Homeobox A10: Difference between revisions

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Revision as of 01:42, 27 October 2017

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene.^[1]^[2]^[3]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.^[3]

Interactions

Homeobox A10 has been shown to interact with PTPN6.^[4]

References

↑ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
↑ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
↑ ^3.0 ^3.1 "Entrez Gene: HOXA10 homeobox A10".
↑ Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (Sep 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry. 277 (39): 36878–88. doi:10.1074/jbc.M203917200. PMID 12145285.

Eun Kwon H, Taylor HS (Dec 2004). "The role of HOX genes in human implantation". Annals of the New York Academy of Sciences. 1034: 1–18. doi:10.1196/annals.1335.001. PMID 15731295.
Lowney P, Corral J, Detmer K, LeBeau MM, Deaven L, Lawrence HJ, Largman C (Jun 1991). "A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells". Nucleic Acids Research. 19 (12): 3443–9. doi:10.1093/nar/19.12.3443. PMC 328346. PMID 1676505.
Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ (Nov 1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proceedings of the National Academy of Sciences of the United States of America. 86 (21): 8536–40. doi:10.1073/pnas.86.21.8536. PMC 298317. PMID 2573064.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK (Dec 1994). "Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12223–7. doi:10.1073/pnas.91.25.12223. PMC 45409. PMID 7527557.
Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C (Oct 1995). "Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells". Experimental Hematology. 23 (11): 1160–6. PMID 7556525.
Satokata I, Benson G, Maas R (Mar 1995). "Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice". Nature. 374 (6521): 460–3. doi:10.1038/374460a0. PMID 7700356.
Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M (Jan 1994). "Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype". Biochemical Pharmacology. 47 (1): 137–43. doi:10.1016/0006-2952(94)90447-2. PMID 7906121.
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK (Jan 1997). "Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia". Molecular and Cellular Biology. 17 (1): 495–505. doi:10.1128/mcb.17.1.495. PMC 231774. PMID 8972230.
Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. PMC 232497. PMID 9343407.
Taylor HS, Vanden Heuvel GB, Igarashi P (Dec 1997). "A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes". Biology of Reproduction. 57 (6): 1338–45. doi:10.1095/biolreprod57.6.1338. PMID 9408238.
Taylor HS, Arici A, Olive D, Igarashi P (Apr 1998). "HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium". The Journal of Clinical Investigation. 101 (7): 1379–84. doi:10.1172/JCI1057. PMC 508715. PMID 9525980.
Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE (May 1999). "Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells". Leukemia. 13 (5): 687–98. doi:10.1038/sj/leu/2401410. PMID 10374871.
Eklund EA, Jalava A, Kakar R (Jun 2000). "Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines". The Journal of Biological Chemistry. 275 (26): 20117–26. doi:10.1074/jbc.M907915199. PMID 10766757.
Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, Humphries RK (Apr 2001). "Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo". Blood. 97 (8): 2286–92. doi:10.1182/blood.V97.8.2286. PMID 11290589.
Cermik D, Karaca M, Taylor HS (Jul 2001). "HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract". The Journal of Clinical Endocrinology and Metabolism. 86 (7): 3387–92. doi:10.1210/jc.86.7.3387. PMID 11443215.
Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.

External links

HOXA10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[pmid1973146-1] McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.

[pmid1358459-2] Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.

[entrez-3] 3.0 ^3.1 "Entrez Gene: HOXA10 homeobox A10".

[pmid12145285-4] Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (Sep 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry. 277 (39): 36878–88. doi:10.1074/jbc.M203917200. PMID 12145285.

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[3]

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Homeobox protein Hox-A10''' is a [[protein]] that in humans is encoded by the ''HOXA10'' [[gene]].<ref name="pmid1973146">{{cite journal | vauthors = McAlpine PJ, Shows TB | title = Nomenclature for human homeobox genes | journal = Genomics | volume = 7 | issue = 3 | pages = 460 | date = Jul 1990 | pmid = 1973146 | pmc =  | doi = 10.1016/0888-7543(90)90186-X }}</ref><ref name="pmid1358459">{{cite journal | vauthors = Scott MP | title = Vertebrate homeobox gene nomenclature | journal = Cell | volume = 71 | issue = 4 | pages = 551–3 | date = Nov 1992 | pmid = 1358459 | pmc =  | doi = 10.1016/0092-8674(92)90588-4 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HOXA10 homeobox A10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Homeobox A10
- | HGNCid = 5100
- | Symbol = HOXA10
- | AltSymbols =; PL; HOX1; HOX1.8; HOX1H; MGC12859
- | OMIM = 142957
- | ECnumber =
- | Homologene = 7365
- | MGIid = 96171
- | GeneAtlas_image1 = PBB_GE_HOXA10_213150_at_tn.png
- | GeneAtlas_image2 = PBB_GE_HOXA10_213147_at_tn.png
- | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3206
-    | Hs_Ensembl = ENSG00000153807
-    | Hs_RefseqProtein = NP_061824
-    | Hs_RefseqmRNA = NM_018951
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 27177382
-    | Hs_GenLoc_end = 27180399
-    | Hs_Uniprot = P31260
-    | Mm_EntrezGene = 15395
-    | Mm_Ensembl = ENSMUSG00000000938
-    | Mm_RefseqmRNA = NM_008263
-    | Mm_RefseqProtein = NP_032289
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 52160780
-    | Mm_GenLoc_end = 52164522
-    | Mm_Uniprot = P31310
-  }}
-}}
-'''Homeobox A10''', also known as '''HOXA10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HOXA10 homeobox A10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: HOXA10 homeobox A10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3206| accessdate = }}</ref>
-}}
-==See also==
+== Interactions ==
+Homeobox A10 has been shown to [[Protein-protein interaction|interact]] with [[PTPN6]].<ref name=pmid12145285>{{cite journal | vauthors = Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R | title = SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 36878–88 | date = Sep 2002 | pmid = 12145285 | doi = 10.1074/jbc.M203917200 }}</ref>
+== See also ==
 * [[Homeobox]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Eun Kwon H, Taylor HS | title = The role of HOX genes in human implantation | journal = Annals of the New York Academy of Sciences | volume = 1034 | issue =  | pages = 1–18 | date = Dec 2004 | pmid = 15731295 | doi = 10.1196/annals.1335.001 }}
-| citations =
+* {{cite journal | vauthors = Lowney P, Corral J, Detmer K, LeBeau MM, Deaven L, Lawrence HJ, Largman C | title = A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells | journal = Nucleic Acids Research | volume = 19 | issue = 12 | pages = 3443–9 | date = Jun 1991 | pmid = 1676505 | pmc = 328346 | doi = 10.1093/nar/19.12.3443 }}
-*{{cite journal  | author=Eun Kwon H, Taylor HS |title=The role of HOX genes in human implantation. |journal=Ann. N. Y. Acad. Sci. |volume=1034 |issue=  |pages= 1-18 |year= 2005 |pmid= 15731295 |doi= 10.1196/annals.1335.001 }}
+* {{cite journal | vauthors = Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ | title = Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 21 | pages = 8536–40 | date = Nov 1989 | pmid = 2573064 | pmc = 298317 | doi = 10.1073/pnas.86.21.8536 }}
-*{{cite journal  | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551-3 |year= 1992 |pmid= 1358459 |doi=  }}
+* {{cite journal | vauthors = Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E | title = The human HOX gene family | journal = Nucleic Acids Research | volume = 17 | issue = 24 | pages = 10385–402 | date = Dec 1989 | pmid = 2574852 | pmc = 335308 | doi = 10.1093/nar/17.24.10385 }}
-*{{cite journal  | author=Lowney P, Corral J, Detmer K, ''et al.'' |title=A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells. |journal=Nucleic Acids Res. |volume=19 |issue= 12 |pages= 3443-9 |year= 1991 |pmid= 1676505 |doi=  }}
+* {{cite journal | vauthors = Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK | title = Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 25 | pages = 12223–7 | date = Dec 1994 | pmid = 7527557 | pmc = 45409 | doi = 10.1073/pnas.91.25.12223 }}
-*{{cite journal  | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=  }}
+* {{cite journal | vauthors = Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C | title = Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells | journal = Experimental Hematology | volume = 23 | issue = 11 | pages = 1160–6 | date = Oct 1995 | pmid = 7556525 | doi =  }}
-*{{cite journal  | author=Shen WF, Largman C, Lowney P, ''et al.'' |title=Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 21 |pages= 8536-40 |year= 1989 |pmid= 2573064 |doi=  }}
+* {{cite journal | vauthors = Satokata I, Benson G, Maas R | title = Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice | journal = Nature | volume = 374 | issue = 6521 | pages = 460–3 | date = Mar 1995 | pmid = 7700356 | doi = 10.1038/374460a0 }}
-*{{cite journal  | author=Acampora D, D'Esposito M, Faiella A, ''et al.'' |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385-402 |year= 1990 |pmid= 2574852 |doi=  }}
+* {{cite journal | vauthors = Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M | title = Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype | journal = Biochemical Pharmacology | volume = 47 | issue = 1 | pages = 137–43 | date = Jan 1994 | pmid = 7906121 | doi = 10.1016/0006-2952(94)90447-2 }}
-*{{cite journal  | author=Sauvageau G, Lansdorp PM, Eaves CJ, ''et al.'' |title=Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 25 |pages= 12223-7 |year= 1995 |pmid= 7527557 |doi=  }}
+* {{cite journal | vauthors = Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B | title = Fine mapping of human HOX gene clusters | journal = Cytogenetics and Cell Genetics | volume = 73 | issue = 1-2 | pages = 114–5 | year = 1996 | pmid = 8646877 | doi = 10.1159/000134320 }}
-*{{cite journal  | author=Lawrence HJ, Sauvageau G, Ahmadi N, ''et al.'' |title=Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. |journal=Exp. Hematol. |volume=23 |issue= 11 |pages= 1160-6 |year= 1995 |pmid= 7556525 |doi=  }}
+* {{cite journal | vauthors = Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK | title = Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia | journal = Molecular and Cellular Biology | volume = 17 | issue = 1 | pages = 495–505 | date = Jan 1997 | pmid = 8972230 | pmc = 231774 | doi =  10.1128/mcb.17.1.495}}
-*{{cite journal  | author=Satokata I, Benson G, Maas R |title=Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. |journal=Nature |volume=374 |issue= 6521 |pages= 460-3 |year= 1995 |pmid= 7700356 |doi= 10.1038/374460a0 }}
+* {{cite journal | vauthors = Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C | title = AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins | journal = Molecular and Cellular Biology | volume = 17 | issue = 11 | pages = 6448–58 | date = Nov 1997 | pmid = 9343407 | pmc = 232497 | doi =  }}
-*{{cite journal  | author=Castronovo V, Kusaka M, Chariot A, ''et al.'' |title=Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. |journal=Biochem. Pharmacol. |volume=47 |issue= 1 |pages= 137-43 |year= 1994 |pmid= 7906121 |doi=  }}
+* {{cite journal | vauthors = Taylor HS, Vanden Heuvel GB, Igarashi P | title = A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes | journal = Biology of Reproduction | volume = 57 | issue = 6 | pages = 1338–45 | date = Dec 1997 | pmid = 9408238 | doi = 10.1095/biolreprod57.6.1338 }}
-*{{cite journal  | author=Apiou F, Flagiello D, Cillo C, ''et al.'' |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114-5 |year= 1996 |pmid= 8646877 |doi=  }}
+* {{cite journal | vauthors = Taylor HS, Arici A, Olive D, Igarashi P | title = HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium | journal = The Journal of Clinical Investigation | volume = 101 | issue = 7 | pages = 1379–84 | date = Apr 1998 | pmid = 9525980 | pmc = 508715 | doi = 10.1172/JCI1057 }}
-*{{cite journal  | author=Thorsteinsdottir U, Sauvageau G, Hough MR, ''et al.'' |title=Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. |journal=Mol. Cell. Biol. |volume=17 |issue= 1 |pages= 495-505 |year= 1997 |pmid= 8972230 |doi=  }}
+* {{cite journal | vauthors = Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE | title = Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells | journal = Leukemia | volume = 13 | issue = 5 | pages = 687–98 | date = May 1999 | pmid = 10374871 | doi = 10.1038/sj/leu/2401410 }}
-*{{cite journal  | author=Shen WF, Montgomery JC, Rozenfeld S, ''et al.'' |title=AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 11 |pages= 6448-58 |year= 1997 |pmid= 9343407 |doi=  }}
+* {{cite journal | vauthors = Eklund EA, Jalava A, Kakar R | title = Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines | journal = The Journal of Biological Chemistry | volume = 275 | issue = 26 | pages = 20117–26 | date = Jun 2000 | pmid = 10766757 | doi = 10.1074/jbc.M907915199 }}
-*{{cite journal  | author=Taylor HS, Vanden Heuvel GB, Igarashi P |title=A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. |journal=Biol. Reprod. |volume=57 |issue= 6 |pages= 1338-45 |year= 1998 |pmid= 9408238 |doi=  }}
+* {{cite journal | vauthors = Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, Humphries RK | title = Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo | journal = Blood | volume = 97 | issue = 8 | pages = 2286–92 | date = Apr 2001 | pmid = 11290589 | doi = 10.1182/blood.V97.8.2286 }}
-*{{cite journal  | author=Taylor HS, Arici A, Olive D, Igarashi P |title=HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. |journal=J. Clin. Invest. |volume=101 |issue= 7 |pages= 1379-84 |year= 1998 |pmid= 9525980 |doi=  }}
+* {{cite journal | vauthors = Cermik D, Karaca M, Taylor HS | title = HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 86 | issue = 7 | pages = 3387–92 | date = Jul 2001 | pmid = 11443215 | doi = 10.1210/jc.86.7.3387 }}
-*{{cite journal  | author=Kawagoe H, Humphries RK, Blair A, ''et al.'' |title=Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. |journal=Leukemia |volume=13 |issue= 5 |pages= 687-98 |year= 1999 |pmid= 10374871 |doi=  }}
+* {{cite journal | vauthors = Shen WF, Krishnan K, Lawrence HJ, Largman C | title = The HOX homeodomain proteins block CBP histone acetyltransferase activity | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7509–22 | date = Nov 2001 | pmid = 11585930 | pmc = 99922 | doi = 10.1128/MCB.21.21.7509-7522.2001 }}
-*{{cite journal  | author=Eklund EA, Jalava A, Kakar R |title=Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 20117-26 |year= 2000 |pmid= 10766757 |doi= 10.1074/jbc.M907915199 }}
-*{{cite journal  | author=Buske C, Feuring-Buske M, Antonchuk J, ''et al.'' |title=Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. |journal=Blood |volume=97 |issue= 8 |pages= 2286-92 |year= 2001 |pmid= 11290589 |doi=  }}
-*{{cite journal  | author=Cermik D, Karaca M, Taylor HS |title=HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 7 |pages= 3387-92 |year= 2001 |pmid= 11443215 |doi=  }}
-*{{cite journal  | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509-22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001 }}
-}}
 {{refend}}
@@ Line 92: / Line 42: @@
 {{NLM content}}
-{{protein-stub}}
-{{Transcription factors}}
+{{Transcription factors|g3}}
 [[Category:Transcription factors]]
-{{WikiDoc Sources}}
+{{gene-7-stub}}

Homeobox A10: Difference between revisions

Revision as of 01:42, 27 October 2017

Contents

Function

Interactions

See also

References

Further reading

External links

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