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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Inhibitor of growth protein 2''' is a [[protein]] that in humans is encoded by the ''ING2'' [[gene]].<ref name="pmid10072587">{{cite journal | vauthors = Shimada Y, Saito A, Suzuki M, Takahashi E, Horie M | title = Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor | journal = Cytogenetics and Cell Genetics | volume = 83 | issue = 3-4 | pages = 232–5 | date = Mar 1999 | pmid = 10072587 | pmc =  | doi = 10.1159/000015188 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ING2 inhibitor of growth family, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3622| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_ING2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wes.
| PDB = {{PDB2|1wes}}, {{PDB2|2g6q}}
| Name = Inhibitor of growth family, member 2
| HGNCid = 6063
| Symbol = ING2
| AltSymbols =; ING1L; p33ING2
| OMIM = 604215
| ECnumber = 
| Homologene = 20388
| MGIid = 1916510
| GeneAtlas_image1 = PBB_GE_ING2_205981_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0016602 |text = CCAAT-binding factor complex}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3622
    | Hs_Ensembl = ENSG00000168556
    | Hs_RefseqProtein = NP_001555
    | Hs_RefseqmRNA = NM_001564
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 184663214
    | Hs_GenLoc_end = 184669243
    | Hs_Uniprot = Q9H160
    | Mm_EntrezGene = 69260
    | Mm_Ensembl = ENSMUSG00000063049
    | Mm_RefseqmRNA = XM_992381
    | Mm_RefseqProtein = XP_997475
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 49165995
    | Mm_GenLoc_end = 49173975
    | Mm_Uniprot = Q4VAD7
  }}
}}
'''Inhibitor of growth family, member 2''', also known as '''ING2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ING2 inhibitor of growth family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3622| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
| section_title =  
| summary_text = This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: ING2 inhibitor of growth family, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3622| accessdate = }}</ref>
}}


==References==
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.<ref name="entrez" />
{{reflist|2}}


==Further reading==
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
| citations =
* {{cite journal | vauthors = Nagashima M, Shiseki M, Miura K, Hagiwara K, Linke SP, Pedeux R, Wang XW, Yokota J, Riabowol K, Harris CC | title = DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 17 | pages = 9671–6 | date = Aug 2001 | pmid = 11481424 | pmc = 55510 | doi = 10.1073/pnas.161151798 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D | title = Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) | journal = Molecular and Cellular Biology | volume = 22 | issue = 3 | pages = 835–48 | date = Feb 2002 | pmid = 11784859 | pmc = 133546 | doi = 10.1128/MCB.22.3.835-848.2002 }}
*{{cite journal  | author=Shimada Y, Saito A, Suzuki M, ''et al.'' |title=Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 232-5 |year= 1999 |pmid= 10072587 |doi=  }}
* {{cite journal | vauthors = Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J | title = The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor | journal = Cell | volume = 114 | issue = 1 | pages = 99–111 | date = Jul 2003 | pmid = 12859901 | doi = 10.1016/S0092-8674(03)00480-X }}
*{{cite journal | author=Nagashima M, Shiseki M, Miura K, ''et al.'' |title=DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 17 |pages= 9671-6 |year= 2001 |pmid= 11481424 |doi= 10.1073/pnas.161151798 }}
* {{cite journal | vauthors = Sironi E, Cerri A, Tomasini D, Sirchia SM, Porta G, Rossella F, Grati FR, Simoni G | title = Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes | journal = Journal of Cutaneous Pathology | volume = 31 | issue = 4 | pages = 318–22 | date = Apr 2004 | pmid = 15005689 | doi = 10.1111/j.0303-6987.2004.0187.x }}
*{{cite journal | author=Kuzmichev A, Zhang Y, Erdjument-Bromage H, ''et al.'' |title=Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1). |journal=Mol. Cell. Biol. |volume=22 |issue= 3 |pages= 835-48 |year= 2002 |pmid= 11784859 |doi= }}
* {{cite journal | vauthors = Chattopadhyay C, Hawke D, Kobayashi R, Maity SN | title = Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro | journal = Nucleic Acids Research | volume = 32 | issue = 12 | pages = 3632–41 | year = 2004 | pmid = 15243141 | pmc = 484179 | doi = 10.1093/nar/gkh692 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = He GH, Helbing CC, Wagner MJ, Sensen CW, Riabowol K | title = Phylogenetic analysis of the ING family of PHD finger proteins | journal = Molecular Biology and Evolution | volume = 22 | issue = 1 | pages = 104–16 | date = Jan 2005 | pmid = 15356280 | doi = 10.1093/molbev/msh256 }}
*{{cite journal | author=Gozani O, Karuman P, Jones DR, ''et al.'' |title=The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. |journal=Cell |volume=114 |issue= 1 |pages= 99-111 |year= 2003 |pmid= 12859901 |doi= }}
* {{cite journal | vauthors = Chin MY, Ng KC, Li G | title = The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells | journal = Experimental Cell Research | volume = 304 | issue = 2 | pages = 531–43 | date = Apr 2005 | pmid = 15748897 | doi = 10.1016/j.yexcr.2004.11.023 }}
*{{cite journal | author=Sironi E, Cerri A, Tomasini D, ''et al.'' |title=Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes. |journal=J. Cutan. Pathol. |volume=31 |issue= 4 |pages= 318-22 |year= 2004 |pmid= 15005689 |doi= }}
* {{cite journal | vauthors = Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL | title = High-throughput mapping of a dynamic signaling network in mammalian cells | journal = Science | volume = 307 | issue = 5715 | pages = 1621–5 | date = Mar 2005 | pmid = 15761153 | doi = 10.1126/science.1105776 }}
*{{cite journal | author=Chattopadhyay C, Hawke D, Kobayashi R, Maity SN |title=Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. |journal=Nucleic Acids Res. |volume=32 |issue= 12 |pages= 3632-41 |year= 2004 |pmid= 15243141 |doi= 10.1093/nar/gkh692 }}
* {{cite journal | vauthors = Pedeux R, Sengupta S, Shen JC, Demidov ON, Saito S, Onogi H, Kumamoto K, Wincovitch S, Garfield SH, McMenamin M, Nagashima M, Grossman SR, Appella E, Harris CC | title = ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation | journal = Molecular and Cellular Biology | volume = 25 | issue = 15 | pages = 6639–48 | date = Aug 2005 | pmid = 16024799 | pmc = 1190357 | doi = 10.1128/MCB.25.15.6639-6648.2005 }}
*{{cite journal | author=He GH, Helbing CC, Wagner MJ, ''et al.'' |title=Phylogenetic analysis of the ING family of PHD finger proteins. |journal=Mol. Biol. Evol. |volume=22 |issue= 1 |pages= 104-16 |year= 2005 |pmid= 15356280 |doi= 10.1093/molbev/msh256 }}
* {{cite journal | vauthors = Okano T, Gemma A, Hosoya Y, Hosomi Y, Nara M, Kokubo Y, Yoshimura A, Shibuya M, Nagashima M, Harris CC, Kudoh S | title = Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer | journal = Oncology Reports | volume = 15 | issue = 3 | pages = 545–9 | date = Mar 2006 | pmid = 16465410 | doi = 10.3892/or.15.3.545 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Wang J, Chin MY, Li G | title = The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation | journal = Cancer Research | volume = 66 | issue = 4 | pages = 1906–11 | date = Feb 2006 | pmid = 16488987 | doi = 10.1158/0008-5472.CAN-05-3444 }}
*{{cite journal  | author=Chin MY, Ng KC, Li G |title=The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells. |journal=Exp. Cell Res. |volume=304 |issue= 2 |pages= 531-43 |year= 2005 |pmid= 15748897 |doi= 10.1016/j.yexcr.2004.11.023 }}
* {{cite journal | vauthors = Lu F, Dai DL, Martinka M, Ho V, Li G | title = Nuclear ING2 expression is reduced in human cutaneous melanomas | journal = British Journal of Cancer | volume = 95 | issue = 1 | pages = 80–6 | date = Jul 2006 | pmid = 16755297 | pmc = 2360493 | doi = 10.1038/sj.bjc.6603205 }}
*{{cite journal | author=Barrios-Rodiles M, Brown KR, Ozdamar B, ''et al.'' |title=High-throughput mapping of a dynamic signaling network in mammalian cells. |journal=Science |volume=307 |issue= 5715 |pages= 1621-5 |year= 2005 |pmid= 15761153 |doi= 10.1126/science.1105776 }}
* {{cite journal | vauthors = Wang Y, Wang J, Li G | title = Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis | journal = FEBS Letters | volume = 580 | issue = 16 | pages = 3787–93 | date = Jul 2006 | pmid = 16782091 | doi = 10.1016/j.febslet.2006.05.065 }}
*{{cite journal | author=Pedeux R, Sengupta S, Shen JC, ''et al.'' |title=ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. |journal=Mol. Cell. Biol. |volume=25 |issue= 15 |pages= 6639-48 |year= 2005 |pmid= 16024799 |doi= 10.1128/MCB.25.15.6639-6648.2005 }}
* {{cite journal | vauthors = Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD | title = Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling | journal = Journal of the American Chemical Society | volume = 129 | issue = 20 | pages = 6498–506 | date = May 2007 | pmid = 17469822 | pmc = 2553394 | doi = 10.1021/ja070195b }}
*{{cite journal | author=Okano T, Gemma A, Hosoya Y, ''et al.'' |title=Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer. |journal=Oncol. Rep. |volume=15 |issue= 3 |pages= 545-9 |year= 2006 |pmid= 16465410 |doi= }}
*{{cite journal | author=Wang J, Chin MY, Li G |title=The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation. |journal=Cancer Res. |volume=66 |issue= 4 |pages= 1906-11 |year= 2006 |pmid= 16488987 |doi= 10.1158/0008-5472.CAN-05-3444 }}
*{{cite journal | author=Lu F, Dai DL, Martinka M, ''et al.'' |title=Nuclear ING2 expression is reduced in human cutaneous melanomas. |journal=Br. J. Cancer |volume=95 |issue= 1 |pages= 80-6 |year= 2006 |pmid= 16755297 |doi= 10.1038/sj.bjc.6603205 }}
*{{cite journal | author=Wang Y, Wang J, Li G |title=Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis. |journal=FEBS Lett. |volume=580 |issue= 16 |pages= 3787-93 |year= 2006 |pmid= 16782091 |doi= 10.1016/j.febslet.2006.05.065 }}
*{{cite journal | author=Huang W, Zhang H, Davrazou F, ''et al.'' |title=Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. |journal=J. Am. Chem. Soc. |volume=129 |issue= 20 |pages= 6498-506 |year= 2007 |pmid= 17469822 |doi= 10.1021/ja070195b }}
}}
{{refend}}
{{refend}}


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* {{MeshName|ING2+protein,+human}}
* {{MeshName|ING2+protein,+human}}


{{Transcription factors|g2}}
{{PDB Gallery|geneid=3622}}


{{protein-stub}}
{{gene-4-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription factors}}
 
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 23:52, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2 gene.[1][2]

Function

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.[2]

References

  1. ↑ Shimada Y, Saito A, Suzuki M, Takahashi E, Horie M (Mar 1999). "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor". Cytogenetics and Cell Genetics. 83 (3–4): 232–5. doi:10.1159/000015188. PMID 10072587.
  2. ↑ 2.0 2.1 "Entrez Gene: ING2 inhibitor of growth family, member 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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