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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger protein Helios''' is a [[protein]] that in humans is encoded by the ''IKZF2'' [[gene]].<ref name="pmid9512513">{{cite journal | vauthors = Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST | title = Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin | journal = Genes & Development | volume = 12 | issue = 6 | pages = 782–96 | date = Mar 1998 | pmid = 9512513 | pmc = 316626 | doi = 10.1101/gad.12.6.782 }}</ref><ref name="pmid9560339">{{cite journal | vauthors = Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA | title = Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors | journal = Current Biology | volume = 8 | issue = 9 | pages = 508–15 | date = Apr 1998 | pmid = 9560339 | pmc =  | doi = 10.1016/S0960-9822(98)70202-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22807| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = IKAROS family zinc finger 2 (Helios)
| HGNCid = 13177
| Symbol = IKZF2
| AltSymbols =; HELIOS; MGC34330; ZNF1A2; ZNFN1A2
| OMIM = 606234
| ECnumber =
| Homologene = 22659
| MGIid = 1342541
| GeneAtlas_image1 = PBB_GE_IKZF2_220567_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22807
    | Hs_Ensembl = ENSG00000030419
    | Hs_RefseqProtein = NP_001072994
    | Hs_RefseqmRNA = NM_001079526
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 213579589
    | Hs_GenLoc_end = 213724578
    | Hs_Uniprot = Q9UKS7
    | Mm_EntrezGene = 22779
    | Mm_Ensembl = ENSMUSG00000025997
    | Mm_RefseqmRNA = NM_011770
    | Mm_RefseqProtein = NP_035900
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 69470598
    | Mm_GenLoc_end = 69620348
    | Mm_Uniprot = Q8C8A3
  }}
}}
'''IKAROS family zinc finger 2 (Helios)''', also known as '''IKZF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22807| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22807| accessdate = }}</ref>
}}


==References==
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22807| accessdate = }}</ref>
{{reflist|2}}


==Further reading==
== References ==
{{reflist}}
{{clear}}
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rebollo A, Schmitt C | title = Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies | journal = Immunology and Cell Biology | volume = 81 | issue = 3 | pages = 171–5 | date = Jun 2003 | pmid = 12752680 | doi = 10.1046/j.1440-1711.2003.01159.x }}
| citations =
* {{cite journal | vauthors = Sridharan R, Smale ST | title = Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes | journal = The Journal of Biological Chemistry | volume = 282 | issue = 41 | pages = 30227–38 | date = Oct 2007 | pmid = 17681952 | doi = 10.1074/jbc.M702541200 }}
*{{cite journal | author=Rebollo A, Schmitt C |title=Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies. |journal=Immunol. Cell Biol. |volume=81 |issue= 3 |pages= 171-5 |year= 2004 |pmid= 12752680 |doi= }}
* {{cite journal | vauthors = Tabayashi T, Ishimaru F, Takata M, Kataoka I, Nakase K, Kozuka T, Tanimoto M | title = Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies | journal = Cancer Science | volume = 98 | issue = 2 | pages = 182–8 | date = Feb 2007 | pmid = 17297655 | doi = 10.1111/j.1349-7006.2006.00372.x }}
*{{cite journal | author=Sridharan R, Smale ST |title=Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes. |journal=J. Biol. Chem. |volume=282 |issue= 41 |pages= 30227-38 |year= 2007 |pmid= 17681952 |doi= 10.1074/jbc.M702541200 }}
* {{cite journal | vauthors = Sun L, Kerawalla H, Wu X, Lehnert MS, Uckun FM | title = Expression of a unique helios isoform in human leukemia cells | journal = Leukemia & Lymphoma | volume = 43 | issue = 4 | pages = 841–9 | date = Apr 2002 | pmid = 12153174 | doi = 10.1080/10428190290016980 }}
*{{cite journal | author=Tabayashi T, Ishimaru F, Takata M, ''et al.'' |title=Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies. |journal=Cancer Sci. |volume=98 |issue= 2 |pages= 182-8 |year= 2007 |pmid= 17297655 |doi=  }}
* {{cite journal | vauthors = Durand C, Kerfourn F, Charlemagne J, Fellah JS | title = Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors | journal = European Journal of Immunology | volume = 32 | issue = 6 | pages = 1748–52 | date = Jun 2002 | pmid = 12115658 | doi = 10.1002/1521-4141(200206)32:6<1748::AID-IMMU1748>3.0.CO;2-B }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Nakase K, Ishimaru F, Fujii K, Tabayashi T, Kozuka T, Sezaki N, Matsuo Y, Harada M | title = Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia | journal = Experimental Hematology | volume = 30 | issue = 4 | pages = 313–7 | date = Apr 2002 | pmid = 11937265 | doi = 10.1016/S0301-472X(01)00796-2 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Perdomo J, Holmes M, Chong B, Crossley M | title = Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities | journal = The Journal of Biological Chemistry | volume = 275 | issue = 49 | pages = 38347–54 | date = Dec 2000 | pmid = 10978333 | doi = 10.1074/jbc.M005457200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Hosokawa Y, Maeda Y, Seto M | title = Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern | journal = Immunogenetics | volume = 50 | issue = 1-2 | pages = 106–8 | date = Oct 1999 | pmid = 10541817 | doi = 10.1007/s002510050696 }}
*{{cite journal | author=Sun L, Kerawalla H, Wu X, ''et al.'' |title=Expression of a unique helios isoform in human leukemia cells. |journal=Leuk. Lymphoma |volume=43 |issue= 4 |pages= 841-9 |year= 2002 |pmid= 12153174 |doi= }}
*{{cite journal | author=Durand C, Kerfourn F, Charlemagne J, Fellah JS |title=Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors. |journal=Eur. J. Immunol. |volume=32 |issue= 6 |pages= 1748-52 |year= 2002 |pmid= 12115658 |doi= 10.1002/1521-4141(200206)32:6<1748::AID-IMMU1748>3.0.CO;2-B }}
*{{cite journal | author=Nakase K, Ishimaru F, Fujii K, ''et al.'' |title=Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia. |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 313-7 |year= 2002 |pmid= 11937265 |doi= }}
*{{cite journal | author=Perdomo J, Holmes M, Chong B, Crossley M |title=Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38347-54 |year= 2001 |pmid= 10978333 |doi= 10.1074/jbc.M005457200 }}
*{{cite journal | author=Hosokawa Y, Maeda Y, Seto M |title=Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern. |journal=Immunogenetics |volume=50 |issue= 1-2 |pages= 106-8 |year= 1999 |pmid= 10541817 |doi= }}
*{{cite journal  | author=Kelley CM, Ikeda T, Koipally J, ''et al.'' |title=Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors. |journal=Curr. Biol. |volume=8 |issue= 9 |pages= 508-15 |year= 1998 |pmid= 9560339 |doi=  }}
*{{cite journal  | author=Hahm K, Cobb BS, McCarty AS, ''et al.'' |title=Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. |journal=Genes Dev. |volume=12 |issue= 6 |pages= 782-96 |year= 1998 |pmid= 9512513 |doi=  }}
}}
{{refend}}
{{refend}}


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* {{MeshName|IKZF2+protein,+human}}
* {{MeshName|IKZF2+protein,+human}}


 
{{gene-2-stub}}
{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
{{Transcription factors|g2}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Revision as of 03:11, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene.[1][2][3]

Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]

References

  1. ↑ Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST (Mar 1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes & Development. 12 (6): 782–96. doi:10.1101/gad.12.6.782. PMC 316626. PMID 9512513.
  2. ↑ Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (Apr 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Current Biology. 8 (9): 508–15. doi:10.1016/S0960-9822(98)70202-7. PMID 9560339.
  3. ↑ 3.0 3.1 "Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)".

Further reading

  • Rebollo A, Schmitt C (Jun 2003). "Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies". Immunology and Cell Biology. 81 (3): 171–5. doi:10.1046/j.1440-1711.2003.01159.x. PMID 12752680.
  • Sridharan R, Smale ST (Oct 2007). "Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes". The Journal of Biological Chemistry. 282 (41): 30227–38. doi:10.1074/jbc.M702541200. PMID 17681952.
  • Tabayashi T, Ishimaru F, Takata M, Kataoka I, Nakase K, Kozuka T, Tanimoto M (Feb 2007). "Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies". Cancer Science. 98 (2): 182–8. doi:10.1111/j.1349-7006.2006.00372.x. PMID 17297655.
  • Sun L, Kerawalla H, Wu X, Lehnert MS, Uckun FM (Apr 2002). "Expression of a unique helios isoform in human leukemia cells". Leukemia & Lymphoma. 43 (4): 841–9. doi:10.1080/10428190290016980. PMID 12153174.
  • Durand C, Kerfourn F, Charlemagne J, Fellah JS (Jun 2002). "Identification and expression of Helios, a member of the Ikaros family, in the Mexican axolotl: implications for the embryonic origin of lymphocyte progenitors". European Journal of Immunology. 32 (6): 1748–52. doi:10.1002/1521-4141(200206)32:6<1748::AID-IMMU1748>3.0.CO;2-B. PMID 12115658.
  • Nakase K, Ishimaru F, Fujii K, Tabayashi T, Kozuka T, Sezaki N, Matsuo Y, Harada M (Apr 2002). "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia". Experimental Hematology. 30 (4): 313–7. doi:10.1016/S0301-472X(01)00796-2. PMID 11937265.
  • Perdomo J, Holmes M, Chong B, Crossley M (Dec 2000). "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". The Journal of Biological Chemistry. 275 (49): 38347–54. doi:10.1074/jbc.M005457200. PMID 10978333.
  • Hosokawa Y, Maeda Y, Seto M (Oct 1999). "Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern". Immunogenetics. 50 (1–2): 106–8. doi:10.1007/s002510050696. PMID 10541817.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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