ILF2: Difference between revisions

Jump to navigation Jump to search
Newer edit →
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Interleukin enhancer-binding factor 2''' is a [[protein]] that in humans is encoded by the ''ILF2'' [[gene]].<ref name="pmid7519613">{{cite journal | vauthors = Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B | title = Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90 | journal = The Journal of Biological Chemistry | volume = 269 | issue = 32 | pages = 20691–9 | date = Aug 1994 | pmid = 7519613 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3608| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interleukin enhancer binding factor 2, 45kDa
| HGNCid = 6037
| Symbol = ILF2
| AltSymbols =; MGC8391; NF45; PRO3063
| OMIM = 603181
| ECnumber = 
| Homologene = 26894
| MGIid = 1915031
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003725 |text = double-stranded RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3608
    | Hs_Ensembl = ENSG00000143621
    | Hs_RefseqProtein = NP_004506
    | Hs_RefseqmRNA = NM_004515
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 151900905
    | Hs_GenLoc_end = 151910148
    | Hs_Uniprot = Q12905
    | Mm_EntrezGene = 67781
    | Mm_Ensembl = ENSMUSG00000001016
    | Mm_RefseqmRNA = NM_026374
    | Mm_RefseqProtein = NP_080650
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 90562128
    | Mm_GenLoc_end = 90574306
    | Mm_Uniprot = Q3UXI9
  }}
}}
'''Interleukin enhancer binding factor 2, 45kDa''', also known as '''ILF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3608| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.<ref name="entrez">{{cite web | title = Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3608| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ILF2 has been shown to [[Protein-protein interaction|interact]] with [[CDC5L]]<ref name=pmid11101529>{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}</ref> and [[DNA-PKcs]].<ref name=pmid9442054>{{cite journal | vauthors = Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP | title = DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 2136–45 | date = Jan 1998 | pmid = 9442054 | doi = 10.1074/jbc.273.4.2136 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Marcoulatos P, Koussidis G, Mamuris Z, Velissariou V, Vamvakopoulos NC | title = Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates | journal = Journal of Interferon & Cytokine Research | volume = 16 | issue = 12 | pages = 1035–8 | date = Dec 1996 | pmid = 8974006 | doi = 10.1089/jir.1996.16.1035 }}
*{{cite journal | author=Kao PN, Chen L, Brock G, ''et al.'' |title=Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. |journal=J. Biol. Chem. |volume=269 |issue= 32 |pages= 20691-9 |year= 1994 |pmid= 7519613 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP | title = DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 4 | pages = 2136–45 | date = Jan 1998 | pmid = 9442054 | doi = 10.1074/jbc.273.4.2136 }}
*{{cite journal | author=Marcoulatos P, Koussidis G, Mamuris Z, ''et al.'' |title=Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates. |journal=J. Interferon Cytokine Res. |volume=16 |issue= 12 |pages= 1035-8 |year= 1997 |pmid= 8974006 |doi= }}
* {{cite journal | vauthors = Langland JO, Kao PN, Jacobs BL | title = Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR | journal = Biochemistry | volume = 38 | issue = 19 | pages = 6361–8 | date = May 1999 | pmid = 10320367 | doi = 10.1021/bi982410u }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH | title = Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity | journal = The Journal of Biological Chemistry | volume = 274 | issue = 49 | pages = 34598–604 | date = Dec 1999 | pmid = 10574923 | doi = 10.1074/jbc.274.49.34598 }}
*{{cite journal | author=Ting NS, Kao PN, Chan DW, ''et al.'' |title=DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2136-45 |year= 1998 |pmid= 9442054 |doi= }}
* {{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6569–81 | date = Dec 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}
*{{cite journal | author=Langland JO, Kao PN, Jacobs BL |title=Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR. |journal=Biochemistry |volume=38 |issue= 19 |pages= 6361-8 |year= 1999 |pmid= 10320367 |doi= 10.1021/bi982410u }}
* {{cite journal | vauthors = Parker LM, Fierro-Monti I, Mathews MB | title = Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 32522–30 | date = Aug 2001 | pmid = 11438540 | doi = 10.1074/jbc.M104408200 }}
*{{cite journal | author=Satoh M, Shaheen VM, Kao PN, ''et al.'' |title=Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity. |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 34598-604 |year= 2000 |pmid= 10574923 |doi= }}
* {{cite journal | vauthors = Reichman TW, Muñiz LC, Mathews MB | title = The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells | journal = Molecular and Cellular Biology | volume = 22 | issue = 1 | pages = 343–56 | date = Jan 2002 | pmid = 11739746 | pmc = 134226 | doi = 10.1128/MCB.22.1.343-356.2002 }}
*{{cite journal | author=Ajuh P, Kuster B, Panov K, ''et al.'' |title=Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6569-81 |year= 2001 |pmid= 11101529 |doi= 10.1093/emboj/19.23.6569 }}
* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Parker LM, Fierro-Monti I, Mathews MB |title=Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32522-30 |year= 2001 |pmid= 11438540 |doi= 10.1074/jbc.M104408200 }}
* {{cite journal | vauthors = Shin HJ, Kim SS, Cho YH, Lee SG, Rho HM | title = Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA | journal = Archives of Virology | volume = 147 | issue = 3 | pages = 471–91 | date = Mar 2002 | pmid = 11958450 | doi = 10.1007/s007050200001 }}
*{{cite journal | author=Reichman TW, Muñiz LC, Mathews MB |title=The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 1 |pages= 343-56 |year= 2002 |pmid= 11739746 |doi= }}
* {{cite journal | vauthors = Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ | title = Functional proteomic analysis of human nucleolus | journal = Molecular Biology of the Cell | volume = 13 | issue = 11 | pages = 4100–9 | date = Nov 2002 | pmid = 12429849 | pmc = 133617 | doi = 10.1091/mbc.E02-05-0271 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi= }}
* {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of alternative splicing by SRrp86 and its interacting proteins | journal = Molecular and Cellular Biology | volume = 23 | issue = 21 | pages = 7437–47 | date = Nov 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }}
*{{cite journal | author=Shin HJ, Kim SS, Cho YH, ''et al.'' |title=Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA. |journal=Arch. Virol. |volume=147 |issue= 3 |pages= 471-91 |year= 2002 |pmid= 11958450 |doi= }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = Jan 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal | author=Scherl A, Couté Y, Déon C, ''et al.'' |title=Functional proteomic analysis of human nucleolus. |journal=Mol. Biol. Cell |volume=13 |issue= 11 |pages= 4100-9 |year= 2003 |pmid= 12429849 |doi= 10.1091/mbc.E02-05-0271 }}
* {{cite journal | vauthors = Zhao G, Shi L, Qiu D, Hu H, Kao PN | title = NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function | journal = Experimental Cell Research | volume = 305 | issue = 2 | pages = 312–23 | date = May 2005 | pmid = 15817156 | doi = 10.1016/j.yexcr.2004.12.030 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Nie Y, Ding L, Kao PN, Braun R, Yang JH | title = ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing | journal = Molecular and Cellular Biology | volume = 25 | issue = 16 | pages = 6956–63 | date = Aug 2005 | pmid = 16055709 | pmc = 1190226 | doi = 10.1128/MCB.25.16.6956-6963.2005 }}
*{{cite journal | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi= }}
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | author=Zhao G, Shi L, Qiu D, ''et al.'' |title=NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function. |journal=Exp. Cell Res. |volume=305 |issue= 2 |pages= 312-23 |year= 2005 |pmid= 15817156 |doi= 10.1016/j.yexcr.2004.12.030 }}
*{{cite journal  | author=Nie Y, Ding L, Kao PN, ''et al.'' |title=ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. |journal=Mol. Cell. Biol. |volume=25 |issue= 16 |pages= 6956-63 |year= 2005 |pmid= 16055709 |doi= 10.1128/MCB.25.16.6956-6963.2005 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ILF2+protein,+human}}
* {{MeshName|ILF2+protein,+human}}
{{NLM content}}
{{Transcription factors|g2}}




{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-1-stub}}

Revision as of 16:04, 8 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[1][2]

Function

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[2]

Interactions

ILF2 has been shown to interact with CDC5L[3] and DNA-PKcs.[4]

References

  1. ↑ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (Aug 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry. 269 (32): 20691–9. PMID 7519613.
  2. ↑ 2.0 2.1 "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".
  3. ↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
  4. ↑ Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (Jan 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry. 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=ILF2&oldid=1410902"