembl

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Wikidata
View/Edit Human

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4G gene.[1][2][3]

See also

References

  1. ↑ "Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma".
  2. ↑ Drewes T, Senkel S, Holewa B, Ryffel GU (March 1996). "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes". Mol. Cell. Biol. 16 (3): 925–31. doi:10.1128/mcb.16.3.925. PMC 231074. PMID 8622695.
  3. ↑ Wisely GB, Miller AB, Davis RG, Thornquest AD, Johnson R, Spitzer T, Sefler A, Shearer B, Moore JT, Miller AB, Willson TM, Williams SP (September 2002). "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure. 10 (9): 1225–34. doi:10.1016/S0969-2126(02)00829-8. PMID 12220494.

Further reading

External links


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